CO2022014157A2 - Conjugados para reactividad selectiva a dioles vecinales - Google Patents
Conjugados para reactividad selectiva a dioles vecinalesInfo
- Publication number
- CO2022014157A2 CO2022014157A2 CONC2022/0014157A CO2022014157A CO2022014157A2 CO 2022014157 A2 CO2022014157 A2 CO 2022014157A2 CO 2022014157 A CO2022014157 A CO 2022014157A CO 2022014157 A2 CO2022014157 A2 CO 2022014157A2
- Authority
- CO
- Colombia
- Prior art keywords
- vicinal
- diol
- diols
- sensors
- drug substance
- Prior art date
Links
- 150000002009 diols Chemical group 0.000 title abstract 9
- 230000009257 reactivity Effects 0.000 title 1
- 239000008186 active pharmaceutical agent Substances 0.000 abstract 3
- 229940088679 drug related substance Drugs 0.000 abstract 3
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 150000001639 boron compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002124 endocrine Effects 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 150000002402 hexoses Chemical class 0.000 abstract 1
- MGXWVYUBJRZYPE-YUGYIWNOSA-N incretin Chemical class C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)[C@@H](C)O)[C@@H](C)CC)C1=CC=C(O)C=C1 MGXWVYUBJRZYPE-YUGYIWNOSA-N 0.000 abstract 1
- 239000000859 incretin Substances 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Obesity (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Las modalidades de la presente descripción refieren a sensores que pueden unirse selectivamente a dioles vecinales específicos en presencia de otros dioles. Estos compuestos boronados de sensores que responden a dioles vecinales pueden detectar niveles de dioles vecinales específicos y responder a estas moléculas en el cuerpo. En determinadas modalidades, el diol vecinal es un cis diol, por ejemplo, una hexosa tal como la glucosa. En determinadas modalidades, los sensores se conjugan con una sustancia farmacológica, y los sensores pueden cambiar las características biofísicas, la farmacocinética y/o la actividad de la sustancia farmacológica en respuesta al diol vecinal. La sustancia farmacológica puede ser o incluir un polipéptido, tal como una insulina, un péptido endocrino o de incretina humano, o un análogo de este, y puede contener uno o más aminoácidos modificados que contienen un sensor que responde al diol vecinal.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063002662P | 2020-03-31 | 2020-03-31 | |
| PCT/US2021/025261 WO2021202802A1 (en) | 2020-03-31 | 2021-03-31 | Conjugates for selective responsiveness to vicinal diols |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2022014157A2 true CO2022014157A2 (es) | 2023-03-27 |
Family
ID=75588297
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2022/0014157A CO2022014157A2 (es) | 2020-03-31 | 2022-10-03 | Conjugados para reactividad selectiva a dioles vecinales |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20230134116A1 (es) |
| EP (1) | EP4126058A1 (es) |
| JP (1) | JP2023520049A (es) |
| KR (1) | KR20220161422A (es) |
| CN (1) | CN115843257A (es) |
| AU (1) | AU2021247169A1 (es) |
| BR (1) | BR112022019687A2 (es) |
| CA (1) | CA3173417A1 (es) |
| CL (1) | CL2022002662A1 (es) |
| CO (1) | CO2022014157A2 (es) |
| CR (1) | CR20220555A (es) |
| EC (1) | ECSP22076278A (es) |
| GB (1) | GB2610490A (es) |
| IL (1) | IL296804A (es) |
| MX (1) | MX2022012208A (es) |
| PE (1) | PE20230457A1 (es) |
| WO (1) | WO2021202802A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2021382599A1 (en) * | 2020-11-19 | 2023-06-22 | Protomer Technologies Inc. | Aromatic boron-containing compounds and insulin analogs |
| WO2023225534A1 (en) | 2022-05-18 | 2023-11-23 | Protomer Technologies Inc. | Aromatic boron-containing compounds and related insulin analogs |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US906028A (en) | 1908-03-27 | 1908-12-08 | Herbert E Jennison | Adjustable foot-block for radiators. |
| US4421685A (en) | 1980-03-27 | 1983-12-20 | Eli Lilly And Company | Process for producing an insulin |
| BR9407508A (pt) | 1993-09-17 | 1997-01-07 | Novo Nordisk As | Derivado de insulina composição farmaceutica e processo para o tratamento de diabete em um paciente com necessidade deste tratamento |
| US6869930B1 (en) | 1993-09-17 | 2005-03-22 | Novo Nordisk A/S | Acylated insulin |
| US6011007A (en) | 1993-09-17 | 2000-01-04 | Novo Nordisk A/S | Acylated insulin |
| US5461031A (en) | 1994-06-16 | 1995-10-24 | Eli Lilly And Company | Monomeric insulin analog formulations |
| US5504188A (en) | 1994-06-16 | 1996-04-02 | Eli Lilly And Company | Preparation of stable zinc insulin analog crystals |
| US5474978A (en) | 1994-06-16 | 1995-12-12 | Eli Lilly And Company | Insulin analog formulations |
| US5547929A (en) | 1994-09-12 | 1996-08-20 | Eli Lilly And Company | Insulin analog formulations |
| US5693609A (en) | 1994-11-17 | 1997-12-02 | Eli Lilly And Company | Acylated insulin analogs |
| YU18596A (sh) | 1995-03-31 | 1998-07-10 | Eli Lilly And Company | Analogne formulacije monomernog insulina |
| US5866538A (en) | 1996-06-20 | 1999-02-02 | Novo Nordisk A/S | Insulin preparations containing NaCl |
| PE79099A1 (es) | 1997-06-13 | 1999-08-24 | Lilly Co Eli | Formulaciones de insulina estables |
| US6444641B1 (en) | 1997-10-24 | 2002-09-03 | Eli Lilly Company | Fatty acid-acylated insulin analogs |
| CN1276731A (zh) | 1997-10-24 | 2000-12-13 | 伊莱利利公司 | 不溶性胰岛素组合物 |
| ZA989744B (en) | 1997-10-31 | 2000-04-26 | Lilly Co Eli | Method for administering acylated insulin. |
| DE69924232D1 (de) | 1998-01-09 | 2005-04-21 | Novo Nordisk As | Stabilisierte insulin-zubereitungen |
| US6586207B2 (en) | 2000-05-26 | 2003-07-01 | California Institute Of Technology | Overexpression of aminoacyl-tRNA synthetases for efficient production of engineered proteins containing amino acid analogues |
| JP2005526009A (ja) * | 2001-12-02 | 2005-09-02 | ノボ ノルディスク アクティーゼルスカブ | 新規グルコース依存性インスリン |
| EP1490677A4 (en) | 2002-02-27 | 2006-01-18 | California Inst Of Techn | COMPUTER METHOD FOR DESIGNING ENZYMES FOR THE INCORPORATION OF AMINO ACID ANALOGUES INTO PROTEINS |
| ATE496064T1 (de) | 2002-05-07 | 2011-02-15 | Novo Nordisk As | Lösliche formulierungen, die monomeres insulin und acyliertes insulin enthalten |
| US7229634B2 (en) | 2004-01-23 | 2007-06-12 | California Institute Of Technology | Engineered proteins, and methods of making and using |
| JP2007519422A (ja) | 2004-02-02 | 2007-07-19 | アンブレツクス・インコーポレイテツド | 修飾されたヒト四螺旋バンドルポリペプチド及びそれらの使用 |
| ATE541934T1 (de) | 2004-12-22 | 2012-02-15 | Ambrx Inc | Zusammensetzungen von aminoacyl-trna-synthetase und verwendungen davon |
| AU2005322019B2 (en) | 2004-12-22 | 2010-08-26 | Ambrx, Inc. | Formulations of human growth hormone comprising a non-naturally encoded amino acid |
| WO2007047668A2 (en) | 2005-10-14 | 2007-04-26 | California Institute Of Technology | Use of non-canonical amino acids as metabolic markers for rapidly-dividing cells |
| US8518666B2 (en) | 2006-03-03 | 2013-08-27 | California Institute Of Technology | Site-specific incorporation of amino acids into molecules |
| WO2007130453A2 (en) | 2006-05-02 | 2007-11-15 | Allozyne, Inc. | Non-natural amino acid substituted polypeptides |
| US20080096819A1 (en) | 2006-05-02 | 2008-04-24 | Allozyne, Inc. | Amino acid substituted molecules |
| NZ603812A (en) | 2007-11-20 | 2014-06-27 | Ambrx Inc | Modified insulin polypeptides and their uses |
| US9996862B2 (en) | 2012-07-23 | 2018-06-12 | @Pay Ip Holdings Llc | Point of sale email-based e-commerce |
| US9867869B2 (en) * | 2012-12-12 | 2018-01-16 | Massachusetts Institute Of Technology | Insulin derivatives for diabetes treatment |
| US10640546B2 (en) | 2014-06-10 | 2020-05-05 | California Institute Of Technology | Non-canonical insulins and their uses |
| WO2017070617A1 (en) * | 2015-10-21 | 2017-04-27 | Case Western Reserve University | Diol-modified insulin analogues containing a glucose-regulated conformational switch |
| CN117624207A (zh) * | 2017-11-09 | 2024-03-01 | 诺和诺德股份有限公司 | 葡萄糖敏感性白蛋白结合衍生物 |
| CN112423741A (zh) * | 2018-04-16 | 2021-02-26 | 犹他大学研究基金会 | 葡萄糖反应性胰岛素 |
| TW202112397A (zh) * | 2019-03-29 | 2021-04-01 | 丹麥商諾佛．儂迪克股份有限公司 | 葡萄糖敏感型胰島素衍生物 |
| EP4003426A4 (en) * | 2019-07-31 | 2023-07-05 | Thermalin Inc. | INSULIN ANALOGUES WITH GLUCOSE-REGULATED CONFORMATION SWITCH |
-
2021
- 2021-03-31 MX MX2022012208A patent/MX2022012208A/es unknown
- 2021-03-31 AU AU2021247169A patent/AU2021247169A1/en active Pending
- 2021-03-31 EP EP21720368.6A patent/EP4126058A1/en active Pending
- 2021-03-31 BR BR112022019687A patent/BR112022019687A2/pt not_active Application Discontinuation
- 2021-03-31 CA CA3173417A patent/CA3173417A1/en active Pending
- 2021-03-31 KR KR1020227037611A patent/KR20220161422A/ko unknown
- 2021-03-31 IL IL296804A patent/IL296804A/en unknown
- 2021-03-31 JP JP2022559876A patent/JP2023520049A/ja active Pending
- 2021-03-31 WO PCT/US2021/025261 patent/WO2021202802A1/en unknown
- 2021-03-31 CN CN202180038883.3A patent/CN115843257A/zh active Pending
- 2021-03-31 PE PE2022002154A patent/PE20230457A1/es unknown
- 2021-03-31 GB GB2214274.9A patent/GB2610490A/en active Pending
- 2021-03-31 CR CR20220555A patent/CR20220555A/es unknown
- 2021-03-31 US US17/907,711 patent/US20230134116A1/en active Pending
-
2022
- 2022-09-28 CL CL2022002662A patent/CL2022002662A1/es unknown
- 2022-09-30 EC ECSENADI202276278A patent/ECSP22076278A/es unknown
- 2022-10-03 CO CONC2022/0014157A patent/CO2022014157A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP4126058A1 (en) | 2023-02-08 |
| CA3173417A1 (en) | 2021-10-07 |
| IL296804A (en) | 2022-11-01 |
| WO2021202802A1 (en) | 2021-10-07 |
| GB2610490A (en) | 2023-03-08 |
| CN115843257A (zh) | 2023-03-24 |
| CL2022002662A1 (es) | 2023-07-21 |
| BR112022019687A2 (pt) | 2022-12-20 |
| ECSP22076278A (es) | 2022-12-30 |
| MX2022012208A (es) | 2022-12-15 |
| KR20220161422A (ko) | 2022-12-06 |
| GB202214274D0 (en) | 2022-11-16 |
| CR20220555A (es) | 2023-01-23 |
| US20230134116A1 (en) | 2023-05-04 |
| JP2023520049A (ja) | 2023-05-15 |
| AU2021247169A1 (en) | 2022-10-20 |
| PE20230457A1 (es) | 2023-03-10 |
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