CL2017002101A1 - Dispositivo, plataforma y ensayo para evaluación de células - Google Patents

Dispositivo, plataforma y ensayo para evaluación de células

Info

Publication number
CL2017002101A1
CL2017002101A1 CL2017002101A CL2017002101A CL2017002101A1 CL 2017002101 A1 CL2017002101 A1 CL 2017002101A1 CL 2017002101 A CL2017002101 A CL 2017002101A CL 2017002101 A CL2017002101 A CL 2017002101A CL 2017002101 A1 CL2017002101 A1 CL 2017002101A1
Authority
CL
Chile
Prior art keywords
response
platform
provides
assay
cell evaluation
Prior art date
Application number
CL2017002101A
Other languages
English (en)
Inventor
Cox Juan Pablo Acevedo
Original Assignee
Cells For Cells S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cells For Cells S A filed Critical Cells For Cells S A
Publication of CL2017002101A1 publication Critical patent/CL2017002101A1/es

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5029—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on cell motility
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0694—Creating chemical gradients in a fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/069—Absorbents; Gels to retain a fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

<p>ESTA INVENCIÓN PROPORCIONA DISPOSITIVOS CAPACES DE EVALUAR LA RESPUESTA DE MIGRACIÓN EN LA PRESENCIA DE UN GRADIENTE ESTABLE ENCAPSULADO DE UN FACTOR O COMBINACIÓN DE FACTORES, Y CUANTIFICAR LA RESPUESTA DE ADHERENCIA DENTRO DE LOS MICRO CANALES, EN LA PRESENCIA DE DIFERENTES FACTORES. ESTA INVENCIÓN TAMBIÉN PROPORCIONA UNA PLATAFORMA PARA OBTENER INFORMACIÓN RELACIONADA CON LA PUNTUACIÓN DE MIGRACIÓN O LA CUANTIFICACIÓN DE LAS CÉLULAS ADHERIDAS A TRAVÉS DEL USO DE LOS DISPOSITIVOS DE LA PRESENTE INVENCIÓN, Y PERMITE QUE ESTA INFORMACIÓN SEA UTILIZADA PARA EVALUAR EL POTENCIAL TERAPÉUTICO. ADICIONALMENTE, LA INVENCIÓN BRINDA UN MÉTODO PARA CUANTIFICAR LA RESPUESTA DE MIGRACIÓN DE LAS CÉLULAS Y LA RESPUESTA DE ADHERENCIA CELULAR.</p>
CL2017002101A 2015-02-20 2017-08-17 Dispositivo, plataforma y ensayo para evaluación de células CL2017002101A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2015/051317 WO2016132182A1 (en) 2015-02-20 2015-02-20 Devices for studying chemotaxis/adherence in cells wherein gradients and channels are formed using hydrogels

Publications (1)

Publication Number Publication Date
CL2017002101A1 true CL2017002101A1 (es) 2018-03-23

Family

ID=52684599

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2017002101A CL2017002101A1 (es) 2015-02-20 2017-08-17 Dispositivo, plataforma y ensayo para evaluación de células

Country Status (7)

Country Link
US (1) US10766029B2 (es)
EP (1) EP3259066A4 (es)
JP (1) JP2018505691A (es)
CL (1) CL2017002101A1 (es)
MX (1) MX2017010569A (es)
PE (1) PE20180045A1 (es)
WO (2) WO2016132182A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018063914A1 (en) * 2016-09-29 2018-04-05 Animantis, Llc Methods and apparatus for assessing immune system activity and therapeutic efficacy
CN108619575A (zh) * 2018-06-15 2018-10-09 天津工业大学 一种可缓释生长因子的表层分子印迹高强度水凝胶膜的制备方法
CN109358009B (zh) * 2018-10-26 2021-08-10 武汉百德瑞康生物技术有限公司 胱抑素c测定试剂盒及其制备方法和检测方法
CN111695389B (zh) * 2019-03-15 2023-06-20 北京四维图新科技股份有限公司 一种车道线聚类方法及装置
KR20220108795A (ko) * 2019-12-02 2022-08-03 선전 바이오락스 바이오테크놀로지 컴퍼니 리미티드 캐미컬 딜리버리 시스템, 장치 및 그 방법
CN111138723B (zh) * 2019-12-10 2021-07-20 四川农业大学 一种3d打印梯度抗菌膜的制备方法、产品及其应用
CO2020015994A1 (es) 2020-12-18 2022-06-21 Inst Distrital De Ciencia Biotecnologia E Innovacion En Salud Idcbis Método in vitro para evaluación funcional de progenitores hematopoyéticos
CN112903637B (zh) * 2021-01-18 2022-06-03 江西英大生物技术有限公司 尿胰蛋白酶原-2的检测试剂盒、适配的检测装置及检测方法
CN113416644B (zh) * 2021-06-17 2023-01-13 上海睿钰生物科技有限公司 一种确定细胞的迁移能力的方法和系统

Family Cites Families (13)

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US5637469A (en) 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US6699665B1 (en) * 2000-11-08 2004-03-02 Surface Logix, Inc. Multiple array system for integrating bioarrays
JP2005523710A (ja) * 2002-04-24 2005-08-11 サーフェイス ロジックス，インコーポレイティド 白血球遊走のモニター装置及び方法
US7857849B2 (en) * 2004-10-05 2010-12-28 The Board Of Trustees Of The Leland Stanford Junior Iniversity Artificial corneal implant
US20090136982A1 (en) * 2005-01-18 2009-05-28 Biocept, Inc. Cell separation using microchannel having patterned posts
EP1846567A4 (en) 2005-01-20 2009-12-09 Univ California CELL MICROARRAYS FOR SCREENING DIFFERENTIATION FACTORS
US8921122B2 (en) * 2008-02-11 2014-12-30 The General Hospital Corporation System and method for quantitative assessment of biological migration behavior
CA2720261C (en) * 2008-04-08 2020-09-22 Massachusetts Institute Of Technology Three-dimensional microfluidic platforms and methods of use thereof
JP5228826B2 (ja) * 2008-11-17 2013-07-03 大日本印刷株式会社 細胞画像解析装置および細胞画像解析方法
WO2010108095A2 (en) * 2009-03-19 2010-09-23 The General Hospital Corporation Microfluidic cell motility assay
WO2012050981A1 (en) * 2010-09-29 2012-04-19 Massachusetts Institute Of Technology Device for high throughput investigations of cellular interactions
CN116179323A (zh) * 2011-05-27 2023-05-30 不列颠哥伦比亚大学 用于高通量分析的微流控细胞捕获和分析设备
KR101311325B1 (ko) * 2012-09-13 2013-09-30 이상재 합성 디자인된 3차원 미세환경 구조물

Also Published As

Publication number Publication date
PE20180045A1 (es) 2018-01-15
WO2016132221A3 (en) 2016-10-13
JP2018505691A (ja) 2018-03-01
US20180236442A1 (en) 2018-08-23
WO2016132221A2 (en) 2016-08-25
US10766029B2 (en) 2020-09-08
EP3259066A2 (en) 2017-12-27
EP3259066A4 (en) 2018-12-05
WO2016132182A1 (en) 2016-08-25
MX2017010569A (es) 2018-07-06

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