CN219652925U - Multichannel chip type protein purification instrument - Google Patents
Multichannel chip type protein purification instrument Download PDFInfo
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- CN219652925U CN219652925U CN202320887033.7U CN202320887033U CN219652925U CN 219652925 U CN219652925 U CN 219652925U CN 202320887033 U CN202320887033 U CN 202320887033U CN 219652925 U CN219652925 U CN 219652925U
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- peristaltic pump
- chip
- protein purification
- type protein
- pipetting
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- 238000001742 protein purification Methods 0.000 title claims abstract description 17
- 230000002572 peristaltic effect Effects 0.000 claims abstract description 50
- 238000000746 purification Methods 0.000 claims abstract description 26
- 238000011068 loading method Methods 0.000 claims abstract description 9
- 230000005291 magnetic effect Effects 0.000 claims description 61
- 238000010438 heat treatment Methods 0.000 claims description 18
- 239000003153 chemical reaction reagent Substances 0.000 claims description 17
- 239000002699 waste material Substances 0.000 claims description 16
- 239000002184 metal Substances 0.000 claims description 12
- 230000010355 oscillation Effects 0.000 claims description 11
- 230000005389 magnetism Effects 0.000 claims description 9
- 239000012528 membrane Substances 0.000 claims description 9
- 238000005057 refrigeration Methods 0.000 claims description 6
- 230000007246 mechanism Effects 0.000 claims description 4
- -1 and samples Substances 0.000 claims description 3
- 230000003578 releasing effect Effects 0.000 claims description 3
- 239000007788 liquid Substances 0.000 abstract description 30
- 102000004169 proteins and genes Human genes 0.000 abstract description 8
- 108090000623 proteins and genes Proteins 0.000 abstract description 8
- 238000011403 purification operation Methods 0.000 abstract description 3
- 238000012864 cross contamination Methods 0.000 abstract description 2
- 238000001514 detection method Methods 0.000 abstract description 2
- 230000004907 flux Effects 0.000 abstract description 2
- 239000011324 bead Substances 0.000 description 33
- 239000000523 sample Substances 0.000 description 18
- 238000004140 cleaning Methods 0.000 description 13
- 230000009471 action Effects 0.000 description 10
- 239000003480 eluent Substances 0.000 description 9
- 238000006243 chemical reaction Methods 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 4
- 230000005294 ferromagnetic effect Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000007599 discharging Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 230000004075 alteration Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- 239000012521 purified sample Substances 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The utility model relates to the technical field of detection equipment, in particular to a multichannel chip type protein purification instrument, which comprises an equipment frame and is characterized in that: the multi-channel chip type protein purification instrument has the advantages of high precision, large flux and high efficiency, can be used for full-automatic purification and can be used for simultaneously purifying various proteins, peristaltic liquid discharge is adopted for protein purification, and purified liquid independently exists in each independent channel, so that cross contamination between two purifications is avoided; once sample loading, equipment automation carries out purification operation, liberates manpower, eliminates the human error, has greatly improved purification rate of accuracy and efficiency.
Description
Technical Field
The utility model relates to the technical field of detection equipment, in particular to a multichannel chip type protein purifier.
Background
The protein purification instrument is a device for separating and purifying protein, can also purify biological samples such as antibodies, blood and the like, has the advantages that the traditional manual purification operation is very good in examination of experience of operators during pipetting, the purification time is not well controlled, the artificial error is difficult to eliminate, the conventional single-channel purification efficiency is relatively low, and a large amount of preliminary screening of protein samples is needed in the discovery and research and development processes of modern biological medicines or biological products.
In summary, the present utility model solves the problems by designing a multi-channel chip-type protein purifier.
Disclosure of Invention
The utility model aims to provide a multichannel chip type protein purifier so as to solve the problems in the background technology.
In order to achieve the above purpose, the present utility model provides the following technical solutions:
the utility model provides a multichannel chip formula protein purification appearance, includes equipment frame, its characterized in that: the top of the equipment frame is provided with a pipetting component, the pipetting component is provided with a pipetting gantry structure and a full-automatic pipetting unit, the bottom of the inner side of the equipment frame is provided with a peristaltic pump component, the peristaltic pump component is provided with a peristaltic pump and a heating film component, the heating film component is provided with a heating film, the top of the heating film is provided with a multichannel parallel chip, the peristaltic pump is provided with a waste liquid discharge port, one end of the bottom of the inner side of the equipment frame is provided with a refrigeration oscillation component, the utility model discloses a solution cooling device, including equipment frame, bottom fixed block, guide post, strong magnetic module, jacking executor, strong magnetic lifting assembly, strong magnetic module, strong magnetic lifting assembly and strong magnetic module are installed to the top of oscillating be equipped with on the subassembly is oscillated in the cold-stored subassembly that oscillates, solution consumptive material box is installed at the top of oscillating cold-stored metallic bath, strong magnetic lifting assembly is installed at the top of the inboard baffle of equipment frame, the bottom fixed block is installed at the bottom both ends of bottom fixed block, strong magnetic module is installed at the top of guide post, jacking executor is installed between the top center department of bottom fixed block and the bottom center department of strong magnetic module.
As the preferable scheme of the utility model, the pipetting assembly uses a linear motor module mechanism, a single channel is assembled on a linear motor and can move up and down, gun loading and gun releasing actions are completed, the pipetting gantry structure is formed by a gantry type module formed by three linear motors, the position of a sliding block can be precisely controlled by a driver, and the full-automatic pipetting unit can realize movement of a Z axis.
As a preferable scheme of the utility model, the peristaltic pump assembly is driven by a motor driver to realize forward and reverse rotation, and the peristaltic pump and the multichannel parallel chip are connected in series.
As a preferable scheme of the utility model, the cold storage oscillation assembly integrates a metal bath module with cold storage and oscillation functions, solution reagents can be cooled at a low temperature of-2-8 degrees, the oscillation cold storage metal bath is a standard consumable box-packed various reagents, and samples, products, samples and multiple chips are all in one-to-one correspondence.
As a preferable scheme of the utility model, the strong magnetism lifting components are arranged on the mounting block in an array manner, compared with the whole square strong magnetism, the lifting actuator is provided with the guide posts on two sides respectively, and the lifting of the strong magnetism lifting components ensures no inclination in parallel lifting and high bonding degree with the chip.
As a preferable scheme of the utility model, the heating film component is a PI electrothermal film, is attached to the bottom of the chip, has controllable temperature, and can adjust corresponding purification temperature according to different samples.
Compared with the prior art, the utility model has the beneficial effects that:
1. according to the utility model, the designed multi-channel chip type protein purifier has the advantages of high precision, large flux, high efficiency, full-automatic purification and capability of purifying a plurality of proteins simultaneously, peristaltic liquid drainage is adopted for protein purification, and the purified liquid independently exists in each independent channel, so that cross contamination between two purifications is avoided; once sample loading, equipment automation carries out purification operation, liberates manpower, eliminates the human error, has greatly improved purification rate of accuracy and efficiency.
Drawings
FIG. 1 is a schematic diagram of the overall structure of the present utility model;
FIG. 2 shows the basic structure of the protein purification instrument of the utility model;
FIG. 3 is a basic structure of a pipetting assembly of the utility model;
FIG. 4 is a schematic representation of the peristaltic pump assembly of the present utility model;
FIG. 5 is a schematic illustration of a refrigerated oscillating assembly according to the present utility model;
FIG. 6 shows a ferromagnetic lift assembly of the present utility model.
In the figure: 1. a pipetting assembly; 101. a pipetting gantry structure; 102. a full-automatic pipetting unit; 2. a peristaltic pump assembly; 201. a peristaltic pump; 202. a multi-channel parallel chip; 203. a waste liquid discharge port; 3. refrigerating and vibrating components; 301. vibrating and refrigerating the metal bath; 302. a solution consumable box; 4. a ferromagnetic lifting assembly; 401. a bottom fixing block; 402. a guide post; 403. a ferromagnetic module; 404. jacking an actuator; 5. heating the membrane assembly; 501. heating the film; 6. and a device frame.
Detailed Description
The technical solutions of the embodiments of the present utility model will be clearly and completely described below in conjunction with the embodiments of the present utility model, and it is apparent that the described embodiments are only some embodiments of the present utility model, but not all embodiments, and all other embodiments obtained by those skilled in the art without making any inventive effort based on the embodiments of the present utility model are within the scope of protection of the present utility model.
In order that the utility model may be readily understood, several embodiments of the utility model will be described more fully hereinafter with reference to the accompanying drawings, in which, however, the utility model may be embodied in many different forms and is not limited to the embodiments described herein, but instead is provided for the purpose of providing a more thorough and complete disclosure of the utility model.
It will be understood that when an element is referred to as being "mounted" on another element, it can be directly on the other element or intervening elements may also be present, and when an element is referred to as being "connected" to the other element, it may be directly connected to the other element or intervening elements may also be present, the terms "vertical", "horizontal", "left", "right" and the like are used herein for the purpose of illustration only.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this utility model belongs, and the terms used herein in this description of the utility model are for the purpose of describing particular embodiments only and are not intended to be limiting of the utility model, with the term "and/or" as used herein including any and all combinations of one or more of the associated listed items.
Referring to fig. 1-6, the present utility model provides a technical solution:
the utility model provides a multichannel chip formula protein purification appearance, including equipment frame 6, pipetting module 1 is installed at the top of equipment frame 6, be equipped with pipetting portal structure 101 and full-automatic pipetting unit 102 on pipetting module 1, peristaltic pump assembly 2 is installed to the inboard bottom of equipment frame 6, be equipped with peristaltic pump 201 and heating membrane assembly 5 on the peristaltic pump assembly 2, be equipped with heating membrane 501 on the heating membrane assembly 5, multichannel parallel chip 202 is installed at the top of heating membrane 501, waste liquid outlet 203 has been seted up on the peristaltic pump 201, cold-stored vibration subassembly 3 is installed to inboard bottom one end of equipment frame 6, be equipped with on the cold-stored vibration subassembly 3 and vibrate cold-stored metal bath 301, solution consumable box 302 is installed at the top of vibrate cold-stored metal bath 301, strong magnetism lifting assembly 4 is installed at the top of the inboard baffle of equipment frame 6, bottom fixed block 401 is installed at the bottom of strong magnetism lifting assembly 4, guide post 402 is installed at the top both ends of bottom fixed block 401, strong magnetism module 403 is installed at the top center of bottom fixed block 401 and jacking executor 404 is installed at the bottom center of strong magnetism module 403.
Specifically, referring to fig. 1 and 2, the pipetting assembly 1 uses a linear motor module mechanism, a single channel is assembled on a linear motor, and can move up and down, and the gun loading and gun releasing actions are completed, and the pipetting gantry structure 101 is formed by three linear motors to form a gantry type module, the position of the slide block can be precisely controlled by a driver, and the full-automatic pipetting unit 102 can realize the movement of a Z axis. Therefore, the multi-directional quick movement of the working unit is realized, the pipetting operation of each reagent is facilitated, the gun head replacing function of the loading and unloading gun is realized, the mutual pollution among the reagents is avoided during pipetting, and the full-automatic gun head replacement is realized among different samples.
Further, the peristaltic pump assembly 2 is driven by a motor driver to realize forward and reverse rotation, and the peristaltic pump 201 and the multichannel parallel chips 202 are connected in series, so that liquid can reciprocate in the chips, liquid discharging and magnetic bead mixing operation can be performed, the multichannel peristaltic pump can simultaneously perform parallel operation on a plurality of chips, efficiency is improved, control accuracy of the peristaltic pump 201 is high, liquid level in the chips is directly controlled by forward and reverse operation, liquid level is accurate, and finally purified product yield is high.
Further, the strong magnets of the strong magnetic lifting assembly 4 are arranged in an array on the mounting block, compared with the whole square strong magnets, two sides of the jacking actuator 404 are respectively provided with a guide post, and the strong magnetic module is lifted to ensure parallel lifting without inclination, so that the jacking actuator is high in bonding degree with the chip. Therefore, the structure effectively utilizes magnetic pole force to effectively fix the magnetic beads, the adsorption rate is increased, and the purification efficiency is high.
Further, the heating film component 5 is a PI electrothermal film, is attached to the bottom of the chip, has controllable temperature, and can adjust corresponding purification temperature according to different samples, so that when reagents such as magnetic bead solution and the like and the samples are refrigerated and stored, the heating film is immediately heated after being transferred onto the chip, the reagents and the samples do not need to be recovered to normal temperature for purification, the time is greatly shortened, and the purification efficiency is improved.
Specifically, referring to fig. 1 and 4, the refrigeration oscillation component 3 integrates a metal bath module with refrigeration and oscillation functions, the solution reagent can be refrigerated at a low temperature of 2-8 degrees, the oscillation refrigeration metal bath 301 is a standard consumable box-packed various reagents, and the samples are in one-to-one correspondence with the products and the samples and the multi-connected chips, so that a large amount of magnetic bead solution can be loaded at one time, and the samples can be subjected to multiple purification reactions, so that the method is more convenient; the vibration module can effectively prevent the magnetic beads from sinking, the purification efficiency is improved, meanwhile, the sample adding and the sample discharging are clear, and the standard consumable box has strong universality; directly placed on the metal bath, and the operation is simple.
The working flow of the utility model is as follows: a multichannel chip type protein purification appearance that uses this scheme design, when the instrument operation, one: preparing consumable materials outside an instrument: firstly, preparing an external consumable of an instrument: 96-well plate 3, multi-well plate 3, purifying chip 3, gun head box containing gun head, empty gun head box, several samples, magnetic bead solution containing capture antibody, cleaning liquid and eluent; and (3) filling the reagent outside the instrument: adding a sample into a 96-well plate, and adding a magnetic bead solution, a cleaning solution and an eluent into a multi-well plate; consumable feeding machine: the consumable on-machine option is selected on the instrument, at this time, the motion mechanism is zeroed, the oscillation function is stopped, and the peristaltic pump 201 function is stopped. Opening the cabin door, sequentially loading gun head boxes containing gun heads and empty gun head boxes according to the functional areas, and containing sample 96-well plates, 96-well plates and reagent 6-well plates.
And II: establishing experiment numbers: and scanning the two-dimensional code on the surface of the purified chip by using a camera of the pad, establishing an experiment number, loading the purified chip according to the requirement, closing a cabin door, prompting to select a chip reaction area on the pad according to the record information of the database, selecting a purification reaction channel, and recording the chip information and the used reaction area by the pad.
Thirdly,: the experimental procedure was performed:
1, a reagent area starts to vibrate, and magnetic beads are uniformly mixed.
And 2, after the end, the pipetting channel starts to move the waste gun head area, removes the old gun head, moves to the new gun head area to load the new gun head, moves to the reagent area and sucks 2u l magnetic bead solution.
And 3, moving the liquid transfer channel to a chip sample adding area, injecting 2u l magnetic bead solution, moving the liquid transfer channel to a waste gun head area, and removing the old gun head.
4, the temperature of the warm bath area starts to rise to 2-8 ℃, the magnetic force area starts to rise to the lower part of the purification chip, the peristaltic pump 201 starts to move forward, the magnetic beads move to the upper part of the magnetic force area under the action of the peristaltic pump 201 and are captured by a magnetic field, and the magnetic bead diluent enters the waste liquid area through a hose under the action of the peristaltic pump 201.
And 5, moving the liquid channel to a new gun head area to load a new gun head, moving the new gun head area to a sample 96-well plate to absorb 2u l samples, moving the new gun head area to a chip sample adding area, injecting 5u l sample solution, moving the liquid channel to a waste gun head area, and removing the old gun head.
And 6, repeating the steps 4-5 according to the frame selection reaction area.
7, the magnetic force area starts to descend, the peristaltic pump 201 starts to move forward, and the sample moves to the magnetic force area to re-dissolve the magnetic beads under the action of the peristaltic pump 201; peristaltic pump 201 begins to reverse motion and the sample bead complex solution moves to the warm bath area; the peristaltic pump 201 alternates forward-reverse motion, causing the sample bead complex solution to reciprocate within the purification chip for X-Z minutes.
8, the magnetic force area starts to rise to the lower part of the purification chip, the peristaltic pump 201 starts to move forward, the sample magnetic bead complex solution moves to the upper part of the magnetic force area under the action of the peristaltic pump 201, the magnetic beads are captured by the magnetic field, and the sample magnetic bead complex solution enters the waste liquid area through the hose under the action of the peristaltic pump 201.
9, the pipetting channel moves to a new gun head area to load a new gun head, moves to a reagent area, absorbs 8u l cleaning liquid, sequentially moves to a chip sample adding area, respectively injects 6u l cleaning liquid, moves to a waste gun head area and removes the old gun head.
10, the magnetic force area starts to descend, the peristaltic pump 201 starts to move forward, and the cleaning liquid moves to the magnetic force area to re-dissolve the magnetic beads under the action of the peristaltic pump 201; the peristaltic pump 201 starts to move reversely, and the cleaning liquid magnetic bead complex solution moves to the warm bath area; the peristaltic pump 201 alternates the forward-reverse motion, causing the cleaning solution bead complex solution to reciprocate within the purification chip for 10 minutes.
11, the magnetic force area starts to rise to the lower part of the purification chip, the peristaltic pump 201 starts to move forward, the cleaning liquid magnetic bead complex solution moves to the upper part of the magnetic force area under the action of the peristaltic pump 201, the magnetic beads are captured by a magnetic field, the cleaning liquid magnetic bead complex solution enters the waste liquid area through a hose under the action of the peristaltic pump 201, and the steps 4-9 to 4-11 are repeated once.
12, the pipetting channel moves to a new gun head area to load a new gun head, moves to a reagent area, absorbs 64u l eluent, sequentially moves to a chip sample adding area, respectively injects 2u l eluent, moves to a waste gun head area, and removes the old gun head.
13, the magnetic force area starts to descend, the peristaltic pump 201 starts to move forward, and the eluent moves to the magnetic force area to re-dissolve the magnetic beads under the action of the peristaltic pump 201; peristaltic pump 201 begins to move in reverse, and the eluent magnetic bead complex solution moves to the warm bath area; the peristaltic pump 201 alternates forward-reverse motion, causing the eluent bead complex solution to reciprocate within the purification chip for 10 minutes.
14, the magnetic force area starts to rise to the lower part of the purification chip, the peristaltic pump 201 starts to move reversely, the magnetic beads are captured by the magnetic bead area, and the eluting solution magnetic bead complex solution moves to the chip sample adding port. The magnetic force zone is lowered.
15, the pipetting channel moves to a new gun head area to load a new gun head, moves to a chip sample adding port, sucks 6u l eluent magnetic bead complex solution, moves to a purified sample placing area, and injects 5u l eluent magnetic bead complex solution. The pipetting channel is moved to the waste gun head area to remove the old gun head.
16, repeating the steps 4-15 according to the frame selection reaction area.
And (3) moving the 17-step pipetting channel to a new gun head area for loading new gun heads, moving to a reagent area, sucking 5u l cleaning liquid, sequentially moving to a chip sample adding area, respectively injecting 2u l cleaning liquid, moving the pipetting channel to a waste gun head area, and removing the old gun heads.
The peristaltic pump 201 starts to move forward, the cleaning liquid moves to the position above the magnetic force area under the action of the peristaltic pump 201, and the magnetic beads are dissolved again and enter the waste liquid area through the hose.
Fourth, the method comprises the following steps: selecting and replacing consumable materials:
opening the cabin door, taking out the used purification chip, repeating 2 the experimental preparation flow, or repeating 3 the experimental numbering flow.
Fifth step: end of experiment:
and taking out the used purification chip, taking out the used consumable, and cleaning the waste liquid tank.
Although embodiments of the present utility model have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the utility model, the scope of which is defined in the appended claims and their equivalents.
Claims (6)
1. A multichannel chip-type protein purification instrument, comprising an equipment frame (6), characterized in that: the utility model discloses a device frame, including equipment frame (6), multichannel parallel chip (202) is installed at the top of equipment frame (6), be equipped with pipetting portal structure (101) and full-automatic pipetting unit (102) on pipetting module (1), peristaltic pump assembly (2) are installed to the inboard bottom of equipment frame (6), be equipped with peristaltic pump (201) and heating membrane subassembly (5) on peristaltic pump assembly (2), be equipped with heating membrane (501) on heating membrane subassembly (5), multichannel parallel chip (202) is installed at the top of heating membrane (501), waste drain (203) have been seted up on peristaltic pump (201), cold-stored vibration subassembly (3) are installed to inboard bottom one end of equipment frame (6), be equipped with on cold-stored vibration refrigeration metal bath (301) of vibration, solution consumable box (302) are installed at the top of vibration refrigeration metal bath (301), strong magnetic lifting subassembly (4) are installed at the top of inboard baffle of equipment frame (6), bottom fixed block (401) are installed to the bottom of strong magnetic lifting subassembly (4), fixed block (403) are installed at the top (402) both ends of guide post (402), a jacking actuator (404) is arranged between the top center of the bottom fixed block (401) and the bottom center of the strong magnetic module (403).
2. The multi-channel chip type protein purification apparatus according to claim 1, wherein: the pipetting component (1) uses a linear motor module mechanism, a single channel is assembled on a linear motor and can move up and down, gun loading and gun releasing actions are completed, the pipetting gantry structure (101) is formed by three linear motors to form a gantry type module, the position of a sliding block can be accurately controlled by a driver, and the full-automatic pipetting unit (102) can realize movement of a Z axis.
3. The multi-channel chip type protein purification apparatus according to claim 1, wherein: the peristaltic pump assembly (2) is driven by a motor driver to realize forward and reverse rotation, and the peristaltic pump (201) and the multichannel parallel chip (202) are connected in series.
4. The multi-channel chip type protein purification apparatus according to claim 1, wherein: the cold storage oscillation component (3) integrates a cold storage and oscillation function metal bath module, solution reagents can be cooled at a low temperature of 2-8 degrees, the oscillation cold storage metal bath (301) is a standard consumable box-packed various reagents, and samples, products, samples and multiple chips are all in one-to-one correspondence.
5. The multi-channel chip type protein purification apparatus according to claim 1, wherein: the strong magnetism lifting assembly (4) is arranged in an array on the mounting block, compared with the whole square strong magnetism, the lifting actuator (404) is provided with guide posts on two sides respectively, and the lifting module is lifted to ensure parallel lifting without inclination, so that the lifting device is high in chip bonding degree.
6. The multi-channel chip type protein purification apparatus according to claim 1, wherein: the heating film component (5) is a PI electrothermal film, is attached to the bottom of the chip, has controllable temperature, and can adjust corresponding purification temperature according to different samples.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320887033.7U CN219652925U (en) | 2023-04-20 | 2023-04-20 | Multichannel chip type protein purification instrument |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320887033.7U CN219652925U (en) | 2023-04-20 | 2023-04-20 | Multichannel chip type protein purification instrument |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219652925U true CN219652925U (en) | 2023-09-08 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202320887033.7U Active CN219652925U (en) | 2023-04-20 | 2023-04-20 | Multichannel chip type protein purification instrument |
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| CN (1) | CN219652925U (en) |
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2023
- 2023-04-20 CN CN202320887033.7U patent/CN219652925U/en active Active
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