CN212622642U - Sample processing device - Google Patents
Sample processing device Download PDFInfo
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- CN212622642U CN212622642U CN202021554082.1U CN202021554082U CN212622642U CN 212622642 U CN212622642 U CN 212622642U CN 202021554082 U CN202021554082 U CN 202021554082U CN 212622642 U CN212622642 U CN 212622642U
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Abstract
The utility model discloses a sample processing device, this sample processing device include the device body, the portion is placed to sample, reagent and reaction hole have on the device body, the sample place the portion the reagent place the portion with the reaction hole is established last and arrange the setting along the first direction of device body. The utility model discloses a place portion, reagent and the reaction hole setting is on same device body with the sample to arrange along same direction, can make sample processing apparatus only remove along a direction and just can place the object transfer reaction hole in portion with sample and reagent, not only simplify the action step of automation equipment, still avoided the cross infection between the sample.
Description
Technical Field
The utility model relates to a biomedical equipment field, concretely relates to sample processing apparatus.
Background
In the current liquid processing apparatus, a sample to be processed and a reaction plate for processing a reagent of the sample are basically placed at different working positions, and when the sample is processed by an automated device, it is necessary to transfer the liquid in the reaction plate at different directions to a reaction container placed at another position for reaction. In this process, not only the automation equipment is complicated, but also the sample may be cross-contaminated, thereby causing a deviation in the detection result.
SUMMERY OF THE UTILITY MODEL
The to-be-solved technical problem of the utility model is to provide a sample processing device in order to overcome the above-mentioned defect among the prior art.
The utility model discloses an above-mentioned technical problem is solved through following technical scheme:
a sample processing device includes a device body having thereon a sample placement section, a reagent placement section, and a reaction well, the sample placement section, the reagent placement section, and the reaction well being provided on the device body and arranged in a first direction.
In this scheme, adopt above-mentioned structural style, place portion, reagent and reaction hole through placing the sample on same device body to arrange along same direction, can make the device body only move along a direction and just can shift the object in sample portion and the reagent portion of placing to the reaction hole, not only simplified the action step of automation equipment, still avoided the cross infection between the sample, increase the accuracy of testing result.
Preferably, the sample placement section is provided at a side surface of the apparatus body, the side surface being perpendicular to the first direction;
the sample placing part comprises a placing cavity, and an opening of the placing cavity is arranged upwards.
In this scheme, adopt above-mentioned structural style, establish the sample portion of placing in the side of device body, be convenient for on the one hand place the sample pipe on the sample portion of placing, on the other hand be convenient for the sweep sign indicating number device in front of the device body scans the information on the sample pipe.
Preferably, a notch is formed in the side wall of the placing cavity, the notch is communicated with the placing cavity, and the notch faces to the first direction.
In this scheme, adopt above-mentioned structural style, the yard device of sweeping of the device body front side of being convenient for scans the information on the sample pipe.
Preferably, the reagent holding part and the reaction well are provided on an upper surface of the device body.
In this scheme, adopt above-mentioned structural style, be convenient for take out the reagent in the reagent placing part, be convenient for simultaneously to add reagent or sample in the reaction hole to and take out the liquid in the reaction hole.
Preferably, the sample processing device further comprises a magnetic attraction component, and the magnetic attraction component is arranged below the reaction hole in a lifting manner;
the magnetic attraction component is used for attracting magnetic beads in the reaction holes to the bottoms of the reaction holes after the reaction of the liquid in the reaction holes is finished.
Preferably, the magnetic attraction component comprises a permanent magnet and a lifting component, the permanent magnet is mounted on the lifting component, and the lifting component is used for driving the permanent magnet to lift so that the permanent magnet approaches to or is far away from the reaction hole.
In this scheme, adopt above-mentioned structural style, the reaction hole is kept away from to the sample in the reaction hole through lifting unit messenger permanent magnet when reacting, avoids producing the influence to the magnetic bead in the reaction hole, and the sample reaction in the reaction hole is accomplished the back, makes the permanent magnet be close to the reaction hole through lifting unit in order to adsorb the magnetic bead, conveniently takes out the reaction liquid in the reaction hole.
Preferably, the sample processing device further comprises a temperature control member for controlling the temperature of the liquid in the reaction hole.
In this scheme, adopt above-mentioned structural style, make the liquid in the reaction hole be in suitable reaction temperature through the temperature control spare, increase reaction efficiency, and be favorable to improving the quantity of reaction product.
Preferably, the sample processing device further comprises an amplification part having a plurality of amplification grooves arranged along the first direction, the openings of the amplification grooves being provided on the upper surface of the device body, and the amplification grooves being used for placing reaction products obtained in the reaction wells.
In this scheme, adopt above-mentioned structural style, set up the amplification portion in the first direction of device body, be convenient for shift the required reaction product to the amplification portion and amplify after reaction of reaction well liquid for the device body only moves along a direction all the time, has further simplified automation equipment's action.
Preferably, the sample processing device further comprises a tip placement groove, an opening of which is provided on an upper surface of the device body and is aligned with the reaction well in the first direction.
In the scheme, the structure is adopted, so that the device body can be changed into different liquid suction heads only by moving along one direction.
Preferably, the sample processing apparatus further includes a waste liquid tank disposed on the upper surface of the apparatus body and arranged with the reaction holes along the first direction, the waste liquid tank being configured to store a reaction waste liquid generated in the reaction holes.
In this scheme, adopt above-mentioned structural style for the device body only needs to move along one direction just can transfer the waste liquid in the reaction hole to the waste liquid inslot, has simplified automation equipment's structure and action.
Preferably, the sample processing device comprises a slide guiding assembly, the slide guiding assembly is arranged on the lower bottom surface of the device body, and the slide guiding assembly is used for being matched with an external guide rail to slide.
In this scheme, adopt above-mentioned structural style, be convenient for outside actuating mechanism control sample processing apparatus to follow fixed orbit and remove.
Preferably, the reaction hole comprises an upper accommodating cavity and a lower accommodating cavity, the lower accommodating cavity is of an inward tightening structure from top to bottom, and the upper accommodating cavity and the lower accommodating cavity are in arc-shaped surface transition.
In this scheme, adopt above-mentioned structural style, can avoid liquid spill when adding liquid or magnetic bead to the reaction hole.
On the basis of the common knowledge in the field, the above preferred conditions can be combined at will to obtain the preferred embodiments of the present invention.
The utility model discloses an actively advance the effect and lie in: the utility model discloses a sample processing apparatus places portion and reaction hole setting on same device body through placing the sample, reagent to arrange along same direction, can make sample processing apparatus only remove along a direction and just can place the object in portion and the reagent portion of placing with the sample and transfer to the reaction hole, not only simplified the action step of automation equipment, still avoided the cross infection between the sample.
Drawings
Fig. 1 is a schematic structural diagram of a sample processing device according to a preferred embodiment of the present invention.
Fig. 2 is a front view of a sample processing device according to a preferred embodiment of the present invention.
Fig. 3 is a top view of a sample processing device according to a preferred embodiment of the present invention.
Fig. 4 is a schematic cross-sectional view taken at a-a in fig. 3.
Fig. 5 is a schematic cross-sectional view at B-B in fig. 3.
Fig. 6 is a schematic structural view of a reaction part assembly according to a preferred embodiment of the present invention.
Fig. 7 is a schematic structural view of a reaction part assembly according to a preferred embodiment of the present invention.
Fig. 8 is a schematic bottom view of a sample processing device according to a preferred embodiment of the present invention.
Description of reference numerals:
Hand-held part 1201
Upper receiving cavity 1212A
Lower receiving cavity 1212B
Suction head placing groove 1213
Waste liquid tank 1223
Driving motor 1401
Detailed Description
The present invention is further illustrated by way of the following examples, but is not intended to be limited thereby within the scope of the following examples.
As shown in fig. 1 to 5, the sample processing device 100 of the present embodiment includes a device body, the device body includes a mounting frame 110 and a reaction assembly 120, an upper surface of the mounting frame 110 has a mounting groove (not shown), the reaction assembly 120 is disposed in the mounting groove, a bottom of the reaction assembly 120 has a circle of protrusions extending around, and the reaction assembly 120 is clamped in the mounting groove of the mounting frame 110 by the protrusions.
Of course, in other embodiments, the mounting bracket 110 and the reaction assembly 120 of the apparatus body may be of unitary construction.
As shown in fig. 1 to 5, in the present embodiment, a resilient catch 1101 is provided on the mounting bracket 110 at one side of the mounting groove, the resilient catch 1101 abuts against a side surface of the reaction portion assembly 120 when the reaction portion assembly 120 is placed in the mounting groove to prevent the reaction portion assembly 120 from loosening when the sample processing device 100 moves, and the resilient catch 1101 is preferably provided at the side surface of the reaction portion assembly 120 in the moving direction of the sample processing device 100. Accordingly, a hand-held portion 1201 is provided on the side of the reaction component 120 opposite to the elastic snaps 1101, and the hand-held portion 1201 facilitates mounting the reaction component 120 on the mounting groove or removing the reaction component 120 from the mounting groove. Specifically, during installation, an operator puts the other end of the reaction component 120 into the installation groove by holding the handheld portion 1201, presses the elastic clamping piece 1101 through the reaction component 120, releases the handheld portion 1201 after the reaction component 120 is completely installed on the installation groove, and the elastic clamping piece 1101 presses the reaction component 120 under the action of own elasticity; when the reaction component 120 is taken down, an operator firstly holds the handheld part 1201 to push the reaction component 120 to one side of the elastic clamping piece 1101, and then lifts one end of the handheld part 1201, so that the reaction component 120 can be taken down.
The device body has a sample placement section 130, a reagent placement section, and a reaction well 1212, and the sample placement section 130, the reagent placement section, and the reaction well 1212 are provided on the device body and arranged in a first direction. By arranging the sample placing section 130, the reagent placing section, and the reaction well 1212 on the same apparatus body and in the same direction, it is possible to transfer the objects in the sample placing section 130 and the reagent placing section to the reaction well 1212 by moving the sample processing apparatus 100 only in one direction, which not only simplifies the operation steps of the automated equipment, but also avoids cross-contamination between samples.
Specifically, as shown in FIGS. 1 to 7, in the present embodiment, a reagent placement portion and a reaction well 1212 are provided on the reaction portion 121 of the reaction assembly 120, the reagent placement portion has a plurality of reagent placement grooves 1211, the reagent placement grooves 1211 are used for storing reagents and magnetic beads for reaction, and openings of the reagent placement grooves 1211 and the reaction well 1212 are located on the upper surface of the reaction assembly 120, so as to facilitate taking out the reagents and magnetic beads in the reagent placement grooves 1211, and simultaneously facilitate adding the reagents, magnetic beads or samples to the reaction well 1212, and taking out the liquid in the reaction well 1212.
As shown in fig. 4-5, the upper receiving cavity 1212A of the reaction hole 1212 is a cylindrical structure, the lower receiving cavity 1212B of the reaction hole 1212 is an inwardly tightened structure from top to bottom, and the upper receiving cavity 1212A and the lower receiving cavity 1212B are in arc-shaped surface transition.
The sample placement section 130 is provided on the mount 110, the sample placement section 130 is provided on a side surface of the mount 110, the side surface being perpendicular to the first direction, the sample placement section 130 includes a placement chamber 131, and an opening of the placement chamber 131 is provided upward. Place the lateral wall of chamber 131 and seted up breach 132, breach 132 with place chamber 131 intercommunication, breach 132 orientation first direction. The sample placing section 130 is disposed at the side of the mounting frame 110, which facilitates the placement of the sample tube on the sample placing section 130, and facilitates the scanning of the information on the sample tube by the code scanning device at the front side of the sample processing device.
In other embodiments, the sample placement portion 130 may be disposed on the reaction component 120, but the notch 132 on the sidewall of the placement chamber 131 faces the first direction, so that the information on the sample tube in the placement chamber 131 can be scanned by the code scanning device.
Of course, in other embodiments, the sample placing portion 130 may be made of a transparent material, so that the notch 132 does not need to be formed on the sidewall of the placing cavity 131.
In this embodiment, the sample processing apparatus 100 further includes a magnetic assembly 140, wherein the magnetic assembly 140 is disposed below the reaction hole 1212 in a lifting manner; the magnetic assembly 140 is used to attract the magnetic beads in the reaction well 1212 to the bottom of the reaction well 1212 after the reaction of the liquid in the reaction well 1212 is finished.
The magnetic attraction assembly 140 includes a permanent magnet 1404 and a lifting assembly, wherein the permanent magnet 1404 is mounted on the lifting assembly, and the lifting assembly is used for driving the permanent magnet 1404 to lift so as to enable the permanent magnet 1404 to approach or move away from the reaction hole 1212. When a sample in the reaction hole 1212 reacts, the permanent magnet 1404 is far away from the reaction hole 1212 through the lifting assembly, thereby avoiding affecting magnetic beads in the reaction hole 1212, and after the reaction of the sample in the reaction hole 1212 is completed, the permanent magnet 1404 is close to the reaction hole 1212 through the lifting assembly so as to adsorb the magnetic beads, thereby facilitating the taking out of a reaction solution in the reaction hole 1212.
Specifically, as shown in fig. 1-5, the magnetically attractive assembly 140 includes a drive motor 1401, a gear 1402, a rack 1403, a permanent magnet 1404, a guide post 1405, and a guide block 1406. A gear 1402 is fixed on an output shaft of the driving motor 1401, a guide slider 1406 is slidably arranged on the guide post 1405, a rack 1403 is fixed on one side of the guide slider 1406, a permanent magnet 1404 is fixed on the upper end of the guide slider 1406, the rack 1403 is meshed with the gear 1402, and the guide slider 1406 can move up and down on the guide post 1405 along with the forward and reverse rotation of the driving motor 1401, so that the permanent magnet 1404 is driven to move up and down to be close to the reaction hole 1212 or far away from the reaction hole 1212.
Of course, in other embodiments, the up and down movement of the permanent magnet 1404 can be achieved by other mechanical mechanisms, such as by pneumatic or hydraulic telescoping rods, and other types of structures will not be described in detail herein.
In this embodiment, the sample processing device 100 further comprises a temperature control member 150, and the temperature control member 150 is used for controlling the temperature of the liquid in the reaction hole 1212. The temperature control member 150 may be disposed inside the reaction well 1212, may be disposed outside the reaction well 1212, or may be integrated around the inner wall of the reaction well 1212. The liquid in the reaction hole 1212 is brought to a suitable reaction temperature by the temperature control member 150, increasing the reaction efficiency and facilitating the increase of the amount of the desired reaction product.
As shown in FIGS. 1 to 7, the amplification part 122 of the reaction assembly 120 has a plurality of amplification placing holes 1221 arranged in a first direction, an amplification chamber assembly 1222 is placed on the amplification placing holes 1221, the amplification chamber assembly 1222 includes a plurality of amplification chambers, openings of the amplification chambers are formed in an upper surface of the reaction assembly 120, sealing films having information barcodes are sealed in the openings of the amplification chambers, and the amplification chambers are used for placing reaction products obtained in the reaction holes 1212, so as to amplify the obtained reaction products. As shown in FIG. 7, the reaction portion assembly 120 of the present embodiment is formed by connecting two parts of the reaction portion 121 and the amplification portion 122 by a snap-fit connection, so that the amplification portion 122 can be taken down separately and sent to the amplification device for amplification treatment.
The amplification unit 122 is also provided along the first direction of the sample processing apparatus 100, so that a desired reaction product can be transferred to the amplification chamber for amplification after the reaction of the liquid in the reaction well 1212 is completed, and the sample processing apparatus 100 can be moved only in one direction at all times, thereby further simplifying the operation of the automated equipment.
As shown in fig. 1, 3, 4, 6, and 7, the sample processing device 100 further includes a tip placement groove 1213, and an opening of the tip placement groove 1213 is provided on an upper surface of the reaction portion 121 and aligned with the reaction hole 1212 in the first direction. The provision of the tip placement groove 1213 facilitates the replacement of tips during movement of the sample processing device 100 and allows the sample processing device 100 to be moved in only one direction for the replacement of different liquid tips.
As shown in FIGS. 3 and 4, and FIGS. 6 and 7, the sample processing apparatus 100 further includes a waste liquid tank 1223, the waste liquid tank 1223 is provided on the amplification part 122, an opening of the waste liquid tank 1223 is located on the upper surface of the amplification part 122 and is aligned with the reaction well 1212 in the first direction, and the waste liquid tank 1223 is used for holding a reaction waste liquid generated in the reaction well 1212. This allows the sample processing apparatus 100 to move in only one direction to transfer the waste liquid in the reaction well to the waste liquid tank, simplifying the structure and operation of the automated apparatus.
Of course, in other embodiments, the waste liquid tank 1223 may be disposed on the reaction part 121 of the reaction assembly 120 or on the mounting frame 110.
As shown in fig. 8, the sample processing device 100 includes a sliding guide assembly 1103, the sliding guide assembly 1103 is disposed on two sides of the lower bottom surface of the mounting frame 110, and the sliding guide assembly 1103 is configured to slide in cooperation with an external guide rail. The sample processing device is conveniently controlled by an external driving mechanism to move along a fixed track. The middle position of the lower bottom surface of the mounting frame 110 is further provided with a clamping portion 1102, and the clamping portion 1102 is used for clamping with an external driving device driving belt or driving chain so as to move along with the movement of the driving belt or driving chain.
Although specific embodiments of the present invention have been described above, it will be understood by those skilled in the art that this is by way of example only and that the scope of the invention is defined by the appended claims. Various changes and modifications to these embodiments may be made by those skilled in the art without departing from the spirit and the principles of the present invention, and these changes and modifications are all within the scope of the present invention.
Claims (12)
1. A sample processing device comprising a device body having a sample placement section, a reagent placement section, and a reaction well, wherein the sample placement section, the reagent placement section, and the reaction well are provided on the device body and arranged in a first direction.
2. The sample processing device according to claim 1, wherein the sample placement section is provided to a side surface of the device body, the side surface being perpendicular to the first direction;
the sample placing part comprises a placing cavity, and an opening of the placing cavity is arranged upwards.
3. The sample processing device of claim 2, wherein a sidewall of the placement chamber defines a notch, the notch communicating with the placement chamber, the notch facing in the first direction.
4. The sample processing device according to claim 1, wherein the reagent placement section and the reaction well are provided on an upper surface of the device body.
5. The sample processing device of claim 4, further comprising a magnetic assembly, wherein the magnetic assembly is arranged below the reaction well in a lifting manner;
the magnetic attraction component is used for attracting magnetic beads in the reaction holes to the bottoms of the reaction holes after the reaction of the liquid in the reaction holes is finished.
6. The sample processing device of claim 5, wherein the magnetically attractive assembly comprises a permanent magnet and a lifting assembly, the permanent magnet is mounted on the lifting assembly, and the lifting assembly is configured to move the permanent magnet up and down to move the permanent magnet toward or away from the reaction well.
7. The sample processing device of claim 4, further comprising a temperature control member for temperature controlling the liquid within the reaction well.
8. The sample processing device according to claim 1, further comprising an amplification section having a plurality of amplification grooves provided in the first direction, the openings of the amplification grooves being provided on an upper surface of the device body, the amplification grooves being used for placing reaction products obtained in the reaction wells.
9. The sample processing device according to claim 1, further comprising a tip placement groove having an opening provided on an upper surface of the device body and aligned with the reaction well in the first direction.
10. The specimen-processing apparatus according to claim 1, further comprising a waste liquid tank provided on an upper surface of the apparatus body and arranged with the reaction well in the first direction, the waste liquid tank being for holding a reaction waste liquid generated in the reaction well.
11. The sample processing device of claim 1, wherein the sample processing device comprises a slide guide assembly disposed on a bottom surface of the device body, the slide guide assembly configured to slide in cooperation with an external guide rail.
12. The sample processing device of claim 1, wherein the reaction well comprises an upper receiving chamber and a lower receiving chamber, the lower receiving chamber is in an inwardly-tightened structure from top to bottom, and the upper receiving chamber and the lower receiving chamber are in arc-shaped surface transition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021554082.1U CN212622642U (en) | 2020-07-30 | 2020-07-30 | Sample processing device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021554082.1U CN212622642U (en) | 2020-07-30 | 2020-07-30 | Sample processing device |
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| CN212622642U true CN212622642U (en) | 2021-02-26 |
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| CN202021554082.1U Active CN212622642U (en) | 2020-07-30 | 2020-07-30 | Sample processing device |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113652350A (en) * | 2021-08-30 | 2021-11-16 | 成都微康生物科技有限公司 | Full-automatic PCR analysis system for molecular diagnosis by using microfluidic chip |
| CN113699026A (en) * | 2021-08-30 | 2021-11-26 | 成都微康生物科技有限公司 | Full-automatic PCR analytic system kit installation and controlling means |
| CN114062693A (en) * | 2020-07-30 | 2022-02-18 | 苏州创澜生物科技有限公司 | Sample processing device |
-
2020
- 2020-07-30 CN CN202021554082.1U patent/CN212622642U/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114062693A (en) * | 2020-07-30 | 2022-02-18 | 苏州创澜生物科技有限公司 | Sample processing device |
| CN113652350A (en) * | 2021-08-30 | 2021-11-16 | 成都微康生物科技有限公司 | Full-automatic PCR analysis system for molecular diagnosis by using microfluidic chip |
| CN113699026A (en) * | 2021-08-30 | 2021-11-26 | 成都微康生物科技有限公司 | Full-automatic PCR analytic system kit installation and controlling means |
| CN113699026B (en) * | 2021-08-30 | 2023-11-14 | 成都微康生物科技有限公司 | Full-automatic PCR analysis system kit installation and control device |
| CN113652350B (en) * | 2021-08-30 | 2024-04-26 | 成都微康生物科技有限公司 | Full-automatic PCR analysis system for molecular diagnosis by using microfluidic chip |
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