CN217628384U - Automatic sterility testing incubator - Google Patents
Automatic sterility testing incubator Download PDFInfo
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- CN217628384U CN217628384U CN202221074179.1U CN202221074179U CN217628384U CN 217628384 U CN217628384 U CN 217628384U CN 202221074179 U CN202221074179 U CN 202221074179U CN 217628384 U CN217628384 U CN 217628384U
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Abstract
The utility model discloses an automatic sterility test incubator, including the frame, be equipped with in the frame and train the detection cavity, train the detection cavity and include cavity frame, triaxial moving platform, aseptic detection mechanism and rack, be equipped with electronic clamping jaw on the triaxial moving platform, electronic clamping jaw sets up in the rack top, and aseptic detection mechanism is including location base, vision camera, laser emitter and laser receiver, and the vision camera setting is in the oblique below of location base, and laser emitter and laser receiver set up in location base top. The utility model provides an automatic aseptic examination incubator equipment through detecting aseptic examination sample real-time status, carries out automatic interpretation based on objective data, reduces the misjudgement risk, reduces operating personnel professional requirement, realizes that computer data easily traces back, can also shorten latency simultaneously, improves inspection efficiency.
Description
Technical Field
The utility model belongs to the technical field of aseptic inspection technique and specifically relates to an automatic aseptic inspection incubator is related to.
Background
In the prior art, the sterility test of drugs generally comprises placing a sterility test culture bottle sample in a traditional constant temperature incubator, and regularly observing whether microorganisms grow in the sterility test culture bottle by manual work. However, the result of visual observation has the problems of strong subjectivity, difficult judgment, complex quality control, higher professional requirement of operators, difficult data tracing and the like. And the growth of the microorganisms in the culture process is not obvious, so that the time for waiting the growth of the microorganisms until the microorganisms are visible to naked eyes is too long, and the inspection efficiency is low. Therefore, the application designs an automatic aseptic examination incubator equipment, through the real-time status that detects the aseptic examination sample, carries out automatic interpretation based on objective data, reduces the misjudgment risk, reduces operating personnel professional requirement, realizes that computer data easily traces back, can also shorten latency simultaneously, improves inspection efficiency.
Chinese patent application publication No. CN109628273A, the publication date is 2019, 16.04.15, entitled "an intelligent sterility test device and control system thereof", discloses an intelligent sterility test device and control system thereof, including organism, bottle support, incubator fluid-discharge tank, peristaltic pump, inside motor, speed regulator, first switching power supply, second switching power supply, the controller of being equipped with of organism, the touch-control display screen has been inlayed on the casing of organism, the peristaltic pump sets up the up end at the organism, the output shaft of motor runs through the up end of organism and the transmission is connected the peristaltic pump, be equipped with foot switch on the interconnecting link of motor and external power supply, speed regulator control connection the motor, the touch-control display screen with the controller connect, controller control connection the speed regulator, the controller is the outside label printer of control connection still. However, this sterility test device still employs manual determination, and the above-described problem still remains.
Disclosure of Invention
The utility model discloses an it is not obvious to overcome among the prior art sterile inspection's the culture process in microorganism growth phenomenon, lead to needing to wait for microorganism growth to macroscopic time overlength, the not enough of check efficiency low, an automatic aseptic inspection incubator equipment is provided, through detecting aseptic inspection sample real-time status, carry out automatic interpretation based on objective data, reduce the misjudgement risk, reduce operating personnel professional requirement, realize that computer data easily traces back, can also shorten latency simultaneously, improve the efficiency of software inspection.
In order to achieve the above purpose, the utility model adopts the following technical scheme:
the utility model provides an automatic sterility test incubator, which comprises a frame, be equipped with in the frame and train the detection cavity, it includes the cavity frame to train the detection cavity, triaxial moving platform, aseptic detection mechanism and rack, triaxial moving platform is fixed with the cavity frame, the last electronic clamping jaw that is equipped with of triaxial moving platform, electronic clamping jaw sets up in the rack top, aseptic detection mechanism fixes on the cavity frame, aseptic detection mechanism is including fixing a position the base, the vision camera, laser emitter and laser receiver, the vision camera sets up in the oblique below of base of fixing a position, laser emitter and laser receiver set up in the base of fixing a position top, and laser emitter and laser receiver set up the both sides at the base of fixing a position relatively.
Among the above-mentioned technical scheme, place the tray on cultivateing the rack in the detection chamber, arrange a plurality of blake bottle in proper order in the tray. When needing to examine, remove the blake bottle position that needs detected with electronic clamping jaw through triaxial moving platform, electronic clamping jaw is carried behind the blake bottle and is removed the blake bottle to aseptic detection mechanism through triaxial moving platform on, be equipped with the standing groove that is used for placing the blake bottle on the location base, the blake bottle is placed the back of targetting in place, carry out visual detection through the vision camera, carry out carbon dioxide through laser emitter and laser receiver simultaneously and detect, as long as a sensor in two kinds of sensors detects out the microorganism, it has microorganism to exist in this blake bottle to record promptly, and the blake bottle is putThe length, note the information of this blake bottle, then report to the police and remind the staff, then put the blake bottle back the normal position through triaxial moving platform and electronic clamping jaw to it detects to get another blake bottle. Two detection methods in the application can accelerate the principle of detection and discrimination: the bottom of the culture bottle contains a sensor, and the microorganism grows to produce CO 2 Dissolving in culture solution to form HCO 3 — The sensor is caused to generate color change, and the vision camera is used for identifying the two-dimensional code at the bottom of the sterility inspection culture bottle and the color change of the sensor; method for detecting CO in air at top of culture bottle caused by microbial growth by using semiconductor laser absorption spectrum technology 2 And judging whether microorganisms exist or not according to the change of the concentration. Different strains have different metabolites and growth characteristics, and when the metabolites are alkaline, the HCO is neutralized 3 — The detection time of the bottom sensor can be prolonged, or CO generated when the strain floats on the surface of the culture solution 2 Quickly discharged into the air at the top, wherein CO in the air at the top of the culture bottle 2 The concentration change is better than the bottom sensor change; if the metabolite is not alkaline, or the strain floats in the culture solution to grow, the change of the inductor at the bottom of the culture bottle is better than that of the CO in the air at the top 2 The concentration changes, and priority discrimination is made. The device realizes accelerated interpretation by a double detection method.
Preferably, a shaking table driving mechanism is arranged in the chamber frame, the placing frame is rotatably connected with the chamber frame through an eccentric rotating wheel, and the shaking table driving mechanism drives the placing frame to perform rotary motion. The shaking table driving mechanism comprises a driving motor, a synchronous belt structure and an eccentric rotating wheel structure, the driving motor drives a driven belt wheel to rotate through the synchronous belt structure, the driven belt wheel drives the eccentric rotating wheel to rotate, and then the placing frame is driven to do rotary motion. The structure can make liquid level and the air of top fully contact with the culture solution in the sterility test blake bottle at the culture in-process, improves dissolved oxygen area, promotes aerobic microorganism and accelerates to grow, makes the bottom inductor discolour in advance, discovers the blake bottle that has microorganism to grow as early as possible.
Preferably, a proximity switch is arranged on the chamber frame, an induction sheet is arranged on the placing frame, and the proximity switch and the induction sheet are arranged oppositely. Proximity switch can sense whether return of response piece, and when electronic clamping jaw snatched the blake bottle at every turn, need guarantee that electronic clamping jaw accurately snatched the blake bottle that corresponds, made the blake bottle one-to-one of testing result and every position, avoided the result in disorder.
Preferably, the tray is arranged on the placing frame and is in sliding connection with the placing frame through a sliding rail. The structure is convenient for storing and taking the culture bottle.
Preferably, a locking mechanism for locking the tray is arranged on the placing frame. Locking mechanism is used for fixed tray, prevents that the tray from deviating from when the rack waves. The locking mechanism adopts a common electric locking mechanism, and the relative position of the tray and the placing rack can be fixed.
Preferably, a dust cover is arranged on the outer side of the vision camera and fixed with the positioning base. The dust cover prevents dust from affecting the visual camera performance.
Preferably, a temperature sensor is arranged in the chamber frame. The temperature sensor is combined with the temperature control module and used for detecting whether the temperature in the cavity reaches a set culture temperature.
Preferably, an electronic lock is arranged on the outer side of the chamber frame. The electronic lock is used for locking the door of the culture detection chamber and is opened by an operator with login authority through a touch control screen, so that the culture process and the detection result are ensured not to be interfered by other people.
Preferably, the three-axis moving platform comprises a first transverse moving mechanism, a second transverse moving mechanism and a lifting mechanism, wherein the first transverse moving mechanism is arranged on the second transverse moving mechanism, the second transverse moving mechanism is arranged on the lifting mechanism, and the lifting mechanism is fixed with the chamber frame. The first transverse moving mechanism, the second transverse moving mechanism and the lifting mechanism can be common linear driving mechanisms such as a screw rod nut mechanism driven by a motor, a gear rack mechanism driven by the motor, a push rod motor and the like. The three-axis moving platform is used for sequentially moving all sterile inspection culture bottle samples to the sterile detection mechanism for detection.
Preferably, the rack is provided with a touch screen, an indicator light, a code scanning gun and an electric control assembly. The touch control screen is used for input operation of equipment; the code scanning gun is used for detecting code scanning information input of a sample; the indicator light is used for prompting the current running state of the equipment.
The utility model has the advantages that: (1) The double detection method realizes accelerated interpretation of the equipment, and can discover culture bottles with microorganism growth as early as possible; (2) In the process of culture, the liquid level in the sterility test culture bottle is fully contacted with the air above the liquid level in the sterility test culture bottle, the dissolved oxygen area is increased, aerobic microorganisms are promoted to accelerate growth, the bottom sensor is changed color in advance, and the culture bottle with microorganism growth is found in time.
Drawings
FIG. 1 is a schematic view of the present invention;
FIG. 2 is a schematic diagram of the structure of the culture detection chamber;
FIG. 3 is a partial schematic view of the culture detection chamber;
fig. 4 is a schematic configuration diagram of the sterility test mechanism.
In the figure: the device comprises a rack 1, a culture detection chamber 2, a chamber frame 2.1, a three-axis moving platform 2.2, a sterility detection mechanism 2.3, a positioning base 2.3.1, a vision camera 2.3.2, a laser emitter 2.3.3, a laser receiver 2.3.4, a dust cover 2.3.5, a placing rack 2.4, an electric clamping jaw 2.5, a table driving mechanism 2.6, a proximity switch 2.7, an induction sheet 2.8, a tray 2.9, a sliding rail 2.10, a locking mechanism 2.11, a temperature sensor 2.12, an electronic lock 2.13, a touch screen 3, an indicator light 4 and a code scanning gun 5.
Detailed Description
The invention is further described with reference to the following figures and specific embodiments.
Example 1:
as shown in figure 1, an automatic sterility test incubator comprises a frame 1, wherein the frame 1 is provided with a culture detection chamber 2, a touch screen 3, an indicator lamp 4, a code scanning gun 5 and an electric control assembly. As shown in fig. 2 and fig. 3, the cultivation detection chamber 2 includes a chamber frame 2.1, a three-axis moving platform 2.2, a sterility detection mechanism 2.3 and a placing frame 2.4, the three-axis moving platform 2.2 is fixed to the chamber frame 2.1, the three-axis moving platform 2.2 includes a first transverse moving mechanism, a second transverse moving mechanism and a lifting mechanism, the first transverse moving mechanism is disposed on the second transverse moving mechanism, the second transverse moving mechanism is disposed on the lifting mechanism, and the lifting mechanism is fixed to the chamber frame 2.1. Be equipped with electronic clamping jaw 2.5 on the first sideslip machine, electronic clamping jaw 2.5 sets up in rack 2.4 top, aseptic detection mechanism 2.3 is fixed at cavity frame 2.1, as shown in fig. 4, aseptic detection mechanism 2.3 is including location base 2.3.1, vision camera 2.3.2, laser emitter 2.3.3 and laser receiver 2.3.4, vision camera 2.3.2 sets up in location base 2.3.1 oblique below, laser emitter 2.3.3 and laser receiver 2.3.4 set up in location base 2.3.1 top, and laser emitter 2.3.3 and laser receiver 2.3.4 set up in the both sides of location base 2.3.1 relatively. The outer side of the vision camera 2.3.2 is provided with a dust cover 2.3.5, and the dust cover 2.3.5 is fixed with the positioning base 2.3.1.
As shown in fig. 2 and 3, a tray 2.9 is arranged on the placing rack 2.4, and the tray 2.9 is slidably connected with the placing rack 2.4 through a sliding rail 2.10. And a locking mechanism 2.11 for locking the tray 2.9 is arranged on the placing rack 2.4. A temperature sensor 2.12 and a shaking table driving mechanism 2.6 are arranged in the chamber frame 2.1, the placing frame 2.4 is rotatably connected with the chamber frame 2.1 through an eccentric rotating wheel arranged on a bottom plate of the chamber frame, and the shaking table driving mechanism 2.6 drives the placing frame 2.4 to do rotary motion. The rotation axis of eccentric runner sets up perpendicular cavity frame bottom plate, and shaking table actuating mechanism 2.6 includes driving motor, synchronous belt structure, driven pulleys and eccentric runner structure, and the eccentric runner is fixed on driven pulleys, is equipped with the eccentric shaft with rack 2.4 articulated on the eccentric runner, and driving motor passes through synchronous belt structure and drives driven pulleys and rotate, and driven pulleys drive eccentric runner and rotate, then drives rack 2.4 and be rotary motion on cavity frame bottom plate. In order to improve the rotation stability of the placing rack, a plurality of eccentric rotating wheels can be arranged on the bottom surface of the placing rack corresponding to the eccentric rotating wheels. The chamber frame 2.1 is provided with a proximity switch 2.7, the placing frame 2.4 is provided with an induction sheet 2.8, and the proximity switch 2.7 and the induction sheet 2.8 are arranged oppositely. The outer side of the chamber frame 2.1 is provided with an electronic lock 2.13.
In the technical scheme, the tray 2.9 is placed on the placing rack 2.4 in the culture detection chamber 2, and a plurality of culture trays are sequentially arranged in the tray 2.9And (5) cultivating bottles. When detection is needed, the electric clamping jaw 2.5 is moved to a position of a culture bottle to be detected through the three-axis moving platform 2.2, the culture bottle is moved to the sterility detection mechanism 2.3 through the three-axis moving platform 2.2 after the culture bottle is clamped by the electric clamping jaw 2.5, a placing groove for placing the culture bottle is formed in the positioning base 2.3.1, after the culture bottle is placed in place, visual detection is carried out through the visual camera 2.3.2, carbon dioxide detection is carried out through the laser emitter 2.3.3 and the laser receiver 2.3.4, as long as one of the two sensors detects microorganisms, namely, the growth of the microorganisms existing in the culture bottle is recorded, the information of the culture bottle is recorded, then an alarm is given to remind a worker, then the culture bottle is placed back to the original position through the three-axis moving platform 2.2.2 and the electric clamping jaw 2.5, and the other culture bottle is taken for detection. Two detection methods in the application can accelerate the principle of detection and discrimination: the bottom of the culture bottle contains a sensor, and the microorganism grows to produce CO 2 Dissolving in culture solution to form HCO 3 — The sensor is caused to have color change, and the vision camera 2.3.2 is used for identifying the two-dimensional code at the bottom of the sterile inspection culture bottle and the color change of the sensor; method for detecting CO in air at top of culture bottle caused by microbial growth by using semiconductor laser absorption spectrum technology 2 And judging whether microorganisms exist or not according to the change of the concentration. Different strains have different metabolites and growth characteristics, and when the metabolites are alkaline, the HCO is neutralized 3 — The detection time of the bottom sensor is prolonged, or CO is generated when the strain floats on the surface of the culture solution 2 Quickly discharged into the air at the top of the culture flask, wherein CO in the air at the top of the culture flask is discharged 2 The concentration change is better than the bottom sensor change; if the metabolite is not alkaline, or the strain floats in the culture solution to grow, the change of the inductor at the bottom of the culture bottle is better than that of the CO in the air at the top 2 The concentration changes, and priority discrimination is made. The device realizes accelerated interpretation by a double detection method. The shaking table driving mechanism 2.6 can make the liquid level in the sterile examination culture bottle fully contact with the air above the liquid level in the culture bottle and the culture solution in the culture process, improve the dissolved oxygen area, promote the aerobic microorganisms to accelerate the growth, make the bottom sensor change color in advance, and discover the culture bottle with the microorganism growth as soon as possible.
The application method of the incubator comprises the following steps: 1) Scanning a two-dimensional code on a sample of the sterility test culture bottle by using a code scanning gun 5, and recording specific information of the sample; 2) Unlocking the electronic lock 2.13, opening the door, releasing the locking mechanism 2.11, drawing out the tray 2.9, putting in the sample, pushing back the tray 2.9, locking the tray 2.9, and closing the door; 3) The operation is started on the touch control screen, a detection switch is attached to the electric clamping jaw 2.5, whether a sterile inspection culture bottle sample exists at the current position can be detected, if yes, the three-axis moving platform 2.2 drives the electric clamping jaw 2.5 to grab the sample and place the sample at a sterile detection position, and if not, the three-axis moving platform moves to the next position for detection, and the detection of the samples at all the positions of the tray 2.9 is completed in sequence; 4) After detection is finished, the system automatically identifies and sets the culture temperature, if the temperature is 20-25 ℃, the system is used for culturing aerobic microorganisms, shaking table culture can be started, if the temperature is 30-35 ℃, the system is used for culturing anaerobic microorganisms, and if an anaerobic layer exists in the culture solution, the shaking table cannot be started; 5) And (3) pausing the shaking table before the next round of detection, driving the electric clamping jaw 2.5 by the three-axis moving platform 2.2 to perform full-scale detection again, sequentially looping, judging the sample into a positive result, taking out the sample, and continuously judging the sample if the sample is a negative result.
The beneficial effects of the utility model are that: (1) The double detection method realizes accelerated interpretation of the equipment, and can discover culture bottles with microorganism growth as early as possible; (2) In the process of culturing, the liquid level in the sterility test culture bottle is fully contacted with the air above the liquid level in the sterility test culture bottle, the dissolved oxygen area is increased, aerobic microorganisms are promoted to accelerate growth, the bottom sensor is changed color in advance, and the culture bottle with the growth of the microorganisms is found in time.
Claims (10)
1. The utility model provides an automatic sterility test incubator, which is characterized by, which comprises a frame, be equipped with in the frame and train the detection cavity, it includes the cavity frame to train the detection cavity, triaxial moving platform, aseptic detection mechanism and rack, triaxial moving platform is fixed with the cavity frame, the last electronic clamping jaw that is equipped with of triaxial moving platform, electronic clamping jaw sets up in the rack top, aseptic detection mechanism fixes on the cavity frame, aseptic detection mechanism is including fixing a position the base, the vision camera, laser emitter and laser receiver, the vision camera sets up in the oblique below of base of fixing a position, laser emitter and laser receiver set up in the base of fixing a position top, and laser emitter and laser receiver set up the both sides at the base of fixing a position relatively.
2. The automatic sterilization examination incubator as claimed in claim 1, wherein a table driving mechanism is provided in the chamber frame, the rack is rotatably connected to the chamber frame via an eccentric wheel, and the table driving mechanism drives the rack to perform a rotation motion.
3. The automatic sterilization-inspection incubator according to claim 2, wherein the chamber frame is provided with a proximity switch, the rack is provided with a sensing piece, and the proximity switch is disposed opposite to the sensing piece.
4. An automatic sterility test incubator as claimed in claim 1, 2 or 3, wherein the holding frame is provided with a tray, and the tray is connected with the holding frame by a slide rail in a sliding manner.
5. An automated sterility inspection incubator as recited in claim 4, wherein the rack is provided with a locking mechanism for locking the trays.
6. An automated sterility inspection incubator as recited in claim 1, 2 or 3, wherein the vision camera is provided with a dust cover on the outside thereof, the dust cover being secured to the positioning base.
7. An automated sterility inspection incubator according to claim 1, 2 or 3, wherein a temperature sensor is provided within the chamber frame.
8. An automated sterility inspection incubator according to claim 1, 2 or 3, characterised in that the chamber frame is provided with an electronic lock on the outside.
9. An automated sterility inspection incubator as recited in claim 1, 2 or 3 wherein the three-axis motion stage comprises a first traverse mechanism disposed on a second traverse mechanism and a lift mechanism disposed on the lift mechanism, the lift mechanism being secured to the chamber frame.
10. An automated sterility inspection incubator according to claim 1, 2 or 3 wherein the frame is provided with a touch screen, indicator lights, a yard scanning gun and an electronic control assembly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202221074179.1U CN217628384U (en) | 2022-04-29 | 2022-04-29 | Automatic sterility testing incubator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202221074179.1U CN217628384U (en) | 2022-04-29 | 2022-04-29 | Automatic sterility testing incubator |
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| CN217628384U true CN217628384U (en) | 2022-10-21 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202221074179.1U Active CN217628384U (en) | 2022-04-29 | 2022-04-29 | Automatic sterility testing incubator |
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| CN (1) | CN217628384U (en) |
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