CO2023014807A2 - Compuesto cíclico que contiene acción inhibidora selectiva en kras por sobre hras y nras - Google Patents
Compuesto cíclico que contiene acción inhibidora selectiva en kras por sobre hras y nrasInfo
- Publication number
- CO2023014807A2 CO2023014807A2 CONC2023/0014807A CO2023014807A CO2023014807A2 CO 2023014807 A2 CO2023014807 A2 CO 2023014807A2 CO 2023014807 A CO2023014807 A CO 2023014807A CO 2023014807 A2 CO2023014807 A2 CO 2023014807A2
- Authority
- CO
- Colombia
- Prior art keywords
- hras
- nras
- cyclic compound
- inhibitory action
- kras
- Prior art date
Links
- 150000001923 cyclic compounds Chemical class 0.000 title abstract 4
- 101150117869 Hras gene Proteins 0.000 title 1
- 101150073096 NRAS gene Proteins 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 108010038807 Oligopeptides Chemical class 0.000 abstract 3
- 102000015636 Oligopeptides Human genes 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se encontraron compuestos cíclicos y compuestos oligopéptidos que inhiben selectivamente a KRAS. También se encontraron compuestos oligopéptidos y aminoácidos no naturales útiles para producir un compuesto cíclico. Además, se encontró que los compuestos cíclicos y los compuestos oligopéptidos interactúan con un residuo de aminoácido específico de KRAS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021079012 | 2021-05-07 | ||
| PCT/JP2022/019544 WO2022234853A1 (ja) | 2021-05-07 | 2022-05-06 | Ｈｒａｓおよびｎｒａｓに対して選択的なｋｒａｓ阻害作用を有する環状化合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2023014807A2 true CO2023014807A2 (es) | 2023-11-20 |
Family
ID=83932768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2023/0014807A CO2023014807A2 (es) | 2021-05-07 | 2023-10-31 | Compuesto cíclico que contiene acción inhibidora selectiva en kras por sobre hras y nras |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20240158446A1 (es) |
| EP (1) | EP4309741A1 (es) |
| JP (1) | JPWO2022234853A1 (es) |
| KR (1) | KR20240005777A (es) |
| CN (1) | CN117279933A (es) |
| AR (1) | AR125796A1 (es) |
| AU (1) | AU2022268781A1 (es) |
| BR (1) | BR112023022755A2 (es) |
| CA (1) | CA3218182A1 (es) |
| CL (1) | CL2023003137A1 (es) |
| CO (1) | CO2023014807A2 (es) |
| CR (1) | CR20230572A (es) |
| IL (1) | IL307605A (es) |
| MX (1) | MX2023013139A (es) |
| TW (1) | TW202309063A (es) |
| WO (1) | WO2022234853A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202406927A (zh) * | 2022-05-06 | 2024-02-16 | 日商中外製藥股份有限公司 | 相對於ｈｒａｓ與ｎｒａｓ具有選擇性之ｋｒａｓ抑制作用的環狀化合物 |
| CN115385867A (zh) * | 2022-09-19 | 2022-11-25 | 安徽普利药业有限公司 | 一种氨基酸及其类似物的成环反应与开环方法 |
| WO2024085235A1 (ja) * | 2022-10-20 | 2024-04-25 | 中外製薬株式会社 | 環状ペプチドの結晶の製造方法 |
| WO2024102421A2 (en) * | 2022-11-09 | 2024-05-16 | Revolution Medicines, Inc. | Compounds, complexes, and methods for their preparation and of their use |
| WO2024101386A1 (ja) * | 2022-11-09 | 2024-05-16 | 中外製薬株式会社 | Ｈｒａｓおよびｎｒａｓに対して選択的なｋｒａｓ阻害作用を有する環状化合物 |
| WO2024101402A1 (ja) * | 2022-11-09 | 2024-05-16 | 中外製薬株式会社 | Ｈｒａｓおよびｎｒａｓに対して選択的なｋｒａｓ阻害作用を有する環状化合物を含む医薬組成物 |
| CN117567589B (zh) * | 2023-04-23 | 2024-03-26 | 山东第一医科大学(山东省医学科学院) | 一种具有抗菌活性的订书肽及其制备方法和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8987412B2 (en) | 2011-03-04 | 2015-03-24 | New York University | Hydrogen bond surrogate macrocycles as modulators of Ras |
| EP3974563A1 (en) | 2011-12-28 | 2022-03-30 | Chugai Seiyaku Kabushiki Kaisha | Cyclic peptides |
| WO2017181061A1 (en) | 2016-04-15 | 2017-10-19 | Ra Pharmaceuticals, Inc. | Ras binding peptides and methods of use |
| CN110869544B (zh) | 2017-06-09 | 2024-03-08 | 中外制药株式会社 | 膜透过性高的环状肽化合物及包含其的文库 |
| JP7229158B2 (ja) | 2017-06-09 | 2023-02-27 | 中外製薬株式会社 | Ｎ－置換アミノ酸を含むペプチドの合成方法 |
| CN118184532A (zh) * | 2018-12-12 | 2024-06-14 | 中外制药株式会社 | 具有能形成分子内氢键的官能团的氨基酸、包含该氨基酸的肽化合物、及其制备方法 |
| MX2022005302A (es) * | 2019-11-07 | 2022-05-24 | Chugai Pharmaceutical Co Ltd | Compuesto de peptidos ciclicos que tiene accion inhibidora de kras. |
-
2022
- 2022-05-06 EP EP22798957.1A patent/EP4309741A1/en active Pending
- 2022-05-06 MX MX2023013139A patent/MX2023013139A/es unknown
- 2022-05-06 JP JP2023518700A patent/JPWO2022234853A1/ja active Pending
- 2022-05-06 AU AU2022268781A patent/AU2022268781A1/en active Pending
- 2022-05-06 KR KR1020237040757A patent/KR20240005777A/ko unknown
- 2022-05-06 AR ARP220101203A patent/AR125796A1/es unknown
- 2022-05-06 CA CA3218182A patent/CA3218182A1/en active Pending
- 2022-05-06 WO PCT/JP2022/019544 patent/WO2022234853A1/ja active Application Filing
- 2022-05-06 IL IL307605A patent/IL307605A/en unknown
- 2022-05-06 CN CN202280032929.5A patent/CN117279933A/zh active Pending
- 2022-05-06 BR BR112023022755A patent/BR112023022755A2/pt unknown
- 2022-05-06 US US18/289,592 patent/US20240158446A1/en active Pending
- 2022-05-06 CR CR20230572A patent/CR20230572A/es unknown
- 2022-05-06 TW TW111117092A patent/TW202309063A/zh unknown
-
2023
- 2023-10-20 CL CL2023003137A patent/CL2023003137A1/es unknown
- 2023-10-31 CO CONC2023/0014807A patent/CO2023014807A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112023022755A2 (pt) | 2024-01-02 |
| JPWO2022234853A1 (es) | 2022-11-10 |
| US20240158446A1 (en) | 2024-05-16 |
| IL307605A (en) | 2023-12-01 |
| AR125796A1 (es) | 2023-08-16 |
| MX2023013139A (es) | 2023-11-28 |
| KR20240005777A (ko) | 2024-01-12 |
| CA3218182A1 (en) | 2022-11-10 |
| CN117279933A (zh) | 2023-12-22 |
| EP4309741A1 (en) | 2024-01-24 |
| CR20230572A (es) | 2024-01-25 |
| WO2022234853A1 (ja) | 2022-11-10 |
| CL2023003137A1 (es) | 2024-06-14 |
| TW202309063A (zh) | 2023-03-01 |
| AU2022268781A1 (en) | 2023-12-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO2023014807A2 (es) | Compuesto cíclico que contiene acción inhibidora selectiva en kras por sobre hras y nras | |
| AR117101A1 (es) | Síntesis mejorada del intermedio clave del compuesto inhibidor de g12c de kras | |
| UY38057A (es) | Inhibidores de sarcómero cardíaco | |
| UY39526A (es) | Inhibidores de kras g12d | |
| CL2021000737A1 (es) | Fabricación de compuestos y composiciones para inhibir la actividad de shp2 | |
| ECSP22042309A (es) | Sales y formas cristalinas de un inhibidor de pd-1/pd-l1 | |
| AR120394A1 (es) | Compuesto de péptido cíclico que tiene acción inhibitoria de kras | |
| CL2013002617A1 (es) | Proceso para preparar una composicion de inhibidores de jak(pirrolo(2,3-d)pirimidin-4-il)pirazolil-3-ciclopentilpropanonitrilo tratando un exceso enantiometrico r o s mediante una reaccion de epimerizacion en presencia de base o una retro adicion de michael. | |
| CO5700772A2 (es) | Composiciones de pirazole utiles como inhibidores de gsk-3 | |
| CL2021001461A1 (es) | Moduladores de trex1 | |
| ECSP21016009A (es) | Inhibidores de sarcómeros cardíacos | |
| ECSP099708A (es) | Nuevos métodos | |
| BRPI0710199A2 (pt) | Processo para preparação de inibidores de hiv protease | |
| SV2010003523A (es) | Metodo para producir 2' -desoxi - 5- azacitidina ( decitabina ) ref. prd2888-pct-slv-/fv/im | |
| MX2024002885A (es) | Inhibidor de la proteasa 3clpro. | |
| CL2023003312A1 (es) | Inhibidores de nlrp3 | |
| CL2020002217A1 (es) | Uso de alcoxipirazoles como inhibidores de la nitrificación | |
| ECSP088319A (es) | Síntesis de inhibidores de renina que involucra una reacción de cicloadición | |
| ECSP23088732A (es) | Moduladores de trex1 | |
| CL2019002795A1 (es) | Proceso para preparar 2-exo-(2-metilbenciloxi)-1-metil-4-isopropil-7-oxabiciclo[2.2.1]heptano. | |
| MX2024004515A (es) | Formas cristalinas de un benzimidazol sustituido que actua como inhibidor de cdk9 y sus usos. | |
| CL2022002106A1 (es) | Moduladores de nampt. | |
| UY39172A (es) | Análogos de nucleósido bi- y monocíclicos para el tratamiento de la hepatitis e | |
| BR112022011572A2 (pt) | Análogos de cistina diamida para cistinúria | |
| UY38072A (es) | Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos |