MX2021004955A - Compuestos de pirimidinodiona biciclica sustituidos con tetrahidropirano (thp). - Google Patents

Compuestos de pirimidinodiona biciclica sustituidos con tetrahidropirano (thp).

Info

Publication number
MX2021004955A
MX2021004955A MX2021004955A MX2021004955A MX2021004955A MX 2021004955 A MX2021004955 A MX 2021004955A MX 2021004955 A MX2021004955 A MX 2021004955A MX 2021004955 A MX2021004955 A MX 2021004955A MX 2021004955 A MX2021004955 A MX 2021004955A
Authority
MX
Mexico
Prior art keywords
thp
tetrahydropyran
substituted bicyclic
compounds
pyrimidinedione
Prior art date
Application number
MX2021004955A
Other languages
English (en)
Inventor
Brian Kane
Min Zhong
Johan Oslob
Fabienne Thompson
Mark Grillo
Original Assignee
Myokardia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Myokardia Inc filed Critical Myokardia Inc
Publication of MX2021004955A publication Critical patent/MX2021004955A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

La presente invención se refiere a nuevos compuestos de pirimidinodiona bicíclicos sustituidos con tetrahidropirano (THP) que son útiles para el tratamiento de la cardiomiopatía hipertrófica (HCM) y las condiciones asociadas con la hipertrofia ventricular izquierda o la disfunción diastólica, y/o los síntomas asociados a la misma. Se describe la síntesis y caracterización de los compuestos, así como los métodos para tratar la HCM y otras formas de enfermedad cardíaca.
MX2021004955A 2018-10-29 2019-10-28 Compuestos de pirimidinodiona biciclica sustituidos con tetrahidropirano (thp). MX2021004955A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862752278P 2018-10-29 2018-10-29
PCT/US2019/058297 WO2020092208A1 (en) 2018-10-29 2019-10-28 Tetrahydropyran (thp)-substituted bicyclic-pyrimidinedione compounds

Publications (1)

Publication Number Publication Date
MX2021004955A true MX2021004955A (es) 2021-07-21

Family

ID=68841171

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021004955A MX2021004955A (es) 2018-10-29 2019-10-28 Compuestos de pirimidinodiona biciclica sustituidos con tetrahidropirano (thp).

Country Status (17)

Country Link
US (4) US11034693B2 (es)
EP (1) EP3873904A1 (es)
JP (1) JP7447110B2 (es)
KR (1) KR20210086673A (es)
CN (1) CN113056465A (es)
AR (1) AR116880A1 (es)
AU (1) AU2019373206A1 (es)
BR (1) BR112021008077A2 (es)
CA (1) CA3118293A1 (es)
CL (1) CL2021001083A1 (es)
CO (1) CO2021005540A2 (es)
EA (1) EA202191152A1 (es)
IL (1) IL282740A (es)
MX (1) MX2021004955A (es)
PE (1) PE20211780A1 (es)
SG (1) SG11202104218SA (es)
WO (1) WO2020092208A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111868063B (zh) 2018-01-17 2023-08-01 葛兰素史克知识产权开发有限公司 PI4KIIIβ抑制剂
CN114149423B (zh) * 2020-09-08 2023-12-12 江苏恒瑞医药股份有限公司 四氢吡啶并嘧啶二酮类衍生物、其制备方法及其在医药上的应用
CN114456163B (zh) * 2020-11-09 2023-08-11 江苏恒瑞医药股份有限公司 四氢吡啶并嘧啶二酮类衍生物、其制备方法及其在医药上的应用
US20240010639A1 (en) 2020-11-20 2024-01-11 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Triazine dione derivative, preparation method therefor and application thereof in medicine
WO2024026058A1 (en) 2022-07-29 2024-02-01 MyoKardia, Inc. Crystalline forms of (6s,7s)-6-fluoro-7-(2-fluoro-5-methylphenyl)- 3-(tetrahydro-2h-pyran-4-yl)-5,6,7,8-tetrahydropyrido[2,3- d]pyrimidine-2,4(lh,3h)-dione

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6603213B2 (ja) * 2013-06-21 2019-11-06 マイオカーディア，インク 心臓状態に対するピリミジンジオン化合物
US9663516B2 (en) 2014-12-18 2017-05-30 MyoKardia, Inc. Bicyclic-pyrimidinedione compounds

Also Published As

Publication number Publication date
TW202030189A (zh) 2020-08-16
IL282740A (en) 2021-06-30
SG11202104218SA (en) 2021-05-28
CA3118293A1 (en) 2020-05-07
US11034693B2 (en) 2021-06-15
CL2021001083A1 (es) 2021-09-24
US20200165247A1 (en) 2020-05-28
KR20210086673A (ko) 2021-07-08
JP7447110B2 (ja) 2024-03-11
BR112021008077A2 (pt) 2021-08-03
JP2022506524A (ja) 2022-01-17
EP3873904A1 (en) 2021-09-08
CN113056465A (zh) 2021-06-29
US20240025894A1 (en) 2024-01-25
US20220340569A1 (en) 2022-10-27
AR116880A1 (es) 2021-06-23
AU2019373206A1 (en) 2021-06-17
EA202191152A1 (ru) 2022-01-19
WO2020092208A1 (en) 2020-05-07
CO2021005540A2 (es) 2021-07-30
PE20211780A1 (es) 2021-09-08
US20220106314A1 (en) 2022-04-07

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