CN220305330U - Biochemical analyzer - Google Patents

Abstract

The utility model discloses a biochemical analyzer, comprising: a reaction disc provided with a plurality of reaction vessels which are circularly arranged; a plurality of reagent disks which are arranged in an independent rotation way, wherein a single reagent disk is provided with a circular inner ring track and an outer ring track, and a plurality of reagent containers are arranged on the single reagent disk; the single reagent disk corresponds to the two reagent needles, the single reagent needle rotates independently, and the rotating directions of the two reagent needles corresponding to the same reagent disk are opposite when the same action is executed; the sample dispensing mechanism comprises a sample adding needle for adding a collected sample into the reaction container; the mixing mechanism extends out of the mixing device and drives the mixing device to move so as to intersect the reaction container, and the mixing device is rotationally arranged. According to the utility model, the mixing mechanism is arranged to uniformly mix the reagent and the sample in the reaction container, the rotation directions of the two reagent needles are controlled to avoid firing pins, and the two reagent needles can independently rotate to any corresponding positions of the inner ring track, the outer ring track and the reaction container, so that the reagent collection efficiency is improved.

Description

Biochemical analyzer

Technical Field

The utility model relates to the technical field of medical detection equipment, in particular to a biochemical analyzer.

Background

The biochemical analyzer is a clinical routine analyzer in hospital, mainly used for measuring various biochemical indexes in human body fluid, including routine biochemical indexes such as blood, myocardial zymogram, blood sugar and blood fat, liver function, immunoglobulin, etc., a plurality of reagent trays for placing reagent containers are usually arranged in the current biochemical analyzer, and the reagent is sucked by a reagent needle and injected into a reaction container placed in the reaction tray, so that a plurality of reagents are mixed in the reaction tray and waiting for inspection, and in order to ensure analysis efficiency, the reagent volume in a single reagent tray is generally distributed into an inner circle and an outer circle, and the suction of the inner ring and the outer ring of the reagent containers and the filling of the reaction containers are respectively carried out by two reagent needles.

Therefore, based on the structure and the use basis of the biochemical analyzer, the conventional biochemical analyzer is found to have the following problems that on one hand, the conventional biochemical analyzer can generate bubbles in the rotating process of the reagent disk and the sucking and injecting processes of the reagent needles, the bubbles can influence the mixing degree of the reagent and the sample after the reagent is mixed, so that the reagent and the sample are difficult to uniformly mix in the reaction disk, on the other hand, the inner ring and the outer ring of the single reagent disk respectively suck the reagent through the two reagent needles, the two reagent needles rotate and suck the reagent needles simultaneously, the sucking process can be guaranteed not to generate a firing pin problem, and the reagent needles do not load at partial time intervals due to the difference of the reagent positions of the inner ring and the outer ring, so that the reagent needles are wasted.

Disclosure of Invention

Accordingly, the present utility model is directed to a biochemical analyzer, which can uniformly mix the reagent and the sample and improve the transfer efficiency of the reagent.

In order to achieve the above purpose, the present utility model provides the following technical solutions:

a biochemical analyzer, comprising:

the reaction disk is rotatably provided with a plurality of reaction containers which are circularly arranged;

the reagent disk is arranged in an independent rotating mode, a round inner ring track and an outer ring track are arranged on each reagent disk, and a plurality of reagent containers are arranged on each inner ring track and each outer ring track;

the reagent needles are correspondingly arranged on the single reagent disk, the single reagent needle is driven by an independent rotating reagent arm to intersect with the inner ring track, the outer ring track and the reaction container, and the two reagent needles corresponding to the same reagent disk can independently rotate to any corresponding positions of the inner ring track, the outer ring track and the reaction container;

the sample dispensing mechanism comprises a sample adding needle which is rotatably arranged for adding collected samples into the reaction container;

the mixing mechanism is provided with a mixing device in a stretching mode, the mixing mechanism drives the mixing device to move so as to intersect with the reaction container, and the mixing device is used for mixing the solution in the reaction container.

Preferably, in the biochemical analyzer, the reaction container is enclosed in the reaction disk to form two concentric circles, and two reagent needles in a single reagent disk correspond to two circles of the reaction container.

Preferably, in the biochemical analyzer, the sample dispensing mechanism includes two sample injection needles that are independently disposed, and the two sample injection needles respectively perform sample injection on the inner and outer circles of the reagent disk.

Preferably, in the biochemical analyzer, the sample addition needle is disposed downstream of the reagent needle in a rotation direction of the reaction disk, and the mixer is disposed downstream of the sample addition needle in the rotation direction of the reaction disk.

Preferably, in the biochemical analyzer, the mixing device mixes the reaction solution with a piezoelectric vibration device, two mixing mechanisms are arranged around the reaction disc, and the two mixing mechanisms respectively correspond to the two circles of reaction containers.

Preferably, in the biochemical analyzer, three groups of the mixing devices are arranged on a single mixing mechanism, two-stage cleaning tanks are arranged around the mixing mechanism, and when any one mixing device stretches into the reaction container to stir, the other two mixing devices respectively perform stage cleaning in the cleaning tanks.

Preferably, in the biochemical analyzer, a reagent rack capable of being taken and placed independently is arranged in the reagent disk, a plurality of reagent racks are arranged on the inner ring track and the outer ring track, and the reagent racks can be used for placing a plurality of different reagent bottles in a compatible mode.

Preferably, in the biochemical analyzer, the biochemical analyzer further comprises a cleaning module, wherein the cleaning module stretches into a plurality of reaction containers to clean the reaction containers when the reaction disk stops rotating, and the cleaning module is arranged at the downstream of the mixer and at the upstream of the reagent needle in the rotating direction of the reaction disk.

Preferably, in the biochemical analyzer, the biochemical analyzer further comprises an inner ring photoelectric detection module and an outer ring photoelectric detection module for detecting the operation state of the reaction container.

Preferably, in the biochemical analyzer, two reagent trays are disposed on the same side of the reaction tray, and each reagent tray is disposed on the same side of the reaction tray.

Preferably, in the biochemical analyzer, the reaction disk rotates in a counterclockwise direction.

As can be seen from the above technical solution, the biochemical analyzer provided by the present utility model includes a reaction disk, a reagent disk, reagent pins, a sample dispensing mechanism and a mixing mechanism, where the reaction disk is rotatably disposed and has a plurality of reaction containers disposed therein, the reaction containers are used for providing reaction sites for collected biological samples and reagents, the plurality of reaction containers are circularly arranged, the reagent disk is used for placing reagent containers, in particular, the reagent disk can be provided with a plurality of reagent containers according to the types and numbers of reagents, and the plurality of reagent disks are independently rotatably disposed, and simultaneously, in order to improve the placement number and extraction efficiency of the reagent containers, a single reagent disk is provided with a circular inner ring track and an outer ring track, the inner ring track and the outer ring track are respectively provided with a plurality of reagent containers, and it is required to be explained that, the inner ring track and the outer ring track are disposed to enable the reagent containers to form a space in a ring configuration, so as to facilitate the extraction of reagents in the reagent containers, while the reagent containers are operated by the reagent pins, the single reagent disk is correspondingly provided with two reagent pins, each reagent pin is driven by a reagent arm that is independently rotated, in particular, the reagent arm drives the reagent pins to move, and the path of the reagent pins can be intersected with the reagent pins and the two reagent containers to the same as the inner ring track and the reagent containers, and the outer ring track is rotatably disposed in the same position and the same as the corresponding position and the reagent container, and the reagent container is required to be rotatably disposed in the same place, and the corresponding position, and the reagent container is required to be rotatably and rotated, and the outer ring track is required to be rotatably and placed in the reagent container, in the utility model, when two reagent needles corresponding to the same reagent disk simultaneously execute the sucking or discharging action of the reagent, one of the two reagent needles rotates clockwise, and the other one rotates anticlockwise, which reduces the firing pin probability of the reagent needle compared with the prior art, so that the action of any reagent needle is more independent; the sample dispensing mechanism is provided with a sample adding needle which is used for sequentially adding the collected biological samples into the reaction container on the reaction disc, and the sample adding needle is preferably arranged at the downstream of the reagent needle in the rotation direction of the reaction disc, so that the samples are added after the reagents are added into the reaction container, the sample exposure time is prevented from being excessively long and polluted, and meanwhile, in order to ensure that the samples and the reagents are uniformly mixed in the reaction container after the samples are filled, the sample dispensing mechanism is further provided with a mixing mechanism, a mixer is arranged on the mixing mechanism in an extending mode, the mixing mechanism drives a movement path of the mixer to intersect with the reaction container, the mixer is rotatably arranged to extend into the reaction container to mix the samples and the reagents, and the mixer is also arranged at the downstream of the sample adding needle in the rotation direction of the reaction disc. According to the biochemical analyzer provided by the utility model, two independently moving reagent needles are correspondingly arranged on each reagent disk, and the rotation directions of the two reagent needles are opposite when the same action is executed, so that the probability of firing pins of the two reagent needles is reduced, and the movement paths of the two reagent needles are intersected with the inner ring track and the outer ring track on the corresponding reagent disk, so that the two reagent needles can absorb reagents on one or two tracks according to actual detection requirements.

Drawings

In order to more clearly illustrate the embodiments of the utility model or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, it being obvious that the drawings in the following description are only some embodiments of the utility model, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.

FIG. 1 is a schematic diagram of a biochemical analyzer according to an embodiment of the present utility model;

FIG. 2 is a schematic top view of a reaction plate according to an embodiment of the present utility model;

wherein 10 is a reaction disk, 110 is a reaction container, 20 is a reagent disk, 210 is an inner ring track, 220 is an outer ring track, 230 is a reagent container, 30 is a reagent arm, 310 is a reagent needle, 40 is a sample dispensing mechanism, 410 is a sample adding needle, 50 is a mixing mechanism, 510 is a mixer, 520 is a primary cleaning tank, 530 is a secondary cleaning tank, 60 is a cleaning module, 710 is an inner ring photoelectric detection module, 720 is an outer ring photoelectric detection module;

the A area and the B area are reagent adding areas, the C area is a sample adding area, the D area and the E area are stirring and mixing areas, and the F area is a cleaning and photometry area.

Detailed Description

The core of the utility model is to disclose a biochemical analyzer, so that the mixing of the reagent and the sample is more uniform, and the transfer efficiency of the reagent is improved.

In order to make the solution of the utility model better understood by a person skilled in the art, embodiments of the utility model are described below with reference to the accompanying drawings, and furthermore the embodiments shown below do not have any limiting effect on the inventive content described in the claims. The whole contents of the constitution shown in the following examples are not limited to the solution of the utility model described in the claims.

As shown in fig. 1 and 2, the biochemical analyzer provided by the embodiment of the utility model comprises a reaction tray 10, a reagent tray 20, a reagent needle 310, a sample dispensing mechanism 40 and a mixing mechanism 50, wherein the reaction tray 10 is rotatably provided with a plurality of reaction containers 110, the reaction containers 110 are used for providing reaction sites for collected biological samples and reagents, the plurality of reaction containers 110 are circularly arranged, the reagent tray 20 is used for placing reagent containers 230, in particular, the reagent tray 20 can be provided with a plurality of reagent trays according to the types and the number of the reagents, and the plurality of reagent trays 20 are independently and rotatably arranged so as to supply the reagents at the position of the region a and/or the region B shown in fig. 2, meanwhile, in order to improve the placement number and the extraction efficiency of the reagent containers 230, a circular inner ring rail 210 and an outer ring rail 220 are arranged on the single reagent tray 20, and a plurality of reagent containers 230 are respectively arranged on the inner ring rail 210 and the outer ring rail 220.

It should be noted that, the inner ring track 210 and the outer ring track 220 may be configured to form the reagent container 230 with a ring-shaped configuration to form a space therebetween, so as to facilitate the extraction of the reagent in the reagent container 230.

The reagent in the reagent container 230 is extracted by the reagent needles 310, two reagent needles 310 are correspondingly disposed on the single reagent disk 20, each reagent needle 310 is driven by a reagent arm 30 that rotates independently, in particular, the path of the reagent arm 30 driving the reagent needles 310 to move can intersect with the inner ring track 210, the outer ring track 220 and the reaction container 110, so that the reagent needles 310 can suck the reagent in the reagent container 230 on the inner ring track 210 and the outer ring track 220 and discharge the reagent when reaching the position of the reaction container 110, and the rotation directions of the two reagent needles 310 disposed corresponding to the same reagent disk 20 are opposite when executing the same action.

It should be noted that, in the embodiment of the present utility model, when two reagent needles 310 corresponding to the same reagent disk 20 perform the sucking or discharging operations of the reagent simultaneously, one of the two reagent needles 310 rotates clockwise, and the other rotates counterclockwise, which reduces the probability of firing pins of the reagent needles 310 compared to the prior art, so that the operations of any reagent needle 310 are more independent.

The sample dispensing mechanism 40 is provided with a sample adding needle 410, the sample adding needle 410 is used for sequentially adding collected biological samples into the reaction vessel 110 rotating to the position of the region C on the reaction disk 10, and preferably the sample adding needle 410 is arranged at the downstream of the reagent needle 310 in the rotating direction of the reaction disk 10, namely, the positions of the region D and the region E shown in fig. 2, so that the reagent is added into the reaction vessel 110 first, and then the samples are added, thereby avoiding pollution caused by overlong exposure time of the samples.

According to the biochemical analyzer provided by the embodiment of the utility model, two independently moving reagent needles 310 are correspondingly arranged for each reagent disk 20, and the rotation directions of the two reagent needles 310 are opposite when the same action is executed, so that the firing pin probability of the two reagent needles 310 is reduced, and the movement paths of the two reagent needles 310 are intersected with the inner ring track 210 and the outer ring track 220 on the corresponding reagent disk 20, so that the two reagent needles 310 can absorb one or two reagents on the tracks according to the actual detection requirement, and it is required to say that the position of the reagent needles 310 for absorbing the reagents can be preset according to the rotation period of the reagent disk 20, and the reagent information of the reagent container 230 can also be detected through a visual sensor, so that the position of the reagent needles 310 can be adjusted by feeding back the corresponding reagent arms 30.

Further, in an embodiment of the present utility model, the reaction vessels 110 are enclosed in the reaction disk 10 to form two concentric circular structures, so that more reaction vessels 110 can be carried on the reaction disk 10, and the reaction vessels 110 with two circles of circular structures can be designed to correspond to the two reagent needles 310 of the single reagent disk 20, specifically, the two reagent needles 310 corresponding to the single reagent disk 20 are respectively responsible for reagent addition of the reaction vessels 110 on the two circular structures, so as to reduce the difficulty in controlling reagent addition.

It should be noted that, the single reagent disk 20 adopts the dual independent reagent needle 310 to set up correspondingly, can carry out independent application of sample and cleaning action to the sample of inner and outer circle respectively, avoided the carrying pollution of sample between the inner and outer circles, simultaneously, the independent motion track setting of dual independent reagent needle 310 can realize independently adding conventional sample and emergency sample's purpose, and the emergency sample can both realize short-term test in the inner and outer circles to satisfy multiple operating mode demand.

Correspondingly, in an embodiment of the present utility model, the sample dispensing mechanism 40 includes two sample injection needles 410 that are independently disposed, the two sample injection needles 410 respectively perform sample injection on the inner and outer ring tracks of the reaction disk (10), and the two sample injection needles 410 can be independently cleaned to avoid cross contamination of the reagent containers 230 in the inner and outer ring tracks, and in addition, the two sample injection needles 410 that independently move can also adapt to the injection requirements of the inner and outer ring regular samples and the urgent samples.

Further, in a preferred embodiment of the present utility model, the loading needle 410 is disposed downstream of the reagent needle 310 in the rotational direction of the reaction disk 10, and the mixer 510 is disposed downstream of the loading needle 410 in the rotational direction of the reaction disk 10.

On the basis of the above embodiment, the mixing mechanism 50 for uniformly stirring the reaction containers 110 adopts the vibration device to uniformly mix the reaction solution, which may be provided with a single mixing mechanism 50, and the single mixing mechanism 50 simultaneously stretches into the mixer 510 to stir the two layers of reaction containers 110 to the two circular structures on the reaction tray 10 during a single stirring action, but the above technical scheme needs that the single mixing mechanism 50 corresponds to two insertion positions at a single time, and is easy to generate deviation to cause stirring failure, so in a preferred embodiment of the utility model, the mixing mechanism 50 is provided with two mixing mechanisms around the reaction tray 10, and the two mixing mechanisms 50 correspond to the two circles of reaction containers 110 respectively, so that the single mixing mechanism 50 only needs to be aligned to one position during a single stirring, thereby reducing the operation difficulty and risk.

In order to avoid cross contamination of the mixing mechanism 50 to stir the sample and the reagent in the reaction vessel 110 caused by repeated actions, and to clean the mixing device 510 in time, in a specific embodiment of the present utility model, three groups of mixing devices 510 are disposed on the single mixing mechanism 50, the three groups of mixing devices 510 are circumferentially disposed, two stages of cleaning tanks, namely, a first stage cleaning tank 520 and a second stage cleaning tank 530, are correspondingly disposed around the mixing mechanism 50, and the two stages of cleaning tanks are disposed so that when any one mixing device 510 extends into the reaction vessel 110 to perform a stirring action, the other two mixing devices 510 are respectively disposed in the first stage cleaning tank 520 and the second stage cleaning tank 530 and clean by rotation action of the mixing devices 510, and after the next action cycle of the mixing mechanism 50 is completed, the mixing devices 510 disposed in the second stage cleaning tank 530 rotate into the reaction vessel 110, and the positions of the other two mixing devices 510 are sequentially transferred, so that the mixing devices 510 smoothly circulate.

It should be noted that the same or two types of cleaning solutions may be placed in the two-stage cleaning tanks, so that the mixer 510 is completely cleaned.

It should be further noted that, the single mixing mechanism 50 may further be provided with four mixers 510, so that the single mixer 510 has a standby action of a position to be mixed in addition to the primary cleaning, the secondary cleaning and the mixing actions.

Further, in order to facilitate the placement of the reagent container 230 on the reagent tray 20 and the reagent sucking action of the reagent needle 310 on the reagent container 230 on the inner ring rail 210 and the outer ring rail 220, in an embodiment of the present utility model, the reagent container 230 is a reagent rack that can be individually taken and placed, and a plurality of reagent racks are respectively disposed on the inner ring rail 210 and the outer ring rail 220, so that the reagent racks that are independently disposed are easier to take and place, and any reagent rack can be compatible for placing a plurality of different reagent bottles.

Further, the biochemical analyzer provided by the embodiment of the utility model further includes a cleaning module 60, where the cleaning module 60 is configured to extend into the plurality of reaction containers 110 to clean the reaction containers 110 when the reaction disk 10 stops rotating after the detection is completed, and the cleaning module 60 is disposed downstream of the mixer 510 and upstream of the reagent needle 310 in the rotation direction of the reaction disk 10, i.e. in the F-zone position as shown in fig. 2, the cleaning module 60 is configured to clean the detected reaction containers 110, and the cleaned reaction containers 110 are ready for a subsequent reagent adding operation process.

In order to further optimize the above technical solution, the biochemical analyzer provided in the embodiments of the present utility model further includes an inner ring photoelectric detection module 710 and an outer ring photoelectric detection module 720, where the inner ring photoelectric detection module 710 and the outer ring photoelectric detection module 720 are configured to detect the single-ring reaction vessel 110 with a circular configuration at the position of the F-zone as shown in fig. 2, or detect two rings of reaction vessels 110 with a circular structure respectively, and the inner ring photoelectric detection module 710 and the outer ring photoelectric detection module 720 can detect whether the rotation speed of the reaction disk 10 is reasonable or not, and feedback an error when the rotation of the reaction disk 10 is abnormal.

Further, in a preferred embodiment of the present utility model, two reagent trays 20 are provided corresponding to a single reaction tray 10, and two reagent trays 20 are used for containing two reagents, and two reagent needles 310 are provided corresponding to each reaction tray 10 to effect reagent addition to the reaction vessel 110.

Based on the above embodiment, two reagent trays 20 are disposed on the same side of the reaction tray 10 to facilitate the placement and replacement of the reagent containers 230.

Further, in one embodiment of the present utility model, the reaction plate rotates in a counterclockwise direction.

The terms first, second, left and right in the description and the claims of the present utility model and in the above-described drawings, etc. are used for distinguishing between different objects and not for describing a particular sequential order. Furthermore, the terms "comprise" and "have," as well as any variations thereof, are intended to cover a non-exclusive inclusion. For example, a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to the listed steps or elements but may include steps or elements not expressly listed.

The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present utility model. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the utility model. Thus, the present utility model is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims (11)

1. A biochemical analyzer, comprising:

a reaction disk (10) rotatably provided with a plurality of reaction vessels (110) arranged in a circular shape;

the reagent trays (20), a plurality of reagent trays (20) are independently and rotatably arranged, a round inner ring track (210) and an outer ring track (220) are arranged on each reagent tray (20), and a plurality of reagent containers (230) are arranged on each inner ring track (210) and each outer ring track (220);

the reagent needles (310), the two reagent needles (310) are correspondingly arranged on the single reagent disk (20), the single reagent needle (310) is driven by the independent rotating reagent arm (30) to intersect with the inner ring track (210), the outer ring track (220) and the reaction container (110), and the two reagent needles (310) corresponding to the same reagent disk (20) can independently rotate to any corresponding positions of the inner ring track (210), the outer ring track (220) and the reaction container (110);

a sample dispensing mechanism (40) comprising a sample addition needle (410) rotatably arranged for adding a collected sample into the reaction vessel (110);

the mixing mechanism (50) stretches out and is provided with a mixing device (510), the mixing mechanism (50) drives the mixing device (510) to move so as to intersect with the reaction container (110), and the mixing device (510) is used for mixing the solution in the reaction container (110).

2. A biochemical analyzer according to claim 1, wherein said reaction vessels (110) are enclosed within said reaction disk (10) to form two concentric circular structures, and two of said reagent needles (310) in a single said reagent disk (20) correspond to two circles of said reaction vessels (110).

3. A biochemical analyzer according to claim 1, wherein said sample dispensing mechanism (40) comprises two separate sample application needles (410), said sample application needles (410) applying samples to the inner and outer circles of said reaction disk (10) respectively.

4. The biochemical analyzer according to claim 1, wherein the sample addition needle (410) is disposed downstream of the reagent needle (310) in a rotation direction of the reaction disk (10), and the mixer (510) is disposed downstream of the sample addition needle (410) in the rotation direction of the reaction disk (10).

5. A biochemical analyzer according to claim 1, wherein said mixer (510) mixes the reaction solution by using a piezoelectric vibrator, two mixing mechanisms (50) are provided around said reaction plate (10), and two mixing mechanisms (50) correspond to two circles of said reaction containers (110), respectively.

6. A biochemical analyzer according to claim 1, wherein three sets of said mixing devices (510) are provided on a single mixing device (50), two-stage washing tanks are provided around said mixing device (50), and when any one of said mixing devices (510) is inserted into said reaction vessel (110) to stir, the other two mixing devices (510) are respectively washed in stages in said washing tanks.

7. A biochemical analyzer according to claim 1, wherein the reagent tray (20) is provided with a reagent rack capable of being taken and placed separately, and a plurality of reagent racks are provided on the inner ring rail (210) and the outer ring rail (220), and the reagent racks are capable of being compatible for placing a plurality of different reagent bottles.

8. A biochemical analyzer according to claim 1, further comprising a cleaning module (60), said cleaning module (60) extending into a plurality of said reaction vessels (110) for cleaning said reaction vessels (110) when said reaction disk (10) is stopped, said cleaning module (60) being disposed downstream of said mixer (510) and upstream of said reagent needles (310) in the direction of rotation of said reaction disk (10).

9. A biochemical analyzer according to claim 1, further comprising an inner ring photo detection module (710) and an outer ring photo detection module (720) for detecting an operational state of said reaction vessel (110).

10. A biochemical analyzer according to claim 1, characterized in that two reagent trays (20) are provided for each reaction tray (10), the two reagent trays (20) being provided on the same side of the reaction tray (10).

11. A biochemical analyzer according to any of claims 1-10, characterized in that said reaction disc (10) rotates in a counter-clockwise direction.