BR112013006498A2 - composto - Google Patents

composto

Info

Publication number
BR112013006498A2
BR112013006498A2 BR112013006498A BR112013006498A BR112013006498A2 BR 112013006498 A2 BR112013006498 A2 BR 112013006498A2 BR 112013006498 A BR112013006498 A BR 112013006498A BR 112013006498 A BR112013006498 A BR 112013006498A BR 112013006498 A2 BR112013006498 A2 BR 112013006498A2
Authority
BR
Brazil
Prior art keywords
compound
prostate
methods
radiotracer
new
Prior art date
Application number
BR112013006498A
Other languages
English (en)
Inventor
Edward George Robins
Eric Ofori Aboagye
Graham Smith
Yongjun Zhao
Original Assignee
Ge Healthcare Ltd E Imp College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Ltd E Imp College filed Critical Ge Healthcare Ltd E Imp College
Publication of BR112013006498A2 publication Critical patent/BR112013006498A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/08—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with only one hydroxy group and one amino group bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/06—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton from hydroxy amines by reactions involving the etherification or esterification of hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/08—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom
    • C07C217/10—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

composto. novo radiotraçador(es) para a formação de imagem por tomografia por emissão de pósitron (pet) ou tomografia computadorizada por emissão de fóton (spect) de estados de doença relacionados ao metabolismo de colina alterado (por exemplo, a formação de imagem de tumor da próstata, mama, cérebro, esôfago, ovário, endométrio, pulmões e câncer da próstata - tumor primário, doença nodal ou metástase). a presente invenção também descreve intermediário(s), composição(ões) farmacêutica(s), métodos de produção e métodos de uso do novo(s) radiotraçador(es).
BR112013006498A 2010-09-21 2011-09-20 composto BR112013006498A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38489110P 2010-09-21 2010-09-21
PCT/US2011/052239 WO2012040133A2 (en) 2010-09-21 2011-09-20 Novel precursor

Publications (1)

Publication Number Publication Date
BR112013006498A2 true BR112013006498A2 (pt) 2016-07-12

Family

ID=44736061

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013006498A BR112013006498A2 (pt) 2010-09-21 2011-09-20 composto

Country Status (11)

Country Link
US (1) US20130178653A1 (pt)
EP (1) EP2619171A2 (pt)
JP (1) JP2013537239A (pt)
KR (2) KR20130127012A (pt)
CN (1) CN103339101A (pt)
AU (1) AU2011305661A1 (pt)
BR (1) BR112013006498A2 (pt)
CA (1) CA2811092A1 (pt)
MX (1) MX2013003185A (pt)
RU (1) RU2013112851A (pt)
WO (1) WO2012040133A2 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013542187A (ja) * 2010-09-21 2013-11-21 ジーイー・ヘルスケア・リミテッド 新規放射性トレーサー
US10280401B2 (en) 2015-04-16 2019-05-07 Biotranex, Llc Method of measuring inhibition of phosphatidylcholine export transport and/or formation activity
CZ2016117A3 (cs) * 2016-02-29 2017-09-13 Ústav makromolekulární chemie AV ČR, v. v. i. Jodovaná radioznačitelná analoga cholinu, jejich příprava a použití jako léčiva

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE588558A (pt) * 1959-03-13 1960-09-12
JP2809145B2 (ja) * 1995-08-03 1998-10-08 ダイキン工業株式会社 含フッ素コリン化合物の１８ｆ標識体、その製造方法および陽電子断層撮影診断用試薬としての応用
US6780982B2 (en) * 1996-07-12 2004-08-24 Third Wave Technologies, Inc. Charge tags and the separation of nucleic acid molecules
WO2001082864A2 (en) 2000-04-28 2001-11-08 Duke University 18f-labeled choline analogs
US8796267B2 (en) * 2006-10-23 2014-08-05 Concert Pharmaceuticals, Inc. Oxazolidinone derivatives and methods of use
WO2009089234A2 (en) * 2008-01-07 2009-07-16 Auspex Pharmaceuticals Substituted dibenzhydrylpiperazines
JP2013542187A (ja) * 2010-09-21 2013-11-21 ジーイー・ヘルスケア・リミテッド 新規放射性トレーサー

Also Published As

Publication number Publication date
US20130178653A1 (en) 2013-07-11
CA2811092A1 (en) 2012-03-29
JP2013537239A (ja) 2013-09-30
RU2013112851A (ru) 2014-10-27
KR20130127012A (ko) 2013-11-21
CN103339101A (zh) 2013-10-02
MX2013003185A (es) 2014-01-31
WO2012040133A2 (en) 2012-03-29
EP2619171A2 (en) 2013-07-31
WO2012040133A3 (en) 2012-05-10
KR20130122944A (ko) 2013-11-11
AU2011305661A1 (en) 2013-03-28

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2386 DE 27-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.