CN114698558A - Sleep deprivation squirrel cage device for electric shock rats and mice - Google Patents
Sleep deprivation squirrel cage device for electric shock rats and mice Download PDFInfo
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- CN114698558A CN114698558A CN202210232523.3A CN202210232523A CN114698558A CN 114698558 A CN114698558 A CN 114698558A CN 202210232523 A CN202210232523 A CN 202210232523A CN 114698558 A CN114698558 A CN 114698558A
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- sleep
- sleep deprivation
- deprivation
- box
- organic glass
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- 208000010340 Sleep Deprivation Diseases 0.000 title claims abstract description 97
- 241000699670 Mus sp. Species 0.000 title claims abstract description 8
- 241000555745 Sciuridae Species 0.000 title claims description 5
- 241000700159 Rattus Species 0.000 title abstract description 16
- 239000011521 glass Substances 0.000 claims abstract description 31
- 241000699666 Mus <mouse, genus> Species 0.000 claims abstract description 21
- 229910000831 Steel Inorganic materials 0.000 claims abstract description 12
- 239000010959 steel Substances 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000010813 municipal solid waste Substances 0.000 claims abstract description 9
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 4
- 229910052742 iron Inorganic materials 0.000 claims description 2
- 241001465754 Metazoa Species 0.000 abstract description 12
- 238000010171 animal model Methods 0.000 abstract description 12
- 230000002618 waking effect Effects 0.000 abstract description 4
- 238000000034 method Methods 0.000 description 13
- 238000002474 experimental method Methods 0.000 description 7
- 230000007812 deficiency Effects 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 230000000638 stimulation Effects 0.000 description 4
- 230000007547 defect Effects 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 208000019116 sleep disease Diseases 0.000 description 3
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 206010022437 insomnia Diseases 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 208000001145 Metabolic Syndrome Diseases 0.000 description 1
- 208000019022 Mood disease Diseases 0.000 description 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 description 1
- 230000003542 behavioural effect Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 208000026278 immune system disease Diseases 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 208000020685 sleep-wake disease Diseases 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
- A01K1/03—Housing for domestic or laboratory animals
- A01K1/031—Cages for laboratory animals; Cages for measuring metabolism of animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
- A01K1/035—Devices for use in keeping domestic animals, e.g. fittings in housings or dog beds
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- General Health & Medical Sciences (AREA)
- Catching Or Destruction (AREA)
Abstract
The invention relates to a device for sleep deprivation of rats and mice by electric shock, which can effectively solve the problems that experimental models are easy to introduce other interference factors and experimental animals are easy to infect and die for a long time, and the technical proposal is that the bottom of a sleep deprivation box body is arranged on a sleep deprivation base, the top of the sleep deprivation box body is provided with a sleep deprivation box cover, the sleep deprivation base is provided with a plurality of sleep deprivation stations with different sizes, a garbage tray is arranged below the sleep deprivation base, the sleep deprivation box body is made of organic glass which is divided into a plurality of compartments, through holes are uniformly distributed on an organic glass side plate at the lower part of the sleep deprivation box body, a conductive steel wire which passes through the through holes is distributed below the sleep deprivation box body and is connected with a voltage regulator through a socket, the invention does not need the continuous movement of the animals to maintain the waking state, does not need the animals to be in a humid water environment for a long time, and can maintain the sleep deprivation for a long period, is an innovation on the device for depriving the mouse cage from sleep of the electric shock rats.
Description
Technical Field
The invention relates to the technical field of experimental instruments, in particular to a device for sleep deprivation of mouse cages by electric shock for rats and mice.
Background
The sleep deprivation instrument for the big and small mice is a behavioral instrument required for researching sleep deficiency and sleep disorder, the sleep deficiency becomes a common social phenomenon along with the increasing of social competition and the increasing of working and living pressure and the popularization of electronic products such as computers, mobile phones and the like, and the risk of suffering from cardiovascular and cerebrovascular diseases, metabolic syndrome, mood disorder and immune diseases can be greatly increased due to the sleep deficiency. However, the mechanism of the disease caused by insufficient sleep is still unclear and needs to be studied intensively. The sleep deprivation experimental animal model is a common method for researching sleep insufficiency, but the prior sleep deprivation equipment is still immature, and has a plurality of defects.
The sleep deprivation devices commonly used at present mainly include the following: the experimental mouse is driven in a rotary cylinder mode to deprive the experimental mouse of sleep and in a rotating cage mode, and the rotating cage is driven by the motor to continuously rotate to deprive animals of sleep, a deprivation rod sleep deprivation method, a light touch stimulation method, a horizontal table mode of sleep deprivation, a medicine sleep deprivation method and the like. Three methods, namely, a rotating cylinder mode driving experimental mouse to deprive the experimental mouse of sleep, a motor driving a rotating cage to continuously rotate a sleep deprivation instrument, a deprivation rod sleep deprivation method and the like, need the animal to continuously move to maintain a waking state, so that the condition that the animal model is mostly in a static state when the animal model works or watches electronic products in daily life is greatly different from the condition that the animal model is mostly in a static state when the animal model works or watches electronic products; the light touch stimulation method is mainly used for stimulating a mouse to keep clear-headed by sound, light, touch and the like when the mouse enters a sleep state through observation of an experimenter or brain wave monitoring, but the method is only suitable for short sleep deprivation. Sleep deprivation in a horizontal table mode, under the condition of long-time experiment deprivation, because animals are in a humid environment for a long time, other interference factors are easily introduced into an experiment model, and the animals are easily infected and died after long-time experiment; the sleep deprivation animal model induced by the drug sleep deprivation method better meets the symptoms of the insomnia animal model, is greatly different from the sleep deficiency caused by external factors, and shows that the conventional sleep deprivation equipment has many defects. Therefore, the improvement of sleep deprivation devices is a problem that needs to be solved at present.
Disclosure of Invention
Aiming at the situation, in order to solve the defects of the prior art, the invention aims to provide the device for the sleep deprivation mouse cage of the rats with electric shock, which can effectively solve the problems that other interference factors are easily introduced into an experimental model, and animals are easily infected and die after long-time experiment; the sleep deprivation animal model induced by the drug sleep deprivation method is more in line with the symptoms of the insomnia animal model, and has a larger difference from the sleep deficiency caused by external factors.
The sleep deprivation box body is made of organic glass which is divided into a plurality of compartments, through holes are uniformly distributed on an organic glass side plate at the lower part of the sleep deprivation box body, and a conductive steel wire which penetrates through the through holes is arranged below the sleep deprivation box body and is connected with a voltage regulator through the socket.
The invention does not need the animal to continuously move to maintain the waking state, does not need the animal to be in a humid water environment for a long time, can maintain the sleep deprivation for a longer period, is convenient and quick to clean, has good sanitary condition, and is an innovation on the device of the sleep deprivation squirrel cage for the electric shock rats and mice.
Drawings
FIG. 1 is a schematic structural diagram of the present invention.
FIG. 2 is a structural diagram of a sleep deprivation case of the present invention.
FIG. 3 is a diagram of a sleep-deprivation case cover according to the present invention.
FIG. 4 is a diagram of a sleep deprivation station configuration of the present invention.
Detailed Description
The following describes embodiments of the present invention in further detail with reference to the accompanying drawings.
As shown in figures 1-4, the sleep deprivation box comprises a sleep deprivation box body 1, a sleep deprivation platform 2, a sleep deprivation base 3, a sleep deprivation box cover 4 and a socket 5, wherein the bottom of the sleep deprivation box body 1 is arranged on the sleep deprivation base 3, the sleep deprivation box cover 4 is arranged on the top of the sleep deprivation box body, a plurality of sleep deprivation platforms 2 with different sizes are arranged on the sleep deprivation base 3, a garbage tray 6 is placed below the sleep deprivation platforms, the sleep deprivation box body 1 is made of organic glass which is divided into a plurality of compartments, through holes are uniformly distributed on an organic glass side plate at the lower part of the sleep deprivation box body 1, and a conductive steel wire 7 which penetrates through the through holes is distributed below the sleep deprivation box body 1 and is connected with a voltage regulator through the socket 5.
In order to ensure the using effect, the sleep deprivation box body 1 is square, the side length of the bottom is 20-30cm, and the height of the compartment is 20-60cm, generally 45 cm.
The positive electrode and the negative electrode of the conductive steel wire are alternately arranged below the sleep deprivation box body 1 in parallel and are separated from the sleep deprivation base 3 by 0.5 cm.
The diameter of the through holes is 2mm, the interval between the through holes is 0.4-0.8cm, and the distance between the through hole at the lowest part and the sleep deprivation base is 30.2-1 cm.
The sleep deprivation platform 2 is composed of a platform 2-2 arranged on a platform support 2-1, the platform support 2-1 is a cylinder made of non-conductive rubber, the diameter of the cylinder is 1.5-3cm, screws are arranged below the platform support 2-1, screw holes are formed in the upper portion of the cylinder, the screws below the platform support are fixed on an organic glass plate of a sleep deprivation box base, external threads matched with the screw holes above the platform support are arranged at one end of the platform 2-2, the main diameter of the platform is 2.5-6cm, and a rat and a mouse can stand during experiments, and platforms of different models can be replaced according to different sizes of experimental animals.
The sleep deprivation box base is made of an organic glass plate, the length and the width of the organic glass plate are respectively 4-8cm larger than those of the sleep deprivation box body 1, small holes with the diameter of 0.5-1cm are uniformly distributed on the organic glass plate and are used for discharging excrement of rats and mice to a garbage tray in the experimental process, universal wheels are respectively installed at four corners of the organic glass plate and are convenient to move, two sides of four edges of the organic glass plate are respectively provided with a long oval notch with the length of 2-8cm and the width of 0.2-0.8cm, the distance between the notch and the edge is 2cm, the horizontal included angle is 30 degrees, screws are arranged in the notches and can move in the long oval notches, the sleep deprivation box body can be placed on the organic glass plate, and the sleep deprivation box body is fixed through the distance and the elasticity of the edge screws.
The garbage tray 8 can be freely moved to be stored, the length and the width of the bottom of the garbage tray are the same as those of the sleep deprivation box body 1, and the box depth is 4-8 cm.
The sleep-deprivation box cover 4 is composed of a box cover main body 4-1 and a water feeding box 4-2, the box cover main body 4-1 is made of transparent organic glass and is matched with the sleep-deprivation box body in size, the box cover main body 4-1 is divided into areas which are the same as and correspond to compartments of the sleep-deprivation box body in size, a rectangular notch with the length of 10-20cm and the width of 6-12cm is arranged in the middle of each area, the water feeding box 4-2 which is woven by iron wires and can be freely detached is fixed below the notches, the water feeding box 4-2 is divided into two areas, food is placed on one side of each area, and a water bottle is placed on the other side of each area.
The voltage regulator is a voltage regulator sold in the market, the output voltage can be regulated to be 0-220V, and the output voltage end is connected with a socket at the tail end of the conductive steel wire 7.
The invention is characterized in that the sleep-depriving mouse cage device comprises a sleep-depriving box body, a sleep-depriving box base and a sleep-depriving box cover, the sleep-depriving box body is made of organic glass and is divided into a plurality of compartments, conductive steel wires are uniformly arranged at the lower part of the sleep-depriving box body, after the power supply is switched on, if a mouse or a rat falls down from a platform after sleeping, the mouse or the rat is in contact with the conductive steel wires at the bottom and is stimulated by electric shock with certain intensity, the rat needs to jump back to the platform again for avoiding the electric shock, so as to achieve the effect of sleep deprivation, the current intensity at the bottom can be adjusted according to the experimental requirements, in addition, a cylindrical sleep-depriving platform can be placed in each compartment for the rat to stand, the sleep-depriving platforms with different diameters can be changed according to the sizes of experimental animals, and are fixed on the organic glass base plate of the base through screws, the sleep-depriving box base is composed of organic glass plates, evenly distributed has the aperture of size fixed on the organic glass board, big or small mouse excrement can be followed the aperture on the organic glass of bottom and discharged to the garbage pan of bottommost in the experimentation, sleep deprives on the organic glass bottom plate that the box can be fixed in the bottom, fix the back well, sleep deprives about 0.5cm apart from the organic glass bottom plate the electrically conductive steel wire of bottom half, effectively avoid the short circuit of bottom steel wire, sleep deprives and has food box and water supply bottle in the design on the case lid, can effectively avoid the soaking stimulation that current sleep deprives the device existence, or continuous motion stimulation, improve sanitary conditions simultaneously, can satisfy the needs that the experiment was deprived in the persistent sleep, except this usage, can also be used to the relevant experiment of electric shock stress.
The experimental device has the advantages that the experimental device does not need the animal to continuously move to maintain a waking state, does not need the animal to be in a humid water environment for a long time, can maintain sleep deprivation for a long period, the mouse or the rat is placed on a specific sleep deprivation platform, after the power supply is switched on, the conductive net below the platform is electrified, if the mouse or the rat falls off the sleep deprivation platform after sleeping, the mouse or the rat is in contact with the conductive steel wire on the bottom plate and is stimulated by slight electric shock, the big mouse needs to jump back to the platform again to avoid the electric shock, the sleep deprivation effect is achieved, the current intensity at the bottom of the sleep deprivation box can be adjusted according to the experimental requirements, the animal body cannot be damaged, the excrement of the big mouse and the small mouse can be discharged into the garbage tray at the bottommost from the small holes on the organic glass at the bottom in the experimental process, the short circuit of the bottom steel wire is effectively avoided, the cleaning is convenient and quick, the sanitary condition is good, the using method is simple, the application is wide, the manufacturing cost is low, and the popularization and application value is good.
Claims (9)
1. The utility model provides a squirrel cage device is deprived in sleep of electric shock size mouse, deprive the box including sleep, sleep deprives the platform, sleep deprives the base, sleep deprives case lid and socket, a serial communication port, sleep deprives box (1) bottom dress on sleep deprivation base (3), be provided with sleep deprivation case lid (4) on the top, sleep deprives and is provided with a plurality of sleep deprivation platform (2) that vary in size on base (3), garbage tray (6) have been placed to the below, sleep deprivation box (1) is made by the organic glass who cuts apart into a plurality of compartment, evenly distributed has the through-hole on the organic glass curb plate of sleep deprivation box (1) lower part, sleep deprivation box (1) below is laid and is equipped with electrically conductive steel wire (7) that pass the through-hole, and link to each other with the voltage regulator through socket (5).
2. The device of claim 1, wherein the sleep deprivation cage body (1) is square, with a bottom side length of 20-30cm and a compartment height of 20-60 cm.
3. The device of claim 1, wherein the positive and negative poles of the conductive wire are alternately arranged in parallel under the sleep deprivation box (1) and spaced 0.5cm from the sleep deprivation base (3).
4. The device of claim 1 wherein the holes have a diameter of 2mm, the holes are spaced 0.4-0.8cm apart, and the lowest hole is 0.2-1cm from the sleep deprivation base.
5. The device according to claim 1, wherein the sleep deprivation platform (2) comprises a platform (2-2) mounted on a platform support (2-1), the platform support (2-1) is cylindrical and made of non-conductive rubber, the diameter of the platform support is 1.5-3cm, screws are mounted on the lower portion of the platform support (2-1), screw holes are formed in the upper portion of the platform support, the lower screws are fixed on an organic glass plate of a base of the sleep deprivation box, external threads matched with the screw holes in the upper portion of the platform support are formed in one end of the platform (2-2), and the main diameter of the platform is 2.5-6 cm.
6. The device of claim 1, wherein the base of the sleep deprivation box is made of an organic glass plate, the length and width of the organic glass plate are respectively 4-8cm larger than the length and width of the sleep deprivation box body (1), small holes with the diameter of 0.5-1cm are uniformly distributed on the organic glass plate, universal wheels are respectively arranged at four corners of the organic glass plate, two sides of four edges of the organic glass plate are respectively provided with an oblong cut with the length of 2-8cm and the width of 0.2-0.8cm, the cut is 2cm away from the edge, the horizontal included angle is 30 degrees, and screws are arranged in the cut.
7. The device of claim 1, wherein the length and width of the bottom of the trash tray (8) is the same as the length and width of the bottom of the sleep deprivation box (1), and the box depth is 4-8 cm.
8. The sleep-deprivation squirrel cage device of electric shocked mice as claimed in claim 1, wherein the sleep-deprivation cover (4) is composed of a cover main body (4-1) and a water box (4-2), the cover main body (4-1) is made of transparent organic glass and has a size matched with that of the sleep-deprivation case, the cover main body (4-1) is divided into areas with the same size and corresponding to the compartments of the sleep-deprivation case, a rectangular notch with a length of 10-20cm and a width of 6-12cm is arranged in the middle of each area, the freely detachable water box (4-2) woven by iron wires is fixed below the notch, the water box (4-2) is divided into two areas, one side is used for placing food, and the other side is used for placing a water bottle.
9. The device of claim 1, wherein the voltage regulator is a commercially available voltage regulator, the output voltage of the voltage regulator is adjustable between 0 and 220V, and the output voltage terminal of the voltage regulator is connected to a socket at the end of the conductive wire (7).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210232523.3A CN114698558A (en) | 2022-03-09 | 2022-03-09 | Sleep deprivation squirrel cage device for electric shock rats and mice |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210232523.3A CN114698558A (en) | 2022-03-09 | 2022-03-09 | Sleep deprivation squirrel cage device for electric shock rats and mice |
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| Publication Number | Publication Date |
|---|---|
| CN114698558A true CN114698558A (en) | 2022-07-05 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210232523.3A Pending CN114698558A (en) | 2022-03-09 | 2022-03-09 | Sleep deprivation squirrel cage device for electric shock rats and mice |
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| CN (1) | CN114698558A (en) |
Citations (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201591058U (en) * | 2010-01-19 | 2010-09-29 | 中国人民解放军第四军医大学 | Mouse sleep depriving device for medical experiment |
| CN201775854U (en) * | 2010-07-30 | 2011-03-30 | 淮北正华生物仪器设备有限公司 | Sleep deprivation device |
| CN202043525U (en) * | 2011-04-02 | 2011-11-23 | 山东省中医药研究院 | Accelerated experiment device for preparing animal model of syndrome of deficiency of both qi and yin of heart |
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| CN213044675U (en) * | 2020-07-29 | 2021-04-27 | 云南中医药大学 | Rat platform water environment sleep deprivation box |
-
2022
- 2022-03-09 CN CN202210232523.3A patent/CN114698558A/en active Pending
Patent Citations (15)
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| CN201591058U (en) * | 2010-01-19 | 2010-09-29 | 中国人民解放军第四军医大学 | Mouse sleep depriving device for medical experiment |
| CN201775854U (en) * | 2010-07-30 | 2011-03-30 | 淮北正华生物仪器设备有限公司 | Sleep deprivation device |
| CN202043525U (en) * | 2011-04-02 | 2011-11-23 | 山东省中医药研究院 | Accelerated experiment device for preparing animal model of syndrome of deficiency of both qi and yin of heart |
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Application publication date: 20220705 |