CL2021001083A1 - Compuestos de pirimidinodiona bicíclicos sustituidos con tetrahidropirano (thp) - Google Patents

Compuestos de pirimidinodiona bicíclicos sustituidos con tetrahidropirano (thp)

Info

Publication number
CL2021001083A1
CL2021001083A1 CL2021001083A CL2021001083A CL2021001083A1 CL 2021001083 A1 CL2021001083 A1 CL 2021001083A1 CL 2021001083 A CL2021001083 A CL 2021001083A CL 2021001083 A CL2021001083 A CL 2021001083A CL 2021001083 A1 CL2021001083 A1 CL 2021001083A1
Authority
CL
Chile
Prior art keywords
thp
tetrahydropyran
substituted bicyclic
compounds
pyrimidinedione
Prior art date
Application number
CL2021001083A
Other languages
English (en)
Inventor
Grillo Mark
Kane Brian
Oslob Johan
Zhong Min
Thompson Fabienne
Original Assignee
Myokardia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Myokardia Inc filed Critical Myokardia Inc
Publication of CL2021001083A1 publication Critical patent/CL2021001083A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención proporciona nuevos compuestos de pirimidinodiona bicíclicos sustituidos con tetrahidropirano (THP) que son útiles para el tratamiento de la cardiomiopatía hipertrófica (HCM) y las condiciones asociadas con la hipertrofia ventricular izquierda o la disfunción diastólica, y/o los síntomas asociados a la misma. Se describe la síntesis y caracterización de los compuestos, así como los métodos para tratar la HCM y otras formas de enfermedad cardíaca.
CL2021001083A 2018-10-29 2021-04-27 Compuestos de pirimidinodiona bicíclicos sustituidos con tetrahidropirano (thp) CL2021001083A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862752278P 2018-10-29 2018-10-29

Publications (1)

Publication Number Publication Date
CL2021001083A1 true CL2021001083A1 (es) 2021-09-24

Family

ID=68841171

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2021001083A CL2021001083A1 (es) 2018-10-29 2021-04-27 Compuestos de pirimidinodiona bicíclicos sustituidos con tetrahidropirano (thp)

Country Status (17)

Country Link
US (4) US11034693B2 (es)
EP (1) EP3873904A1 (es)
JP (2) JP7447110B2 (es)
KR (1) KR20210086673A (es)
CN (1) CN113056465A (es)
AR (1) AR116880A1 (es)
AU (1) AU2019373206A1 (es)
BR (1) BR112021008077A2 (es)
CA (1) CA3118293A1 (es)
CL (1) CL2021001083A1 (es)
CO (1) CO2021005540A2 (es)
EA (1) EA202191152A1 (es)
IL (1) IL282740A (es)
MX (1) MX2021004955A (es)
PE (1) PE20211780A1 (es)
SG (1) SG11202104218SA (es)
WO (1) WO2020092208A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11649238B2 (en) 2018-01-17 2023-05-16 Glaxosmithkline Intellectual Property Development Limited Substituted pyrazolo[1,5-a]pyrimidines as PI4K inhibitors

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114149423B (zh) * 2020-09-08 2023-12-12 江苏恒瑞医药股份有限公司 四氢吡啶并嘧啶二酮类衍生物、其制备方法及其在医药上的应用
CN114456163B (zh) * 2020-11-09 2023-08-11 江苏恒瑞医药股份有限公司 四氢吡啶并嘧啶二酮类衍生物、其制备方法及其在医药上的应用
CN116323598A (zh) 2020-11-20 2023-06-23 江苏恒瑞医药股份有限公司 三嗪二酮类衍生物、其制备方法及其在医药上的应用
WO2024026058A1 (en) 2022-07-29 2024-02-01 MyoKardia, Inc. Crystalline forms of (6s,7s)-6-fluoro-7-(2-fluoro-5-methylphenyl)- 3-(tetrahydro-2h-pyran-4-yl)-5,6,7,8-tetrahydropyrido[2,3- d]pyrimidine-2,4(lh,3h)-dione

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY190860A (en) * 2013-06-21 2022-05-12 Myokardia Inc Pyrimidinedione compounds against cardiac conditions
US9663516B2 (en) * 2014-12-18 2017-05-30 MyoKardia, Inc. Bicyclic-pyrimidinedione compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11649238B2 (en) 2018-01-17 2023-05-16 Glaxosmithkline Intellectual Property Development Limited Substituted pyrazolo[1,5-a]pyrimidines as PI4K inhibitors

Also Published As

Publication number Publication date
JP2024063091A (ja) 2024-05-10
BR112021008077A2 (pt) 2021-08-03
CA3118293A1 (en) 2020-05-07
WO2020092208A1 (en) 2020-05-07
JP2022506524A (ja) 2022-01-17
US20240025894A1 (en) 2024-01-25
AR116880A1 (es) 2021-06-23
CO2021005540A2 (es) 2021-07-30
US20220106314A1 (en) 2022-04-07
US20200165247A1 (en) 2020-05-28
IL282740A (en) 2021-06-30
CN113056465A (zh) 2021-06-29
EP3873904A1 (en) 2021-09-08
MX2021004955A (es) 2021-07-21
EA202191152A1 (ru) 2022-01-19
JP7447110B2 (ja) 2024-03-11
AU2019373206A1 (en) 2021-06-17
PE20211780A1 (es) 2021-09-08
KR20210086673A (ko) 2021-07-08
SG11202104218SA (en) 2021-05-28
TW202030189A (zh) 2020-08-16
US11034693B2 (en) 2021-06-15
US20220340569A1 (en) 2022-10-27

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