CO2021008158A2 - Glicósidos de esteviol de alta pureza - Google Patents

Glicósidos de esteviol de alta pureza

Info

Publication number
CO2021008158A2
CO2021008158A2 CONC2021/0008158A CO2021008158A CO2021008158A2 CO 2021008158 A2 CO2021008158 A2 CO 2021008158A2 CO 2021008158 A CO2021008158 A CO 2021008158A CO 2021008158 A2 CO2021008158 A2 CO 2021008158A2
Authority
CO
Colombia
Prior art keywords
rebaudioside
stevioside
steviol glycosides
steviolbioside
high purity
Prior art date
Application number
CONC2021/0008158A
Other languages
English (en)
Inventor
Avetik Markosyan
Siew Yin Chow
Bin Nawi Khairul Nizam
Kristina Chkhan
Bin Hasim Mohamad Afzaal
Saravanan A/L Ramandach
Original Assignee
Purecircle Usa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purecircle Usa Inc filed Critical Purecircle Usa Inc
Publication of CO2021008158A2 publication Critical patent/CO2021008158A2/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/24Condensed ring systems having three or more rings
    • C07H15/256Polyterpene radicals
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52Adding ingredients
    • A23L2/56Flavouring or bittering agents
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52Adding ingredients
    • A23L2/60Sweeteners
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30Artificial sweetening agents
    • A23L27/33Artificial sweetening agents containing sugars or derivatives
    • A23L27/36Terpene glycosides
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/88Taste or flavour enhancing agents
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D19/00Degasification of liquids
    • B01D19/02Foam dispersion or prevention
    • B01D19/04Foam dispersion or prevention by addition of chemical substances
    • B01D19/0404Foam dispersion or prevention by addition of chemical substances characterised by the nature of the chemical substance
    • B01D19/0495Foam dispersion or prevention by addition of chemical substances characterised by the nature of the chemical substance containing hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00Processes for the preparation of sugar derivatives
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1051Hexosyltransferases (2.4.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/44Preparation of O-glycosides, e.g. glucosides
    • C12P19/56Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y204/00Glycosyltransferases (2.4)
    • C12Y204/01Hexosyltransferases (2.4.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y204/00Glycosyltransferases (2.4)
    • C12Y204/01Hexosyltransferases (2.4.1)
    • C12Y204/01013Sucrose synthase (2.4.1.13)
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Seasonings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Saccharide Compounds (AREA)
  • Cosmetics (AREA)

Abstract

RESUMEN Se describen los métodos para preparar glicósidos de esteviol altamente purificados, particularmente el esteviolmonósido, esteviolmonósido A, esteviolbiósido, esteviolbiósido D, rubusósido, esteviolbiósido A, esteviolbiósido B, rebaudiósido B, esteviósido, rebaudiósido G, esteviósido A, esteviósido B, esteviósido C, rebaudiósido A, rebaudiósido E, rebaudiósido E2, rebaudiósido E4, rebaudiósido E6, rebaudiósido E3, rebaudiósido D, rebaudiósido I, rebaudiósido AM, rebaudiósido D7, rebaudiósido M, rebaudiósido M4, rebaudiósido 1a, rebaudiósido 1b, rebaudiósido 1c, rebaudiósido 1d, rebaudiósido 1e, rebaudiósido 1f, rebaudiósido 1g, rebaudiósido 1h, rebaudiósido 1i, rebaudiósido 1j, rebaudiósido 1k, rebaudiósido 1l, rebaudiósido 1m, rebaudiósido 1n, rebaudiósido 2a y/o SvG7. Los métodos incluyen usar preparaciones enzimáticas y microorganismos recombinantes para convertir diversas composiciones de partida en glicósidos de esteviol objetivo. Los glicósidos de esteviol altamente purificados son útiles como edulcorante no calórico, potenciador de sabor, potenciador de dulzor y supresor de espuma en composiciones comestibles y masticables, tales como cualesquiera bebidas, golosinas, productos de panadería, galletas, y gomas de mascar.
CONC2021/0008158A 2018-11-27 2021-06-22 Glicósidos de esteviol de alta pureza CO2021008158A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862771937P 2018-11-27 2018-11-27
PCT/US2019/063543 WO2020112957A1 (en) 2018-11-27 2019-11-27 High-purity steviol glycosides

Publications (1)

Publication Number Publication Date
CO2021008158A2 true CO2021008158A2 (es) 2021-08-30

Family

ID=70854114

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2021/0008158A CO2021008158A2 (es) 2018-11-27 2021-06-22 Glicósidos de esteviol de alta pureza

Country Status (12)

Country Link
US (1) US20220017557A1 (es)
EP (1) EP3887383A4 (es)
JP (1) JP2022513616A (es)
KR (1) KR20210125474A (es)
CN (1) CN113227111A (es)
AU (1) AU2019389030A1 (es)
BR (1) BR112021010189A2 (es)
CA (1) CA3120867A1 (es)
CL (1) CL2021001360A1 (es)
CO (1) CO2021008158A2 (es)
MX (1) MX2021006051A (es)
WO (1) WO2020112957A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3094203A1 (en) * 2018-03-16 2019-09-19 Purecircle Usa Inc. High-purity steviol glycosides
KR20210129679A (ko) * 2019-02-15 2021-10-28 퓨어써클 유에스에이 잉크. 고순도 스테비올 글리코사이드
EP4176070A1 (en) 2020-07-03 2023-05-10 c-LEcta GmbH One-pot cell-free glycosylation process
CN112206236A (zh) * 2020-08-28 2021-01-12 唐传生物科技(厦门)有限公司 一种l-阿拉伯糖抑制山梨醇肠道产气方面的用途
JP2024503099A (ja) * 2021-01-15 2024-01-24 フィルメニッヒ インコーポレイテッド モグロシドを含む甘味料組成物およびその使用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108329365B (zh) * 2013-03-15 2022-04-05 可口可乐公司 甜菊醇糖苷、其组合物以及其纯化
JP6109437B2 (ja) * 2014-09-30 2017-04-05 サントリー食品インターナショナル株式会社 炭酸飲料、炭酸飲料の調製に用いられるシロップ、炭酸飲料の製造方法、及び炭酸飲料の泡立ちを抑制する方法
US10463062B2 (en) * 2014-11-05 2019-11-05 Manus Bio Inc. Microbial production of steviol glycosides
US10711024B2 (en) * 2014-12-17 2020-07-14 Cargill, Incorporated Steviol glycoside compounds, compositions for oral ingestion or use, and method for enhancing steviol glycoside solubility
SG11201705606PA (en) * 2015-01-30 2017-08-30 Evolva Sa Production of steviol glycosides in recombinant hosts
WO2016156616A1 (en) * 2015-04-03 2016-10-06 Dsm Ip Assets B.V. Steviol glycosides
EP4159050A1 (en) * 2015-11-30 2023-04-05 Cargill, Incorporated Steviol glycoside compositions for oral ingestion or use
CN105838759A (zh) * 2016-03-28 2016-08-10 南京诺云生物科技有限公司 一种甜菊糖衍生物的制备方法
SG10202012673SA (en) * 2016-06-17 2021-01-28 Cargill Inc Steviol glycoside compositions for oral ingestion or use
AU2016411413B2 (en) * 2016-06-17 2022-01-13 Cargill, Incorporated Steviol glycoside compositions for oral ingestion or use
WO2018213290A1 (en) * 2017-05-15 2018-11-22 Purecircle Usa Inc. High-purity steviol glycosides
WO2019178471A1 (en) * 2018-03-16 2019-09-19 Purecircle Usa Inc. High-purity steviol glycosides

Also Published As

Publication number Publication date
EP3887383A4 (en) 2022-11-09
US20220017557A1 (en) 2022-01-20
JP2022513616A (ja) 2022-02-09
BR112021010189A2 (pt) 2021-11-09
CN113227111A (zh) 2021-08-06
WO2020112957A1 (en) 2020-06-04
MX2021006051A (es) 2021-07-06
CL2021001360A1 (es) 2022-01-07
KR20210125474A (ko) 2021-10-18
AU2019389030A1 (en) 2021-06-17
EP3887383A1 (en) 2021-10-06
CA3120867A1 (en) 2020-06-04

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