CO4990952A1 - Novedosos derivados de cromano sustituido con sulfonamida utiles como agonistas del adrenoreceptor beta 3 - Google Patents

Novedosos derivados de cromano sustituido con sulfonamida utiles como agonistas del adrenoreceptor beta 3

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Publication number
CO4990952A1
CO4990952A1 CO98067870A CO98067870A CO4990952A1 CO 4990952 A1 CO4990952 A1 CO 4990952A1 CO 98067870 A CO98067870 A CO 98067870A CO 98067870 A CO98067870 A CO 98067870A CO 4990952 A1 CO4990952 A1 CO 4990952A1
Authority
CO
Colombia
Prior art keywords
alkyl
cor2
phenyl
substituted
novelties
Prior art date
Application number
CO98067870A
Other languages
English (en)
Inventor
H Ladouceur Gaetan
Richard D Connell
Jeremy Baryza
Ann-Marie Campbell
Timothy G Lease
James H Cook
Original Assignee
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Corp filed Critical Bayer Corp
Publication of CO4990952A1 publication Critical patent/CO4990952A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

Un compuesto de la fórmula I: en la cual R es hidrógeno, hidroxi, oxo, halo, haloalquilo C1 -C10 , alquilo C1 -C10 , ciano, nitro, NR1 R1 , SR1 , OR1 , SO2 R2 , COR2 , NR1 COR2 , COR2 , NR1 SO2 R2 , NR1 CO2 R1 , Pirrol o Ar2 optativamente sustituido con hidroxi, halógeno, ciano, NR1 R1 , SR1 , trifluorometilo, OR1 , cicloalquilo C3 -C8 , fenilo, NR1 COR2 , COR2 , SO2 R2 , OCOR2 , NR1 SO2 R2 o NR1 CO2 R1 ;R1 es hidrógeno, alquilo C1 -C10 optativamente sustituido con 1 a 4 sustituyentes seleccionados entre hidroxi, halógeno, CO2 H, CO2 alquilo C1 -C10 , SO2 alquilo C1 -C10 , alcoxi C1 -C10 o cicloalquilo C3 -C8 , fenilo o naftilo, cada uno de los cuales está optativamente sustituido con 1 a 4 sustituyentes seleccionados halógeno, nitro, oxo, alquilo C1 -C10 , alcoxi C1 -C10 y alquiltio C1 -C10 ; R2 es R1 o NR1 R1 ,R3 es hidrógeno, alquilo C1 -C10 o HO½ R -- Ar1 -- CH2 -CH2 ;Ar1 es Ar1 -O-CH2 , fenilo o un anillo heterocíclico de 5 ó 6 miembros con 1 a 4 heteroátomos seleccionados entre O, S y N, estando cada porción optativamente fusionada a un anillo heterocíclico de 5 miembros que contiene de 1 a 4 heteroátomos seleccionados entre O, S y N, anillo heterocíclicofusionado que está optativamente fusionado a un anillo de fenilo o sustituido con oxo;m es 1, 2 ó 3;(CH2 )m puede ser optativamente reemplazado con C-O-(CH2 )m ;X es SO2 -piperazinilo, NR3 -SO2 o SO2 NR3 ; ...
CO98067870A 1997-12-19 1998-11-18 Novedosos derivados de cromano sustituido con sulfonamida utiles como agonistas del adrenoreceptor beta 3 CO4990952A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US99458597A 1997-12-19 1997-12-19

Publications (1)

Publication Number Publication Date
CO4990952A1 true CO4990952A1 (es) 2000-12-26

Family

ID=25540825

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98067870A CO4990952A1 (es) 1997-12-19 1998-11-18 Novedosos derivados de cromano sustituido con sulfonamida utiles como agonistas del adrenoreceptor beta 3

Country Status (12)

Country Link
EP (1) EP1054881B1 (es)
JP (1) JP2001526281A (es)
AR (1) AR016691A1 (es)
AT (1) ATE402933T1 (es)
AU (1) AU751015B2 (es)
CA (1) CA2314925A1 (es)
CO (1) CO4990952A1 (es)
DE (1) DE69839821D1 (es)
IL (1) IL136688A0 (es)
TW (1) TW502032B (es)
WO (1) WO1999032475A1 (es)
ZA (1) ZA9810489B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000256331A (ja) * 1999-01-08 2000-09-19 Nippon Bayer Agrochem Co Ltd テトラゾリノン誘導体および除草剤としてのその用途
ATE280167T1 (de) 1999-07-23 2004-11-15 Pfizer Prod Inc Zwischenprodukte und ein verfahren zur herstellung von beta3-adrenergischer rezeptor- agoniste
JP4988128B2 (ja) * 2000-07-13 2012-08-01 イーライ リリー アンド カンパニー β３アドレナリン作動性アゴニスト
CZ20013076A3 (cs) 2000-08-29 2002-04-17 Kuraray Co., Ltd. Způsob výroby chromankarboxylové kyseliny
BR0213094A (pt) 2001-10-04 2004-10-13 Wyeth Corp Derivados de cromano como ligandos de 5-hidroxi-triptamina-6
US7323462B2 (en) 2002-12-10 2008-01-29 Pfizer Inc. Morpholine dopamine agonists
US7034051B2 (en) 2003-08-28 2006-04-25 Adolor Corporation Fused bicyclic carboxamide derivatives and methods of their use
US20050222247A1 (en) * 2003-12-13 2005-10-06 Bayer Healthcare Ag Chroman derivatives
JPWO2011007819A1 (ja) 2009-07-17 2012-12-27 塩野義製薬株式会社 ラクタムまたはベンゼンスルホンアミド化合物を含有する医薬
EP2536693A4 (en) * 2010-02-17 2014-08-06 UNIVERSITé LAVAL SUBSTITUTED 2-IMIDAZOLIDONES AND THE LIKE
CN108218845B (zh) * 2016-12-21 2022-11-29 江苏柯菲平医药股份有限公司 一类色满-6-磺酰胺RORγ调节剂及其用途
CN112107583A (zh) * 2020-07-31 2020-12-22 东南大学 一种色满-6-磺酰胺RORγ调节剂的A晶型化合物的组合物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0091749A3 (en) * 1982-04-08 1984-12-05 Beecham Group Plc Ethanolamine derivatives, process for their preparation and pharmaceutical compositions containing them
US5451677A (en) * 1993-02-09 1995-09-19 Merck & Co., Inc. Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity
IL113410A (en) * 1994-04-26 1999-11-30 Merck & Co Inc Substituted sulfonamides having an asymmetric center and pharmaceutical compositions containing them
US5663194A (en) * 1995-07-25 1997-09-02 Mewshaw; Richard E. Chroman-2-ylmethylamino derivatives
FR2746395B1 (fr) * 1996-03-22 1998-04-17 Adir Nouveaux derives d'arylethanolamine et d'aryloxypropanolamine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP0801060A1 (en) * 1996-04-09 1997-10-15 Pfizer Inc. Heterocyclic Beta-3 Adrenergenic Agonists

Also Published As

Publication number Publication date
WO1999032475A1 (en) 1999-07-01
TW502032B (en) 2002-09-11
ATE402933T1 (de) 2008-08-15
CA2314925A1 (en) 1999-07-01
DE69839821D1 (de) 2008-09-11
ZA9810489B (en) 1999-05-20
AR016691A1 (es) 2001-07-25
JP2001526281A (ja) 2001-12-18
EP1054881B1 (en) 2008-07-30
IL136688A0 (en) 2001-06-14
EP1054881A1 (en) 2000-11-29
AU1418399A (en) 1999-07-12
AU751015B2 (en) 2002-08-08

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