CO2019000235A2 - Nueva proteína y su aplicación - Google Patents
Nueva proteína y su aplicaciónInfo
- Publication number
- CO2019000235A2 CO2019000235A2 CONC2019/0000235A CO2019000235A CO2019000235A2 CO 2019000235 A2 CO2019000235 A2 CO 2019000235A2 CO 2019000235 A CO2019000235 A CO 2019000235A CO 2019000235 A2 CO2019000235 A2 CO 2019000235A2
- Authority
- CO
- Colombia
- Prior art keywords
- protein
- sdss1
- oligomer
- oxidized
- bind
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 12
- 108090000623 proteins and genes Proteins 0.000 title abstract 12
- 102000036770 Islet Amyloid Polypeptide Human genes 0.000 abstract 2
- 108010041872 Islet Amyloid Polypeptide Proteins 0.000 abstract 2
- 238000009825 accumulation Methods 0.000 abstract 2
- -1 Aβ oligomer Proteins 0.000 abstract 1
- 102000003886 Glycoproteins Human genes 0.000 abstract 1
- 108090000288 Glycoproteins Proteins 0.000 abstract 1
- 208000025500 Hutchinson-Gilford progeria syndrome Diseases 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 abstract 1
- 241000288906 Primates Species 0.000 abstract 1
- 208000007932 Progeria Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 abstract 1
- 230000003013 cytotoxicity Effects 0.000 abstract 1
- 231100000135 cytotoxicity Toxicity 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 102000035122 glycosylated proteins Human genes 0.000 abstract 1
- 108091005608 glycosylated proteins Proteins 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000003248 secreting effect Effects 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 230000004083 survival effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/861—Adenoviral vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/867—Retroviral vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Abstract
Se proporciona una proteína sDSS1 secretora de un primate superior. La proteína se puede detectar en suero sanguíneo y líquido cefalorraquídeo humanos. La proteína sDSS1 puede unirse, bajo condiciones no enzimáticas, con una proteína oxidada para formar un polímero, o unirse con un polipéptido Aβ para reducir la formación de un oligómero Aβ. En cultivo, la proteína sDSS1 puede proteger contra la citotoxicidad inducida por una proteína oxidada, oligómero Aβ, oligómero de amilina o proteína glicosilada. La proteína sDSS1 puede prolongar significativamente la supervivencia de un modelo de progeria en ratones. La proteína se puede utilizar para prevenir y tratar una enfermedad causada por la acumulación de una proteína oxidada, glicoproteína, proteína Aβ o amilina, o por la generación o acumulación de otra proteína patogénica con una propiedad similar.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610519038.9A CN107573412B (zh) | 2016-07-04 | 2016-07-04 | 一种新型天然蛋白及其应用 |
| PCT/CN2017/090785 WO2018006750A1 (zh) | 2016-07-04 | 2017-06-29 | 一种新型天然蛋白及其应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2019000235A2 true CO2019000235A2 (es) | 2019-02-08 |
Family
ID=60911986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2019/0000235A CO2019000235A2 (es) | 2016-07-04 | 2019-01-11 | Nueva proteína y su aplicación |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US10815282B2 (es) |
| EP (1) | EP3444270A4 (es) |
| JP (5) | JP2019513023A (es) |
| KR (2) | KR102602486B1 (es) |
| CN (2) | CN113150105B (es) |
| AU (3) | AU2017293023B2 (es) |
| BR (1) | BR112019000118A2 (es) |
| CA (1) | CA3029458A1 (es) |
| CL (1) | CL2019000012A1 (es) |
| CO (1) | CO2019000235A2 (es) |
| EA (1) | EA201990179A1 (es) |
| IL (2) | IL301949A (es) |
| MX (1) | MX2019000192A (es) |
| PH (1) | PH12018550214A1 (es) |
| SG (1) | SG11201811555VA (es) |
| WO (1) | WO2018006750A1 (es) |
| ZA (1) | ZA201900209B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113150105B (zh) | 2016-07-04 | 2024-02-20 | 上海普佑生物医药有限公司 | 一种新型天然蛋白及其应用 |
| CN109913483A (zh) * | 2017-12-12 | 2019-06-21 | 上海清流生物医药科技有限公司 | 一种蛋白药物的发酵生产工艺 |
| CN109985230B (zh) * | 2018-01-02 | 2023-10-17 | 上海普佑生物医药有限公司 | 一种蛋白在制备预防和治疗肾病药物中的应用 |
| CN109985231A (zh) * | 2018-01-02 | 2019-07-09 | 上海清流生物医药科技有限公司 | 一种蛋白在制备预防和治疗痴呆症的药物中的应用 |
| CN110004105B (zh) * | 2018-01-05 | 2023-09-29 | 上海普佑生物医药有限公司 | 一种蛋白在细胞培养中的应用 |
| CN110302362B (zh) * | 2018-03-20 | 2024-04-05 | 上海普佑生物医药有限公司 | 一种蛋白在制备预防和治疗糖尿病并发症的药物中的应用 |
| CN110882378A (zh) * | 2018-09-10 | 2020-03-17 | 上海清流生物医药科技有限公司 | 一种蛋白在制备预防和治疗动脉粥样硬化及并发症药物的应用 |
| CN118510793A (zh) * | 2021-09-15 | 2024-08-16 | 上海普佑生物医药有限公司 | 新型多肽 |
| CN115287276A (zh) * | 2022-03-07 | 2022-11-04 | 兰州大学 | Sem1蛋白、表达sem1蛋白工程化益生菌在制备治疗和/或预防心脏病药物中的应用 |
| WO2024056028A1 (en) * | 2022-09-15 | 2024-03-21 | Shanghai Puyou Biochemical Co., Ltd. | Analgesic polypeptide |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1947112B1 (en) * | 1999-04-09 | 2012-05-16 | Heska Corporation | Flea head, nerve cord, hindgut and malpighian tubule nucleic acid molecules, proteins and uses thereof |
| JP2004121445A (ja) * | 2002-10-01 | 2004-04-22 | Akira Sakai | 酸化ストレス消去材、それを有する透析液循環回路及び酸化ストレス消去法 |
| WO2010072228A1 (en) * | 2008-12-22 | 2010-07-01 | Xigen S.A. | Novel transporter constructs and transporter cargo conjugate molecules |
| US9134318B2 (en) * | 2009-12-11 | 2015-09-15 | Purdue Research Foundation | Detection of oxidized polypeptides |
| CN102755317A (zh) * | 2011-04-28 | 2012-10-31 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 一类2-吲哚酮衍生物及其药用盐用于制备抗氧化药物的用途 |
| CN113150105B (zh) | 2016-07-04 | 2024-02-20 | 上海普佑生物医药有限公司 | 一种新型天然蛋白及其应用 |
-
2016
- 2016-07-04 CN CN202110372331.8A patent/CN113150105B/zh active Active
- 2016-07-04 CN CN201610519038.9A patent/CN107573412B/zh active Active
-
2017
- 2017-06-29 EA EA201990179A patent/EA201990179A1/ru unknown
- 2017-06-29 MX MX2019000192A patent/MX2019000192A/es unknown
- 2017-06-29 KR KR1020217030992A patent/KR102602486B1/ko active IP Right Grant
- 2017-06-29 JP JP2018551999A patent/JP2019513023A/ja not_active Withdrawn
- 2017-06-29 AU AU2017293023A patent/AU2017293023B2/en active Active
- 2017-06-29 IL IL301949A patent/IL301949A/en unknown
- 2017-06-29 EP EP17823562.8A patent/EP3444270A4/en active Pending
- 2017-06-29 IL IL263987A patent/IL263987B2/en unknown
- 2017-06-29 BR BR112019000118A patent/BR112019000118A2/pt not_active IP Right Cessation
- 2017-06-29 KR KR1020187028456A patent/KR20180127382A/ko not_active IP Right Cessation
- 2017-06-29 WO PCT/CN2017/090785 patent/WO2018006750A1/zh active Application Filing
- 2017-06-29 SG SG11201811555VA patent/SG11201811555VA/en unknown
- 2017-06-29 CA CA3029458A patent/CA3029458A1/en active Pending
-
2018
- 2018-09-28 US US16/145,251 patent/US10815282B2/en active Active
- 2018-12-27 PH PH12018550214A patent/PH12018550214A1/en unknown
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2019
- 2019-01-03 CL CL2019000012A patent/CL2019000012A1/es unknown
- 2019-01-11 CO CONC2019/0000235A patent/CO2019000235A2/es unknown
- 2019-01-11 ZA ZA2019/00209A patent/ZA201900209B/en unknown
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2020
- 2020-03-17 JP JP2020046451A patent/JP2020114833A/ja active Pending
- 2020-09-15 AU AU2020233647A patent/AU2020233647B2/en active Active
- 2020-09-22 US US17/028,769 patent/US11198712B2/en active Active
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2021
- 2021-11-08 US US17/521,286 patent/US20220135631A1/en active Pending
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2022
- 2022-04-25 JP JP2022071556A patent/JP2022101661A/ja active Pending
- 2022-04-25 JP JP2022071555A patent/JP2022101660A/ja active Pending
- 2022-04-25 JP JP2022071554A patent/JP7386923B2/ja active Active
- 2022-05-27 AU AU2022203613A patent/AU2022203613B2/en active Active
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