CN219326781U - Intelligent incubator for endometrial assembly - Google Patents

Abstract

The utility model discloses an intelligent incubator for an endometrial assembly, which comprises a base and an incubator, wherein the base is connected with the incubator through a rotating assembly, the incubator is divided into an incubator through a partition plate, a culture dish placing assembly is arranged in the incubator, an adjusting assembly is arranged in the incubator, and a transparent sealing cover is arranged at the open end of the incubator through a sealing mechanism. According to the utility model, the plurality of culture chambers are arranged on the same base, so that different cells can be cultivated simultaneously, the cultivation efficiency is improved, meanwhile, observation and recording of the cell cultivation progress of the different culture chambers can be conveniently carried out, the whole culture chamber can be conveniently rotated by the rotating assembly, the observation and recording are convenient, and the transparent sealing cover and the sealing mechanism can ensure the safety of the cultivation process and the cultivation effect while the normal observation and recording are not influenced.

Description

Intelligent incubator for endometrial assembly

Technical Field

The utility model relates to the technical field of endometrium assembly culture, in particular to an intelligent incubator for endometrium assemblies.

Background

The class assembly refers to a novel micro-organ with a spatial tissue structure produced with a variety of cell types. The micro-organ with space tissue structure produced by culturing multiple cell types is called a quasi-assembly body after the quasi-organ, and the novel micro-organ can surpass the quasi-organ, is closer to real human tissue in structure and function, and can help researchers to understand the function of the tissue and the mechanism of disease occurrence more deeply. In the field of obstetrics and gynecology, the endometrial assembly is used for bringing stroma cells, immune cells, blood vessels and the like into the existing endometrial organoids, so that a more complete endometrial model can be constructed, and the endometrial model can be combined with a blastoid, so that implantation of the blastoid can be better simulated; in addition, the in-vitro model of diseases such as endometrial cancer and the like can be used for simulating in-vivo structures more accurately, and the in-vitro model can be widely focused as a preclinical disease research model, so that the in-vitro model becomes a hot spot of medical research. However, when the organoid is prepared, different cells or organoids need to be cultured, and the culture conditions of the different types of cells and organoids are slightly different, so that one cell is cultured at a time during the culture, the efficiency is low, or the cells are simultaneously cultured in a plurality of groups of culture chambers respectively, and the observation and the record of a plurality of cells are inconvenient.

Disclosure of Invention

The utility model aims to provide an intelligent incubator for an endometrial assembly, which solves the problems in the background technology.

In order to achieve the above purpose, the present utility model provides the following technical solutions: the utility model provides an endometrial class assembly intelligent cultivation ware, includes base and breeding device, is connected through rotating the subassembly between base and the breeding device, and breeding device is inside to separate into the culture chamber through the baffle, and the culture chamber is inside to be equipped with the culture dish and places the subassembly to be equipped with adjusting part in the culture chamber, the open end of culture chamber is equipped with transparent sealed cowling through sealing mechanism.

Preferably, in order to conveniently bring the culture apparatus to rotate, be convenient for observe the record to the culture chamber, rotate the subassembly and rotate the seat including setting up at the rotation of base top middle part, rotate the seat on and rotate and be equipped with the bull stick, bull stick and culture apparatus fixed connection.

Preferably, in order to guarantee the stability when cultivateing, avoid taking place to rock or slide, avoid taking place to empty the condition, the culture dish is placed the subassembly and is placed the backup pad of subassembly including setting up at the inside backup pad of culture chamber, is fixed to be equipped with in the backup pad and places the seat, is equipped with on the seat inner wall with culture dish assorted slipmat.

Preferably, in order to ensure the tightness in the culture process, bacteria and the like in the outside are prevented from entering the culture chamber, the sealing mechanism comprises a sealing clamping groove formed in the side wall of the opening end of the culture chamber, and a sealing clamping block is arranged in the sealing clamping groove in a sliding manner and is matched with the transparent sealing cover.

Preferably, in order to temporarily position the opened transparent sealing cover when placing or taking out the culture dish, the operation is convenient, the top inside the sealing clamping groove is provided with a fixed magnet, and the bottom end of the sealing clamping block is provided with a fixed magnet with the opposite magnetism to the fixed magnet.

Preferably, in order to adjust the oxygen content and the like according to different cultured cells, the adjusting component comprises an air outlet arranged at the top end inside the culture chamber, a connecting pipe is arranged at the top end of the air outlet, the connecting pipe penetrates out of the culture device and extends to the top end to be provided with an air inlet pipe, and an electric control valve is arranged on the connecting pipe.

Preferably, in order to be able to adjust the temperature etc. according to different cells of cultivation, guarantee to cultivate with the best regulation, the regulation subassembly symmetry sets up the heating rod on the inside top of cultivateing the room, and the both ends of heating rod are through installation piece and breeding device fixed connection, are equipped with the sensor group in the backup pad, heating rod, automatically controlled valve all with sensor group electric connection.

Compared with the prior art, the utility model has the beneficial effects that:

through setting up a plurality of culture chambers on same base, not only can realize cultivating different cells simultaneously, improve the efficiency of cultivateing, can conveniently observe the record to the cell culture progress of different culture chambers simultaneously to the rotating assembly that is equipped with can conveniently rotate whole, is convenient for observe the record, and transparent sealed cowling and sealing mechanism can not influence normal observation record simultaneously, still can guarantee the safety of cultivateing the process, guarantee the effect of cultivateing;

the temperature, oxygen content and the like in the culture chambers can be independently regulated according to the cells cultured in each culture chamber through the regulating assembly, so that the culture can be carried out under optimal culture conditions, the efficiency of cell culture is ensured, the mutual noninterference is avoided, the culture efficiency is ensured, the subsequent different cells and biological materials are conveniently combined to form a similar assembly body, and the subsequent research and use are convenient.

Drawings

FIG. 1 is a schematic diagram of an intelligent incubator for endometrial assemblies according to the present utility model;

FIG. 2 is a schematic view of a part of the structure of an intelligent incubator for endometrial assembly according to the present utility model;

FIG. 3 is a schematic diagram showing the overall structure of an intelligent incubator for endometrial assembly according to the present utility model;

fig. 4 is a schematic structural view of a sealing mechanism in an intelligent incubator for endometrial assemblies according to the present utility model;

fig. 5 is a schematic view of a part of the structure of a sealing mechanism in an intelligent incubator for endometrial assemblies according to the present utility model.

In the figure: 1. a base; 2. a rotating seat; 3. a cultivation device; 4. a rotating rod; 5. a partition plate; 6. a culture chamber; 7. a transparent sealing cover; 8. a sensor group; 9. a placement seat; 10. an anti-slip pad; 11. an air inlet pipe; 12. an air outlet; 13. a mounting block; 14. a heating rod; 15. a support plate; 16. a connecting pipe; 17. an electric control valve; 18. sealing the clamping groove; 19. fixing the magnetic attraction I; 20. sealing the clamping block; 21. and fixing the second magnetic attraction.

Detailed Description

The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.

Referring to fig. 1-5, an embodiment of the present utility model is provided: an intelligent incubator for an endometrial assembly is used for supporting the incubator and guaranteeing stable base 1, wherein four universal wheels can be arranged at the bottom end of the base 1 vertically through bolts, the incubator is convenient to move integrally, the incubator is convenient to use, rotation adjustment is carried out on the incubator by the aid of a baffle 5 for conveniently observing different conditions of the incubator 6, a rotation assembly is arranged on the base 1, the rotation assembly comprises a rotation seat 2 (the principle and a bearing of the rotation seat 2) welded at the middle of the top end of the base 1, a rotating rod 4 is rotatably arranged on the rotation seat 2, the rotating rod 4 is fixedly welded with the middle of the incubator 3, different culture conditions are needed when different cell types of the assembly are cultured through research of a culture assembly, the incubator 3 is divided into four incubators 6 (three, five and the like according to use requirements), the incubator is convenient to culture different types of cells, the incubator is convenient to be combined with biological materials to form the assembly (a technology which is not mature), and further the incubator is convenient to research on the tumor or gynecological medicine of a gynecological embryo.

Referring to fig. 1-5, for convenience in placing the culture dish, ensuring stability in the culture chambers 6, a culture dish placement component is provided in the culture chambers 6, wherein the culture chambers comprise a support plate 15 welded in the culture chambers 6, a circular placement seat 9 is welded at the top end of the support plate 15, an anti-slip pad 10 for increasing contact friction with the culture dish is adhered on the inner wall of the placement seat 9, further, internal stability can be ensured, sliding or shaking and the like during rotation are avoided, safety of culture is ensured, tilting is avoided, and in order to regulate temperature and oxygen for culturing different cells, each culture chamber 6 is internally provided with an adjusting component, the adjusting component comprises an air outlet 12 arranged at the top end of the culture chamber 6, the top end of the air outlet 12 penetrates out of the top end of the culture device 3 through a connecting pipe 16, the shape of the connecting pipe 16 is L-shaped, the horizontal section is connected with an air inlet pipe 11 (wherein the air inlet pipe 11 is connected with oxygen, carbon dioxide, nitrogen and the like, a plurality of groups can be arranged, the air inlet pipe can be adjusted according to the content of the internal oxygen, the culture of different cells is adapted), an electric control valve 17 is arranged on a connecting pipe 16, heating rods 14 (also can be heating wires and the like, and are convenient for adjusting the internal temperature) are symmetrically arranged at the top end of a culture chamber 6, the heating rods 14 are welded and fixed with a culture device 3 through a mounting block 13, in order to ensure that the temperature, the oxygen content and the like of the culture chamber 6 are detected and then adjusted, a sensor group 8 (can be a temperature sensor, an oxygen concentration sensor and the like) is arranged on a supporting plate 15, a temperature and humidity sensor, a corresponding temperature and humidity adjusting device and the like can also be arranged, and the adjustment of each cell culture is preset through the control of a programmable PLC (programmable logic controller), is convenient to adjust during culture (a more mature technology is not described in detail herein), and the culture chamber 6 is also provided with a release valve which is convenient for exhausting, so that the internal pressure is prevented from being too high during the culture process.

Referring to fig. 1-5, in order to ensure tightness in the cultivation process and cultivation effect, it is convenient to observe the internal condition of each cultivation room 6, the open end of the cultivation room 6 is provided with a transparent sealing cover 7 (made of glass or other transparent materials) through a sealing mechanism, the cultivation room 6 can be closed and sealed in the cultivation process, bacteria in the air and the like are prevented from entering the interior, meanwhile, the internal condition can be observed conveniently, a sealing clamping groove 18 with a T-shaped section is formed in the open end of the cultivation room 6, sealing clamping blocks 20 which are convenient to move in the sealing clamping groove 18 are welded on the side walls of the two ends of the transparent sealing cover 7, sealing strips can be adhered in the sealing clamping groove 18, and in order to temporarily position the transparent sealing cover 7 when the transparent sealing cover 7 is opened upwards, dropping is avoided, a fixed magnet 19 is adhered to the inner top end of the sealing clamping groove 18, a fixed magnet 21 (opposite to the fixed magnet 19) is adhered to the side wall of the bottom end of the sealing clamping block 20, and the two fixed magnets are contacted and attracted when opened, so that the two fixed magnets are not influenced to take out the culture dish in the cultivation room 6 or place.

It will be evident to those skilled in the art that the utility model is not limited to the details of the foregoing illustrative embodiments, and that the present utility model may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are, therefore, to be considered in all respects as illustrative and not restrictive, the scope of the utility model being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.

Claims (7)

1. An intelligent incubator for endometrial assemblies, which comprises a base (1) and an incubator (3), and is characterized in that: the culture device is characterized in that the base (1) is connected with the culture device (3) through a rotating component, the culture device (3) is internally divided into a culture chamber (6) through a partition board (5), a culture dish placement component is arranged in the culture chamber (6), an adjusting component is arranged in the culture chamber (6), and a transparent sealing cover (7) is arranged at the open end of the culture chamber (6) through a sealing mechanism.

2. An intelligent incubator for endometrial assemblies as defined in claim 1, wherein: the rotating assembly comprises a rotating seat (2) arranged in the middle of the top end of the base (1), a rotating rod (4) is rotatably arranged on the rotating seat (2), and the rotating rod (4) is fixedly connected with the cultivating device (3).

3. An intelligent incubator for endometrial assemblies as defined in claim 2, wherein: the culture dish placement component comprises a support plate (15) arranged inside the culture room (6), a placement seat (9) is fixedly arranged on the support plate (15), and an anti-slip pad (10) matched with the culture dish is arranged on the inner wall of the placement seat (9).

4. An intelligent incubator for endometrial assemblies as defined in claim 3, wherein: the sealing mechanism comprises a sealing clamping groove (18) formed in the side wall of the opening end of the culture chamber (6), a sealing clamping block (20) is arranged in the sealing clamping groove (18) in a sliding mode, and the sealing clamping block (20) is matched with the transparent sealing cover (7).

5. An intelligent incubator for endometrial assemblies as defined in claim 4, wherein: the sealing clamping groove (18) is characterized in that a first fixed magnetic attraction device (19) is arranged at the top end inside the sealing clamping groove, and a second fixed magnetic attraction device (21) with the magnetism opposite to that of the first fixed magnetic attraction device (19) is arranged at the bottom end of the sealing clamping block (20).

6. An intelligent incubator for endometrial assemblies as defined in claim 5, wherein: the adjusting component comprises an air outlet (12) arranged at the top end inside the culture chamber (6), a connecting pipe (16) is arranged at the top end of the air outlet (12), the connecting pipe (16) penetrates out of the culture device (3) and extends to the top end to be provided with an air inlet pipe (11), and an electric control valve (17) is arranged on the connecting pipe (16).

7. An intelligent incubator for endometrial assemblies as defined in claim 6, wherein: the utility model discloses a cultivation device, including cultivation room (6), adjusting part, heating rod (14) on the inside top of cultivation room (6), heating rod (14) both ends through installation piece (13) with breeding device (3) fixed connection, be equipped with sensor group (8) on backup pad (15), heating rod (14) automatically controlled valve (17) all with sensor group (8) electric connection.

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