CN205072870U - A move and integrate capability test device for cerebral ischemia damage mouse - Google Patents
A move and integrate capability test device for cerebral ischemia damage mouse Download PDFInfo
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- CN205072870U CN205072870U CN201520660981.2U CN201520660981U CN205072870U CN 205072870 U CN205072870 U CN 205072870U CN 201520660981 U CN201520660981 U CN 201520660981U CN 205072870 U CN205072870 U CN 205072870U
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Abstract
The utility model provides a move and integrate capability test device for cerebral ischemia damage mouse, the device comprises support part, fretwork square test part, supports partial bottom and connects the rubber suction cups, and fretwork square test part designs and is fit for experiment mouse size, bears a heavy burden in test procedure through the statistical test animal and steps on the sky circumstances, evaluates its motion function damage. The utility model provides a animal models of pathogenic mechanism research and drug screening in -process of ischemic brain damage select professional poor, the ununified problem of design standard by oneself, provide valid data the support to developing of all kinds of relevant experiments.
Description
Technical field
This utility model relates to animal movement integration ability test set, particularly relates to the experimental provision that a kind of mouse movement integration ability for cerebral ischemia is tested.
Background technology
Ischemic brain injury is blocked by cerebral vessels, makes the irreversible damage of one that this blood supply brain district of blood vessel institute occurs.This disease has become global first disabling disease, the third-largest fatal disease.The main group of people at high risk of this disease is 50 years old later crowd, and its group of people at high risk has the tendency being tending towards rejuvenation at present.This disease has become the key factor threatening human health and affect quality of life.Ischemic brain injury has become the focus of global neuroscience basis and clinical staff concern.
Brain is except the basic function such as sensation, motion of main department organism, or the high-level center of organism, as emotion, decision-making, memory etc.Cerebral tissue is kept at the skull chamber interior be made up of hard skull, carries out blood supply, supplies nutrients, oxygen take away metabolic waste by blood vessel.Due to the existence of blood brain barrier, the molecule existed in some peripheral bloods enters less than in brain, ensure that the normal operation of brain.But have some molecules to be by blood brain barrier, as lipid, can pile up in cerebral vessels, cause local vascular chamber to narrow, these will cause potential cerebral ischemia inducement.
It is assessment Animal Model whether success and the whether effective powerful of means of intervention that Animal Behavior Science detects, especially be used widely in neurobiology field, it not only can by the pathological change after nervous system injury when not drawing materials to experimental subject sacrifice, the change in corresponding brain district can be shown by the change in behavioristics, the corresponding function situation in brain district can also be carried out representing incisively and vividly.Therefore, Animal Behavior Science is than simple tissue pathological slice, dyeing, and protein purification concentration determination and nucleic acid extraction and mensuration, more have cogency, and effect monitoring aspect, functional rehabilitation aspect has irreplaceable effect especially.
In mammalian laboratory animals, because mice is small, feeding and management is convenient, and be easy to control, Reproduction is fast, and have clear and definite quality control standard, therefore in each subject experimentation, consumption is maximum, and purposes is the widest.In addition, scientist has completed the murine genes atlas analysis of 95%, and can find corresponding gene by the murine genes comparing discovery 99% in human body gene, therefore, mice is often as the experimental subject of physianthropy basic research.
For when Forebrain Ischemia current state of experimental research, with adult male mice for laboratory animal, design a kind of integration aptitude tests device, analysis is carried out for collection valid data, carries out effective evaluation significant.
Summary of the invention
The purpose of this utility model is to provide a kind of integration ability for ischemic brain injury mice to carry out the experimental provision tested, solve the animal model behavior analysis problem in the pathogenesis of ischemic brain injury and drug screening process, its reasonable in design, simple to operate, safe and reliable, provide effective data supporting for carrying out of all kinds of related experiment.
This utility model can laboratory animal be rodent, adult male mice.
This utility model adopts following technical scheme:
This is used for the integration aptitude tests device of ischemic brain injury mice, comprises support bar, rubber suction cups, hollow out grid software test district three part.
Described support bar has four altogether, is stainless steel, is highly set to 80-100 centimetre and fixes so that the form of inlaying is vertical with angle, four, hollow out grid software test district.
Described rubber suction cups, is set to tubaeform, inlays and is connected to bottom support bar, kiss the earth, the stability of holdout device, reduces the noise produced in moving process.
Described hollow out grid software test district, arranging length is 40-60 centimetre, and width is 20-30 centimetre, and period forms multiple grids of 4 square centimeters in vertical direction by horizontal, longitudinal isometric stainless steel strip, and grid size, to facilitate mouse movement, not easily drops and be advisable.
Whole apparatus design rationally, simply, Pass Test requirement, use simple to operate, solve the animal model behavior analysis problem in the pathogenesis of ischemic brain injury and drug screening process, provide effective data supporting for carrying out of all kinds of related experiment.
Accompanying drawing explanation
Fig. 1 is structural representation of the present utility model.
1, hollow out grid software test district; 2, support bar; 3, rubber suction cups.
Detailed description of the invention
As shown in Figure 1, formulate hollow out grid software test district overall dimensions for long 40 centimetres, wide 20 centimetres, become vertical direction to form multiple grids of 4 square centimeters with horizontal, longitudinal isometric stainless steel strip therebetween.Support bar arranges the rustless steel strip pillar that length is 1 meter, inlays respectively and connect tubaeform rubber suction cups below corner.
In device hollow out grid software test district, place beneath places a videocorder, uses in order to experimentation video recording.
By the experiment adult male mice after cerebral ischemia, be positioned over one end, hollow out grid software test district, trained experiment mice moves in hollow out grid software test district freely, open video recording equipment simultaneously, record the video data of 1 minute, statistical experiment animal movement total step number and front and back limb bear a heavy burden and step on sky situation, mark according to score basis.
The heavy burden limbs of animal bodies center of gravity, in the grid directly treading in hollow out or step down in stainless steel strip slips into and be heavy burden in hollow out lattice and step on sky, by measuring the front and back limb gait error situation in heavy burden situation, detect the Behavior-Based control ability of the action that has a down dip, and susceptibility to damage.
Claims (1)
1. the integration aptitude tests device for cerebral ischemia mice, comprise support bar, rubber suction cups, hollow out grid software test district three part, it is characterized in that: support bar height is 80-100 centimetre, bottom is inlayed and is connected rubber suction cups for fixing whole device, hollow out grid software test district is fixedly connected on support bar top, and length is 40-60 centimetre, and width is 20-30 centimetre, multiple horizontal, longitudinal stainless steel strip is vertically set therebetween, forms multiple grids of 4 square centimeters.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520660981.2U CN205072870U (en) | 2015-08-28 | 2015-08-28 | A move and integrate capability test device for cerebral ischemia damage mouse |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520660981.2U CN205072870U (en) | 2015-08-28 | 2015-08-28 | A move and integrate capability test device for cerebral ischemia damage mouse |
Publications (1)
| Publication Number | Publication Date |
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| CN205072870U true CN205072870U (en) | 2016-03-09 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201520660981.2U Expired - Fee Related CN205072870U (en) | 2015-08-28 | 2015-08-28 | A move and integrate capability test device for cerebral ischemia damage mouse |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106448405A (en) * | 2016-11-18 | 2017-02-22 | 中国科学院深圳先进技术研究院 | Rodent animal height fear test experiment device and experiment method |
| CN111144380A (en) * | 2020-01-06 | 2020-05-12 | 南通大学 | Animal misstep behavior analysis method based on automatic image recognition |
-
2015
- 2015-08-28 CN CN201520660981.2U patent/CN205072870U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106448405A (en) * | 2016-11-18 | 2017-02-22 | 中国科学院深圳先进技术研究院 | Rodent animal height fear test experiment device and experiment method |
| CN111144380A (en) * | 2020-01-06 | 2020-05-12 | 南通大学 | Animal misstep behavior analysis method based on automatic image recognition |
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Address after: 471031 No. 2 Huaxia West Road, Jianxi District, Henan, Luoyang Patentee after: central hospital of the Chinese People's Liberation Army the or five Address before: 471003 No. 2 Huaxia West Road, hi tech Zone, Henan, Luoyang Patentee before: central hospital of the Chinese People's Liberation Army the or five |
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160309 Termination date: 20170828 |
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| CF01 | Termination of patent right due to non-payment of annual fee |