CN85109243A - 一种制备抗高血压的八氢-6-氮杂吲哚二肽衍生物的方法 - Google Patents
一种制备抗高血压的八氢-6-氮杂吲哚二肽衍生物的方法 Download PDFInfo
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- CN85109243A CN85109243A CN85109243A CN85109243A CN85109243A CN 85109243 A CN85109243 A CN 85109243A CN 85109243 A CN85109243 A CN 85109243A CN 85109243 A CN85109243 A CN 85109243A CN 85109243 A CN85109243 A CN 85109243A
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- azaindole
- alkyl
- octahydro
- ethoxycarbonyl
- mol
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- 125000001624 naphthyl group Chemical group 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000010502 orange oil Substances 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
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- LWHYKTAISUZRAD-UHFFFAOYSA-L palladium(2+);carbonate Chemical compound [Pd+2].[O-]C([O-])=O LWHYKTAISUZRAD-UHFFFAOYSA-L 0.000 description 1
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- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
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- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
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- BWAUQTFFVCLSOS-UHFFFAOYSA-N sodiosodium hydrate Chemical compound O.[Na].[Na] BWAUQTFFVCLSOS-UHFFFAOYSA-N 0.000 description 1
- PANBYUAFMMOFOV-UHFFFAOYSA-N sodium;sulfuric acid Chemical compound [Na].OS(O)(=O)=O PANBYUAFMMOFOV-UHFFFAOYSA-N 0.000 description 1
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- HBEJJYHFTZDAHZ-QMMMGPOBSA-N tert-butyl (2s)-2-amino-4-methylpentanoate Chemical compound CC(C)C[C@H](N)C(=O)OC(C)(C)C HBEJJYHFTZDAHZ-QMMMGPOBSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8432532 | 1984-12-21 | ||
| GB848432532A GB8432532D0 (en) | 1984-12-21 | 1984-12-21 | Therapeutic agents |
| GB8514634 | 1985-06-10 | ||
| GB858514634A GB8514634D0 (en) | 1985-06-10 | 1985-06-10 | Therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN85109243A true CN85109243A (zh) | 1986-09-17 |
Family
ID=26288610
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN85109243A Pending CN85109243A (zh) | 1984-12-21 | 1985-12-19 | 一种制备抗高血压的八氢-6-氮杂吲哚二肽衍生物的方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4711882A (enExample) |
| EP (1) | EP0186431B1 (enExample) |
| CN (1) | CN85109243A (enExample) |
| AU (1) | AU558427B2 (enExample) |
| CS (1) | CS250699B2 (enExample) |
| DE (1) | DE3561551D1 (enExample) |
| DK (1) | DK595385A (enExample) |
| ES (1) | ES8702923A1 (enExample) |
| FI (1) | FI855112A7 (enExample) |
| GR (1) | GR853117B (enExample) |
| HU (1) | HUT40125A (enExample) |
| NO (1) | NO855214L (enExample) |
| NZ (1) | NZ214649A (enExample) |
| PL (1) | PL256935A1 (enExample) |
| PT (1) | PT81722B (enExample) |
| YU (1) | YU199485A (enExample) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL58849A (en) * | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
| FR2487829A2 (fr) * | 1979-12-07 | 1982-02-05 | Science Union & Cie | Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
| ATE20469T1 (de) * | 1980-10-23 | 1986-07-15 | Schering Corp | Carboxyalkyl-dipeptide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel. |
| DE3302125A1 (de) * | 1983-01-22 | 1984-07-26 | Boehringer Ingelheim KG, 6507 Ingelheim | Aminosaeure-derivate, verfahren zu ihrer herstellung und verwendung |
-
1985
- 1985-12-17 CS CS859388A patent/CS250699B2/cs unknown
- 1985-12-18 EP EP85309229A patent/EP0186431B1/en not_active Expired
- 1985-12-18 DE DE8585309229T patent/DE3561551D1/de not_active Expired
- 1985-12-19 PT PT81722A patent/PT81722B/pt unknown
- 1985-12-19 ES ES550149A patent/ES8702923A1/es not_active Expired
- 1985-12-19 YU YU01994/85A patent/YU199485A/xx unknown
- 1985-12-19 US US06/811,253 patent/US4711882A/en not_active Expired - Lifetime
- 1985-12-19 CN CN85109243A patent/CN85109243A/zh active Pending
- 1985-12-19 PL PL25693585A patent/PL256935A1/xx unknown
- 1985-12-20 DK DK595385A patent/DK595385A/da not_active Application Discontinuation
- 1985-12-20 NZ NZ214649A patent/NZ214649A/en unknown
- 1985-12-20 HU HU854930A patent/HUT40125A/hu unknown
- 1985-12-20 FI FI855112A patent/FI855112A7/fi not_active Application Discontinuation
- 1985-12-20 GR GR853117A patent/GR853117B/el unknown
- 1985-12-20 NO NO855214A patent/NO855214L/no unknown
- 1985-12-20 AU AU51512/85A patent/AU558427B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| FI855112A0 (fi) | 1985-12-20 |
| YU199485A (en) | 1988-04-30 |
| NO855214L (no) | 1986-06-23 |
| DE3561551D1 (de) | 1988-03-10 |
| ES8702923A1 (es) | 1987-01-16 |
| HUT40125A (en) | 1986-11-28 |
| FI855112A7 (fi) | 1986-06-22 |
| PT81722B (en) | 1987-10-19 |
| CS250699B2 (en) | 1987-05-14 |
| PL256935A1 (en) | 1987-02-23 |
| DK595385A (da) | 1986-06-22 |
| GR853117B (enExample) | 1986-04-22 |
| EP0186431A1 (en) | 1986-07-02 |
| NZ214649A (en) | 1988-02-12 |
| EP0186431B1 (en) | 1988-02-03 |
| ES550149A0 (es) | 1987-01-16 |
| DK595385D0 (da) | 1985-12-20 |
| PT81722A (en) | 1986-01-01 |
| AU5151285A (en) | 1986-06-26 |
| AU558427B2 (en) | 1987-01-29 |
| US4711882A (en) | 1987-12-08 |
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