CO2020008834A2 - Nuevo método para preparar compuesto para formación de imágenes - Google Patents

Nuevo método para preparar compuesto para formación de imágenes

Info

Publication number
CO2020008834A2
CO2020008834A2 CONC2020/0008834A CO2020008834A CO2020008834A2 CO 2020008834 A2 CO2020008834 A2 CO 2020008834A2 CO 2020008834 A CO2020008834 A CO 2020008834A CO 2020008834 A2 CO2020008834 A2 CO 2020008834A2
Authority
CO
Colombia
Prior art keywords
imaging
new method
prepare compound
compound
tauopathies
Prior art date
Application number
CONC2020/0008834A
Other languages
English (en)
Inventor
Mathias Berndt
Melean Johnny Castillo
Emanuele Gabellieri
Heiko Kroth
Hanno Schieferstein
Marion Zerna
Vincent Darmency
Jérôme Molette
Original Assignee
Life Molecular Imaging Sa
Ac Immune Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Life Molecular Imaging Sa, Ac Immune Sa filed Critical Life Molecular Imaging Sa
Publication of CO2020008834A2 publication Critical patent/CO2020008834A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Injection Moulding Of Plastics Or The Like (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

La presente invención se refiere a un método novedoso para preparar un compuesto de la fórmula I. También se describen composiciones de diagnóstico y su uso en la detección selectiva de trastornos y anormalidades asociadas con agregados de Tau tales como la enfermedad de Alzheimer (AD) y otras tauopatías, por ejemplo, usando la formación de imágenes de la tomografía por emisión de positrones (PET).
CONC2020/0008834A 2018-01-24 2020-07-16 Nuevo método para preparar compuesto para formación de imágenes CO2020008834A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18153326 2018-01-24
PCT/EP2019/051500 WO2019145294A1 (en) 2018-01-24 2019-01-22 Novel method of preparing an imaging compound

Publications (1)

Publication Number Publication Date
CO2020008834A2 true CO2020008834A2 (es) 2020-10-30

Family

ID=61192646

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2020/0008834A CO2020008834A2 (es) 2018-01-24 2020-07-16 Nuevo método para preparar compuesto para formación de imágenes

Country Status (14)

Country Link
US (1) US20210038747A1 (es)
EP (1) EP3743427B1 (es)
JP (1) JP2021512064A (es)
KR (1) KR20200113234A (es)
CN (1) CN111868062B (es)
AU (1) AU2019212170B2 (es)
CA (1) CA3088219A1 (es)
CO (1) CO2020008834A2 (es)
EA (1) EA202091767A1 (es)
ES (1) ES2930259T3 (es)
IL (1) IL275995B2 (es)
MX (1) MX2020007298A (es)
SG (1) SG11202006543QA (es)
WO (1) WO2019145294A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114835690B (zh) * 2022-07-04 2022-09-27 北京先通国际医药科技股份有限公司 含化合物i的液体组合物的制备方法、及在心肌灌注pet显像中的用途
CN114832118B (zh) * 2022-07-04 2022-09-27 北京先通国际医药科技股份有限公司 化合物i液体组合物、制备方法及其用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2642086T5 (es) * 2010-06-04 2020-04-13 Life Molecular Imaging Sa Procedimiento para la producción de ligandos de beta amiloide marcados con F-18
WO2014194169A1 (en) * 2013-05-31 2014-12-04 The General Hospital Corporation Radiosynthesis of tau radiopharmaceuticals
LT3055308T (lt) 2013-10-08 2018-02-12 F. Hoffmann-La Roche Ag Diazakarbazolo dariniai kaip taupet ligandai
US10662193B2 (en) * 2014-01-21 2020-05-26 Ac Immune Sa Carbazole and carboline compounds for use in the diagnosis, treatment, alleviation or prevention of disorders associated with amyloid or amyloid-like proteins
KR102621513B1 (ko) * 2015-02-02 2024-01-04 유씨비 바이오파마 에스알엘 9h-피롤로-디피리딘 유도체
MX2018016279A (es) * 2016-07-22 2019-09-06 Ac Immune Sa Compuestos para formacion de imagenes de agregados de proteinas tau.
WO2019145293A1 (en) * 2018-01-24 2019-08-01 Ac Immune Sa Diagnostic compositions for pet imaging, a method for manufacturing the diagnostic composition and its use in diagnostics

Also Published As

Publication number Publication date
AU2019212170B2 (en) 2022-12-22
WO2019145294A1 (en) 2019-08-01
CA3088219A1 (en) 2019-08-01
JP2021512064A (ja) 2021-05-13
EP3743427B1 (en) 2022-10-19
BR112020014949A2 (pt) 2020-12-08
BR112020014949A8 (pt) 2022-12-13
CN111868062B (zh) 2023-07-07
TW201932468A (zh) 2019-08-16
EP3743427A1 (en) 2020-12-02
CN111868062A (zh) 2020-10-30
IL275995B1 (en) 2023-05-01
MX2020007298A (es) 2020-09-10
KR20200113234A (ko) 2020-10-06
ES2930259T3 (es) 2022-12-09
IL275995A (en) 2020-08-31
SG11202006543QA (en) 2020-08-28
US20210038747A1 (en) 2021-02-11
EA202091767A1 (ru) 2021-02-16
IL275995B2 (en) 2023-09-01
AU2019212170A1 (en) 2020-07-16

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