CO2019011548A2 - Vacunas contra el gallid herpesvirus 3 recombinante que codifican antígenos patogénicos aviares heterólogos - Google Patents

Vacunas contra el gallid herpesvirus 3 recombinante que codifican antígenos patogénicos aviares heterólogos

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Publication number
CO2019011548A2
CO2019011548A2 CONC2019/0011548A CO2019011548A CO2019011548A2 CO 2019011548 A2 CO2019011548 A2 CO 2019011548A2 CO 2019011548 A CO2019011548 A CO 2019011548A CO 2019011548 A2 CO2019011548 A2 CO 2019011548A2
Authority
CO
Colombia
Prior art keywords
avian
gallid herpesvirus
pathogenic antigens
encoding heterologous
recombinant
Prior art date
Application number
CONC2019/0011548A
Other languages
English (en)
Inventor
Yashar Sadigh
Venugopal Nair
Original Assignee
The Pirbright Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Pirbright Inst filed Critical The Pirbright Inst
Publication of CO2019011548A2 publication Critical patent/CO2019011548A2/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • A61K39/255—Marek's disease virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A61K39/17—Newcastle disease virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/295—Polyvalent viral antigens; Mixtures of viral and bacterial antigens
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16311—Mardivirus, e.g. Gallid herpesvirus 2, Marek-like viruses, turkey HV
    • C12N2710/16334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16311—Mardivirus, e.g. Gallid herpesvirus 2, Marek-like viruses, turkey HV
    • C12N2710/16341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011—Details
    • C12N2720/10011—Birnaviridae
    • C12N2720/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011—Details
    • C12N2720/10011—Birnaviridae
    • C12N2720/10071—Demonstrated in vivo effect

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Cell Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

RESUMEN La invención se refiere a un vector recombinante del Gallid herpesvirus 3 que codifica antígenos patogénicos aviares heterólogos que comprende uno o más polinucleótidos heterólogos insertados en los loci intergénicos UL3/UL4 y/o UL21/UL22. La invención se refiere además a vacunas que comprenden dicho vector recombinante del Gallid herpesvirus 3 y, opcionalmente, un vector adicional del virus de la enfermedad de Marek y a un uso de la vacuna para proteger una especie aviar contra uno o más patógenos aviares. Se proporcionan procedimientos adicionales para tratar una especie aviar para protección contra una o más enfermedades causadas por patógenos aviares y un procedimiento de producción del vector recombinante del Gallid herpesvirus 3 que codifica antígenos patogénicos aviares heterólogos.
CONC2019/0011548A 2017-04-21 2019-10-17 Vacunas contra el gallid herpesvirus 3 recombinante que codifican antígenos patogénicos aviares heterólogos CO2019011548A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17167638.0A EP3391903B1 (en) 2017-04-21 2017-04-21 Recombinant gallid herpesvirus 3 vaccines encoding heterologous avian pathogen antigens
PCT/EP2018/060225 WO2018193110A1 (en) 2017-04-21 2018-04-20 Recombinant gallid herpesvirus 3 vaccines encoding heterologous avian pathogen antigens

Publications (1)

Publication Number Publication Date
CO2019011548A2 true CO2019011548A2 (es) 2020-02-28

Family

ID=58632236

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2019/0011548A CO2019011548A2 (es) 2017-04-21 2019-10-17 Vacunas contra el gallid herpesvirus 3 recombinante que codifican antígenos patogénicos aviares heterólogos

Country Status (13)

Country Link
US (2) US20200121785A1 (es)
EP (2) EP3391903B1 (es)
JP (1) JP2020517307A (es)
KR (1) KR20200002834A (es)
CN (1) CN110536697A (es)
AU (1) AU2018255381A1 (es)
BR (1) BR112019021638A2 (es)
CA (1) CA3059656A1 (es)
CL (1) CL2019002964A1 (es)
CO (1) CO2019011548A2 (es)
MX (1) MX2019012070A (es)
RU (1) RU2019136150A (es)
WO (1) WO2018193110A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109320594B (zh) * 2018-11-13 2021-09-28 四川大学 一种禽传染性支气管炎和新城疫的病毒样颗粒、制备方法及应用
CN109762941B (zh) * 2019-02-14 2021-06-29 中国动物卫生与流行病学中心 一种检测致禽类死亡病原的液态芯片
CN111041004A (zh) * 2019-12-31 2020-04-21 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） 一种表达新城疫病毒f蛋白的传染性喉气管炎重组病毒株及其构建方法和应用
US11299517B2 (en) * 2020-04-15 2022-04-12 The United States Of America, As Represented By The Secretary Of Agriculture Recombinant vaccine against Marek's disease and Newcastle disease
CN116472057A (zh) * 2020-06-17 2023-07-21 勃林格殷格翰动物保健有限公司 表达流感血凝素的重组hvt载体和免疫原性组合物，以及其生产和用途
CN112048484A (zh) * 2020-07-27 2020-12-08 华南农业大学 一株表达传染性法氏囊强毒株vp2蛋白的基因ⅶ型新城疫重组病毒和疫苗
CN111910019A (zh) * 2020-08-04 2020-11-10 广东省实验动物监测所 一种检测鸡传染性喉气管炎病毒rpa扩增方法
CN111909965A (zh) * 2020-08-06 2020-11-10 中国兽医药品监察所 一种表达传染性法氏囊病病毒vp2蛋白重组病毒载体的构建与应用
EP3950948A1 (en) * 2020-08-07 2022-02-09 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Platform vector for modular and simplified insertion of transgenes into alphaherpesvirinae
AU2023235062A1 (en) * 2022-03-14 2024-09-19 University Of Georgia Research Foundation, Inc. Live mycoplasma synoviae vaccine
AU2023249151A1 (en) * 2022-04-06 2024-09-19 University Of Georgia Research Foundation, Inc. Live mycoplasma gallisepticum vaccines

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2241042T3 (es) 1996-10-11 2005-10-16 The Regents Of The University Of California Conjugados de polinucleotido inmunoestimulador/ molecula inmunomoduladora.
EP2768529A1 (en) 2011-10-21 2014-08-27 Intervet International B.V. Recombinant nonpathogenic mdv vector providing multivalent immunity
PT2785374T (pt) * 2011-11-30 2019-05-09 Merial Ltd Vectores recombinantes do herpesvírus 3 dos galídeos (mdv serotipo 2) expressando antigénios de agentes patogénicos aviários e suas utilizações
US9101598B2 (en) * 2011-11-30 2015-08-11 Merial, Inc. Recombinant Gallid herpesvirus 3 (MDV serotype 2) vectors expressing antigens of avian pathogens and uses thereof
WO2017027324A1 (en) 2015-08-10 2017-02-16 The Texas A&M University System Recombinant turkey herpesvirus vaccines and uses thereof

Also Published As

Publication number Publication date
US20220105174A1 (en) 2022-04-07
EP3612220A1 (en) 2020-02-26
MX2019012070A (es) 2019-12-16
EP3391903B1 (en) 2022-02-23
CA3059656A1 (en) 2018-10-25
KR20200002834A (ko) 2020-01-08
EP3391903A1 (en) 2018-10-24
CL2019002964A1 (es) 2020-02-21
AU2018255381A1 (en) 2019-10-17
US20200121785A1 (en) 2020-04-23
BR112019021638A2 (pt) 2020-05-12
JP2020517307A (ja) 2020-06-18
CN110536697A (zh) 2019-12-03
WO2018193110A1 (en) 2018-10-25
RU2019136150A3 (es) 2021-11-15
RU2019136150A (ru) 2021-05-21

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