CO2021001544A2 - Variantes de anticuerpos anti-cd38 y sus usos - Google Patents
Variantes de anticuerpos anti-cd38 y sus usosInfo
- Publication number
- CO2021001544A2 CO2021001544A2 CONC2021/0001544A CO2021001544A CO2021001544A2 CO 2021001544 A2 CO2021001544 A2 CO 2021001544A2 CO 2021001544 A CO2021001544 A CO 2021001544A CO 2021001544 A2 CO2021001544 A2 CO 2021001544A2
- Authority
- CO
- Colombia
- Prior art keywords
- antibody variants
- amino acid
- acid residues
- mutations
- mutation
- Prior art date
Links
- 125000000539 amino acid group Chemical group 0.000 abstract 2
- 230000035772 mutation Effects 0.000 abstract 2
- 239000001825 Polyoxyethene (8) stearate Substances 0.000 abstract 1
- 239000004337 magnesium citrate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Dispersion Chemistry (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862697730P | 2018-07-13 | 2018-07-13 | |
| US201962848874P | 2019-05-16 | 2019-05-16 | |
| PCT/EP2019/069028 WO2020012036A1 (en) | 2018-07-13 | 2019-07-15 | Variants of cd38 antibody and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2021001544A2 true CO2021001544A2 (es) | 2021-03-08 |
Family
ID=67396922
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2021/0001544A CO2021001544A2 (es) | 2018-07-13 | 2021-02-10 | Variantes de anticuerpos anti-cd38 y sus usos |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US20200017600A1 (enExample) |
| EP (1) | EP3820900A1 (enExample) |
| JP (2) | JP7526717B2 (enExample) |
| KR (1) | KR20210031932A (enExample) |
| CN (2) | CN120865412A (enExample) |
| AU (1) | AU2019300223A1 (enExample) |
| BR (1) | BR112020026432A2 (enExample) |
| CA (1) | CA3106146A1 (enExample) |
| CL (1) | CL2021000066A1 (enExample) |
| CO (1) | CO2021001544A2 (enExample) |
| CR (1) | CR20210081A (enExample) |
| DO (2) | DOP2021000006A (enExample) |
| EC (1) | ECSP21010092A (enExample) |
| IL (1) | IL279937A (enExample) |
| MA (1) | MA53122A (enExample) |
| MX (1) | MX2020013631A (enExample) |
| MY (1) | MY205398A (enExample) |
| PE (1) | PE20211858A1 (enExample) |
| PH (1) | PH12021550054A1 (enExample) |
| SG (1) | SG11202012993SA (enExample) |
| TW (1) | TW202019518A (enExample) |
| WO (1) | WO2020012036A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014006217A1 (en) | 2012-07-06 | 2014-01-09 | Genmab B.V. | Dimeric protein with triple mutations |
| MX2020013631A (es) * | 2018-07-13 | 2021-03-25 | Genmab As | Variantes de anticuerpo grupo de diferenciacion (cd38) y usos de las mismas. |
| CN114980927A (zh) * | 2020-01-16 | 2022-08-30 | 健玛保 | Cd38抗体的配制剂及其用途 |
| AU2021283564B2 (en) * | 2020-06-02 | 2025-05-29 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animals with common light chain immunoglobulin locus |
| US20220275090A1 (en) | 2021-02-22 | 2022-09-01 | Janssen Biotech, Inc. | Combination Therapies with Anti-CD38 Antibodies and PARP or Adenosine Receptor Inhibitors |
| WO2023044346A2 (en) | 2021-09-14 | 2023-03-23 | Ausper Biopharma Co., Ltd. | Vaccines for coronavirus prevention and treatment |
| US20240400711A1 (en) * | 2021-09-23 | 2024-12-05 | Sound Biopharmaceuticals Co. Ltd. | Cd38 monoclonal antibody and application thereof |
| WO2023079494A1 (en) | 2021-11-03 | 2023-05-11 | Janssen Biotech, Inc. | Corticosteriod reduction in treatment with anti-cd38 antibodies |
| CN114409788B (zh) * | 2022-03-04 | 2022-10-04 | 四川大学华西医院 | 抗cd38的抗体及其应用 |
| WO2024094660A1 (en) | 2022-10-31 | 2024-05-10 | Genmab A/S | Cd38 antibodies and uses thereof |
| WO2024131849A1 (zh) * | 2022-12-21 | 2024-06-27 | 非同（成都）生物科技有限公司 | Cd38单克隆抗体及其应用 |
| US12173081B2 (en) | 2023-03-21 | 2024-12-24 | Biograph 55, Inc. | CD19/CD38 multispecific antibodies |
| CN120965865A (zh) * | 2025-10-15 | 2025-11-18 | 内蒙古盛健生物科技有限责任公司 | 一种用于特异性治疗奶山羊羔羊口疮的抗体及其应用 |
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| WO2018006052A1 (en) | 2016-06-30 | 2018-01-04 | Protiva Biotherapeutics, Inc. | Compositions and methods for delivering messenger rna |
| US10669344B2 (en) | 2016-08-12 | 2020-06-02 | Janssen Biotech, Inc. | Engineered antibodies and other Fc-domain containing molecules with enhanced agonism and effector functions |
| IL267352B2 (en) | 2016-12-21 | 2023-10-01 | Hoffmann La Roche | Method for in vitro glycoengineering of antibodies |
| AU2017384276B9 (en) | 2016-12-21 | 2020-11-26 | F. Hoffmann-La Roche Ag | In vitro glycoengineering of antibodies |
| US10526284B2 (en) | 2016-12-21 | 2020-01-07 | Arcturus Therapeutics, Inc. | Ionizable cationic lipid for RNA delivery |
| WO2018114878A1 (en) | 2016-12-21 | 2018-06-28 | F. Hoffmann-La Roche Ag | Re-use of enzymes in in vitro glycoengineering of antibodies |
| MX2020013631A (es) * | 2018-07-13 | 2021-03-25 | Genmab As | Variantes de anticuerpo grupo de diferenciacion (cd38) y usos de las mismas. |
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2019
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- 2019-07-15 CN CN202511041049.6A patent/CN120865412A/zh active Pending
- 2019-07-15 US US16/512,206 patent/US20200017600A1/en not_active Abandoned
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- 2019-07-15 BR BR112020026432-6A patent/BR112020026432A2/pt unknown
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- 2019-07-15 MA MA053122A patent/MA53122A/fr unknown
- 2019-07-15 TW TW108124908A patent/TW202019518A/zh unknown
- 2019-07-15 EP EP19742548.1A patent/EP3820900A1/en active Pending
- 2019-07-15 WO PCT/EP2019/069028 patent/WO2020012036A1/en not_active Ceased
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- 2019-07-15 KR KR1020217003848A patent/KR20210031932A/ko not_active Ceased
- 2019-07-15 SG SG11202012993SA patent/SG11202012993SA/en unknown
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- 2019-07-15 PE PE2021000038A patent/PE20211858A1/es unknown
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2020
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2021
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- 2021-01-08 CL CL2021000066A patent/CL2021000066A1/es unknown
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2024
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- 2024-03-26 JP JP2024048842A patent/JP2024075737A/ja active Pending
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| CL2021000066A1 (es) | 2021-05-28 |
| AU2019300223A1 (en) | 2021-01-07 |
| PH12021550054A1 (en) | 2021-09-27 |
| JP7526717B2 (ja) | 2024-08-01 |
| ECSP21010092A (es) | 2021-03-31 |
| CN112513082A (zh) | 2021-03-16 |
| DOP2024000217A (es) | 2024-11-29 |
| EP3820900A1 (en) | 2021-05-19 |
| MX2020013631A (es) | 2021-03-25 |
| JP2024075737A (ja) | 2024-06-04 |
| BR112020026432A2 (pt) | 2021-03-23 |
| US20200165352A1 (en) | 2020-05-28 |
| JP2021524276A (ja) | 2021-09-13 |
| KR20210031932A (ko) | 2021-03-23 |
| PE20211858A1 (es) | 2021-09-21 |
| MY205398A (en) | 2024-10-19 |
| DOP2021000006A (es) | 2021-03-15 |
| CR20210081A (es) | 2021-06-24 |
| US20240317881A1 (en) | 2024-09-26 |
| SG11202012993SA (en) | 2021-02-25 |
| CA3106146A1 (en) | 2020-01-16 |
| US20200017600A1 (en) | 2020-01-16 |
| CN120865412A (zh) | 2025-10-31 |
| IL279937A (en) | 2021-03-01 |
| CN112513082B (zh) | 2025-08-12 |
| MA53122A (fr) | 2021-05-19 |
| TW202019518A (zh) | 2020-06-01 |
| WO2020012036A1 (en) | 2020-01-16 |
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