CO2020008752A2 - Variantes de dominio de fc de igg humana con función efectora mejorada - Google Patents
Variantes de dominio de fc de igg humana con función efectora mejoradaInfo
- Publication number
- CO2020008752A2 CO2020008752A2 CONC2020/0008752A CO2020008752A CO2020008752A2 CO 2020008752 A2 CO2020008752 A2 CO 2020008752A2 CO 2020008752 A CO2020008752 A CO 2020008752A CO 2020008752 A2 CO2020008752 A2 CO 2020008752A2
- Authority
- CO
- Colombia
- Prior art keywords
- human igg
- effector function
- enhanced effector
- domain variants
- domain
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/563—Immunoassay; Biospecific binding assay; Materials therefor involving antibody fragments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C12N2015/8518—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic expressing industrially exogenous proteins, e.g. for pharmaceutical use, human insulin, blood factors, immunoglobulins, pseudoparticles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Plant Pathology (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invención se relaciona con una variante del dominio de Fc de la IgG1 humana con funciones efectoras mejorada y los usos de ella.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762607591P | 2017-12-19 | 2017-12-19 | |
PCT/US2018/065103 WO2019125846A1 (en) | 2017-12-19 | 2018-12-12 | HUMAN IgG Fc DOMAIN VARIANTS WITH IMPROVED EFFECTOR FUNCTION |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2020008752A2 true CO2020008752A2 (es) | 2020-07-31 |
Family
ID=66994162
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2020/0008752A CO2020008752A2 (es) | 2017-12-19 | 2020-07-15 | Variantes de dominio de fc de igg humana con función efectora mejorada |
Country Status (19)
Country | Link |
---|---|
US (2) | US20190300621A1 (es) |
EP (1) | EP3541837A4 (es) |
JP (2) | JP2021507704A (es) |
KR (1) | KR20200100147A (es) |
CN (3) | CN111741973A (es) |
AU (1) | AU2018388791A1 (es) |
BR (1) | BR112020012308A2 (es) |
CA (1) | CA3085472A1 (es) |
CL (1) | CL2020001628A1 (es) |
CO (1) | CO2020008752A2 (es) |
CR (1) | CR20200313A (es) |
EA (1) | EA202091521A1 (es) |
EC (1) | ECSP20040345A (es) |
IL (1) | IL275279A (es) |
MX (1) | MX2020006372A (es) |
PE (1) | PE20201339A1 (es) |
PH (1) | PH12020550930A1 (es) |
SG (1) | SG11202005654QA (es) |
WO (1) | WO2019125846A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20220063188A (ko) * | 2019-08-29 | 2022-05-17 | 비르 바이오테크놀로지, 인코포레이티드 | B형 간염 바이러스 감염을 치료하기 위한 항체 조성물 및 방법 |
TW202140553A (zh) | 2020-01-13 | 2021-11-01 | 美商威特拉公司 | C5ar1抗體分子及其用途 |
TW202246331A (zh) | 2021-01-13 | 2022-12-01 | 美商威特拉公司 | 人源化補體5a受體1抗體及其使用方法 |
WO2023175614A1 (en) | 2022-03-15 | 2023-09-21 | Yeda Research And Development Co. Ltd. | Anti glucocorticoid-induced tnfr-related (gitr) protein antibodies and uses thereof |
WO2023218431A1 (en) * | 2022-05-13 | 2023-11-16 | BioNTech SE | Rna compositions targeting hiv |
WO2024006472A1 (en) * | 2022-06-30 | 2024-01-04 | Vir Biotechnology, Inc. | Antibodies that bind to multiple sarbecoviruses |
Family Cites Families (52)
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US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
AU634186B2 (en) | 1988-11-11 | 1993-02-18 | Medical Research Council | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
GB9206318D0 (en) | 1992-03-24 | 1992-05-06 | Cambridge Antibody Tech | Binding substances |
DE69133476T2 (de) | 1990-08-29 | 2006-01-05 | GenPharm International, Inc., Palo Alto | Transgene Mäuse fähig zur Produktion heterologer Antikörper |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
US5962255A (en) | 1992-03-24 | 1999-10-05 | Cambridge Antibody Technology Limited | Methods for producing recombinant vectors |
US6225447B1 (en) | 1991-05-15 | 2001-05-01 | Cambridge Antibody Technology Ltd. | Methods for producing members of specific binding pairs |
US6492160B1 (en) | 1991-05-15 | 2002-12-10 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
US5871907A (en) | 1991-05-15 | 1999-02-16 | Medical Research Council | Methods for producing members of specific binding pairs |
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ATE207080T1 (de) | 1991-11-25 | 2001-11-15 | Enzon Inc | Multivalente antigen-bindende proteine |
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US5872215A (en) | 1991-12-02 | 1999-02-16 | Medical Research Council | Specific binding members, materials and methods |
US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
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AU4289496A (en) | 1994-12-02 | 1996-06-19 | Chiron Corporation | Method of promoting an immune response with a bispecific antibody |
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US5811097A (en) | 1995-07-25 | 1998-09-22 | The Regents Of The University Of California | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
DE19544393A1 (de) | 1995-11-15 | 1997-05-22 | Hoechst Schering Agrevo Gmbh | Synergistische herbizide Mischungen |
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US7662925B2 (en) | 2002-03-01 | 2010-02-16 | Xencor, Inc. | Optimized Fc variants and methods for their generation |
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EP1919950A1 (en) * | 2004-07-15 | 2008-05-14 | Xencor, Inc. | Optimized fc variants |
JP4652414B2 (ja) | 2004-11-12 | 2011-03-16 | ゼンコー・インコーポレイテッド | FcRnとの変化した結合を有するFc変異体 |
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CA2647524C (en) | 2006-04-05 | 2019-11-26 | The Rockefeller University | Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods |
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US20110150867A1 (en) | 2007-12-14 | 2011-06-23 | The Rockefeller University | Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods |
PL2808343T3 (pl) * | 2007-12-26 | 2019-11-29 | Xencor Inc | Warianty Fc ze zmienionym wiązaniem do FcRn |
AU2009240637A1 (en) | 2008-04-22 | 2009-10-29 | The Rockefeller University | Methods of identifying anti-inflammatory compounds |
RU2012145183A (ru) * | 2010-03-29 | 2014-05-10 | Займворкс, Инк. | Антитела с повышенной или пониженной эффекторной функцией |
AU2012355710B2 (en) | 2011-12-19 | 2017-11-02 | The Rockefeller University | Non-sialylated anti-inflammatory polypeptides |
WO2013163297A1 (en) | 2012-04-25 | 2013-10-31 | Momenta Pharmaceuticals, Inc. | Modified glycoproteins |
BR112018012164A2 (pt) * | 2015-12-15 | 2018-12-04 | Gilead Sciences Inc | anticorpos neutralizantes do vírus da imunodeficiência humana |
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-
2018
- 2018-12-12 PE PE2020000790A patent/PE20201339A1/es unknown
- 2018-12-12 KR KR1020207020950A patent/KR20200100147A/ko not_active Application Discontinuation
- 2018-12-12 MX MX2020006372A patent/MX2020006372A/es unknown
- 2018-12-12 CR CR20200313A patent/CR20200313A/es unknown
- 2018-12-12 AU AU2018388791A patent/AU2018388791A1/en active Pending
- 2018-12-12 BR BR112020012308-0A patent/BR112020012308A2/pt active Search and Examination
- 2018-12-12 CN CN201880089753.0A patent/CN111741973A/zh active Pending
- 2018-12-12 CN CN202410096625.6A patent/CN117924477A/zh active Pending
- 2018-12-12 SG SG11202005654QA patent/SG11202005654QA/en unknown
- 2018-12-12 JP JP2020533798A patent/JP2021507704A/ja active Pending
- 2018-12-12 CN CN202410092669.1A patent/CN117924476A/zh active Pending
- 2018-12-12 EA EA202091521A patent/EA202091521A1/ru unknown
- 2018-12-12 EP EP18882280.3A patent/EP3541837A4/en active Pending
- 2018-12-12 CA CA3085472A patent/CA3085472A1/en active Pending
- 2018-12-12 WO PCT/US2018/065103 patent/WO2019125846A1/en unknown
-
2019
- 2019-05-29 US US16/424,639 patent/US20190300621A1/en not_active Abandoned
-
2020
- 2020-06-10 IL IL275279A patent/IL275279A/en unknown
- 2020-06-17 CL CL2020001628A patent/CL2020001628A1/es unknown
- 2020-06-17 PH PH12020550930A patent/PH12020550930A1/en unknown
- 2020-07-15 CO CONC2020/0008752A patent/CO2020008752A2/es unknown
- 2020-07-15 EC ECSENADI202040345A patent/ECSP20040345A/es unknown
-
2022
- 2022-03-21 US US17/699,716 patent/US20230057150A1/en active Pending
-
2023
- 2023-09-25 JP JP2023160189A patent/JP2023182640A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CN111741973A (zh) | 2020-10-02 |
MX2020006372A (es) | 2020-09-03 |
ECSP20040345A (es) | 2020-09-30 |
EP3541837A1 (en) | 2019-09-25 |
IL275279A (en) | 2020-07-30 |
JP2023182640A (ja) | 2023-12-26 |
PE20201339A1 (es) | 2020-11-25 |
EP3541837A4 (en) | 2020-05-13 |
WO2019125846A1 (en) | 2019-06-27 |
SG11202005654QA (en) | 2020-07-29 |
BR112020012308A2 (pt) | 2020-11-24 |
AU2018388791A1 (en) | 2020-07-16 |
PH12020550930A1 (en) | 2021-05-10 |
CA3085472A1 (en) | 2019-06-27 |
US20230057150A1 (en) | 2023-02-23 |
EA202091521A1 (ru) | 2020-10-22 |
KR20200100147A (ko) | 2020-08-25 |
CL2020001628A1 (es) | 2020-12-28 |
US20190300621A1 (en) | 2019-10-03 |
CR20200313A (es) | 2020-12-01 |
CN117924476A (zh) | 2024-04-26 |
JP2021507704A (ja) | 2021-02-25 |
CN117924477A (zh) | 2024-04-26 |
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