CO4750811A1 - Acidos 3-sustituidos-2-aminobiciclo [3.1.0] hexano-2,6- dicarboxilicos - Google Patents
Acidos 3-sustituidos-2-aminobiciclo [3.1.0] hexano-2,6- dicarboxilicosInfo
- Publication number
- CO4750811A1 CO4750811A1 CO96059737A CO96059737A CO4750811A1 CO 4750811 A1 CO4750811 A1 CO 4750811A1 CO 96059737 A CO96059737 A CO 96059737A CO 96059737 A CO96059737 A CO 96059737A CO 4750811 A1 CO4750811 A1 CO 4750811A1
- Authority
- CO
- Colombia
- Prior art keywords
- group
- aromatic
- monocyclic
- optionally substituted
- heteroaromatic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/47—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of rings being part of condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Un compuesto de fórmula:en la que X representa un enlace, S, O u NRa ; R representa un grupo alquilo C1 -C6 , un grupo alquenilo C2 -C6 ; un grupo alquinilo C2 -C6 ; un grupo aromático opcionalmente sustituido; un grupo heteroaromático opcionalmente sustituido; un grupo carbocíclico no aromático; un grupo heterocíclico no aromático; un grupo carbocíclico monocíclico no aromático condensado con uno o dos grupos aromáticos o heteroaromáticos monocíclicos; un grupo heterocíclico monocíclico no aromático condensado con uno o dos grupos aromáticos o heteroaromáticos monocíclicos; o un grupo alquilo C1 -C6 , alquenilo C2 -C6 o alquinilo C2 -C6 que está sustituido con uno, dos o tres grupos seleccionados de forma independiente entre un grupo aromático opcionalmente sustituido, un grupo heteroaromático opcionalmente sustituido, un grupo carbocíclico no aromático, un grupo heterocíclico no aromático, un grupo carbocíclico monocíclico no aromático condensado con uno o dos grupos aromáticos o heteroaromáticos monocíclicos y un grupo heterocíclico monocíclico no aromático condensado con uno o dos grupos aromáticos o heteroaromáticos monocíclicos; Ra , representa hidrógeno o un grupo de fórmula (CO)n Rb ; n es 0 ó 1; y Rb es como se ha descrito para R; o uno de sus ésteres o amidas metabólicamente lábiles no tóxicos; o una de sus sales farmacéuticamente aceptables.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US687195P | 1995-11-16 | 1995-11-16 | |
GBGB9605430.9A GB9605430D0 (en) | 1996-03-15 | 1996-03-15 | Excitatory amino acid receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
CO4750811A1 true CO4750811A1 (es) | 1999-03-31 |
Family
ID=26308934
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO96059737A CO4750811A1 (es) | 1995-11-16 | 1996-11-13 | Acidos 3-sustituidos-2-aminobiciclo [3.1.0] hexano-2,6- dicarboxilicos |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0774455A1 (es) |
JP (1) | JP2000500752A (es) |
KR (1) | KR19990067597A (es) |
CN (1) | CN1202103A (es) |
AR (2) | AR004600A1 (es) |
AU (1) | AU703093B2 (es) |
BR (1) | BR9611521A (es) |
CA (1) | CA2237598A1 (es) |
CO (1) | CO4750811A1 (es) |
EA (1) | EA000894B1 (es) |
TW (1) | TW427973B (es) |
WO (1) | WO1997017950A1 (es) |
YU (1) | YU60896A (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1000015A1 (en) * | 1997-07-18 | 2000-05-17 | Georgetown University | Bicyclic metabotropic glutamate receptor ligands |
US6825211B1 (en) | 1997-07-18 | 2004-11-30 | Georgetown University | Bicyclic metabotropic glutamate receptor ligands |
EP1396273A1 (en) * | 1998-03-17 | 2004-03-10 | Pfizer Products Inc. | Bicyclo(2.2.1.)heptanes and related compounds |
KR100372981B1 (ko) * | 1998-03-17 | 2003-02-25 | 화이자 프로덕츠 인크. | 비시클로[2.2.1]헵탄 및 관련 화합물 |
DK1110943T3 (da) | 1998-08-31 | 2004-10-11 | Taisho Pharmaceutical Co Ltd | 6-fluorbicyclo[3.1.0]hexanderivater |
CH694053A5 (de) * | 1998-09-03 | 2004-06-30 | Hoffmann La Roche | Verfahren zur Herstellung von 2-Amino-bicyclo[3.1.0]hexan-2,6-dicarbonsäure-Derivaten. |
WO2003061698A1 (fr) | 2001-12-27 | 2003-07-31 | Taisho Pharmaceutical Co.,Ltd. | Derives de 6-fluorobicyclo[3.1.0]hexane |
US8138377B2 (en) * | 2006-11-07 | 2012-03-20 | Dov Pharmaceutical, Inc. | Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use |
TWI520935B (zh) | 2010-11-18 | 2016-02-11 | 美國禮來大藥廠 | 作為mGluR2/3拮抗劑之4-經取代-3-苯基磺醯基甲基-雙環[3.1.0]己烷化合物 |
ES2682959T3 (es) * | 2010-11-18 | 2018-09-24 | Eli Lilly And Company | Compuestos de 3-benciloxi-biciclo[3.1.0]hexano 4-sustituidos como antagonistas de mGLuR 2/3 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3981880A (en) * | 1969-03-14 | 1976-09-21 | The Upjohn Company | Racemic prostaglandins of the 2-series and analogs thereof |
CA1278577C (en) * | 1985-11-18 | 1991-01-02 | Tatsuo Tsuri | Bicyclic sulfonamide derivatives |
WO1996004900A1 (en) * | 1994-08-12 | 1996-02-22 | Eli Lilly And Company | Composition and method for protection against drug dependency |
PL182285B1 (pl) | 1994-08-12 | 2001-12-31 | Lilly Co Eli | Syntetyczne aminokwasy oraz ich estry i srodki farmaceutyczne je zawierajace PL PL PL PL PL PL PL |
ES2162936T3 (es) * | 1994-08-12 | 2002-01-16 | Lilly Co Eli | Tratamiento de la ansiedad. |
-
1996
- 1996-11-12 JP JP9519044A patent/JP2000500752A/ja active Pending
- 1996-11-12 BR BR9611521A patent/BR9611521A/pt active Search and Examination
- 1996-11-12 CN CN96198264A patent/CN1202103A/zh active Pending
- 1996-11-12 EA EA199800380A patent/EA000894B1/ru not_active IP Right Cessation
- 1996-11-12 WO PCT/US1996/018207 patent/WO1997017950A1/en not_active Application Discontinuation
- 1996-11-12 CA CA002237598A patent/CA2237598A1/en not_active Abandoned
- 1996-11-12 AU AU77310/96A patent/AU703093B2/en not_active Ceased
- 1996-11-12 KR KR1019980703623A patent/KR19990067597A/ko not_active Application Discontinuation
- 1996-11-13 TW TW085113882A patent/TW427973B/zh active
- 1996-11-13 CO CO96059737A patent/CO4750811A1/es unknown
- 1996-11-14 EP EP96308215A patent/EP0774455A1/en not_active Withdrawn
- 1996-11-15 AR ARP960105202A patent/AR004600A1/es unknown
- 1996-11-15 AR ARP960105203A patent/AR004601A1/es not_active Application Discontinuation
- 1996-11-15 YU YU60896A patent/YU60896A/sh unknown
Also Published As
Publication number | Publication date |
---|---|
AU703093B2 (en) | 1999-03-18 |
AR004601A1 (es) | 1998-12-16 |
AU7731096A (en) | 1997-06-05 |
AR004600A1 (es) | 1998-12-16 |
KR19990067597A (ko) | 1999-08-25 |
JP2000500752A (ja) | 2000-01-25 |
EP0774455A1 (en) | 1997-05-21 |
YU60896A (sh) | 1998-12-23 |
WO1997017950A1 (en) | 1997-05-22 |
TW427973B (en) | 2001-04-01 |
CA2237598A1 (en) | 1997-05-22 |
BR9611521A (pt) | 1999-06-29 |
CN1202103A (zh) | 1998-12-16 |
EA199800380A1 (ru) | 1998-10-29 |
EA000894B1 (ru) | 2000-06-26 |
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