CO2022008272A2 - Agentes de unión a ilt3 y métodos de uso de los mismos - Google Patents
Agentes de unión a ilt3 y métodos de uso de los mismosInfo
- Publication number
- CO2022008272A2 CO2022008272A2 CONC2022/0008272A CO2022008272A CO2022008272A2 CO 2022008272 A2 CO2022008272 A2 CO 2022008272A2 CO 2022008272 A CO2022008272 A CO 2022008272A CO 2022008272 A2 CO2022008272 A2 CO 2022008272A2
- Authority
- CO
- Colombia
- Prior art keywords
- binding agents
- methods
- same
- ilt3
- ilt3 binding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente divulgación proporciona agentes de unión, tales como anticuerpos, que se unen específicamente a ILT3, incluido ILT3 humano, así como composiciones que comprenden los agentes de unión y métodos para su uso. La divulgación también proporciona polinucleótidos relacionados y vectores que codifican los agentes de unión y células que comprenden los agentes de unión.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962950434P | 2019-12-19 | 2019-12-19 | |
PCT/US2020/065642 WO2021127200A1 (en) | 2019-12-19 | 2020-12-17 | Ilt3-binding agents and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2022008272A2 true CO2022008272A2 (es) | 2022-08-30 |
Family
ID=74554203
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2022/0008272A CO2022008272A2 (es) | 2019-12-19 | 2022-06-13 | Agentes de unión a ilt3 y métodos de uso de los mismos |
Country Status (16)
Country | Link |
---|---|
US (2) | US11760802B2 (es) |
EP (1) | EP4077394A1 (es) |
JP (1) | JP2023507110A (es) |
KR (1) | KR20220130671A (es) |
CN (2) | CN114901691A (es) |
AR (1) | AR120822A1 (es) |
AU (1) | AU2020405036A1 (es) |
BR (1) | BR112022011790A2 (es) |
CA (1) | CA3164642A1 (es) |
CL (1) | CL2022001622A1 (es) |
CO (1) | CO2022008272A2 (es) |
IL (1) | IL293869A (es) |
MX (1) | MX2022007288A (es) |
PE (1) | PE20221263A1 (es) |
TW (1) | TW202136304A (es) |
WO (1) | WO2021127200A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20240038769A (ko) * | 2021-07-28 | 2024-03-25 | 머크 샤프 앤드 돔 엘엘씨 | 항-ilt3 항체를 사용하여 급성 골수성 백혈병을 치료하는 방법 |
US20230220076A1 (en) * | 2021-12-21 | 2023-07-13 | Ngm Biopharmaceuticals, Inc. | Combinational use of an anti-ilt3 antibody and an anti-lair-1 antibody |
WO2023140875A1 (en) * | 2022-01-19 | 2023-07-27 | Ngm Biopharmaceuticals, Inc. | Uses of ilt3-binding agents |
WO2023192850A1 (en) | 2022-03-29 | 2023-10-05 | Ngm Biopharmaceuticals, Inc. | Ilt3 and cd3 binding agents and methods of use thereof |
WO2023209716A1 (en) | 2022-04-25 | 2023-11-02 | Biond Biologics Ltd. | Anti-ilt3 antibodies and use thereof |
WO2023235699A1 (en) * | 2022-05-31 | 2023-12-07 | Jounce Therapeutics, Inc. | Antibodies to lilrb4 and uses thereof |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0644877B2 (ja) | 1986-12-26 | 1994-06-15 | 寳酒造株式会社 | 抗ヒト・フイブロネクチンモノクロ−ナル抗体 |
US20060078564A1 (en) | 2002-05-08 | 2006-04-13 | Immunex Corporation | Family of immunoregulators designated leukocyte immunoglobulin-like receptors (LIR) |
AU2002345878A1 (en) | 2001-06-25 | 2003-01-08 | The Trustees Of Columbia University In The City Of New York | Ilt3 and ilt4-related compositions and methods |
US20040241167A1 (en) | 2001-06-25 | 2004-12-02 | Nicole Suciu-Foca | Ilt3 and ilt4-related compositons and methods |
WO2005017102A2 (en) | 2003-05-30 | 2005-02-24 | Diadexus, Inc. | Compositions, splice variants and methods relating to ovarian specific nucleic acids and proteins |
WO2006036813A2 (en) | 2004-09-24 | 2006-04-06 | Bioxell S.P.A. | 20-cycloalkyl,26,27-alkyl/haloalkyl vitamin d3 compounds and methods of use thereof |
ES2547463T3 (es) | 2005-06-17 | 2015-10-06 | Merck Sharp & Dohme Corp. | Moléculas de unión a ILT3 y usos de las mismas |
US20090202544A1 (en) | 2006-02-02 | 2009-08-13 | The Trustees Of Columbia University In The City Of New York | Methods of Treating Diseases by Targeting Silt3 |
WO2008094176A2 (en) | 2006-06-19 | 2008-08-07 | Tolerx, Inc. | Ilt3 binding molecules and uses therefor |
US9696312B2 (en) | 2011-09-02 | 2017-07-04 | The Trustees Of Columbia University In The City Of New York | Diagnosis and treatment of cancer expressing ILT3 or ILT3 ligand |
WO2013181438A2 (en) | 2012-05-30 | 2013-12-05 | Icahn School Of Medicine At Mount Sinai | Compositions and methods for modulating pro-inflammatory immune response |
BR112015007672A2 (pt) | 2012-10-04 | 2017-08-08 | Dana Farber Cancer Inst Inc | anticorpos anti-pd-l1 monoclonais humanos e métodos de uso |
US20140242077A1 (en) | 2013-01-23 | 2014-08-28 | Abbvie, Inc. | Methods and compositions for modulating an immune response |
SI2992017T1 (sl) | 2013-05-02 | 2021-04-30 | Anaptysbio, Inc. | Protitelesa, usmerjena proti programirani smrti-1 (PD-1) |
IL283834B (en) | 2014-09-28 | 2022-07-01 | Univ California | Modulation of stimulatory and non-stimulatory myeloid cells |
RU2017119185A (ru) | 2014-11-05 | 2018-12-05 | Дженентек, Инк. | Антитела против fgfr2/3 и способы их применения |
CA2976130A1 (en) | 2015-02-11 | 2016-08-18 | University Health Network | Methods and compositions for modulating lilr proteins |
JP6730996B2 (ja) | 2015-03-06 | 2020-07-29 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | 抗lilrb抗体ならびにがんの検出及び処置におけるその使用 |
WO2017069958A2 (en) | 2015-10-09 | 2017-04-27 | The Brigham And Women's Hospital, Inc. | Modulation of novel immune checkpoint targets |
JP2018025554A (ja) | 2016-07-29 | 2018-02-15 | 国立大学法人東北大学 | 炎症性疾患のマーカー |
WO2018067991A1 (en) | 2016-10-07 | 2018-04-12 | The Brigham And Women's Hospital, Inc. | Modulation of novel immune checkpoint targets |
WO2018089300A1 (en) | 2016-11-10 | 2018-05-17 | Merck Sharp & Dohme Corp. | Ilt3 ligand |
WO2018148494A1 (en) | 2017-02-09 | 2018-08-16 | Bluefin Biomedicine, Inc. | Anti-ilt3 antibodies and antibody drug conjugates |
CN111032025A (zh) | 2017-06-20 | 2020-04-17 | 居里研究所 | Suv39h1组蛋白甲基转移酶的抑制剂在癌症联合治疗中的用途 |
EP3710479A2 (en) | 2017-11-17 | 2020-09-23 | Merck Sharp & Dohme Corp. | Antibodies specific for immunoglobulin-like transcript 3 (ilt3) and uses thereof |
EP3740224A4 (en) | 2018-01-18 | 2022-05-04 | Adanate, Inc. | ANTI-LILRB ANTIBODIES AND THEIR USES |
WO2019185792A1 (en) | 2018-03-29 | 2019-10-03 | Philogen S.P.A | Cancer treatment using immunoconjugates and immune check-point inhibitors |
US20220324950A1 (en) | 2019-08-13 | 2022-10-13 | Tohoku University | Immune checkpoint inhibitor, therapeutic agent for immune checkpoint-related disease, immunosuppressant, anti-fibronectin antibody or derivative thereof, fibronectin analog, kit for detecting fibronectin or partial protein thereof, and method for detecting fibronectin or partial protein thereof |
-
2020
- 2020-12-17 BR BR112022011790A patent/BR112022011790A2/pt unknown
- 2020-12-17 CN CN202080087154.2A patent/CN114901691A/zh active Pending
- 2020-12-17 KR KR1020227019891A patent/KR20220130671A/ko unknown
- 2020-12-17 MX MX2022007288A patent/MX2022007288A/es unknown
- 2020-12-17 IL IL293869A patent/IL293869A/en unknown
- 2020-12-17 PE PE2022001110A patent/PE20221263A1/es unknown
- 2020-12-17 CN CN202211579747.8A patent/CN115746138A/zh active Pending
- 2020-12-17 US US17/125,734 patent/US11760802B2/en active Active
- 2020-12-17 WO PCT/US2020/065642 patent/WO2021127200A1/en active Application Filing
- 2020-12-17 CA CA3164642A patent/CA3164642A1/en active Pending
- 2020-12-17 EP EP20851260.8A patent/EP4077394A1/en active Pending
- 2020-12-17 JP JP2022536551A patent/JP2023507110A/ja active Pending
- 2020-12-17 AU AU2020405036A patent/AU2020405036A1/en active Pending
- 2020-12-18 AR ARP200103556A patent/AR120822A1/es unknown
- 2020-12-18 TW TW109144849A patent/TW202136304A/zh unknown
-
2022
- 2022-06-13 CO CONC2022/0008272A patent/CO2022008272A2/es unknown
- 2022-06-15 CL CL2022001622A patent/CL2022001622A1/es unknown
-
2023
- 2023-08-02 US US18/364,285 patent/US20240043533A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP4077394A1 (en) | 2022-10-26 |
KR20220130671A (ko) | 2022-09-27 |
WO2021127200A8 (en) | 2022-07-14 |
CL2022001622A1 (es) | 2023-03-24 |
WO2021127200A1 (en) | 2021-06-24 |
US11760802B2 (en) | 2023-09-19 |
MX2022007288A (es) | 2022-07-12 |
US20210221887A1 (en) | 2021-07-22 |
PE20221263A1 (es) | 2022-08-16 |
JP2023507110A (ja) | 2023-02-21 |
CA3164642A1 (en) | 2021-06-24 |
CN114901691A (zh) | 2022-08-12 |
BR112022011790A2 (pt) | 2022-08-30 |
IL293869A (en) | 2022-08-01 |
CN115746138A (zh) | 2023-03-07 |
US20240043533A1 (en) | 2024-02-08 |
AR120822A1 (es) | 2022-03-23 |
TW202136304A (zh) | 2021-10-01 |
AU2020405036A1 (en) | 2022-07-07 |
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