CO2017003832A2 - Coagonistas de los receptores de glucagón y de glp-1 - Google Patents
Coagonistas de los receptores de glucagón y de glp-1Info
- Publication number
- CO2017003832A2 CO2017003832A2 CONC2017/0003832A CO2017003832A CO2017003832A2 CO 2017003832 A2 CO2017003832 A2 CO 2017003832A2 CO 2017003832 A CO2017003832 A CO 2017003832A CO 2017003832 A2 CO2017003832 A2 CO 2017003832A2
- Authority
- CO
- Colombia
- Prior art keywords
- glucagon
- glp
- receptor
- peptide
- coagonists
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Abstract
Se describen análogos peptídicos de glucagón, que se han modificado para que sean resistentes a la escisión e inactivación por dipeptidilpeptidasa IV (DPP-IV) y paraincrementar la semivida in vivo del análogo peptídico mientras que permite que el análogo peptídico tenga una actividad agonista relativamente equilibrada en el receptor del péptido similar al glucagón 1 (GLP-1) y en el receptor de glucagón (GCG), y al uso de dichos coagonistas de receptor de GLP-1/receptor de GCG para el tratamiento de trastornos metabólicos tales como diabetes, hesteatosis hepática no alcohólica (NAFLD), esteatohepatitis no alcohólica (NASH) y obesidad.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462068157P | 2014-10-24 | 2014-10-24 | |
US201562208869P | 2015-08-24 | 2015-08-24 | |
PCT/US2015/056794 WO2016065090A1 (en) | 2014-10-24 | 2015-10-22 | Co-agonists of the glucagon and glp-1 receptors |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2017003832A2 true CO2017003832A2 (es) | 2017-06-30 |
Family
ID=54397022
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2017/0003832A CO2017003832A2 (es) | 2014-10-24 | 2017-04-20 | Coagonistas de los receptores de glucagón y de glp-1 |
Country Status (26)
Country | Link |
---|---|
US (2) | US20160114000A1 (es) |
EP (2) | EP3825324A1 (es) |
JP (1) | JP6581656B2 (es) |
KR (1) | KR101996739B1 (es) |
CN (1) | CN107108715A (es) |
AU (1) | AU2015335828B2 (es) |
BR (1) | BR112017008160A8 (es) |
CA (2) | CA2964379C (es) |
CL (1) | CL2017000982A1 (es) |
CO (1) | CO2017003832A2 (es) |
CR (1) | CR20170164A (es) |
DO (1) | DOP2017000102A (es) |
EA (1) | EA201790914A1 (es) |
GT (1) | GT201700085A (es) |
IL (1) | IL251741A0 (es) |
MA (1) | MA55068A (es) |
MD (1) | MD20170055A2 (es) |
MX (1) | MX2017005280A (es) |
NI (1) | NI201700048A (es) |
PE (1) | PE20180158A1 (es) |
PH (1) | PH12017500761A1 (es) |
SG (1) | SG11201703238TA (es) |
SV (1) | SV2017005425A (es) |
TN (1) | TN2017000148A1 (es) |
TW (1) | TW201625672A (es) |
WO (1) | WO2016065090A1 (es) |
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UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
UA116553C2 (uk) | 2012-12-21 | 2018-04-10 | Санофі | Пептидна сполука - агоніст рецептора glp-1 i glp |
FI3155017T3 (fi) * | 2014-05-28 | 2024-04-17 | Mederis Diabetes Llc | Parannettuja peptidilääkkeitä insuliiniresistenssiin |
TW201625672A (zh) | 2014-10-24 | 2016-07-16 | 默沙東藥廠 | 升糖素及glp-1受體之共促效劑 |
AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
AR105284A1 (es) | 2015-07-10 | 2017-09-20 | Sanofi Sa | Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón |
WO2017074798A2 (en) | 2015-10-27 | 2017-05-04 | Merck Sharp & Dohme Corp. | Long-acting co-agonists of the glucagon and glp-1 receptors |
MX2020001590A (es) * | 2017-08-09 | 2020-03-20 | Sanofi Sa | Agonistas del receptor de glp-1/glucagon en el tratamiento de la enfermedad del higado graso y la esteatohepetitis. |
WO2019060660A1 (en) * | 2017-09-25 | 2019-03-28 | Merck Sharp & Dohme Corp. | CO-AGONISTS WITH EXTENDED ACTION OF GLUCAGON AND GLP-1 RECEPTORS |
US11419918B2 (en) * | 2017-11-06 | 2022-08-23 | Shenzhen Turier Biotech Co., Ltd. | Treatment of biliary cirrhosis based on oxyntomodulin analogue GLP-1R/GCGR dual-target agonist peptide |
KR20200106173A (ko) * | 2018-01-03 | 2020-09-11 | 메더리스 다이어비티즈, 엘엘씨 | Nash 및 다른 질병의 치료를 위한 개선된 펩티드 약제 |
CN113164559A (zh) * | 2018-10-04 | 2021-07-23 | 韩美药品株式会社 | 胰高血糖素和包括胰高血糖素的组合产品的治疗用途 |
CN111171135B (zh) * | 2018-11-12 | 2023-04-07 | 天津药物研究院有限公司 | 具有双重受体激动作用的胰高血糖素衍生肽及其用途 |
KR20210125028A (ko) * | 2019-02-06 | 2021-10-15 | 엔진 바이오사이언스 리미티드 | 글루카곤-유사 펩타이드-1(glp-1) 작용제 유사체, 이의 제조 방법 및 용도 |
CN110684082B (zh) * | 2019-10-08 | 2021-12-10 | 江苏诺泰澳赛诺生物制药股份有限公司 | Gip和glp-1双激动多肽化合物及药学上可接受的盐与用途 |
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CN112409460B (zh) * | 2020-11-27 | 2022-02-01 | 江苏师范大学 | 一类glp-1/胰高血糖素受体双重激动剂及其应用 |
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CN112608378B (zh) * | 2020-12-09 | 2023-09-08 | 江苏师范大学 | 一类glp-1/胆囊收缩素-1受体双重激动剂及其应用 |
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-
2015
- 2015-10-22 TW TW104134741A patent/TW201625672A/zh unknown
- 2015-10-22 US US14/920,012 patent/US20160114000A1/en not_active Abandoned
- 2015-10-22 CR CR20170164A patent/CR20170164A/es unknown
- 2015-10-22 TN TN2017000148A patent/TN2017000148A1/en unknown
- 2015-10-22 MD MDA20170055A patent/MD20170055A2/ro not_active Application Discontinuation
- 2015-10-22 MX MX2017005280A patent/MX2017005280A/es unknown
- 2015-10-22 BR BR112017008160A patent/BR112017008160A8/pt active Search and Examination
- 2015-10-22 PE PE2017001204A patent/PE20180158A1/es unknown
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