CN114720710A - Sample processing device with double-turntable structure - Google Patents

Abstract

The invention relates to the technical field of automatic sample processing equipment in the medical field, in particular to a sample processing device with a double-turntable structure, which comprises a base and a plurality of consumable receiving racks, wherein the base comprises a first turntable, a plurality of transfer liquid receiving units are arranged in the circumferential direction of the first turntable, a second turntable is arranged in the center of the first turntable, and N consumable receiving racks are arranged on the second turntable; the pipetting module is composed of at least one pipetting subunit, takes up and installs at least one consumable on a consumable receiving rack of the second turntable, and transfers the sample liquid or unloads the consumable in an area outside the second turntable; the beneficial effects are as follows: the invention realizes that the process of loading the Tip head and the process of pipetting or unloading the Tip head do not have spatial overlap, and avoids the cross contamination risk possibly caused by the overlap of the used Tip head motion path and a new loading path.

Description

Sample processing device with double-turntable structure

Technical Field

The invention relates to the technical field of automatic sample processing equipment in the medical field, in particular to a sample processing device with a double-turntable structure.

Background

In recent years, diseases caused by viruses, bacteria and the like are more and more concerned, and historically, public safety incidents with scale damage caused by the viruses are also experimenting human beings, bringing great challenges to the production and life of the human beings, bringing pain and even death to countless people, and simultaneously causing serious obstacles to the economic development of the world. In addition, with the pursuit of human beings for healthy life, more and more detection technologies using human body's own blood, cells, secretions, excretions, and the like as objects are rapidly developed, such as screening of congenital diseases of fetus by using an amniotic fluid sample collected during pregnancy of a pregnant woman, screening of diseases and judgment of rationality of diagnosis and treatment schemes by using a whole blood sample as an object, and screening of diseases by using nasal swabs, pharyngeal swabs, anal swabs, and the like as objects.

Driven by more and other requirements, a Sample processing system with faster speed, lower pollution risk, less human involvement and the like is needed to meet the requirements, and a Sample processing system or related modules developed in the prior art include, US7985375B2 Sample preparation system and method for processing clinical experiments, which disclose a fully automatic consumable material loading device including a pipette, a consumable material loading part, a barcode recognition part and the like in a housing, but due to an unreasonable planning layout, the design has a non-negligible risk of pollution due to aerosol and the like in a Sample liquid processing process. European patent application EP3467511B1 Automatic analyzer and operating method for same discloses a multi-sample analysis system based on a double-turntable sample adding part, which can improve the sample processing speed of the analysis system, but the sample tube adding of the double turntable still has a contamination risk. The scheme disclosed by the invention patent US10613106B2 Reaction vessel handling apparatus, testing apparatus, and methods using same performs spatial overlapping and dislocation design on a sample tube and a transfer receiving part, and the design needs two rotary driving systems with high matching precision, so that accurate transfer of sample liquid in each sample tube which is circumferentially distributed is ensured, the realized technical complexity is higher, and the pollution risk in the system cannot be reduced. The pretreatment system disclosed in U.S. patent application No. US20210293671a1 Devices and components for automated tissue processing and stabilizing and uses therof is based on a special consumable design and a segmented layer structure is designed to reduce contamination, however, such a system cannot be used in combination with a general-purpose deep well plate consumable, resulting in limited popularization and higher cost and complexity.

However, with the use of more sensitive reagents, very minor contamination can also result in an increased probability of false positives in the final diagnostic process, which is also an unacceptably significant risk. Therefore, the design of rationalization of the layout structure is required to reduce the risk of cross contamination that may occur inside the sample liquid processing system, and to be compatible with the design requirement of low cost, which is also a technical problem to be solved urgently.

Disclosure of Invention

The invention aims to overcome the defects in the prior art, and provides a sample processing device with a double-turntable structure, which reduces the cross contamination risk possibly generated in a sample liquid processing system through the reasonable design of a layout structure and is compatible with the design requirement of low cost.

In order to achieve the purpose, the technical scheme provided by the invention is as follows:

the utility model provides a take sample processing apparatus of two carousel structures which characterized in that: the transfer liquid supply device comprises a first rotary disc 10, wherein a plurality of transfer liquid receiving units are arranged in the circumferential direction of the first rotary disc 10, a second rotary disc 20 is arranged at the center of the first rotary disc 10, and N consumable receiving racks 201 are arranged on the second rotary disc 20; the pipetting module 30 is also included, the pipetting module 30 comprises at least one pipetting subunit, the pipetting module 30 takes up and installs at least one consumable on one consumable receiving rack 201 of the second turntable 20, and performs sample liquid transfer or consumable unloading in an area outside the second turntable 20.

Preferably, the transfer liquid receiving unit includes a receiving portion 101, and a deep hole plate is connected to the receiving portion 101 through a first clamping portion 1011.

Preferably, a Tip of a pipette is connected to the consumable receiving rack 201 through the second engaging portion 2011.

Preferably, the first rotary disk 10 and the second rotary disk 20 have independent driving structures, so that the two rotary disks can rotate independently.

Preferably, the first rotary table 10 is driven by a first motor through a meshing gear pair transmission, and the second rotary table 20 is driven by a second motor through a belt wheel transmission.

Preferably, the meshing gear pair is configured to have a low number of teeth in cooperation with a high number of teeth.

Preferably, the high-tooth-number gear is supported by not less than two auxiliary support wheels.

Preferably, the first rotating disc and the second rotating disc are located on the same horizontal plane, and the central axes of the two rotating discs are basically coincident.

Preferably, when the first rotary table (10) completes one rotation, the second rotary table (20) rotates for not less than 1/N of a turn.

Preferably, the number of the transfer liquid receiving units is 6, and the number N of the consumable receiving racks (201) is 2.

Compared with the prior art, the invention has the following advantages:

1. in the scheme of the invention, a plurality of sample liquid receiving units are arranged in the circumferential direction of an outer ring turntable, an inner ring turntable is arranged in the center of the outer ring, N consumable receiving frames are arranged, the consumables can be pipetting Tip heads used by a pipettor, and a pipetting part consisting of not less than 1 pipetting subunit is arranged, the pipetting part takes up and installs at least one pipetting Tip consumable on one consumable receiving frame in the center position, and the operations such as sample liquid transfer or consumable unloading are carried out in an area outside the center of the first turntable, so that the spatial overlapping of the Tip head loading process and the Tip head pipetting or unloading process is avoided, and the cross contamination risk possibly caused by the overlapping of the used Tip head motion path and a new loading path is avoided.

2. The sample liquid receiving unit is arranged as a deep-hole plate consumable (for example, a deep-hole plate with more 96-hole plate 16 sample receiving hole sites is used), the compatibility of a pretreatment system is ensured, the sample liquid receiving unit can be matched with different nucleic acid extractors and the like, such as a GeneRotex nucleic acid extractor in Tianlong technology, and the consumable receiving racks at the central part have more quantity and can meet the requirements of processing a larger number of samples.

3. The invention realizes the satisfaction of different rotation requirements of an inner ring and an outer ring through the drive of an independent drive source such as an independent motor, ensures that the whole double-turntable system can reliably run without mutual interference through the matching use of a gear pair and belt pulley transmission, can be compatible with more transfer liquid receiving units through the matching of high tooth number and low tooth number, can also adapt to the position adjustment of smaller angles, realizes the stable and reliable running of the whole transmission system through matching the auxiliary support of at least two auxiliary support wheels, ensures that the two turntables are basically positioned on the same horizontal plane, and the central shafts of the two turntables are basically superposed, ensures that the operations such as transfer and pickup of pipettors do not have overlarge operation errors through the design, and ensures the reliability of the whole system.

4. According to the invention, after the double rotary disc completes a whole circle of rotary motion according to the outer ring rotary disc, the inner ring rotary disc rotates for at least 1/N circle, so that relative immobilization of installation consumables and replacement and installation of new consumables of a pipettor is realized, the continuity of installation and unloading of the sample liquid receiving unit is also ensured, and compatible reception of different types of deep hole plates of different companies is realized by matching with the liquid transferring sub unit with variable spacing.

Drawings

For a more clear understanding of the present invention, the present disclosure will be further described by reference to the drawings and illustrative embodiments which are provided for illustration and are not to be construed as limiting the disclosure.

FIG. 1 is a schematic diagram of a dual turntable layout structure provided in the present invention;

FIG. 2 is a schematic cross-sectional view of a dual turntable layout structure provided in the present invention;

FIG. 3 is a schematic view of a dual turntable layout with auxiliary wheels according to the present invention;

fig. 4 is a schematic diagram of a movement track of a pipette with a dual turntable structure according to the present invention;

FIG. 5 is a first schematic view of a processing system including a dual turret configuration according to the present invention;

FIG. 6 is a second schematic view of a processing system including a dual turret configuration according to the present invention;

FIG. 7 is a third schematic view of a processing system including a dual turret configuration according to the present invention;

FIG. 8 is a functional block diagram of a sample processing system with a dual turntable structure according to the present invention;

FIG. 9 is a schematic diagram of a sample processing system according to the present invention.

Shown in the figure: the consumable receiving rack comprises a first rotating disk 10, a receiving part 101, a first clamping part 1011, a second rotating disk 20, a second clamping part 2011 of the consumable receiving rack 201, a first driving motor 11, an output gear 112, a driving gear 113, a connecting piece 114, a second driving motor 21, an output belt wheel 211, a belt 212, a driving belt wheel 213, a rotating shaft 214, a first auxiliary supporting wheel 1131 and a second auxiliary supporting wheel 1132.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are some embodiments of the present application, but not all embodiments. The components of the embodiments of the present application, generally described and illustrated in the figures herein, can be arranged and designed in a wide variety of different configurations.

Thus, the following detailed description of the embodiments of the present application, presented in the accompanying drawings, is not intended to limit the scope of the claimed application, but is merely representative of selected embodiments of the application. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures.

Example 1

Fig. 1 is a schematic diagram of a dual-turntable structure according to an embodiment of the present invention, which includes a plurality of metastatic liquid receiving units arranged in a circumferential direction of a first turntable 10, and an in vitro diagnostic technique for detecting a disease infected by a subject has become an early rapid diagnosis scheme for detecting a disease in a subject using human body secretion, excrement, blood, amniotic fluid, nasal swab, pharyngeal swab, anal swab, etc., because the method has the advantages of high sensitivity, early discovery time and the like, the method plays more and more important roles in public safety, medical diagnosis, crime reconnaissance and the like, the transfer liquid receiving unit in the system of the embodiment 1 is the deep-well plate which is most used in molecular diagnosis, and a nucleic acid extraction reaction system can be automatically established by utilizing the sample processing system, so that the manual operation amount is greatly reduced, and the reliability of a detection result is ensured. The deep well plate herein may be of different volumetric types, e.g., sample processing volumes of 1mL, 1.5mL, 2mL, 2.5mL, 3mL, etc. Of course, the dual turntable sample processing system of this embodiment can be used as a stand-alone product and then used in conjunction with a nucleic acid extraction product to perform a fully automated extraction process, such as with the GeneRotex nucleic acid extractor from Tianlong technology, or with other company nucleic acid extraction equipment. It can also be used as a sub-module of an automatic analysis device to complete a fully automatic solution of adding samples to the final result output, and is not limited herein. Here, the first rotary disk 10 includes a plurality of receiving portions 101 capable of receiving deep-hole plates of 5, 6, 7, 8, 9, etc., which are the most widely used structure of 96-hole 16-sample positions, and in order to accommodate deep-hole plates of different capacities, the plurality of receiving portions 101 of the first rotary disk 10 include elastic clamping portions 1011 which can be arranged in pairs, and the openings of different sizes can be formed by using the adjustable characteristics of elastic parts so as to accommodate deep-hole plates of different manufacturers or different models. A second turntable 20 is further disposed at the center of the first turntable, and the second turntable includes N consumable receiving racks 201 (where N is an integer not less than 1), where N is 2, and N may also be 3, 4, 5, and so on in actual use, and is not limited herein. The consumable material here is a disposable material, wherein the most typical is a Tip head of a pipette, the most commonly used commercial Tip head is also usually made into a batch mode of packaging 96 tips, in order to be compatible with a batch commercial model of 96pcs, the second rotary disk 20 ensures that N pipette Tip heads with corresponding quantity are installed by using the clamping part 2011, and in order to ensure the establishment of the reliability of the extraction system, the PK & IC liquid storage part 110 is arranged on the periphery of the first rotary disk 10, so that the effects of removing nuclease in DNA and RNA preparation and buffering to ensure that the reaction conditions of the reaction liquid are not changed too fast, and the specific structure is not limited here.

Example 2

Fig. 2 is a schematic sectional view of a dual turntable structure provided by the present invention, wherein the dual turntable is driven by two independent motors, so that two different rotation angles and different rotation sequence arrangements, even non-interference adjustments in different rotation directions, can be realized. Wherein first driving motor 11 passes through output shaft connection output gear 112 to it is rotatory to drive output gear 112, and output gear 112 meshes the cooperation with the drive gear 113 of first carousel 10, and drive gear 113 can be directly be connected with first carousel 10 through the connecting piece 114 of being no less than 1, and both can realize the rotary motion that does not have relative motion, thereby has accomplished the rotation transmission who turns into first driving motor 11 and has rotated into first carousel 10. In order to ensure the rotation of the first rotary disk 10 with the most fine adjustment angle, the driving gear 113 and the output gear 112 are designed with a high gear ratio, for example, the gear ratio range of the two gears can be 3: 1-10: 1. of course, in one case, the first driving motor 11 may rotate continuously by a predetermined angle, for example, by 60 °, 40 °, etc., each time, and then stop for a certain time to reserve a time required for a pipetting operation, etc., and then continue to rotate, thereby realizing a high-precision continuous operation in which the operation hole site of the pipette is substantially fixed and the upper and lower sample positions are substantially fixed. The second driving motor 21 is connected with the output belt wheel 211 through an output shaft, and is connected with the driving belt wheel 213 of the second turntable 20 at the central position through the belt 212, and the driving belt wheel 213 drives the rotating shaft 214 directly connected with the second turntable 20 to rotate, so that the rotation driving of the second turntable 20 at the central position is realized. The first rotary table 10 and the second rotary table 20 are basically located on the same horizontal plane, and the central axes of the two rotary tables are basically overlapped, so that the simplification of the control of the liquid transfer device matched with the double rotary tables is ensured, and the realization of the system in a low-cost and low-complexity mode is ensured.

Example 3

Fig. 3 is a schematic diagram of a gear transmission local optimization design provided by the present invention, in order to ensure precise angle control of the first turntable, the driving gear 113 needs to have a higher number of teeth, and therefore, it needs to ensure that the driving gear 113 has an adequate radius, and thus, in a long-term working process, a phenomenon that gear engagement is unreliable or even fails may be caused due to radial force and other actions, and therefore, the driving gear 113 with a high number of teeth is supported by at least two auxiliary support wheels 1131 and 1132, so that reliable operation of a system can be ensured in a whole equipment service life, and consideration of engagement accuracy and operation reliability can be achieved at low cost. In combination with fig. 1, a plurality of transfer liquid receiving units can be optimally set to six deep hole plate receiving parts, so that disposable processing of 96 sample volumes can be completed when the deep hole plate positions are fully loaded, meanwhile, the number N of consumable receiving racks contained in the second rotary table at the central part is 2, so that when all the deep hole plates on the outer ring rotary table 10 correctly receive sample liquid of corresponding hole positions, the first rotary table 10 completes one circle of rotation, at the moment, Tip head consumables on one corresponding consumable receiving rack are also consumed, at the moment, the second rotary table 20 can rotate 1/2 circles, new consumables are supplied and rotated to the original position, the complex control that a pipettor picking track is not required to be readjusted is realized, new pipetting operation can be started, new consumables can be reloaded by using the completed consumable receiving racks, and when N is other value, when the first rotary table 10 completes one circle of rotation, the second rotary table 20 rotates for not less than 1/N circle, so that the continuity of the whole operation process is ensured, and the rationality of the whole configuration is also ensured.

Example 4

Fig. 4 is a schematic diagram of a movement track of a pipettor under a dual-turntable structure provided by the present invention, where an outer ring is a first turntable 10, a plurality of pipetting receiving portions are disposed on the first turntable 10, a central region of the outer ring is provided with a second turntable 20, which includes N consumable receiving racks, 30 is a pipetting module, which may include 2, 3, 4, etc. pipetting subunits for transferring sample liquid, 401 is an oscillating and mixing subunit, which may mix and transfer sample liquid, in an actual pipetting process, first, the pipettor enters an inner ring region of the second turntable 20 along a first track of S10, and at this time, the pipettor does not have any used Tip head, thereby avoiding a contamination risk caused by entering a new consumable region with the used Tip head, and then, the pipettor takes a new pipetting Tip head by driving of a movement motor, and after completing the pipetting, crosses a top region of the pipetting receiving portions, at this time, the unused Tip head has no influence on the liquid transferring receiving part, and then the unused Tip head sucks the oscillated sample liquid along the paths S201 and S202 and transfers the sample liquid to the corresponding hole site of the sample liquid receiving part to complete the liquid transferring operation, finally the pipettor carries the used Tip head to directly move to the consumable recycling hole site along the path S30, and the used Tip head consumable is unloaded to carry out centralized recycling treatment. The operation of transferring all sample liquid with low pollution risk can be completed by circulating for many times, under the layout, the trajectories of the new Tip head consumables and the used Tip head consumables are almost not overlapped, the risk of cross pollution is avoided to the maximum extent, in addition, the motion trajectory of the used Tip head consumables does not relate to the central area where the second turntable 20 is located at all, the risk of cross pollution between the new Tip head and the old Tip head is also avoided to the maximum extent, the consumable area of the Tip head can maintain a fixed low pollution risk area, and the pipetting trajectory can be a combined S20 trajectory in practice and is not limited at this place. Certainly, after all hole site samples of one sample liquid receiving portion are transferred, the first rotary disc 10 can rotate by a preset angle to enable a new sample liquid receiving portion which does not receive any sample liquid to rotate to a previous hole site, so that simplicity and convenience in movement track control of the pipettor are realized, accuracy of pipetting operation is also guaranteed, and of course, the second rotary disc 20 in the inner part can also adopt a similar design, so that after consumable materials on one sample rack are used, the second rotary disc 20 rotates by another preset angle, switching of consumable racks is realized, and the method is not limited herein.

Example 5

Fig. 5 shows a sample liquid pretreatment system including the double-disk structure of the present invention, which includes an additional loading unit 60 of sample tubes, to which a number of sample tubes, such as 96, 192, 288, 384, etc., can be added for one-time treatment. A sample tube transfer grip 50 for gripping or unloading a sample tube from the sample tube receiving portion of the loading unit 60, in order to ensure that the transferred sample liquid can contain sufficient detected objects, proper oscillation and uniform mixing of the sample liquid are generally required, and in the prior art, many automatic systems directly integrate and design an oscillation device on a sample loading unit, so as to meet the requirement of sample oscillation and uniform mixing, however, the design has the advantages that all sample tubes need to be oscillated simultaneously, while the sample volume of the sample unit 60 is large in a batch processing system, it is unlikely to realize a one-time simultaneous transfer design, so directly designing an integrated oscillating system would result in high design cost of the whole system, the requirement of maintaining turbulence also has high requirements on the reliability of the system operation, so the present invention does not adopt the design scheme that the oscillation unit is integrated with the sample loading unit 60. The sample liquid pretreatment system may include two or more sample oscillation and mixing submodules 401, and the transfer gripper 50 includes an up-and-down movement track 511 of the Z axis and a front-and-back movement track 512 of the Y axis, and may also include a left-and-right movement track of the X axis, which is not limited herein, so that any position in the sample liquid treatment system may be covered. The transferring gripper 50 can grip the sample tube in the loading unit 60 to the oscillation blending subunit, the oscillation blending subunit can blend the sample liquid according to a predetermined turbulence degree, and of course, the transferring gripper 50 can grip the sample tube from the return oscillation blending subunit after completing the liquid transfer of the sample liquid, so as to return the sample tube after liquid transfer to the corresponding hole position before the loading unit 60.

Example 6

After the oscillating and blending subunit shown in fig. 7 completes oscillating and blending, the sample tube is conveyed to the lower part of the cover opening and closing unit 100, and the oscillating and blending process can be performed simultaneously in the process of transferring the sample tube or a specific time sequence can be directly arranged to complete the oscillating and blending process. The switch cover unit 100 includes two switch cover units 1001 and 1002 consistent with the number of sample tubes in the oscillator subunit, and includes a switch cover clamping jaw and a tube body fixing clamping jaw matched with the tube body, and certainly, a scheme that a card and a fixing portion are arranged in the oscillator subunit to match the switch cover clamping jaw may also be adopted, where it is not limited to adopt any of two ways to perform the cover opening operation of the sample tubes, and of course, the two switch cover units 1001 and 1002 may simultaneously complete the cover opening operation of the two sample tubes, or may respectively perform the opening operation of another sample tube after completing the pipette operation after one sample tube is opened. The pipettor 30 can carry out the pipetting operation after the sample pipe is opened, before this the pipettor can accomplish the operation of ingesting Tip consumptive material at the central second carousel 20 of double-carousel structure, here in order to cooperate the quick demand that shifts the sample liquid of the even subelement of vibration, the pipettor 30 contains two sub-pipetting units 301 and 302, further in order to guarantee that the transfer liquid can adapt to the dimensional characteristic of transfering the liquid receiving part better, the interval of two pipetting subelements is adjustable, the interval scope between them can be 20mm-70mm, the pipettor 30 also contains X, Y, Z axle motion drive mechanism, and in order to guarantee the requirement of the simplicity and convenience and cost reduction and the reliability of system design, wherein the pipettor and the X axle sharing motion track of sample pipe transfer anchor clamps. The pipettor 30 can be simultaneously or respectively matched with the Tip head to suck the sample liquid in the sample tube, then move to the position above the corresponding hole site of the deep hole plate for receiving the sample liquid along the central area where the non-second turntable 20 is located, then simultaneously or respectively remove the transferred sample liquid to the corresponding hole site of the deep hole plate, the transfer is completed, the sample tube after the use is covered by the switch cover module again, the oscillation blending subunit transports the unloaded sample tube, and the pipettor also moves to the unloading hole site along the track without infecting the central area to unload the Tip head. Certainly, before pipetting, the pipettor can transfer an appropriate amount of PK & IC solution from the PK & IC storage part 110 to the corresponding hole site to realize the reliable establishment of the extraction system, so that the liquid is a relatively universal reagent and has no influence on the transfer of the subsequent sample solution, thereby ensuring the simplicity of the design of the pipetting system.

Example 7

Fig. 6 is a schematic view of a sample liquid processing system in another view, which includes a sample information acquiring unit 70, which can identify the bar code, two-dimensional code, FRID, etc. of the sample tube, for example, it can be used with the switch cover device in fig. 7 to perform identification and acquisition of the sample information, the switch cover device can hold the sample tube and then make the sample tube within the field of view of the information acquiring unit 70, and identify the corresponding information of the sample by the rotating motion of the switch cover to move the sample tube, of course, other schemes can be used to complete acquisition of the sample information, and the scheme is not limited herein, and after the pipette finishes pipetting, the used consumable Tip head is unloaded at the consumable receiving hole 801, and the Tip head consumable recycling position is set at the front of the front processing system, in which the waste Tip head finished by using a drawer-like design can be recycled for subsequent centralized processing, and the low contamination risk of the system is also ensured, the pretreatment system also comprises an ultraviolet sterilization unit 90, so that the cleanness of the operation environment is ensured in the treatment process, the pollution risk of the whole sample treatment process is eliminated to the maximum extent by matching with the basic full-automatic operation, and the pretreatment system also can be arranged in a Tip recovery drawer to sterilize and disinfect used Tip heads and the like.

Example 8

Fig. 8 is a schematic diagram of a functional module of a sample processing system with a dual turntable structure according to the present invention, which can be divided into four basic sub-functional units, including a sample loading unit U01 functional module, mainly responsible for detecting whether sample loading and sample loading are in place, and the like, and includes a sample input unit 60 (also referred to as a sample loading unit) for receiving batch input sample tubes and sample carriers, wherein the sample input unit may include a plurality of in-place sensors located at different positions, which may be photoelectric or mechanical types, but not limited herein, and when the sample loading unit U01 is ready after detecting in place. The transfer unit U02 function module, mainly responsible for the transfer operation of the sample tube, which plays a role of bridge before pipetting, includes a sample tube holder 50 for transferring a new sample tube into the oscillating subunit 40 or removing a sample tube that has completed pipetting from the oscillating subunit 40, and the oscillating subunit can have both functions of transportation and mixing. The pipetting unit U03 function module is mainly used for completing the transfer of sample liquid after the sample liquid information is identified and acquired, and includes a code scanning subunit 70, on one hand, sample information can be acquired, on the other hand, whether the system has a correct reagent to receive the sample liquid can be verified, and the cover opening and closing unit 100 also includes two basic functions, 1) opening or closing the cover of the sample tube; 2) the auxiliary code-scanning subunit 70 acquires the sample tube information, and the pipetting module 30 may include a plurality of sub-pipettors for performing the operations of sucking the sample liquid and discharging the sample liquid to the target hole site. The system establishment unit U04 is a functional module, and the system establishment for completing the subsequent operations in this unit, such as the extraction system establishment in this system, includes a dual turntable unit, which covers the deep hole plate carrying turntable located on the outer ring first turntable 10 and the consumable rack receiving part located on the central inner ring second turntable 20, and other micro reagent storage subunit 110 that needs to be added in the reaction process, which in this embodiment may be PK & IC solution required for the extraction process, and is not limited herein.

Example 9

FIG. 9 is a schematic view showing the operation flow of the sample processing system according to the present invention, wherein the sample loading unit receives a sample tube rack manually added or transferred from the cold storage portion by an automated robot as the system starts to run, so as to complete the step of loading the sample tube into the receiving portion, a plurality of sensors are disposed in the sample loading unit to detect whether the sample tube rack is loaded in place or not, whether the sample tube rack is loaded correctly or not, after the sample tube rack is loaded correctly, the sample tube is clamped by the sample tube clamp and transferred to the oscillator unit to complete the mixing, and then the cover opening and closing mechanism can cooperate with the sample tube identification portion to identify and obtain the sample tube information, on one hand, the obtained barcode information is used to establish the data information of the detection object including but not limited to the object identity, the type of the detected disease, the sample status information, whether the urgent processing is required, and on the other hand, the barcode information of the sample tube is verified, including but not limited to sample testing project verification, whether the reagents associated with the system experiment are correct and whether the sample fluid is collected correctly, etc. After the verification is completed, if the sample tube is matched with and collects correct system reagents sufficiently, the subsequent steps can be carried out, the established database information can also be transmitted to other matched equipment through a local area network and the like, if the system reagents are not matched with and collected correct system reagents, warning information is generated, the system can continue to operate under some conditions and only generates a warning signal, and an operator can carry out intervention processing to solve the problem when the warning signal is generated under the condition that some systems cannot solve the problem, and the code scanning identification step can be arranged before the sample liquid oscillation and mixing step. The method comprises the steps that after information acquisition and verification are completed, the cover opening operation is executed by the cover opening and closing unit, a Tip head consumable in the central position of the inner ring is ingested by a liquid transfer device during the period or before, the sample liquid transfer step is executed along a liquid transfer path in the cover opening state, the sample liquid is transferred to a corresponding hole position of the deep hole plate at the position of the sample liquid receiving part, the cover closing operation is executed by a sample tube after the transfer is completed, the oscillation and uniform mixing unit conveys the sample liquid to the unloading position and then is transferred back to the initial position, the liquid transfer device after the sample liquid transfer is completed runs to the Tip head consumable recycling hole position, and the used Tip head consumable is unloaded and the sample liquid is transferred. Of course, the dual turntable structure of the present invention can also be used in a fully automated sample analysis system to complete the processing and analysis of the sample liquid and the final result output with low risk of contamination, and is not limited herein.

It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims (10)

1. The utility model provides a take sample processing apparatus of two carousel structures which characterized in that: the transfer liquid feeding device comprises a first rotary table (10), wherein a plurality of transfer liquid receiving units are arranged in the circumferential direction of the first rotary table (10), a second rotary table (20) is arranged at the center of the first rotary table (10), and N consumable receiving racks (201) are arranged on the second rotary table (20); the liquid transfer device further comprises a liquid transfer module (30), the liquid transfer module (30) comprises at least one liquid transfer subunit, the liquid transfer module (30) is used for mounting at least one consumable on a consumable receiving rack (201) of the second turntable (20) in an uptake mode, and sample liquid transfer or consumable unloading is carried out in an area outside the second turntable (20).

2. The sample processing device with a dual turntable structure of claim 1, wherein: the transfer liquid receiving unit comprises a receiving part (101), and a deep hole plate is connected to the receiving part (101) through a first clamping part (1011).

3. The sample processing device with a dual turntable structure of claim 1, wherein: the consumable receiving frame (201) is connected with a Tip head of a liquid transfer device through a second clamping portion (2011).

4. The sample processing device with a dual turntable structure of claim 1, wherein: the first turntable (10) and the second turntable (20) are provided with independent driving structures, so that the two turntables can rotate independently.

5. The sample processing device with a dual turntable structure of claim 4, wherein: the first rotary table (10) is driven by a first motor through meshing gear pair transmission, and the second rotary table (20) is driven by a second motor through belt wheel transmission.

6. The sample processing device with a dual turntable structure of claim 5, wherein: the meshing gear pair is configured with a low tooth number matched with a high tooth number.

7. The sample processing device with a dual turntable structure of claim 6, wherein: the high-tooth-number gear is supported by at least two auxiliary supporting wheels.

8. The sample processing device with dual turntable structure of claim 1, wherein: the first rotating disc and the second rotating disc are positioned on the same horizontal plane, and the central axes of the two rotating discs are basically coincident.

9. The sample processing device with a dual turntable structure of claim 4, wherein: when the first rotary table (10) completes one circle of rotation, the second rotary table (20) rotates for no less than 1/N circle.

10. A sample processing device with a dual turntable structure as claimed in claim 1, wherein: the number of the transfer liquid receiving units is 6, and the number N of the consumable receiving racks (201) is 2.

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