CN211268074U - Sleep deprivation instrument and deprivation system - Google Patents

Sleep deprivation instrument and deprivation system Download PDF

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Publication number
CN211268074U
CN211268074U CN201922342912.8U CN201922342912U CN211268074U CN 211268074 U CN211268074 U CN 211268074U CN 201922342912 U CN201922342912 U CN 201922342912U CN 211268074 U CN211268074 U CN 211268074U
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deprivation
box body
sleep
touch screen
instrument
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曾凯
林诗竹
吴晓丹
黄盛�
蔡语桐
肖义荣
黄奕江
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First Affiliated Hospital of Fujian Medical University
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First Affiliated Hospital of Fujian Medical University
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Abstract

The utility model relates to an animal experiment technical field, concretely relates to sleep deprivation appearance and deprivation system. The sleep deprivation instrument comprises a first box body, a main deprivation piece and an auxiliary deprivation piece, wherein the first box body is used for accommodating experimental animals; the main deprivation part is arranged in the first box body, and the main deprivation part is connected with the first box body and can move relative to the first box body to provide main deprivation stimulation; the auxiliary deprivation member is configured to provide an auxiliary deprivation stimulus for shifting from a sleep state to an arousal state to the laboratory animal in the first housing. The utility model provides a sleep deprivation instrument's experiment casualty rate is low, the experiment is with low costs, and the deviation of the experimental data that finally acquirees is little.

Description

Sleep deprivation instrument and deprivation system
Technical Field
The utility model relates to an animal experiment field, concretely relates to sleep deprivation appearance and deprivation system.
Background
Sleep is the necessary activities for human body to recover mental and physical strength, and sleep disorder affects the activity and reliability of brain thinking and causes related diseases, so that the human body is converted from a healthy state to a sub-healthy state and even from the healthy state to the disease state. In order to research sleep disorder and develop anti-fatigue drugs and health care products, model experiments are carried out on animals in the early stage to obtain related research data and development data. Among them, the sleep deprivation device is an indispensable experimental device for animal model tests.
In the prior art, 3 kinds of sleep deprivation equipment are generally adopted to carry out animal model experiments, namely a rotating cylinder and middle clapboard deprivation mode, a rotating cage deprivation mode and a horizontal table deprivation mode.
In the deprivation mode of the rotating cylinder and the middle clapboard, when the rotating speed is low, the experimental mouse has a long rest time, so that intermittent sleep deprivation is caused; when the rotating speed is higher, the selection interval of the sleep deprivation mode is shortened. The rotating cage deprives the mode and drives the rotating cage through the motor and continuously rotates, and experimental animals therein run along passively to reach and deprive the sleep purpose, because the design angle defect between food basket and the rotating cage, the head bank mound that appears experimental animals sometimes is between trough and rotating cage, and then leads to the death condition. The horizontal table deprivation mode is mainly used for modifying an animal running table instrument and mainly used for depriving the rapid eye movement stage sleep disorder, and animals are easy to infect and die under the deprivation condition of a long experimental time.
Present 3 kinds of sleep deprivation equipment are all deprived through the single mode, do not consider the other factors that appear among the deprivation process, for example the easy card of experimental animal is died, the casualty condition appears, or the experimental animal still condition appears in continuous deprivation mode or continuous deprivation period, can't compromise these circumstances that the deprivation process appears, then the research data that finally obtain have some deviations. Moreover, because the single mode is adopted for deprivation and the specific deprivation mode is adopted, the casualty rate of the sleep deprivation equipment in the prior art is high, and the test cost is increased.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a sleep deprivation instrument to the sleep deprivation equipment who exists among the solution prior art is because deprived the single and then lead to the technical problem that the research data that the casualty rate is high, the experiment is with high costs and obtain have the deviation because of the mode.
The utility model provides a sleep deprivation instrument, which comprises a first box body, a main deprivation piece and an auxiliary deprivation piece, wherein the first box body is used for accommodating experimental animals; wherein the content of the first and second substances,
the main deprivation piece is arranged in the first box body, and the main deprivation piece is connected with the first box body and is arranged to move relative to the first box body so as to provide main deprivation stimulation;
the auxiliary deprivation member is configured to provide an auxiliary deprivation stimulus for transition from a sleep state to an awake state to the laboratory animal in the first housing.
Further, supplementary depriving spare is the bottom plate of first box, the bottom plate of first box is the circular telegram board.
Further, the main deprivation part comprises a rotating rod and a swinging rod which are arranged in parallel relatively along the height direction of the first box body at intervals, a first connecting rod connected between the first end of the rotating rod and the first end of the swinging rod, and a second connecting rod connected between the second end of the rotating rod and the second end of the swinging rod;
the main deprivation part is arranged to enable the rotating rod to drive the oscillating rod to swing relative to the first box body through the first connecting rod and the second connecting rod.
Further, the deprivation instrument further comprises a second box body with an upper opening, and the first box body is supported on the upper opening;
the bottom plate of the first box body is a grid plate; the deprivation instrument further comprises an excrement collecting device arranged in the second box body, and a collecting opening of the excrement collecting device is opposite to the bottom plate of the first box body.
Further, the excreta collection device comprises a funnel structure and a collection container located below the funnel structure; the large port of the funnel structure is opposite to the bottom plate of the first box body, and the small port of the funnel structure is communicated with the collecting container;
the collecting container comprises a solid collecting container and a liquid collecting container, and a filter screen is arranged in the solid collecting container; the upper port of the solid collection container is communicated with the lower port of the funnel structure, and the upper port of the liquid collection container is communicated with the lower port of the solid collection container.
Further, a weighing sensor is arranged on the filter screen.
The utility model provides a sleep deprivation instrument, wherein the main deprivation piece provides main deprivation stimulation to the experimental animal through relative first box motion. In the process of main deprivation, the experimental animal may stay or stand still at a certain position in a short time or in a gap generated by the movement of the main deprivation piece, and an auxiliary deprivation secondary machine for converting the sleep state into the wake state is provided for the experimental animal through the auxiliary deprivation piece, so that the experimental animal is in a continuous movement state by using the main deprivation stimulation and the auxiliary deprivation stimulation simultaneously. Whether in the continuous deprivation mode or the discontinuous deprivation mode, the sleep deprivation detection of the experimental animal can be completed by assisting the main deprivation stimulus through the auxiliary deprivation stimulus. Because the main deprivation stimulation and the auxiliary deprivation stimulation are used simultaneously, the experimental animal is continuously in the wakefulness state in the deprivation process, so the experimental animal is not easy to enter the sleep state and is blocked or stuck by the main deprivation piece, the casualty rate is low, and the experimental cost is low. In addition, in the deprivation experiment, the experimental animal is in a continuous awakening state, and the state is more suitable for the experiment requirement, so that the finally acquired experiment data has small deviation.
It is another object of the present invention to provide a sleep deprivation system, which comprises the sleep deprivation instrument as described above, and a mobile terminal; wherein the content of the first and second substances,
the sleep deprivation instrument comprises a video monitoring device arranged on the inner side of one side wall of the first box body; the mobile terminal is connected with the video monitoring device and is set to be capable of reading the video information of the video monitoring device in real time.
Furthermore, the sleep deprivation instrument also comprises an illumination device arranged on the inner side of one side wall of the first box body; the mobile terminal is connected with the illumination device and is set to be capable of adjusting the illumination intensity of the illumination device according to the video information of the video monitoring device.
It is another object of the present invention to provide a sleep deprivation system, which comprises the sleep deprivation instrument as described above, and a mobile terminal; wherein the content of the first and second substances,
the sleep deprivation instrument comprises a first touch screen device; the first touch screen device comprises an inclined plate and a first touch screen arranged on the inclined plate, the inclined plate is connected with the top end of one side wall of the first box body, and the first touch screen is arranged to switch an auxiliary deprivation mode of the experimental animal through the first touch screen; the mobile terminal is connected with the first touch screen and is set to be capable of operating the first touch screen through an operation panel of the mobile terminal.
It is another object of the present invention to provide a sleep deprivation system, which comprises the sleep deprivation instrument as described above, and a mobile terminal; wherein the content of the first and second substances,
the sleep deprivation instrument comprises a second touch screen device; the second touch screen device comprises an inclined plate and a second touch screen arranged on the inclined plate, the inclined plate is connected with the top end of one side wall of the first box body, and the second touch screen is arranged to switch the auxiliary deprivation mode of the experimental animal through the second touch screen; the mobile terminal is connected with the second touch screen and is set to be capable of operating the second touch screen through an operation panel of the mobile terminal.
The utility model provides a sleep deprivation system compare in prior art's beneficial effect with the utility model provides a sleep deprivation appearance compares in prior art's beneficial effect the same, and here is no longer repeated.
Drawings
FIG. 1 is a schematic diagram of a sleep deprivation instrument according to an embodiment of the present invention;
FIG. 2 is an exploded view of a sleep deprivation instrument according to an embodiment of the present invention, wherein a first case and a second case are exploded;
fig. 3 is a schematic view of an excreta collection device according to an embodiment of the present invention, wherein a load cell is shown.
Wherein:
100-deprivation instrument; 10-a first box; 20-a second box; 30-a main deprivation member; 40-an auxiliary deprivation member; 50-a faecal collection device; 60-video monitoring devices; 70-an illumination device; 80-access channel; 21-upper opening; 22-a clamping groove; 31-rotating rods; 32-swing link; 33-a first connecting rod; 34-a second connecting rod; 51-funnel configuration; 52-a collection vessel; 91-a first touch screen; 92-a second touch screen; 93-an inclined plate; 521-a solids collection container; 522-a liquid collection container; 523-filter screen; 524-load cell.
Detailed Description
The preferred embodiments of the present invention will be described in detail below with reference to the accompanying drawings so that the objects, features and advantages of the invention can be more clearly understood. It should be understood that the embodiments shown in the drawings are not intended as limitations on the scope of the invention, but are merely illustrative of the true spirit of the technical solution of the invention.
In the following description, for the purposes of illustrating various disclosed embodiments, certain specific details are set forth in order to provide a thorough understanding of the various disclosed embodiments. One skilled in the relevant art will recognize, however, that the embodiments may be practiced without one or more of the specific details. In other instances, well-known devices, structures and techniques associated with this application may not be shown or described in detail to avoid unnecessarily obscuring the description of the embodiments.
Throughout the specification and claims, the word "comprise" and variations thereof, such as "comprises" and "comprising," are to be understood as an open, inclusive meaning, i.e., as being interpreted to mean "including, but not limited to," unless the context requires otherwise.
Referring to fig. 1-2, the present embodiment provides sleep deprivation, 100, comprising a first enclosure 10 and a second enclosure 20. Wherein the first casing 10 is configured to accommodate an experimental animal for performing a sleep deprivation experiment. The first casing 10 has a cubic structure, and an upper cover of the first casing 10 can be opened or closed. The bottom plate of the first box 10 is a grid plate, and the four side walls and the upper cover of the first box 10 are plastic transparent thin plates. The second housing 20 is provided with an excrement collecting device 50 for collecting excrement of the experimental animal for metabolic analysis. Wherein, the second casing 20 has an upper opening 21, and the first casing 10 is detachably clamped on the upper opening 21 of the second casing 20.
In this embodiment, a circle of clamping grooves 22 inclined toward the inner side is arranged on the edge of the upper opening 21 of the second box 20 along the periphery of the edge of the upper opening 21, and the cross section of the first box 10 is slightly smaller than that of the second box 20, so that the first box 10 can be conveniently clamped on the clamping grooves 22, and the first box 10 can be conveniently taken from the second box 20.
Of course, in other embodiments, the first casing 10 may be supported on the second casing 20 by a matching manner such as a slot and a protrusion, or by a plug-in connector penetrating through a through hole in a side wall of the second casing 20, and the embodiment will not be described in detail.
In the present embodiment, the deprivation instrument 100 includes a main deprivation member 30 and an auxiliary deprivation member 40 for assisting the main deprivation member 30 in sleep deprivation. Wherein, main deprivation piece 30 is the mechanical motion subassembly, and main deprivation piece 30 sets up in first box 10, and main deprivation piece 30 is connected with first box 10 and sets up to can move relatively first box 10. In this embodiment, the main deprivation member 10 includes a driving motor, a rotating rod 31 and a swinging rod 32 which are relatively arranged in parallel at intervals along the height direction of the first box 10, a first connecting rod 33 connected between the first end of the rotating rod 31 and the first end of the swinging rod 32, and a second connecting rod 34 connected between the second end of the rotating rod 31 and the second end of the swinging rod 32; the main deprivation member 30 is configured to drive the swing lever 32 to swing relative to the first casing 10 by the rotating lever 31 through the first connecting link 33 and the second connecting link 34, under the drive of the drive motor. The swing link 32 is spaced from the bottom plate of the first box 10 at a predetermined distance, which can be set according to the size of the animal.
Of course, in other embodiments, a sliding bar or a rotating bar may be used for the primary deprivation stimulus. Wherein, can set up the slide that extends along the length direction or the width direction of first box 10 in the first box 10, the slide bar sets up with the parallel interval of the bottom plate of first box 10, slide bar and slide set up and can follow the length direction reciprocating motion of slide. Or, a rotating shaft perpendicular to the bottom plate of the first box 10 may be disposed in the first box 10, a rotating rod is disposed at the top end of the rotating shaft, and the rotating rod rotates relative to the first box under the driving of the motor. The setting method of the main deprivation stimulus is the prior art, and the present embodiment will not be described in detail.
Wherein, supplementary depriving member 40 is the bottom plate of first box 10, and the bottom plate of first box 10 is the circular telegram board, carries out the electro photoluminescence through the bottom plate circular telegram to first box 10, provides the electro photoluminescence that changes from sleep state to awake state then to the laboratory animal.
An inclined plate 93 is arranged on the outer side of the top end of the rear wall of the first box 10, a first touch screen 91 and a second touch screen 92 are arranged on the inclined plate 93, and when an experimenter stands at the front side of the first box 10, the experimenter can conveniently operate the first touch screen 91 and the second touch screen 92. Wherein the first touch screen 91 is configured to switch the laboratory animal auxiliary deprivation mode through the first touch screen 91, wherein the experimenter can select detection modes such as EEG, EMG, sleep analysis and the like through the first touch screen 91. A plurality of access channels 80 are arranged on one side wall of the first box body 10, the access channels 80 can automatically realize sleep analysis, EMG \ EEG detection, optogenetic detection and the like on experimental animals, directly display EEG waveform and EMG waveform, and can store and copy for analysis. The access channel 80 is prior art, and the detailed description thereof is omitted here.
The second touch screen 92 is configured to switch the auxiliary deprivation mode of the experimental animal through the second touch screen 92, wherein the experimenter can select the normal mode or the auxiliary mode through the second touch screen 92. If the experimenter selects the common mode, only the main deprivation stimulation is carried out on the experimental animal in the first box body 10, and the auxiliary deprivation stimulation is not carried out; when the experimenter selects the assist mode, the experimenter performs a main deprivation stimulation and an assist deprivation to the experimenter in the first housing 10.
The side wall of the first casing 10 is provided with a video monitoring device 60, a lighting device 70, a food trough and a drinking trough. Wherein, the food trough and the drinking trough are preferably located on the same side wall, and the video monitoring device 60 and the lighting device 70 are located on different side walls.
The deprivation instrument 100 further comprises a excrement collecting device 50 arranged in the second box 20, a collecting port of the excrement collecting device 50 is opposite to the bottom plate of the first box 10, and the excrement collecting device 50 comprises a funnel structure 51 and a collecting container 52 positioned below the funnel structure 51; the large port of the funnel structure 51 is opposite to the bottom plate of the first container 10, and the small port of the funnel structure 51 communicates with the collection container 52. Specifically, the collection container 52 includes a solid collection container 521 and a liquid collection container 522, and a filter screen 523 is disposed in the solid collection container 521; the upper port of the solids collection vessel 521 communicates with the lower port of the funnel structure 51 and the upper port of the liquid collection vessel 522 communicates with the lower port of the solids collection vessel 521. Thus, the excreta of the experimental animal passes through the openings of the mesh plate from the top to the bottom through the funnel structure 51 into the collection container 52, wherein the solid excreta 521 is retained in the solid collection container 521 by the screen 523, and the liquid excreta flows into the liquid collection container 522.
Referring to fig. 3, a weighing sensor 524 is disposed on the filter screen 523, and the weight of the solid waste is directly obtained by the weighing sensor 524, so as to facilitate metabolic analysis. The outer wall of the liquid collection container 522 is provided with a scale groove, and the volume of liquid in the liquid collection container is directly read through the scale groove so as to facilitate metabolic analysis.
Of course, in other embodiments, the first tank 10 may be removed from the second tank 20, the excreta collection device 50 may be removed from the second tank 20, and the solid excreta and the liquid excreta may be measured after the collection device 52 is removed.
It is another object of the present embodiment to provide a sleep deprivation system including the sleep deprivation instrument as described above, and a mobile terminal; the mobile terminal is connected with the video monitoring device 60 and is set to be capable of reading video information of the video monitoring device 60 in real time, so that experimenters can conveniently know experimental conditions; the mobile terminal is connected with the illumination device 70 and is set to adjust the illumination intensity of the illumination device according to the video information of the video monitoring device 60, and the experimental animal is illuminated and stimulated by adjusting the illumination intensity according to the experimental requirements. Also, the mobile terminal is connected to the first touch screen 91 and is configured to be able to operate the first touch screen 91 through its operation panel, and the mobile terminal is connected to the second touch screen 92 and is configured to be able to operate the second touch screen 92 through its operation panel. Therefore, through telecommunication connection with the mobile terminal, an experimenter can conveniently operate various choices of the sleep deprivation instrument through the mobile terminal.
While the preferred embodiments of the present invention have been described in detail above, it should be understood that aspects of the embodiments can be modified, if necessary, to employ aspects, features and concepts of the various patents, applications and publications to provide yet further embodiments.
These and other changes can be made to the embodiments in light of the above detailed description. In general, in the claims, the terms used should not be construed to be limited to the specific embodiments disclosed in the specification and the claims, but should be construed to include all possible embodiments along with the full scope of equivalents to which such claims are entitled.

Claims (10)

1. A sleep deprivation instrument is characterized by comprising a first box body, a main deprivation piece and an auxiliary deprivation piece, wherein the first box body is used for accommodating experimental animals; wherein the content of the first and second substances,
the main deprivation piece is arranged in the first box body, and the main deprivation piece is connected with the first box body and is arranged to move relative to the first box body so as to provide main deprivation stimulation;
the auxiliary deprivation member is configured to provide an auxiliary deprivation stimulus for transition from a sleep state to an awake state to the laboratory animal in the first housing.
2. The sleep deprivation device of claim 1 wherein said auxiliary deprivation element is a bottom plate of said first case and said bottom plate of said first case is a power-on plate.
3. The sleep deprivation instrument as claimed in claim 1, wherein said main deprivation member comprises a rotation lever and a swing lever which are disposed in a height direction of said first casing at a relatively parallel interval, a first connecting rod connected between a first end of said rotation lever and a first end of said swing lever, a second connecting rod connected between a second end of said rotation lever and a second end of said swing lever;
the main deprivation part is arranged to enable the rotating rod to drive the oscillating rod to swing relative to the first box body through the first connecting rod and the second connecting rod.
4. The sleep deprivation device of claim 1 further comprising a second housing having an upper opening, said first housing supported on said upper opening;
the bottom plate of the first box body is a grid plate; the deprivation instrument further comprises an excrement collecting device arranged in the second box body, and a collecting opening of the excrement collecting device is opposite to the bottom plate of the first box body.
5. The sleep deprivation device of claim 4 wherein said waste collection means comprises a funnel structure and a collection container located below said funnel structure; the large port of the funnel structure is opposite to the bottom plate of the first box body, and the small port of the funnel structure is communicated with the collecting container;
the collecting container comprises a solid collecting container and a liquid collecting container, and a filter screen is arranged in the solid collecting container; the upper port of the solid collection container is communicated with the lower port of the funnel structure, and the upper port of the liquid collection container is communicated with the lower port of the solid collection container.
6. The sleep deprivation instrument as claimed in claim 5 wherein a load cell is provided on the filter mesh.
7. A sleep deprivation system comprising the sleep deprivation instrument according to any of claims 1 to 6, and a mobile terminal; wherein the content of the first and second substances,
the sleep deprivation instrument comprises a video monitoring device arranged on the inner side of one side wall of the first box body; the mobile terminal is connected with the video monitoring device and is set to be capable of reading the video information of the video monitoring device in real time.
8. The sleep deprivation system according to claim 7 wherein said sleep deprivation instrument further comprises a lighting device disposed inside one of the side walls of said first case; the mobile terminal is connected with the illumination device and is set to be capable of adjusting the illumination intensity of the illumination device according to the video information of the video monitoring device.
9. A sleep deprivation system comprising the sleep deprivation instrument according to any of claims 1 to 6, and a mobile terminal; wherein the content of the first and second substances,
the sleep deprivation instrument comprises a first touch screen device; the first touch screen device comprises an inclined plate and a first touch screen arranged on the inclined plate, the inclined plate is connected with the top end of one side wall of the first box body, and the first touch screen is arranged to switch the sleep detection mode of the experimental animal through the first touch screen; the mobile terminal is connected with the first touch screen and is set to be capable of operating the first touch screen through an operation panel of the mobile terminal.
10. A sleep deprivation system comprising the sleep deprivation instrument according to any of claims 1 to 6, and a mobile terminal; wherein the content of the first and second substances,
the sleep deprivation instrument comprises a second touch screen device; the second touch screen device comprises an inclined plate and a second touch screen arranged on the inclined plate, the inclined plate is connected with the top end of one side wall of the first box body, and the second touch screen is arranged to switch an auxiliary deprivation mode of the experimental animal through the second touch screen; the mobile terminal is connected with the second touch screen and is set to be capable of operating the second touch screen through an operation panel of the mobile terminal.
CN201922342912.8U 2019-12-24 2019-12-24 Sleep deprivation instrument and deprivation system Active CN211268074U (en)

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CN201922342912.8U CN211268074U (en) 2019-12-24 2019-12-24 Sleep deprivation instrument and deprivation system

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Application Number Priority Date Filing Date Title
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114145235A (en) * 2021-12-09 2022-03-08 中国科学院深圳先进技术研究院 Sleep deprivation device capable of collecting excrement of small animals
CN114698558A (en) * 2022-03-09 2022-07-05 河南中医药大学 Sleep deprivation squirrel cage device for electric shock rats and mice
CN115316293A (en) * 2022-07-12 2022-11-11 北京大学 Aseptic animal sleep deprives case

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114145235A (en) * 2021-12-09 2022-03-08 中国科学院深圳先进技术研究院 Sleep deprivation device capable of collecting excrement of small animals
WO2023102969A1 (en) * 2021-12-09 2023-06-15 中国科学院深圳先进技术研究院 Sleep deprivation apparatus capable of collecting excrement of small animal
CN114698558A (en) * 2022-03-09 2022-07-05 河南中医药大学 Sleep deprivation squirrel cage device for electric shock rats and mice
CN115316293A (en) * 2022-07-12 2022-11-11 北京大学 Aseptic animal sleep deprives case
CN115316293B (en) * 2022-07-12 2023-10-17 北京大学 Aseptic animal sleep deprivation case

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