CO5080762A1 - Antagonistas de receptor de vitronectina - Google Patents
Antagonistas de receptor de vitronectinaInfo
- Publication number
- CO5080762A1 CO5080762A1 CO99014712A CO99014712A CO5080762A1 CO 5080762 A1 CO5080762 A1 CO 5080762A1 CO 99014712 A CO99014712 A CO 99014712A CO 99014712 A CO99014712 A CO 99014712A CO 5080762 A1 CO5080762 A1 CO 5080762A1
- Authority
- CO
- Colombia
- Prior art keywords
- crg
- nrg
- alkyl
- mfi
- jpeg
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7761098P | 1998-03-10 | 1998-03-10 | |
US9606398P | 1998-08-11 | 1998-08-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5080762A1 true CO5080762A1 (es) | 2001-09-25 |
Family
ID=26759473
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO99014712A CO5080762A1 (es) | 1998-03-10 | 1999-03-10 | Antagonistas de receptor de vitronectina |
Country Status (24)
Country | Link |
---|---|
EP (1) | EP1061921A4 (fr) |
JP (1) | JP2002506033A (fr) |
KR (1) | KR20010041812A (fr) |
CN (1) | CN1299282A (fr) |
AP (1) | AP2000001898A0 (fr) |
AR (1) | AR015241A1 (fr) |
AU (1) | AU758498B2 (fr) |
BG (1) | BG104824A (fr) |
BR (1) | BR9908636A (fr) |
CA (1) | CA2323208A1 (fr) |
CO (1) | CO5080762A1 (fr) |
DZ (1) | DZ2741A1 (fr) |
EA (1) | EA200000921A1 (fr) |
HU (1) | HUP0101143A3 (fr) |
ID (1) | ID26223A (fr) |
IL (1) | IL138245A0 (fr) |
NO (1) | NO20004503L (fr) |
OA (1) | OA12189A (fr) |
PE (1) | PE20000323A1 (fr) |
PL (1) | PL342881A1 (fr) |
SK (1) | SK13292000A3 (fr) |
TR (1) | TR200002625T2 (fr) |
UY (2) | UY25421A1 (fr) |
WO (1) | WO1999045927A1 (fr) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19939981A1 (de) * | 1999-08-24 | 2001-03-01 | Merck Patent Gmbh | Neue Inhibitoren des Integrins alphavß3 |
DE19939980A1 (de) * | 1999-08-24 | 2001-03-01 | Merck Patent Gmbh | Inhibitoren des Integrins alphavbeta¶3¶ |
US6881736B1 (en) | 1999-09-07 | 2005-04-19 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
EG24179A (en) * | 1999-09-07 | 2008-09-28 | Smithkline Beecham Corp | Vitronectin receptor antagonists |
GB9930570D0 (en) * | 1999-12-23 | 2000-02-16 | Pfizer Ltd | Therapy |
US6448278B2 (en) | 1999-12-23 | 2002-09-10 | Pfizer Inc. | Procollagen C-proteinase inhibitors |
FR2808798A1 (fr) * | 2000-05-09 | 2001-11-16 | Hoechst Marion Roussel Inc | Nouveaux derives antagonistes du recepteur de la vitronectine |
PE20020665A1 (es) | 2000-06-15 | 2002-08-14 | Pharmacia Corp | ACIDO CICLOALQUIL FENIL ALCANOICO COMO ANTAGONISTA DE INTEGRINAS OVß3 |
US6531494B1 (en) | 2001-08-29 | 2003-03-11 | Pharmacia Corporation | Gem-substituted αvβ3 antagonists |
US6645993B2 (en) | 2001-03-30 | 2003-11-11 | Warner-Lambert Company | 3-heterocyclylpropanohydroxamic acid PCP inhibitors |
US6716842B2 (en) | 2002-04-05 | 2004-04-06 | Warner-Lambert Company, Llc | Antidiabetic agents |
WO2005049589A2 (fr) * | 2003-10-14 | 2005-06-02 | Cadila Healthcare Limited | Nouveaux composes heterocycliques |
EP1721905A4 (fr) * | 2004-03-05 | 2009-11-18 | Taisho Pharmaceutical Co Ltd | Derive de thiazole |
UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
MX2007013198A (es) | 2005-04-20 | 2008-03-24 | Johnson & Johnson | Moduladores de trombina de n-oxido de piridina fluorado y procedimiento para n-oxidacion de heteroarilos que contienen nitrogeno. |
AU2014312756B2 (en) * | 2013-08-29 | 2018-11-22 | Kyoto Pharmaceutical Industries, Ltd. | Novel aromatic compound and use thereof |
HUE063437T2 (hu) | 2013-09-24 | 2024-01-28 | Fujifilm Corp | Nitrogént tartalmazó vegyületet vagy sóját vagy fémkomplexét tartalmazó gyógyászati készítmény |
KR20160147007A (ko) | 2014-05-30 | 2016-12-21 | 화이자 인코포레이티드 | 선택적인 안드로겐 수용체 조절제로서의 카보니트릴 유도체 |
WO2023275715A1 (fr) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Métabolites de modulateurs sélectifs du récepteur des androgènes |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL327626A1 (en) * | 1995-12-29 | 1998-12-21 | Smithkline Beecham Corp | Antagonists of vitronectin receptor |
IL125034A0 (en) * | 1995-12-29 | 1999-01-26 | Smithkline Beecham Corp | Vitronectin receptor antagonists |
-
1999
- 1999-03-10 ID IDW20001737A patent/ID26223A/id unknown
- 1999-03-10 UY UY25421A patent/UY25421A1/es unknown
- 1999-03-10 KR KR1020007010091A patent/KR20010041812A/ko not_active Application Discontinuation
- 1999-03-10 AP APAP/P/2000/001898A patent/AP2000001898A0/en unknown
- 1999-03-10 DZ DZ990042A patent/DZ2741A1/fr active
- 1999-03-10 AU AU29033/99A patent/AU758498B2/en not_active Ceased
- 1999-03-10 PE PE1999000188A patent/PE20000323A1/es not_active Application Discontinuation
- 1999-03-10 BR BR9908636-0A patent/BR9908636A/pt not_active Application Discontinuation
- 1999-03-10 SK SK1329-2000A patent/SK13292000A3/sk unknown
- 1999-03-10 CN CN99805833A patent/CN1299282A/zh active Pending
- 1999-03-10 WO PCT/US1999/005232 patent/WO1999045927A1/fr not_active Application Discontinuation
- 1999-03-10 EP EP99909952A patent/EP1061921A4/fr not_active Withdrawn
- 1999-03-10 EA EA200000921A patent/EA200000921A1/ru unknown
- 1999-03-10 TR TR2000/02625T patent/TR200002625T2/xx unknown
- 1999-03-10 CO CO99014712A patent/CO5080762A1/es unknown
- 1999-03-10 PL PL99342881A patent/PL342881A1/xx unknown
- 1999-03-10 OA OA00000248A patent/OA12189A/en unknown
- 1999-03-10 CA CA002323208A patent/CA2323208A1/fr not_active Abandoned
- 1999-03-10 JP JP2000535342A patent/JP2002506033A/ja not_active Withdrawn
- 1999-03-10 HU HU0101143A patent/HUP0101143A3/hu unknown
- 1999-03-10 AR ARP990101019A patent/AR015241A1/es not_active Application Discontinuation
- 1999-03-10 IL IL13824599A patent/IL138245A0/xx unknown
- 1999-05-19 UY UY25519A patent/UY25519A1/es unknown
-
2000
- 2000-09-08 NO NO20004503A patent/NO20004503L/no unknown
- 2000-10-03 BG BG104824A patent/BG104824A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
TR200002625T2 (tr) | 2000-12-21 |
UY25519A1 (es) | 1999-12-13 |
EP1061921A1 (fr) | 2000-12-27 |
EA200000921A1 (ru) | 2001-04-23 |
HUP0101143A3 (en) | 2002-12-28 |
IL138245A0 (en) | 2001-10-31 |
NO20004503L (no) | 2000-10-10 |
ID26223A (id) | 2000-12-07 |
AP2000001898A0 (en) | 2000-09-30 |
CA2323208A1 (fr) | 1999-09-16 |
WO1999045927A1 (fr) | 1999-09-16 |
EP1061921A4 (fr) | 2005-03-30 |
OA12189A (en) | 2006-05-09 |
HUP0101143A2 (hu) | 2001-08-28 |
AU758498B2 (en) | 2003-03-20 |
AU2903399A (en) | 1999-09-27 |
UY25421A1 (es) | 2001-07-31 |
CN1299282A (zh) | 2001-06-13 |
SK13292000A3 (sk) | 2001-06-11 |
DZ2741A1 (fr) | 2003-09-08 |
JP2002506033A (ja) | 2002-02-26 |
AR015241A1 (es) | 2001-04-18 |
BR9908636A (pt) | 2002-01-08 |
PL342881A1 (en) | 2001-07-16 |
PE20000323A1 (es) | 2000-05-24 |
BG104824A (en) | 2001-05-31 |
NO20004503D0 (no) | 2000-09-08 |
KR20010041812A (ko) | 2001-05-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO5080762A1 (es) | Antagonistas de receptor de vitronectina | |
DE3781716D1 (de) | Mittel zur ortsspezifischen alkylierung. | |
CA2293247A1 (fr) | Composes 4-phenylpiperidine | |
PE2799A1 (es) | Lactamas e imidas heterociclicas de aralquilo y aralquilideno | |
CO5170512A1 (es) | Derivados de tetrahidroquinolin piperidina | |
DK1312359T3 (da) | Anvendelse af 1,3-propandiolforbindelser | |
DK0791006T3 (da) | Polyanioniske benzylglylcosider som inhibitorer af proliferation af glatte muskelceller | |
DK0918776T3 (da) | Totalsyntese af antitumor acylfulvener | |
DE60220890D1 (de) | Benzoäfüisoindolderivate mit affinität zum ep4-rezeptor | |
PL378201A1 (pl) | Sposób farmaceutyczny oraz związki wytwarzane tym sposobem | |
DE60324685D1 (de) | 2-(phenylthiomethyl)- morpholin-derivate zur verwendung als selektive norepinephrin-wiederaufnahme-inhibitoren | |
PT96421A (pt) | Processo para a preparacao de derivados de piperidina e de pirrolidina antagonistas de receptores muscarinicos | |
PT93687A (pt) | Processo para a preparacao de antagonistas de serotonina de tetra-hidrobenz,d}indole | |
NO990578D0 (no) | Diesel-brennstoff inneholdende oksygenerte forbindelser | |
KR920012004A (ko) | 광학 활성 1-아릴-알킬아민의 라세미화 방법 | |
FI890520A (fi) | Foerfarande foer framstaellning av terapeutiskt anvaendbara 2- (piperidin-4-ylmetyl) -1,2,3,4 -tetrahydroisokinolinderivat. | |
EA200200523A1 (ru) | Новые разветвленные замещенные аминопроизводные 3-амино-1-фенил-1h[1,2,4]триазола, способы их получения и содержащие их фармацевтические композиции | |
EA200500032A1 (ru) | Производные ацилоксипирролидина и их применение в качестве лигандов v1b или v1b и v1a рецепторов | |
CO5090902A1 (es) | Pirroles sustituidos | |
PT1023273E (pt) | Derivados ciclo-hexanicos difuncionalizados em 1,4 na qualidade de ligantes dos receptores 5-ht1a | |
KR920012100A (ko) | 비스포스폰산 유도체, 이의 제조 및 용도 | |
ATE238300T1 (de) | (3,4-dihydro-2h-benzo(1,4)oxazinyl-methyl)-3-(1 - indol-3-yl)-alkylamine | |
ES2128572T3 (es) | Utilizacion de los derivados de cefem como agentes antimetastaticos. | |
RU96115134A (ru) | Соединение 6-(2-имидазолиниламино)хинолина, пригодные в качестве агонистов альфа-2-адреноцепторов | |
DE69909460D1 (de) | Verfahren zur herstellung von arylsulfenylhalogeniden |