CN86105663A - 化合物 - Google Patents

化合物 Download PDF

Info

Publication number
CN86105663A
CN86105663A CN198686105663A CN86105663A CN86105663A CN 86105663 A CN86105663 A CN 86105663A CN 198686105663 A CN198686105663 A CN 198686105663A CN 86105663 A CN86105663 A CN 86105663A CN 86105663 A CN86105663 A CN 86105663A
Authority
CN
China
Prior art keywords
compound
formula
hydrogen
singly
bound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN198686105663A
Other languages
English (en)
Chinese (zh)
Inventor
亨特·道格拉斯·普雷恩
布赖恩·赫伯特·沃林顿
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858517051A external-priority patent/GB8517051D0/en
Priority claimed from GB868606853A external-priority patent/GB8606853D0/en
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Publication of CN86105663A publication Critical patent/CN86105663A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Saccharide Compounds (AREA)
CN198686105663A 1985-07-05 1986-07-05 化合物 Pending CN86105663A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB858517051A GB8517051D0 (en) 1985-07-05 1985-07-05 Chemical compounds
GBGB8517051 1985-07-05
GBGB8606853 1986-03-20
GB868606853A GB8606853D0 (en) 1986-03-20 1986-03-20 Chemical compounds

Publications (1)

Publication Number Publication Date
CN86105663A true CN86105663A (zh) 1987-01-21

Family

ID=26289481

Family Applications (1)

Application Number Title Priority Date Filing Date
CN198686105663A Pending CN86105663A (zh) 1985-07-05 1986-07-05 化合物

Country Status (16)

Country Link
US (1) US4904664A (enrdf_load_stackoverflow)
EP (1) EP0208517B1 (enrdf_load_stackoverflow)
JP (1) JPS6212765A (enrdf_load_stackoverflow)
CN (1) CN86105663A (enrdf_load_stackoverflow)
AT (1) ATE56440T1 (enrdf_load_stackoverflow)
AU (1) AU580677B2 (enrdf_load_stackoverflow)
DE (1) DE3674094D1 (enrdf_load_stackoverflow)
DK (1) DK316986A (enrdf_load_stackoverflow)
ES (1) ES2000209A6 (enrdf_load_stackoverflow)
FI (1) FI862840L (enrdf_load_stackoverflow)
GR (1) GR861719B (enrdf_load_stackoverflow)
HU (1) HUT41393A (enrdf_load_stackoverflow)
IL (1) IL79280A (enrdf_load_stackoverflow)
NO (1) NO862723L (enrdf_load_stackoverflow)
NZ (1) NZ216741A (enrdf_load_stackoverflow)
PT (1) PT82876B (enrdf_load_stackoverflow)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4962110A (en) * 1985-03-12 1990-10-09 Smith Kline & French Laboratories Limited Pyridazinone derivatives
US4970210A (en) * 1987-07-17 1990-11-13 Abbott Laboratories Triazinone lipoxygenase compounds

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4088762A (en) * 1971-02-22 1978-05-09 Bdh Pharmaceuticals Limited 6-(P-PIPERAZINO)-PHENYL-4,5-DIHYDRO-3(2H)pyridazinones
US3975388A (en) * 1971-02-22 1976-08-17 Bdh Pharmaceuticals Limited Pyridazinones
BE790106A (fr) * 1971-10-14 1973-04-13 Basf Ag Dihydropyridazones, leur preparation et leurs utilisations therapeutiques
ATE13294T1 (de) * 1981-03-04 1985-06-15 Ciba Geigy Ag Pyridazinone, verfahren zu ihrer herstellung, pharmazeutische praeparate enthaltend diese verbindungen und deren verwendung.
US4353905A (en) * 1981-09-17 1982-10-12 Warner-Lambert Company Substituted 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and 6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones
HU190412B (en) * 1981-09-17 1986-09-29 Warner-Lambert Co,Us Process for producing substituted 4,5-dihiydro-6-bracket-substituted-bracket closed-phenyl-3-bracket-2h-bracket closed-pyridazinones and 6-bracket-substituted-bracket closed-phenyl-3-bracket-2h-bracket closed-pyridazinones
IT1171604B (it) * 1981-10-22 1987-06-10 Roussel Maestretti Spa Derivati di acido 4-fenil-4-ossobuten-2-oico dotati di proprieta' farmacologiche e loro procedimento di preparazione
JPS58113180A (ja) * 1981-12-28 1983-07-05 Mitsui Toatsu Chem Inc ピリダジノン誘導体
JPS58162577A (ja) * 1982-03-19 1983-09-27 Sankyo Co Ltd ６−フエニルピリダジノン化合物の製造法
DE3212304A1 (de) * 1982-04-02 1983-10-06 Nattermann A & Cie Imidazolylphenyl-tetrahydropyridazine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
NZ208107A (en) * 1983-05-11 1986-12-05 Byk Gulden Lomberg Chem Fab 6-aryl-3(2h)-pyridazinones and pharmaceutical compositions
US4599332A (en) * 1983-12-07 1986-07-08 Warner-Lambert Company 4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl)phenyl]-ethenyl]-3(2H)-pyridazinones and related compounds
JPS60197672A (ja) * 1984-03-16 1985-10-07 Mitsubishi Chem Ind Ltd ビリダジノン誘導体またはその塩類
DE3425632A1 (de) * 1984-07-12 1986-01-16 Basf Ag, 6700 Ludwigshafen (pyrrol-1-yl)-phenyl-dihydropyridazinone, ihre herstellung und verwendung
US4816454A (en) * 1984-09-21 1989-03-28 Cassella Aktiengesellschaft 4,5-dihydro-3(2H)-pyridazinones and their pharmacological use
US4631279A (en) * 1984-10-15 1986-12-23 Eli Lilly And Company 6-(pyridinylphenyl)dihydropyridazinones as inotropic agents

Also Published As

Publication number Publication date
ES2000209A6 (es) 1988-01-16
AU5948886A (en) 1987-01-08
FI862840A7 (fi) 1987-01-06
IL79280A (en) 1990-07-12
DK316986A (da) 1987-01-06
NZ216741A (en) 1988-10-28
JPS6212765A (ja) 1987-01-21
EP0208517A3 (en) 1988-03-23
DK316986D0 (da) 1986-07-03
PT82876B (en) 1988-11-03
GR861719B (en) 1986-11-04
JPH0586951B2 (enrdf_load_stackoverflow) 1993-12-14
DE3674094D1 (de) 1990-10-18
EP0208517B1 (en) 1990-09-12
PT82876A (en) 1986-08-01
HUT41393A (en) 1987-04-28
EP0208517A2 (en) 1987-01-14
FI862840L (fi) 1987-01-06
NO862723L (no) 1987-01-06
NO862723D0 (no) 1986-07-04
FI862840A0 (fi) 1986-07-04
AU580677B2 (en) 1989-01-27
US4904664A (en) 1990-02-27
ATE56440T1 (de) 1990-09-15

Similar Documents

Publication Publication Date Title
US4460581A (en) (1-Hydroxy-2-amino-alkyl)-substituted benzoxazinones and benzoxazolinones
JP4685243B2 (ja) ピリミド［６，１−ａ］イソキノリン−４−オン誘導体
RU2007403C1 (ru) Способ получения пиразолпиридинового производного или его соли
JP2564462B2 (ja) 新規アリールアルキル（チオ）アミド化合物
US20060040933A1 (en) Nonsteroidal antiinflammatory agents
CN1092768A (zh) 吡唑和吡唑并嘧啶
JPS63313775A (ja) ジヒドロピリダジノン誘導体
SE516690C2 (sv) Förfarande för framställning av citalopram
JPH051267B2 (enrdf_load_stackoverflow)
JPS6388181A (ja) アミノイミダゾキノリン誘導体
US5736548A (en) 6-aryl pyrazolo 3,4-D! pyrimidin-4-ones and compositions and method of use thereof
US4118561A (en) 7-(Substituted)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamines
JP2002518377A (ja) アリールアルカノイルピリダジン
JPS6040428B2 (ja) 新規３−アリ−ル−２−オキサゾリジノン誘導体、その製法及び該誘導体を含有する抗抑うつ剤
JPS5989679A (ja) ピラゾロ〔３，４−ｂ〕ピリジン誘導体類およびそれらの製造法
CN1125446A (zh) [1，2，4]三唑并[4，3-α]喹喔啉化合物，它们的制备及其应用
JPS58203993A (ja) 新規アゼピノインド−ル、その製造法およびそれからなる医薬
CN1100759C (zh) 呫吨和吖啶衍生物及其用途
CN1096464C (zh) 2,3-苯并二氮杂䓬衍生物、其制备及中间体和作为药物的应用
US5077290A (en) Morpholine derivatives compositions and use
EP0511031B1 (fr) Dérivés d'aryl-3 oxazolidinone, leur procédé de préparation et leur application en thérapeutique
CN86105663A (zh) 化合物
CN1578768A (zh) 邻氨基苯甲酰胺及其药学应用
JPS6011901B2 (ja) 新規の脂肪族置換された４−フエニル−ピペリジン
JPS6399057A (ja) グリシン誘導体

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
WD01 Invention patent application deemed withdrawn after publication