CO2023011971A2 - Métodos para detectar una cadena ligera de neurofilamento en plasma y fluido cefalorraquídeo - Google Patents

Métodos para detectar una cadena ligera de neurofilamento en plasma y fluido cefalorraquídeo

Info

Publication number
CO2023011971A2
CO2023011971A2 CONC2023/0011971A CO2023011971A CO2023011971A2 CO 2023011971 A2 CO2023011971 A2 CO 2023011971A2 CO 2023011971 A CO2023011971 A CO 2023011971A CO 2023011971 A2 CO2023011971 A2 CO 2023011971A2
Authority
CO
Colombia
Prior art keywords
detecting
methods
cerebrospinal fluid
plasma
light chain
Prior art date
Application number
CONC2023/0011971A
Other languages
English (en)
Inventor
Randall Bateman
Melissa Budelier
David Holtzman
Hong Jiang
Original Assignee
Washington University St Louis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Washington University St Louis filed Critical Washington University St Louis
Publication of CO2023011971A2 publication Critical patent/CO2023011971A2/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • External Artificial Organs (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente divulgación proporciona métodos para detectar y opcionalmente cuantificar Nfl presente en el líquido cefalorraquídeo y la sangre y el uso de los métodos para detectar y opcionalmente medir niveles de biomarcadores de Nfl indicativos de daño neuronal. También se describen anticuerpos anti-Nfl.
CONC2023/0011971A 2021-02-10 2023-09-08 Métodos para detectar una cadena ligera de neurofilamento en plasma y fluido cefalorraquídeo CO2023011971A2 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202163147833P 2021-02-10 2021-02-10
US202163183417P 2021-05-03 2021-05-03
US202163197826P 2021-06-07 2021-06-07
PCT/US2022/015998 WO2022173965A1 (en) 2021-02-10 2022-02-10 Methods for detecting neurofilament light chain in plasma and cerebrospinal fluid

Publications (1)

Publication Number Publication Date
CO2023011971A2 true CO2023011971A2 (es) 2023-09-29

Family

ID=82837306

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2023/0011971A CO2023011971A2 (es) 2021-02-10 2023-09-08 Métodos para detectar una cadena ligera de neurofilamento en plasma y fluido cefalorraquídeo

Country Status (11)

Country Link
EP (1) EP4291892A1 (es)
JP (1) JP2024507755A (es)
KR (1) KR20230154307A (es)
AU (1) AU2022220697A1 (es)
BR (1) BR112023015991A2 (es)
CA (1) CA3207924A1 (es)
CL (1) CL2023002353A1 (es)
CO (1) CO2023011971A2 (es)
CR (1) CR20230441A (es)
IL (1) IL305068A (es)
WO (1) WO2022173965A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117164711B (zh) * 2023-09-28 2024-01-30 北京凯祥弘康生物科技有限公司 一种抗神经纤维丝轻链蛋白的抗体

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090053723A1 (en) * 2007-08-24 2009-02-26 Shangxi Xiao Peripherin and Neurofilament Light Protein Splice Variants in Amyotrophic Lateral Sclerosis (ALS)
US20170315136A9 (en) * 2009-06-19 2017-11-02 Banyan Biomarkers, Inc. Biomarker assay of neurological condition

Also Published As

Publication number Publication date
CL2023002353A1 (es) 2024-03-08
CR20230441A (es) 2023-11-10
EP4291892A1 (en) 2023-12-20
WO2022173965A1 (en) 2022-08-18
IL305068A (en) 2023-10-01
CA3207924A1 (en) 2022-08-18
JP2024507755A (ja) 2024-02-21
KR20230154307A (ko) 2023-11-07
BR112023015991A2 (pt) 2024-01-02
AU2022220697A1 (en) 2023-09-21

Similar Documents

Publication Publication Date Title
CL2018003342A1 (es) Disposición y método para medir la masa biológica de peces y uso de la disposición.
BR112018072627A2 (pt) realização de medições óticas em uma amostra
CO2023011971A2 (es) Métodos para detectar una cadena ligera de neurofilamento en plasma y fluido cefalorraquídeo
AR091861A1 (es) Determinacion de caracteristicas de fluido de un fluido con multiples componentes con componentes compresibles y no compresibles
EA201992748A1 (ru) Диагностические анализы для обнаружения, количественного определения и/или отслеживания микроорганизмов и других аналитов
WO2012006613A3 (en) Tribometer
CL2008001853A1 (es) Procedimiento y dispositivo de inspeccion de ejes motores tubulares por medio de sonda de ultrasonido,que comprende colocar el eje en un banco de control,colocar al menos una sonda de ultrasonido en la superficie externa o interna de la pared del eje,en un primer y segundo lugar elegido, y constituir graficos representativos.
EA201101563A1 (ru) Безколбовый спектрометр
BRPI0909791A8 (pt) Cartucho, dispositivo sensor e método para detecção de componentes alvo em uma amostra líquida, e, uso do cartucho ou do dispositivo sensor.
BR112017021686A2 (pt) método para detectar uma ou várias carbapenemases, dispositivo para detectar imunocromatográfico e uso do dispositivo para detectar imunocromatográfico
CL2017002101A1 (es) Dispositivo, plataforma y ensayo para evaluación de células
PH12020551371A1 (en) Assays to detect neurodegeneration
DE602006007379D1 (de) Positionserfassungssystem mit selbstüberwachung für konnektivitätsfehler
CO2019002607A2 (es) Biomarcadores de metabolitos para enfermedades asociadas con el sistema de activación por contacto
CO2019002608A2 (es) Biomarcadores de arn para angioedema hereditario
AR075741A1 (es) Uso de colorantes hidrofobos para monitorear contaminantes hidrofobos en un proceso de fabricacion de papel
CL2011002509A1 (es) Cartucho para la verificacion y el analisis cuantitativo de analito en un liquido de muestra que incorpora una camara de reactivos, una camara de deteccion; procedimiento para analisis cuantitativo de analito; y uso del cartucho.
ECSP20067828A (es) Una escala para determinar el peso de los organismos
CL2008001854A1 (es) Procedimiento y dispositivo de inspeccion de ejes tubulares por medio de sonda de ultrasonido, que comprende colocar manualmente una sonda de ultrasonido en la superficie externa o interna de la pared del eje, en un primer y segundo lugar elegido, y constituir a partir de los datos adquiridos, graficos representativos.
PE20120592A1 (es) Metodo con biomarcadores para el seguimiento de un tratamiento
GB201117623D0 (en) Fluorescence gas and liquid sensor
BR112022011312A2 (pt) Análise de um analito disposto dentro de um meio
BR112014010235A2 (pt) cartucho para o teste óptico de uma amostra, aparelho sensor para o teste óptico de uma amostra, e método de teste óptico de uma amostra
EA201400571A1 (ru) Специфичные к трансресвератролу антитела и их применение
ATE479901T1 (de) Optisches messverfahren zur ermittlung des ph- werts eines mediums unter anwendung von ageladine a als fluoreszierendem ph-wert-indikator