CO4940482A1 - Composiciones farmaceuticas conteniendo 3-de-o-acylo lipido monofosforilo a y procedimiento de preparacion - Google Patents

Composiciones farmaceuticas conteniendo 3-de-o-acylo lipido monofosforilo a y procedimiento de preparacion

Info

Publication number
CO4940482A1
CO4940482A1 CO98018888A CO98018888A CO4940482A1 CO 4940482 A1 CO4940482 A1 CO 4940482A1 CO 98018888 A CO98018888 A CO 98018888A CO 98018888 A CO98018888 A CO 98018888A CO 4940482 A1 CO4940482 A1 CO 4940482A1
Authority
CO
Colombia
Prior art keywords
monofosforilo
lipido
acylo
pharmaceutical compositions
compositions containing
Prior art date
Application number
CO98018888A
Other languages
English (en)
Inventor
Terry Ulrich Jorj
Alan Worland Wheeler
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of CO4940482A1 publication Critical patent/CO4940482A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Una composición farmacéutica que comprende tirosina, un alergenoopcionalmente modificado, y lípido monofosforilo 3-de-O acilado A (3-DMPL). Un proceso para la preparación de una composición farmacéutica según la reivindicación 1 ó 2, el cual comprende (a) modificar (opcionalmente) un alergeno mediante reacción con un agente de enlazamiento cruzado, (b) mezclar una solución acuosa del alergeno opcionalmente modificado con una solución de tirosina en un ácido acuoso fuerte, (c) neutralizar la mezcla de soluciones precipitando de este modo la tirosina y el alergeno modificado (d) mezclar el producto con lípido monofosforilo 3-de-0 acilado A (3-DMPL), y (e) opcionalmente, agregar un vehículo fisiológicamente aceptable.
CO98018888A 1997-04-05 1998-04-03 Composiciones farmaceuticas conteniendo 3-de-o-acylo lipido monofosforilo a y procedimiento de preparacion CO4940482A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9706957.9A GB9706957D0 (en) 1997-04-05 1997-04-05 Formulation

Publications (1)

Publication Number Publication Date
CO4940482A1 true CO4940482A1 (es) 2000-07-24

Family

ID=10810358

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98018888A CO4940482A1 (es) 1997-04-05 1998-04-03 Composiciones farmaceuticas conteniendo 3-de-o-acylo lipido monofosforilo a y procedimiento de preparacion

Country Status (17)

Country Link
US (2) US7718178B2 (es)
EP (1) EP0975364B1 (es)
JP (1) JP4331798B2 (es)
KR (1) KR100549557B1 (es)
AR (1) AR011707A1 (es)
AT (1) ATE268607T1 (es)
AU (1) AU729631B2 (es)
CA (1) CA2285928C (es)
CO (1) CO4940482A1 (es)
DE (1) DE69824405T2 (es)
ES (1) ES2218819T3 (es)
GB (1) GB9706957D0 (es)
NZ (1) NZ337580A (es)
PT (1) PT975364E (es)
TW (1) TWI240628B (es)
WO (1) WO1998044947A1 (es)
ZA (1) ZA982851B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9706957D0 (en) * 1997-04-05 1997-05-21 Smithkline Beecham Plc Formulation
GB9820525D0 (en) * 1998-09-21 1998-11-11 Allergy Therapeutics Ltd Formulation
GB0000891D0 (en) 2000-01-14 2000-03-08 Allergy Therapeutics Ltd Formulation
CN1775701B (zh) * 2004-11-16 2010-05-26 鸿富锦精密工业（深圳）有限公司 具有超硬镀膜的模仁
GB201106802D0 (en) 2011-04-21 2011-06-01 Allergy Therapeutics Ltd Process for preparing vaccine composition

Family Cites Families (44)

* Cited by examiner, † Cited by third party
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US3541201A (en) 1968-12-18 1970-11-17 Ethan Alan Brown Novel sodium chloride encapsulated injectionable substances
GB1377074A (en) * 1971-07-13 1974-12-11 Beecham Group Ltd Process for preparing injectable compositions
GB1492973A (en) * 1974-02-16 1977-11-23 Beecham Group Ltd Process for preparing injectable compositions
US4070455A (en) 1974-02-16 1978-01-24 Beecham Group Limited Process for preparing injectable desensitizing compositions and products thereof in microparticle form
EP0182442B2 (en) 1978-12-22 1996-04-03 Biogen, Inc. Recombinant DNA molecules and their method of production
US4258029A (en) 1979-04-23 1981-03-24 Connaught Laboratories Limited Synthetic adjuvants for stimulation of antigenic responses
US4528029A (en) * 1980-07-21 1985-07-09 Board Of Control Of Michigan Technological University Self-reducing iron oxide agglomerates
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GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5244663A (en) 1987-01-28 1993-09-14 Medibrevex Therapeutic method against allergy
FR2621916B1 (fr) 1987-10-19 1990-03-09 Bioeurope Derives de la l-tyrosine solubles dans l'eau et procede pour leur preparation
US4912094B1 (en) * 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
GB9106048D0 (en) 1991-03-21 1991-05-08 Smithkline Beecham Biolog Vaccines
EP0640347A1 (en) 1992-03-03 1995-03-01 Daiichi Pharmaceutical Co., Ltd. Oral vaccine
ATE188613T1 (de) 1992-06-25 2000-01-15 Smithkline Beecham Biolog Adjuvantien enthaltende impfstoffzusammensetzung
HU219056B (hu) 1993-03-23 2001-02-28 Smithkline Beecham Biologicals Sa 3-O-Dezacilezett monofoszforil-lipid A-t tartalmazó vakcinakészítmény
US5723130A (en) 1993-05-25 1998-03-03 Hancock; Gerald E. Adjuvants for vaccines against respiratory syncytial virus
CA2167691A1 (en) 1993-08-27 1995-03-02 Martin J. Blaser Campylobacter jejuni antigens, and methods for their production and use
GB9326253D0 (en) 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
US5997873A (en) 1994-01-13 1999-12-07 Mount Sinai School Of Medicine Of The City University Of New York Method of preparation of heat shock protein 70-peptide complexes
US5646115A (en) 1994-10-07 1997-07-08 Heska Corporation Ectoparasite saliva proteins and apparatus to collect such proteins
AU4977896A (en) 1995-02-17 1996-09-04 Immunotherapy, Inc. Immunotherapy screening, prognosis, and treatment methods and compositions
GB9508785D0 (en) * 1995-04-29 1995-06-21 Smithkline Beecham Plc Novel compositions
US5762943A (en) 1996-05-14 1998-06-09 Ribi Immunochem Research, Inc. Methods of treating type I hypersensitivity using monophosphoryl lipid A
US5973128A (en) 1996-11-22 1999-10-26 The Hospital For Sick Children Research And Development Lp Glycolipid mimics and methods of use thereof
US6491919B2 (en) 1997-04-01 2002-12-10 Corixa Corporation Aqueous immunologic adjuvant compostions of monophosphoryl lipid A
JP5019494B2 (ja) 1997-04-01 2012-09-05 コリクサ コーポレーション モノホスホリルリピドａの水性免疫アジュバント組成物
GB9706957D0 (en) * 1997-04-05 1997-05-21 Smithkline Beecham Plc Formulation
AU7983198A (en) 1997-06-23 1999-01-04 Ludwig Institute For Cancer Research Improved methods for inducing an immune response
GB9717953D0 (en) 1997-08-22 1997-10-29 Smithkline Beecham Biolog Vaccine
GB9720585D0 (en) 1997-09-26 1997-11-26 Smithkline Beecham Biolog Vaccine
CA2319380A1 (en) 1997-11-10 1999-05-20 Statens Serum Institut Nucleic acid fragments and polypeptide fragments derived from m. tuberculosis
GB9812613D0 (en) 1998-06-11 1998-08-12 Smithkline Beecham Biolog Vaccine
EP1086228A1 (en) 1998-06-12 2001-03-28 SMITHKLINE BEECHAM BIOLOGICALS s.a. Recombinant production of toxoplasma sag1 antigen
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SI1031347T1 (en) 1999-01-27 2002-10-31 Idea Ag Transnasal transport/immunisation with highly adaptable carriers
ATE481108T1 (de) 1999-02-26 2010-10-15 Novartis Vaccines & Diagnostic Verwendung von bioadhaesiven und adjuvantien für die mukosale anwendung von antigenen
GB9909077D0 (en) 1999-04-20 1999-06-16 Smithkline Beecham Biolog Novel compositions
EE200100552A (et) 1999-04-23 2002-12-16 Pharmexa A/S Meetod kasvuteguri IL-5 aktiivsuse in vivo mahasurumiseks, IL-5 analoog, seda kodeeriv nukleiinhappefragment ning kasutamine immunogeense kompositsiooni valmistamiseks
UA81216C2 (en) 1999-06-01 2007-12-25 Prevention and treatment of amyloid disease
GB9924529D0 (en) 1999-10-15 1999-12-15 Smithkline Beecham Biolog Novel compounds
GB0000891D0 (en) 2000-01-14 2000-03-08 Allergy Therapeutics Ltd Formulation

Also Published As

Publication number Publication date
AR011707A1 (es) 2000-08-30
AU7216098A (en) 1998-10-30
PT975364E (pt) 2004-09-30
ES2218819T3 (es) 2004-11-16
ATE268607T1 (de) 2004-06-15
EP0975364B1 (en) 2004-06-09
JP2001519797A (ja) 2001-10-23
US20100183659A1 (en) 2010-07-22
KR100549557B1 (ko) 2006-02-08
DE69824405T2 (de) 2004-10-07
AU729631B2 (en) 2001-02-08
KR20010005651A (ko) 2001-01-15
NZ337580A (en) 2001-04-27
US8105605B2 (en) 2012-01-31
GB9706957D0 (en) 1997-05-21
ZA982851B (en) 1999-10-04
CA2285928A1 (en) 1998-10-15
US20050123570A1 (en) 2005-06-09
TWI240628B (en) 2005-10-01
EP0975364A1 (en) 2000-02-02
JP4331798B2 (ja) 2009-09-16
US7718178B2 (en) 2010-05-18
CA2285928C (en) 2008-07-08
WO1998044947A1 (en) 1998-10-15
DE69824405D1 (de) 2004-07-15

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