CN216248006U - Full-automatic immunity analyzer - Google Patents

Abstract

The utility model belongs to the field of medical instruments and discloses a full-automatic immunoassay analyzer, wherein a sample is stored in a sample storage and transportation assembly, a reagent is stored in a reagent loading assembly, a certain amount of clean empty reaction cups are loaded on a reaction cup supply assembly, a dispensing assembly dispenses a certain amount of samples and reagents into the reaction cups from the sample storage and transportation assembly, the reaction cups containing the samples and the reagents are uniformly mixed through a uniformly mixing assembly, the sample reagents are fully dispersed, the reaction cup assembly incubates the uniformly mixed reaction cups at constant temperature, a magnetic separation cleaning assembly cleans and separates the reaction cups after the constant temperature incubation of the reaction cup assembly is finished, an optical measurement assembly performs optical signal measurement on the reaction cups added with substrates and stably reacting, a waste liquid recovery assembly performs waste liquid suction on the reaction cups with measured optical signals, and the whole period is ensured to be shortened, the test flux is improved, the operation process is simple, and resources are saved.

Description

Full-automatic immunity analyzer

Technical Field

The utility model relates to the technical field of medical instruments, in particular to a full-automatic immunoassay analyzer.

Background

The chemiluminescence immunoassay is rapidly popularized by virtue of the advantages of high sensitivity, good specificity, high automation degree and the like, and is widely applied to the field of medical diagnosis of tumor markers, infectious diseases, endocrine functions, hormones and the like, so that the current test requirements on chemiluminescence immunoassay instruments are more and more, and the requirements are higher and more.

The chemiluminescence immunoassay analyzer mainly comprises a sample storage and transfer assembly, a reagent loading assembly, a reaction cup supply assembly, a dispensing assembly, a buffer disc assembly, a mixing assembly, a reaction disc assembly, a magnetic separation cleaning assembly, a photometric assembly, a reaction cup transfer assembly and the like, wherein operations of loading and transferring the reaction cup, dispensing a sample reagent, mixing, cleaning, photometric and the like are carried out in a production line manner, a plurality of operations need to share part of assemblies, so that the test speed is limited and difficult to break through, and the actual test flux is relatively low and is not enough to meet the test requirements of relevant mechanisms of future hospitals and the like, therefore, a hospital must purchase a plurality of instruments to be used simultaneously, not only occupies the land used by a test area, but also needs a plurality of people to carry out operation and maintenance, so that the operation flow is complicated and resources are wasted.

SUMMERY OF THE UTILITY MODEL

The utility model aims to provide a full-automatic immunoassay analyzer which is simple in operation process and saves resources.

In order to achieve the above object, the present invention provides a full-automatic immunoassay analyzer, which comprises a sample storage and transportation assembly, a reagent loading assembly, a reagent pre-mixing assembly, a reaction cup supply assembly, a dispensing assembly, a reaction cup transfer assembly, a buffer disc assembly, a mixing assembly, a reaction disc assembly, a magnetic separation cleaning assembly, an optical measurement assembly and a waste liquid recovery assembly, wherein the reagent loading assembly is located at one side of the reagent pre-mixing assembly, the dispensing assembly is located at one side of the reagent loading assembly, the reaction disc assembly is located at one side far away from the reagent pre-mixing assembly, the reaction cup transfer assembly is located at one side of the reaction disc assembly, the mixing assembly is located at one side of the reaction disc assembly, the buffer disc assembly is located at one side of the reaction disc assembly, and the magnetic separation cleaning assembly is located at one side far away from the reaction cup transfer assembly, the liquid waste recovery assembly is located on one side of the reaction cup transfer assembly, the optical measurement assembly is arranged opposite to the liquid waste recovery assembly, the reaction cup supply assembly is located on one side, away from the reagent loading assembly, of the reaction cup assembly, and the sample storage and transportation assembly is located on one side of the reaction cup supply assembly.

Wherein the sample storage and transfer assembly comprises a first sample storage and transfer assembly located adjacent to both sides of the cuvette supply assembly.

Wherein the sample storage and transfer assembly comprises a second sample storage and transfer assembly located on a side of the cuvette supply assembly.

Wherein the dispensing assembly comprises a sample needle member, a first reagent needle member, a second reagent needle member, and a third reagent needle member, the sample needle member being located on one side of the magnetic separation wash assembly, the first, second, and third reagent needle members each being located between the reagent loading assembly and the reaction tray assembly.

Wherein the buffer disk component comprises a first buffer disk component and a second buffer disk component, the first buffer disk component is positioned between the magnetic separation cleaning component and the reaction cup supply component, and the second buffer disk component is positioned between the waste liquid recovery component and the optical measurement component.

The reaction cup transfer component comprises a first reaction cup transfer component, a second reaction cup transfer component and a third reaction cup transfer component, the first reaction cup transfer component is located between the reaction cup supply component and the reaction disc component, the second reaction cup transfer component is located close to one side of the uniformly mixing component, and the third reaction cup transfer component is located far away from the reaction disc component on one side of the magnetic separation cleaning component.

The utility model discloses a full-automatic immunoassay analyzer which mainly comprises a sample storage and transfer assembly, a reagent loading assembly, a reagent pre-mixing and uniform assembly, a reaction cup supply assembly, a separate injection assembly, a cache disc assembly, a uniform mixing assembly, a reaction disc assembly, a magnetic separation and cleaning assembly, an optical measurement assembly, a waste liquid recovery assembly and a reaction cup transfer assembly. The sample storage and transfer component is stored with a sample, the reagent loading component is stored with a reagent, the reaction cup supply component is loaded with a certain amount of clean empty reaction cups for the buffer disk component to use, the dispensing component dispenses a certain amount of sample or reagent into the reaction cups from the sample storage and transfer component or the reagent loading component, the reaction cups containing the sample and the reagent are mixed by the mixing component to fully disperse the sample reagent, the reaction cup component incubates the mixed reaction cups at constant temperature, the magnetic separation cleaning component cleans and separates the reaction cups after incubation at constant temperature of the reaction cup component to remove unbound free substances, the optical measurement component measures optical signals of the reaction cups added with substrates and stably reacting, the waste liquid recovery component absorbs waste liquid of the reaction cups with measured optical signals to achieve the purpose of separating solid waste materials from liquid waste materials, the operation is carried out simultaneously without mutual interference, the simultaneous operation of all the procedures on the assembly line ensures that the whole period time is shortened, the test flux is improved, the test speed of unit floor area is correspondingly improved, the operation flow is simple, and the resources are saved.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.

Fig. 1 is a diagram of a fully automatic immunoassay analyzer according to a first embodiment of the present invention.

Fig. 2 is a diagram of a fully automatic immunoassay analyzer according to a second embodiment of the present invention.

FIG. 3 is a schematic flow chart of an analysis method of the fully automatic immunoassay analyzer provided by the present invention.

1-reagent loading component, 2-reagent pre-mixing component, 3-reaction cup supply component, 4-dispensing component, 5-reaction cup transfer component, 6-cache disk component, 7-mixing component, 8-reaction disk component, 9-magnetic separation cleaning component, 10-optical measurement component and 11-waste liquid recovery component, 12-first sample storage and transfer assembly, 13-second sample storage and transfer assembly, 401-sample needle part, 402-first reagent needle part, 403-second reagent needle part, 404-third reagent needle part, 601-first buffer disk part, 602-second buffer disk part, 501-first reaction cup transfer part, 502-second reaction cup transfer part, 503-third reaction cup transfer part.

Detailed Description

Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are illustrative and intended to be illustrative of the utility model and are not to be construed as limiting the utility model.

In the description of the present invention, it is to be understood that the terms "length", "width", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on the orientations or positional relationships illustrated in the drawings, and are used merely for convenience in describing the present invention and for simplicity in description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed in a particular orientation, and be operated, and thus, are not to be construed as limiting the present invention. Further, in the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.

Referring to fig. 1, a first embodiment of the present invention provides a full-automatic immunoassay analyzer, which includes a sample storage and transportation assembly, a reagent loading assembly 1, a reagent pre-mixing assembly 2, a reaction cup supply assembly 3, a dispensing assembly 4, a reaction cup transfer assembly 5, a buffer disk assembly 6, a mixing assembly 7, a reaction disk assembly 8, a magnetic separation cleaning assembly 9, an optical measurement assembly 10, and a waste liquid recovery assembly 11, wherein the reagent loading assembly 1 is located on one side of the reagent pre-mixing assembly 2, the dispensing assembly 4 is located on one side of the reagent loading assembly 1, the reaction disk assembly 8 is located on one side far from the reagent pre-mixing assembly 2, the reaction cup transfer assembly 5 is located on one side of the reaction disk assembly 8, the mixing assembly 7 is located on one side of the reaction disk assembly 8, and the buffer disk assembly 6 is located on one side of the reaction disk assembly 8, the magnetic separation cleaning assembly 9 is positioned at the side far away from the reaction cup transferring assembly 5, the waste liquid recovery assembly 11 is positioned at the side of the reaction cup transferring assembly 5, the optical measurement assembly 10 is arranged opposite to the waste liquid recovery assembly 11, and the reaction cup supply assembly 3 is positioned at the side far away from the reagent loading assembly 1 of the reaction cup assembly 8; the sample storage and transportation assembly is positioned on one side of the reaction cup supply assembly 3; the sample storage and transportation assembly comprises a first sample storage and transportation assembly 12, wherein the first sample storage and transportation assembly 12 is positioned at two adjacent sides of the reaction cup supply assembly 3

The pipetting assembly 4 comprises a sample needle part 401, a first reagent needle part 402, a second reagent needle part 403 and a third reagent needle part 404, the sample needle part 401 being located at the side of the magnetic separation washing assembly 9, the first reagent needle part 402, the second reagent needle part 403 and the third reagent needle part 404 being located between the reagent loading assembly 1 and the reaction disk assembly 8; the buffer disk assembly 6 comprises a first buffer disk member 601 and a second buffer disk member 602, the first buffer disk member 601 is positioned between the magnetic separation and washing unit 9 and the cuvette feeder unit 3, and the second buffer disk member 602 is positioned between the waste liquid recovery unit 11 and the photometric unit 10; reaction cup shifts subassembly 5 includes first reaction cup transfer unit 501, second reaction cup transfer unit 502 and third reaction cup transfer unit 503, first reaction cup transfer unit 501 is located reaction cup supply assembly 3 with between the reaction dish subassembly 8, second reaction cup transfer unit 502 is located and is close to mixing subassembly 7 one side, third reaction cup transfer unit 503 is located reaction dish subassembly 8 is kept away from magnetic separation washs subassembly 9 one side.

In the present embodiment, the layout of the chemiluminescent immunoassay analyzer mainly includes a sample storage and transfer module, a reagent loading module 1, a reagent pre-mixing module 2, a cuvette feeding module 3, a dispensing module 4, a buffer disk module 6, a mixing module 7, a cuvette module 8, a magnetic separation and cleaning module 9, an optical measurement module 10, a waste liquid recovery module 11, and a cuvette transfer module 5. The first sample storage and transportation assembly 12 stores samples, the reagent loading assembly 1 stores reagents, the reaction cup supply assembly 3 carries a certain amount of clean empty reaction cups for the use of the first cache plate component 601, the sample needle component 401 dispenses a certain amount of samples from the first sample storage and transportation assembly 12 into the reaction cups carried on the first cache plate component 601, the first reagent needle component 402 and the second reagent needle component 403 dispense a certain amount of reagents from the reagent loading assembly 1 into the reaction cups carried on the reaction plate component 8, the third reagent needle component 404 dispenses a certain amount of reagents from the reagent loading assembly 1 into the reaction cups carried on the blending assembly 7, the blending assembly 7 blends the reaction cups containing the samples and the reagents, the sample reagents are fully dispersed, the reaction plate component 8 incubates the blended reaction cups at constant temperature, the magnetic separation cleaning component 9 cleans and separates the reaction cup which is incubated at constant temperature on the reaction disc component 8, removes unbound free substances, retains a bound substance, the optical measurement component 10 performs optical signal measurement on the reaction cup which is added with a substrate and stably reacts, and the waste liquid recovery component 11 performs waste liquid suction on the reaction cup which has measured the optical signal, so that the purpose of separating solid waste from liquid waste is achieved. The reaction cup transfer component 5 is used for transferring reaction cups between the first cache disk component 601, the reaction disk component 8, the magnetic separation cleaning component 9, the blending component 7 and the reaction disk component 8, and the second cache disk component 602 and the reaction disk component 8, and is generally positioned above the components, the upper layer space realizes transfer, and the lower layer space realizes grabbing and placing.

As in the example of fig. 1, the first sample storage and transfer assembly 12 is located on the right side of the whole machine, the sample suction position is located on the transfer assembly on the front side, a large amount of samples can be stored on the right side, and the releasing and taking positions in the mode are arranged close to the front right side, so that the operation is convenient.

The reagent loading assembly 1 is positioned at the left side of the whole machine and is arranged close to the reaction disc, so that the movement stroke of the reagent needle assembly is shortened, and the time is saved; the operation of the reagent is positioned on the left front side of the assembly close to the operator, so that the operation is convenient.

The reagent premixing and homogenizing assembly 2 is positioned at the left front side of the reagent loading assembly 1 and is close to the reagent operating position, so that the reagent can be directly loaded into the reagent loading assembly 1 after being premixed and homogenized conveniently, the operation flow is simplified, and the reagent premixing and homogenizing effect is not influenced

The reaction cup supply component 3 adopts an automatic loading arrangement mode to supply, bulk reaction cups are loaded into a hopper, the component automatically sequences the reaction cups and continuously supplies the reaction cups to the first cache plate component 601, and the reaction cups are arranged on the side edge of the first cache plate component 601 and are matched for use.

The dispensing assembly 4 comprises a sample needle part 401, a first reagent needle part 402, a second reagent needle part 403 and a third reagent needle part 404, wherein the sample needle part 401 is positioned at the right front side of the whole machine, samples are quantitatively sucked at sample positions of the sample storing and transferring assembly between the sample storing and transferring assembly and the first cache disk part 601, and dispensing is carried out in a designated reaction cup on the first cache disk part 601; the first reagent needle component 402 and the second reagent needle component 403 are positioned between the reagent loading component 1 and the reaction disc component 8, quantitatively absorb reagents at reagent absorption positions of the reagent loading component 1, and then perform dispensing in designated reaction cups on the reaction disc component 8, can simultaneously work without mutual interference, and shorten the time required by a cycle, the third reagent needle component 404 is positioned at the rear side of the reagent loading component 1, quantitatively absorb reagents at reagent absorption positions of the reagent loading component 1, and then perform dispensing in designated reaction cups on the blending component 7, and can directly perform blending after dispensing is finished, thereby ensuring sufficient blending time.

The buffer disk assembly 6 comprises a first buffer disk component 601 and a second buffer disk component 602, the first buffer disk component 601 is positioned at the right side of the reaction disk assembly 8 and the magnetic separation cleaning assembly 9, and is mainly used for carrying reaction cups supplied by the reaction cup supply assembly 3, transferring the reaction cups to a sample dispensing position for dispensing by the sample needle component 401, and transferring the reaction cups to the reaction cup transfer assembly 5 for alternate position transfer, so that the components can access the first buffer disk component 601 simultaneously without interference, and can access in a time-sharing manner, and the first buffer disk component 601 can store more test samples for use; the second buffer disk part 602 is located at the rear side of the reaction disk assembly 8, and mainly bears the reaction cup for optical signal measurement, and the reaction cup is respectively transferred to the optical measurement assembly 10, the waste liquid recovery assembly 11 and the reaction cup transfer assembly 5 for interaction, so that the assemblies can access the second buffer disk part 602 at the same time without mutual interference, and sufficient time for optical signal measurement and waste liquid recovery is ensured.

The reaction disc assembly 8 is located in the central area of the whole machine and surrounded by other assemblies, so that the reaction disc assembly 8 can be accessed by other assemblies at the same time without mutual interference, the reaction disc assembly 8 is used for incubating mixed liquid at constant temperature, the mixed liquid comprises mixed liquid of a sample and a reagent, a combination (namely a substance after the sample is combined with the reagent) and mixed liquid of a substrate, the reaction disc assembly 8 is a disc body with a rotating function, holes are formed in corresponding positions of a disc cover, and the reaction cup transfer assembly 5 and the dispensing assembly 4 can be ensured to access all reaction cups in the reaction disc.

The blending component 7 is located at the left rear side of the reaction disc component 8 and is located in a movement overlapping area of the third reagent needle component 404 and the second reaction cup transfer component 502, the third reagent needle component 404 plays a role of blending a sample reagent, the third reagent needle component 404 performs separated injection of the reagent at the blending component 7, after the separated injection of the reagent is completed, the blending operation can be performed, the blending time and the blending effect are ensured, the blending component 7 can bear a plurality of reaction cups and is arranged linearly, the movement structure of the second reaction cup transfer component 502 is simplified, and the fault rate and the precision requirement are reduced.

The magnetic separation cleaning component 9 is positioned at the middle front side of the instrument, the reaction cup interaction position is arranged at the back, the movement area of the reaction cup transfer component 5 is reduced, and meanwhile, an operator and a moving part can be effectively cut off, so that the operator is prevented from being injured by mechanical movement; when maintenance treatment is needed, treatment can be carried out from the front side of the instrument, the operation space is large, and the operation is convenient.

The optical measurement assembly 10 is located at the side of the second cache disk part 602, performs optical measurement in the disk, effectively ensures the stability of the light-shielding and optical measurement environment, is used for performing optical signal measurement on the reaction cup added with the substrate and stably reacting, and performs calculation analysis on the content of the object to be measured according to the measured optical signal.

Waste liquid recovery subassembly 11 is located second buffer memory dish part 602 side, carries out waste liquid recovery to the reaction cup that photometry ended, realizes that solid waste and liquid waste material handle respectively, effectively guarantees operator's safety, the refuse treatment of the laboratory of being more convenient for simultaneously.

The reaction cup transferring assembly 5 comprises a first reaction cup transferring member 501, a second reaction cup transferring member 502 and a third reaction cup transferring member 503, wherein the first reaction cup transferring member 501 is used for transferring reaction cups among the first buffer memory disc member 601, the reaction disc assembly 8 and the magnetic separation cleaning assembly 9, the second reaction cup transferring member 502 is used for transferring reaction cups among the blending assembly 7 and the reaction disc assembly 8, and the third reaction cup transferring member 503 is used for transferring reaction cups among the second buffer memory disc member 602, the waste material discarding port and the reaction disc assembly 8. The reaction tray is used as the center and distributed around the reaction tray assembly 8, reaction cups between the reaction tray assembly 8 and other assemblies are transferred, and the reaction cups are transferred by utilizing the rotation of the reaction tray assembly 8, so that the movement interference between the reaction cup transfer assemblies 5 is effectively avoided.

Referring to fig. 2, a second embodiment of the present invention provides a full-automatic immunoassay analyzer, which includes a sample storage and transportation assembly, a reagent loading assembly 1, a reagent pre-mixing assembly 2, a reaction cup supply assembly 3, a dispensing assembly 4, a reaction cup transfer assembly 5, a buffer disk assembly 6, a mixing assembly 7, a reaction disk assembly 8, a magnetic separation cleaning assembly 9, an optical measurement assembly 10, and a waste liquid recovery assembly 11, wherein the reagent loading assembly 1 is located at one side of the reagent pre-mixing assembly 2, the dispensing assembly 4 is located at one side of the reagent loading assembly 1, the reaction disk assembly 8 is located at one side far from the reagent pre-mixing assembly 2, the reaction cup transfer assembly 5 is located at one side of the reaction disk assembly 8, the mixing assembly 7 is located at one side of the reaction disk assembly 8, and the buffer disk assembly 6 is located at one side of the reaction disk assembly 8, the magnetic separation cleaning assembly 9 is positioned at the side far away from the reaction cup transferring assembly 5, the waste liquid recovery assembly 11 is positioned at the side of the reaction cup transferring assembly 5, the optical measurement assembly 10 is arranged opposite to the waste liquid recovery assembly 11, and the reaction cup supply assembly 3 is positioned at the side far away from the reagent loading assembly 1 of the reaction cup assembly 8; the sample storage and transportation assembly is positioned at two adjacent sides of the reaction cup supply assembly 3, the sample storage and transportation assembly comprises a second sample storage and transportation assembly 13, and the second sample storage and transportation assembly 13 is positioned at one side of the reaction cup supply assembly 3;

the pipetting assembly 4 comprises a sample needle part 401, a first reagent needle part 402, a second reagent needle part 403 and a third reagent needle part 404, the sample needle part 401 being located at the side of the magnetic separation washing assembly 9, the first reagent needle part 402, the second reagent needle part 403 and the third reagent needle part 404 being located between the reagent loading assembly 1 and the reaction disk assembly 8; the buffer disk assembly 6 comprises a first buffer disk member 601 and a second buffer disk member 602, the first buffer disk member 601 is positioned between the magnetic separation and washing unit 9 and the cuvette feeder unit 3, and the second buffer disk member 602 is positioned between the waste liquid recovery unit 11 and the photometric unit 10; reaction cup shifts subassembly 5 includes first reaction cup transfer unit 501, second reaction cup transfer unit 502 and third reaction cup transfer unit 503, first reaction cup transfer unit 501 is located reaction cup supply assembly 3 with between the reaction dish subassembly 8, second reaction cup transfer unit 502 is located and is close to mixing subassembly 7 one side, third reaction cup transfer unit 503 is located reaction dish subassembly 8 is kept away from magnetic separation washs subassembly 9 one side.

In this embodiment, the specific content in this embodiment is substantially the same as that described in the first embodiment of the present invention, where the difference is as shown in the example of fig. 2, the second sample storage and transportation assembly 13 is located at the right side of the whole machine, the sample suction position is located on the second sample storage and transportation assembly 13 at the right side of the whole machine, the right side assembly can store a certain amount of samples, the area for storing the samples is reduced, and the sample storage and suction positions are arranged close to the front and right sides for the use in the case of a small sample test requirement, which is convenient for operation.

The first cache disc component 601 can bear a clean reaction cup and perform sample separate injection, the reaction disc component 8 can perform reagent separate injection, the mixed solution in the reaction cup is incubated at constant temperature, the reaction cup after incubation enters the magnetic separation cleaning component 9 to be cleaned, and the reaction cup added with a substrate and stably reacted is detected. The reaction disc assembly 8 can be accessed by a plurality of assemblies at the same time without mutual interference, the problem that the reaction disc assembly 8 is long in cycle time due to use of a plurality of processes is effectively solved, meanwhile, the blending assembly 7 is provided with a plurality of groups, insufficient blending time due to cycle shortening is avoided, blending effect is poor, the first buffer disc component 601 is added, the reaction cup supply assembly 3 is guaranteed, the sample needle assembly and the reaction cup transfer assembly 5 are operated at the same time without mutual interference, the second buffer disc component 602 is added, the optical measurement assembly 10 is guaranteed, the waste liquid recovery assembly 11 and the third reaction cup transfer component 503 are operated at the same time without mutual interference, the processes on a flow line are operated at the same time, the whole cycle time is guaranteed to be shortened, test flux is improved, and accordingly, the test speed of unit area is improved.

The method can be divided into a one-step method and a two-step method according to the times of adding the reagent, uniformly mixing and incubating, and can be divided into one-time cleaning and two-time cleaning according to the times of magnetic separation cleaning, wherein the magnetic separation cleaning can be carried out or not carried out after the reagent is added, uniformly mixing and incubating are finished every time, but the magnetic separation cleaning operation is carried out at least once every time of testing.

Referring to fig. 3, the present invention provides an analysis method of a full-automatic immunoassay analyzer, which is suitable for the full-automatic immunoassay analyzer, and comprises the following steps:

the reaction cup containing the sample is transferred from the first cache disk component 601 to the reaction disk component 8 through the first reaction cup transfer component 501, then the reagent with the corresponding amount is added into the reaction cup in batches through the dispensing component 4, the reaction cup is transferred to the blending component 7, then the reagent with the corresponding amount is dripped again, and blending operation is carried out through the blending component 7.

After the mixing time is reached, the second reaction cup transfer component 502 transfers the reaction cup to the reaction disc component 8 for constant-temperature incubation, after the incubation time is reached, the reaction cup is transferred to the magnetic separation cleaning component 9 for cleaning and separation, then the separated-injection substrate is mixed uniformly, and the reaction cup is transferred to the reaction disc component 8 for incubation again, after the incubation time is reached, the reaction cup is subjected to photometry and solid-liquid separation, solid waste is collected and treated respectively, and liquid waste is treated and discharged uniformly.

Specifically, the cuvette enters the first buffer disk member 601 from the cuvette supply unit 3, the sample needle member 401 sucks a predetermined amount of sample from a corresponding position of the first sample storage and transfer unit 12 or the second sample storage and transfer unit 13 and dispenses the sample into the cuvette of the first buffer disk member 601, the first cuvette transfer unit 501 transfers the cuvette from the first buffer disk member 601 to the cuvette assembly 8, the reagent needle member respectively sucks a predetermined amount of reagent from a corresponding position of the reagent loading unit 1 and dispenses the reagent into the cuvette in the cuvette assembly 8, the second cuvette transfer unit 502 transfers the cuvette from the cuvette assembly 8 to the kneading unit 7, the third reagent needle member 404 sucks a predetermined amount of reagent from a corresponding position of the reagent loading unit 1 and dispenses the reagent into the cuvette in the kneading unit 7, and then the cuvette is kneaded and reaches the kneading time, the second reaction cup transfer component 502 transfers the reaction cup to the reaction disc component 8 for incubation at constant temperature, when the incubation time is up, the first reaction cup transfer component 501 transfers the reaction cup from the reaction disc component 8 to the magnetic separation cleaning component 9 for cleaning and separation, after the cleaning, the substrate is injected and mixed uniformly, then the first reaction cup transfer component 501 transfers the reaction cup to the reaction disc component 8 for incubation, when the incubation time is up, the third reaction cup transfer component 503 transfers the reaction cup to the second buffer disc component 602 for photometry, after the completion, the solid-liquid separation is carried out, the solid waste is collected and treated respectively, and the liquid waste is treated and discharged uniformly.

Referring to fig. 3, the present invention provides an analysis method of a full-automatic immunoassay analyzer, which is suitable for the full-automatic immunoassay analyzer, and comprises the following steps:

transferring the reaction cups filled with the samples from the first cache disc component 601 to the reaction disc component 8 through the reaction cup transfer component 5, adding reagents with corresponding amounts into the reaction cups in batches through the separate injection component 4, transferring the reaction cups to the blending component 7, then carrying out blending operation through the blending component 7 until the blending time is up, and transferring the reaction cups to the reaction disc component 8 for constant-temperature incubation;

after the incubation time is up, if the reaction cup is washed for the first time, uniformly mixing and incubating at constant temperature, after the incubation time is up, transferring the reaction cup from the reaction disc assembly 8 to the magnetic separation washing assembly 9 for washing and separation, then transferring the reaction cup to the reaction disc assembly 8 for incubation, after the incubation time is up, performing optical measurement and solid-liquid separation on the reaction cup, respectively collecting and treating solid waste materials, and uniformly treating and discharging liquid waste liquid;

if the cleaning is performed twice, the reaction cup is transferred from the reaction disk assembly 8 to the magnetic separation cleaning assembly 9 through the reaction cup transfer assembly 5 for cleaning and separation, and then the reaction cup is transferred to the reaction disk assembly 8 after the cleaning is finished, and then the reaction cup is operated according to a one-time cleaning process.

Specifically, the cuvette enters the first buffer tray member 601 from the cuvette supply unit 3, the sample needle member 401 sucks a predetermined amount of sample from a corresponding position of the first sample storage and transfer unit 12 or the second sample storage and transfer unit 13 and dispenses the sample into the cuvette of the first buffer tray member 601, the first cuvette transfer member 501 transfers the cuvette from the first buffer tray member 601 to the cuvette assembly 8, the reagent needle assembly respectively sucks a predetermined amount of reagent from a corresponding position of the reagent loading unit 1 and dispenses the reagent into the cuvette in the cuvette assembly 8, the second cuvette transfer member 502 transfers the cuvette from the cuvette assembly 8 to the mixing unit 7 and mixes the cuvette, after the mixing time is reached, the second cuvette transfer member 502 transfers the cuvette to the cuvette assembly 8 for incubation at a constant temperature, and after the incubation time is reached, if the reagent is washed once, the reaction cup is transferred from the reaction disc assembly 8 to the blending assembly 7 by the second reaction cup transfer component 502, the third reagent needle component 404 sucks a certain amount of reagent from the corresponding position of the reagent loading assembly 1, dispenses the reagent into the reaction cup in the blending assembly 7, then blends the reaction cup, after the blending time is up, the second reaction cup transfer component 502 transfers the reaction cup to the reaction disc assembly 8 for incubation at constant temperature, after the incubation time is up, the first reaction cup transfer component 501 transfers the reaction cup from the reaction disc assembly 8 to the magnetic separation cleaning component 9 for cleaning and separation, after the substrate dispensing and blending are finished, the reaction cup is transferred to the reaction disc assembly 8 by the first reaction cup transfer component 501 for incubation, after the incubation time is up, the reaction cup is transferred to the second buffer disc component 602 by the third reaction cup transfer component 503 for photometry, after finishing, carrying out solid-liquid separation, respectively collecting and treating solid wastes, and uniformly treating and discharging liquid waste liquid; if the cleaning is performed twice, the first cuvette transfer unit 501 transfers the cuvette from the cuvette assembly 8 to the magnetic separation cleaning unit 9 for cleaning and separation, and then the first cuvette transfer unit 501 transfers the cuvette to the cuvette assembly 8, and then the procedure is the same as the one-time cleaning test procedure.

The utility model discloses a full-automatic immunoassay analyzer, which mainly comprises a sample storage and transfer assembly, a reagent loading assembly 1, a reagent pre-mixing and homogenizing assembly 2, a reaction cup supply assembly 3, a separate injection assembly 4, a buffer disc assembly 6, a mixing assembly 7, a reaction disc assembly 8, a magnetic separation cleaning assembly 9, a light measurement assembly 10, a waste liquid recovery assembly 11 and a reaction cup transfer assembly 5. The sample storing and transferring component is stored with a sample, the reagent loading component 1 is stored with a reagent, the reaction cup supply component 3 is loaded with a certain amount of clean empty reaction cups for the use of the buffer disk component 6, the dispensing component 4 dispenses a certain amount of sample and reagent into the reaction cups from the sample storing and transferring component, and mixes the reaction cups containing the sample and the reagent by the mixing component 7 to fully disperse the sample reagent, the reaction disk component 8 incubates the mixed reaction cups at constant temperature, the magnetic separation cleaning component 9 cleans and separates the reaction cups after incubation at constant temperature of the reaction disk component 8 to remove unbound free objects and retain bound objects, the optical measurement component 10 measures optical signals of the reaction cups added with substrates and stably reacting, the waste liquid recovery component 11 sucks waste liquid from the reaction cups with measured optical signals to achieve the purpose of separating solid waste materials from liquid waste materials, the operation is carried out simultaneously without mutual interference, the simultaneous operation of all the procedures on the assembly line ensures that the whole period time is shortened, the test flux is improved, the test speed of unit floor area is correspondingly improved, the operation flow is simple, and the resources are saved.

While the utility model has been described with reference to a preferred embodiment, it will be understood by those skilled in the art that various changes in form and detail may be made therein without departing from the spirit and scope of the utility model.

Claims (6)

1. A full-automatic immunity analyzer is characterized in that,

the full-automatic immunity analyzer comprises a sample storage and transfer component, a reagent loading component, a reagent pre-mixing component, a reaction cup supply component, a dispensing component, a reaction cup transfer component, a cache disc component, a blending component, a reaction disc component, a magnetic separation cleaning component, an optical measurement component and a waste liquid recovery component, wherein the reagent loading component is positioned on one side of the reagent pre-mixing component, the dispensing component is positioned on one side of the reagent loading component, the reaction disc component is positioned on one side far away from the reagent pre-mixing component, the reaction cup transfer component is positioned on one side of the reaction disc component, the blending component is positioned on one side of the reaction disc component, the cache disc component is positioned on one side of the reaction disc component, the magnetic separation cleaning component is positioned on one side far away from the reaction cup transfer component, and the waste liquid recovery component is positioned on one side of the reaction cup transfer component, the optical measurement assembly is arranged opposite to the waste liquid recovery assembly, the reaction cup supply assembly is positioned on one side, away from the reagent loading assembly, of the reaction plate assembly, and the sample storage and transportation assembly is positioned on one side of the reaction cup supply assembly.

2. The fully automatic immunoassay analyzer of claim 1,

the sample storage and transfer assembly comprises a first sample storage and transfer assembly positioned adjacent to both sides of the cuvette supply assembly.

3. The fully automatic immunoassay analyzer of claim 1,

the sample storage and transfer assembly includes a second sample storage and transfer assembly located on a side of the cuvette supply assembly.

4. The fully automatic immunoassay analyzer of claim 1,

the dispensing assembly includes a sample needle member, a first reagent needle member, a second reagent needle member, and a third reagent needle member, the sample needle member being located on one side of the magnetic separation wash assembly, the first reagent needle member, the second reagent needle member, and the third reagent needle member all being located between the reagent loading assembly and the reaction disk assembly.

5. The fully automatic immunoassay analyzer of claim 1,

the buffer disc component comprises a first buffer disc part and a second buffer disc part, the first buffer disc part is positioned between the magnetic separation cleaning component and the reaction cup supply component, and the second buffer disc part is positioned between the waste liquid recovery component and the optical measurement component.

6. The fully automatic immunoassay analyzer of claim 1,

reaction cup shifts subassembly includes first reaction cup transfer unit, second reaction cup transfer unit and third reaction cup transfer unit, first reaction cup transfer unit is located reaction cup supply assembly with between the reaction dish subassembly, second reaction cup transfer unit is located and is close to mixing subassembly one side, third reaction cup transfer unit is located reaction dish subassembly is kept away from magnetic separation washs subassembly one side.

Images