CO2021005540A2 - Compuestos de pirimidinodiona bicíclicos sustituidos con tetrahidropirano (thp) - Google Patents

Compuestos de pirimidinodiona bicíclicos sustituidos con tetrahidropirano (thp)

Info

Publication number
CO2021005540A2
CO2021005540A2 CONC2021/0005540A CO2021005540A CO2021005540A2 CO 2021005540 A2 CO2021005540 A2 CO 2021005540A2 CO 2021005540 A CO2021005540 A CO 2021005540A CO 2021005540 A2 CO2021005540 A2 CO 2021005540A2
Authority
CO
Colombia
Prior art keywords
thp
tetrahydropyran
substituted bicyclic
compounds
pyrimidinedione
Prior art date
Application number
CONC2021/0005540A
Other languages
English (en)
Spanish (es)
Inventor
Fabienne Thompson
Mark Grillo
Brian Kane
Johan Oslob
Min Zhong
Original Assignee
Myokardia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Myokardia Inc filed Critical Myokardia Inc
Publication of CO2021005540A2 publication Critical patent/CO2021005540A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Hospice & Palliative Care (AREA)
CONC2021/0005540A 2018-10-29 2021-04-28 Compuestos de pirimidinodiona bicíclicos sustituidos con tetrahidropirano (thp) CO2021005540A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862752278P 2018-10-29 2018-10-29
PCT/US2019/058297 WO2020092208A1 (en) 2018-10-29 2019-10-28 Tetrahydropyran (thp)-substituted bicyclic-pyrimidinedione compounds

Publications (1)

Publication Number Publication Date
CO2021005540A2 true CO2021005540A2 (es) 2021-07-30

Family

ID=68841171

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2021/0005540A CO2021005540A2 (es) 2018-10-29 2021-04-28 Compuestos de pirimidinodiona bicíclicos sustituidos con tetrahidropirano (thp)

Country Status (29)

Country Link
US (5) US11034693B2 (https=)
EP (3) EP4736855A2 (https=)
JP (3) JP7447110B2 (https=)
KR (2) KR102797129B1 (https=)
CN (3) CN113056465B (https=)
AR (1) AR116880A1 (https=)
AU (2) AU2019373206B2 (https=)
BR (1) BR112021008077A2 (https=)
CA (1) CA3118293A1 (https=)
CL (1) CL2021001083A1 (https=)
CO (1) CO2021005540A2 (https=)
DK (2) DK3873904T3 (https=)
EA (1) EA202191152A1 (https=)
ES (1) ES2986923T3 (https=)
FI (2) FI3873904T3 (https=)
HR (2) HRP20241065T1 (https=)
HU (1) HUE068265T2 (https=)
IL (2) IL325304A (https=)
LT (2) LT3873904T (https=)
MX (2) MX2021004955A (https=)
PE (1) PE20211780A1 (https=)
PL (1) PL3873904T3 (https=)
PT (1) PT3873904T (https=)
RS (1) RS65963B1 (https=)
SG (1) SG11202104218SA (https=)
SI (2) SI3873904T1 (https=)
SM (1) SMT202400358T1 (https=)
TW (3) TW202521537A (https=)
WO (1) WO2020092208A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3088347A1 (en) 2018-01-17 2019-07-25 Glaxosmithkline Intellectual Property Development Limited Pi4kiii.beta. inhibitors
EA202191152A1 (ru) 2018-10-29 2022-01-19 Миокардиа, Инк. Тетрагидропиран (thp)-замещенные бициклические соединения пиримидиндиона
MX2023002024A (es) 2020-08-28 2023-05-10 Myokardia Inc Métodos de tratamiento con modulador de miosina.
CN114149423B (zh) * 2020-09-08 2023-12-12 江苏恒瑞医药股份有限公司 四氢吡啶并嘧啶二酮类衍生物、其制备方法及其在医药上的应用
CN114456163B (zh) * 2020-11-09 2023-08-11 江苏恒瑞医药股份有限公司 四氢吡啶并嘧啶二酮类衍生物、其制备方法及其在医药上的应用
WO2022105852A1 (zh) 2020-11-20 2022-05-27 江苏恒瑞医药股份有限公司 三嗪二酮类衍生物、其制备方法及其在医药上的应用
CN117083275A (zh) 2021-03-04 2023-11-17 赛特凯恩蒂克公司 心脏肌节抑制剂
CN119053591A (zh) 2022-05-20 2024-11-29 江苏恒瑞医药股份有限公司 一种三嗪二酮类衍生物的晶型及制备方法
IL318417A (en) 2022-07-29 2025-03-01 Myokardia Inc Crystalline forms of (6s,7s)-6-fluoro-7-(2-fluoro-5-methylphenyl)-3-(tetrahydro-2h-pyran-4-yl)-5,6,7,8-tetrahydropyrido[2 ,3-d]pyrimidine-2,4(lh,3h)-dione

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU725689B2 (en) 1995-06-07 2000-10-19 G.D. Searle & Co. Epoxy-steroidal aldosterone antagonist and angiotensin II antagonist combination therapy for treatment of congestive heart failure
GB9715892D0 (en) 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic compounds
SMT202000071T1 (it) * 2013-06-21 2020-03-13 Myokardia Inc Composti di pirimidinadione contro le condizioni cardiache
US9663516B2 (en) * 2014-12-18 2017-05-30 MyoKardia, Inc. Bicyclic-pyrimidinedione compounds
EA202191152A1 (ru) 2018-10-29 2022-01-19 Миокардиа, Инк. Тетрагидропиран (thp)-замещенные бициклические соединения пиримидиндиона

Also Published As

Publication number Publication date
FI4464321T3 (fi) 2026-03-11
TWI876902B (zh) 2025-03-11
IL282740A (en) 2021-06-30
JP2025138748A (ja) 2025-09-25
JP2024063091A (ja) 2024-05-10
EP4736855A2 (en) 2026-05-06
US11034693B2 (en) 2021-06-15
AU2019373206B2 (en) 2024-11-14
PT3873904T (pt) 2024-10-08
PL3873904T3 (pl) 2024-12-23
ES2986923T3 (es) 2024-11-13
AR116880A1 (es) 2021-06-23
WO2020092208A1 (en) 2020-05-07
TWI837202B (zh) 2024-04-01
KR20210086673A (ko) 2021-07-08
JP7703716B2 (ja) 2025-07-15
CN113056465B (zh) 2025-01-28
SI4464321T1 (sl) 2026-03-31
CN119977963A (zh) 2025-05-13
TW202426449A (zh) 2024-07-01
US20250282779A1 (en) 2025-09-11
SMT202400358T1 (it) 2024-11-15
HUE068265T2 (hu) 2024-12-28
US20240025894A1 (en) 2024-01-25
KR102797129B1 (ko) 2025-04-18
SI3873904T1 (sl) 2024-10-30
RS65963B1 (sr) 2024-10-31
JP7447110B2 (ja) 2024-03-11
DK3873904T3 (da) 2024-08-05
HRP20260161T1 (hr) 2026-03-27
EP4464321A2 (en) 2024-11-20
MX2021004955A (es) 2021-07-21
EP3873904B1 (en) 2024-07-10
AU2019373206A1 (en) 2021-06-17
TW202521537A (zh) 2025-06-01
CN113056465A (zh) 2021-06-29
LT4464321T (lt) 2026-03-25
BR112021008077A2 (pt) 2021-08-03
CN119977962A (zh) 2025-05-13
EA202191152A1 (ru) 2022-01-19
EP3873904A1 (en) 2021-09-08
IL325304A (en) 2026-02-01
HRP20241065T1 (hr) 2024-11-08
EP4464321A3 (en) 2025-01-01
DK4464321T3 (da) 2026-02-09
LT3873904T (lt) 2024-11-11
JP2022506524A (ja) 2022-01-17
EP4464321B1 (en) 2026-01-21
MX2024004892A (es) 2024-05-07
SG11202104218SA (en) 2021-05-28
IL282740B1 (en) 2026-01-01
US20220340569A1 (en) 2022-10-27
US12344607B2 (en) 2025-07-01
CA3118293A1 (en) 2020-05-07
TW202030189A (zh) 2020-08-16
AU2025200975A1 (en) 2025-03-06
CL2021001083A1 (es) 2021-09-24
KR20250053228A (ko) 2025-04-21
US20220106314A1 (en) 2022-04-07
PE20211780A1 (es) 2021-09-08
US20200165247A1 (en) 2020-05-28
FI3873904T3 (fi) 2024-08-09

Similar Documents

Publication Publication Date Title
CO2021005540A2 (es) Compuestos de pirimidinodiona bicíclicos sustituidos con tetrahidropirano (thp)
DOP2022000172A (es) Compuestos de piperidina urea 4-metilsulfonil-sustituidos para el tratamiento de miocardiopatía dilatada (mcd)
MX2015017865A (es) Compuestos de pirimidinodiona contra estados cardiacos.
MX2020011565A (es) Analogos de rapamicina ligados a c40, c28 y c-32 como inhibidores de mtor.
CO2019008783A2 (es) Compuestos dinucleotidos ciclicos para el tratamiento del cancer
MX2017006167A (es) Compuestos que interactúan con glicanos y métodos de uso.
JOP20210164A1 (ar) طرق وتركيبات علاج السرطان
MX2022009596A (es) Anticuerpos anti-ror1 y composiciones.
ECSP20061378A (es) COMPUESTOS DIÓLICOS DE AMINOPIRAZINA COMO INHIBIDORES DE PI3K-gamma
CU24608B1 (es) Compuestos de dihidrooxadiazinonas sustituidas útiles en el tratamiento de enfermedades hiperproliferativas y métodos para preparar dichos compuestos
NI201800134A (es) Anticuerpos antifactor de la coagulación xi
EA201890442A1 (ru) Получение фоторецепторов для лечения заболеваний сетчатки
NI201801172A (es) Nuevos compuestos para el tratamiento de enfermedades parasitarias
PE20220645A1 (es) Formas polimorficas de (r)-4- (1-((3- (difluorometil)-1-metil-1h- pirazol-4-il)sulfonil) -1- fluoroetil)-n-(isoxazol-3-il)piperidina -1- carboxamida
MX2016014949A (es) Agonista del receptor 5-ht4 para gastroparesia.
CL2018003159A1 (es) Procesos para la elaboración de derivados de 6-alquinil-piridina.
TH2101002414A (th) สารประกอบไบไซคลิค-ไพริมิดีนไดโอนชนิดถูกแทนที่ด้วยเททระไฮโดรไพแรน (thp)
CO2019001967A2 (es) Compuestos de tiazolo-piridina sustituida como inhibidores de malt1
BR112019004463A2 (pt) formas cristalinas de compostos terapêuticos, seus processos de obtenção e seus métodos de uso
EA201991735A1 (ru) Азолопиримидины для лечения раковых заболеваний
EA202092947A1 (ru) Анти-pvrig/анти-tigit биспецифические антитела и способы их применения
EA202092743A1 (ru) Антитела к il36r