CN202776557U - Mold for animal model for chronic simple psychological fear stress experiment - Google Patents
Mold for animal model for chronic simple psychological fear stress experiment Download PDFInfo
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- CN202776557U CN202776557U CN2012204505463U CN201220450546U CN202776557U CN 202776557 U CN202776557 U CN 202776557U CN 2012204505463 U CN2012204505463 U CN 2012204505463U CN 201220450546 U CN201220450546 U CN 201220450546U CN 202776557 U CN202776557 U CN 202776557U
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Abstract
The utility model relates to mold for an animal model for a chronic simple psychological fear stress experiment. The mold can effectively achieve experimentation and observation of chronic simple psychological fear stress of animals and is characterized in that an alternating current case is a hollow cuboid consisting of organic glass and is divided into nine compartments in the same size by organic glass partitions; the compartment in the center and the compartments at the four corners are animal shock experiment compartments with upper covers; the rest four compartments are onlooking animal experiment compartments; a plurality of layers of smooth concave clamping grooves that are symmetrical vertically are formed in four side walls of the animal shock experiment compartments; rotating shafts connected with handles and extending into the animal shock experiment compartments are mounted in the centers of the upper covers; fixed supports are mounted at the lower ends of the rotating shafts; rubber heads for fixing are arranged at the end parts of the fixed supports; the bottom of the alternating current case is mounted on a removable base; and a current-conducting plate is mounted at the bottom of the alternating current case and connected with a voltage regulator. The mold is novel and unique in structure, convenient to use and good in visual effect, and can be effectively used for an animal shock experiment.
Description
Technical field
This utility model relates to the mould of laboratory animal, particularly a kind of mould that is applicable to prepare chronic simple feared state of mind stress tests animal model.
Background technology
Increase along with natural disaster, accident and social life survival pressure, the feared state of mind stress highlight day by day to human physical and mental health's harm, epidemiological survey and experimentation show: the feared state of mind stress not only affect the physical and mental health of self, also filial generation feelings will state, neurodevelopment and cognitive function thereof is produced Persistent Effect.Yet its mechanism is fuzzy, demands carrying out further basic research urgently.Because the restriction of ethics and experimental technique, zoopery has become the better alternative method of carrying out related basic research, so the successful preparation of model is the key point of assurance zoopery quality, and mould is the key that model prepares.At present the simple feared state of mind stress experimentation still be in the starting stage.The method for preparing feared state of mind stress animal model mainly contains: natural enemy is introduced method, constraint bowssening, foot shock method, traditional electric shocking method and shuttle box laboratory method etc. looked on.Natural enemy introduces method because laboratory animal lacks natural enemy consciousness, is difficult to cause the feared state of mind; Constraint bowssening and foot shock method have the body injury concurrently when bringing out the feared state of mind, be difficult to prepare simple feared state of mind Stress model; Traditional electric shocking method of looking on, just utilize and look on Mus and obtain to close on the electric shock Mus by vision, olfactory sensation, audition and prepare frightened stress animal model because of the frightened information that is subject to foot shock and produces, lack direct fear memory, therefore adaptability is relatively poor, and is multiplex in making acute feared state of mind Stress model; The shuttle box laboratory method is to adopt the foot shock model mouse to make it produce direct fear memory, and provides the safety board of avoiding electric shock for it.Can avoid although it is so causing the body injury, it is frightened theoretical also to meet the situation formula, prepares more simple frightened model, but avoids memory owing to produce easily initiative, so adaptability is relatively poor, multiplex in making acute feared state of mind Stress model.Therefore, the experiment mould that also at present comparatively not desirable chronic simple feared state of mind stress animal model.In view of this, develop a kind of mould that can successfully prepare chronic simple feared state of mind stress tests animal model, effectively to solve the difficult problem of above-mentioned frightened model preparation.
Summary of the invention
For above-mentioned situation, for overcoming the defective of prior art, the purpose of this utility model just provides a kind of mould of chronic simple feared state of mind stress tests animal model, the model that can effectively prepare chronic simple feared state of mind stress tests animal, realize to the chronic simple feared state of mind of animal stress experiment, observation problem.
The technical scheme that this utility model solves is, comprise the interchange case, conductive plate, base and pressure regulator, exchange the hollow cuboid that case is comprised of lucite, hollow cuboid is interior by 9 identical locellus of lucite spacer one-tenth size placed separately, wherein, locellus at center and four jiaos locellus are the electric shock Animal Lab., on each electric shock Animal Lab. loam cake is arranged, all the other 4 for not establishing the Animal Lab. of looking on of loam cake, the up and down smooth draw-in groove of depression of multilamellar symmetry is arranged on the sidewall around the electric shock Animal Lab., to regulate the height of loam cake, the rotating shaft that is connected with handle is equipped with at the center of each loam cake, it is indoor that the electric shock zoopery is stretched in the rotating shaft bottom, the fixed support of cross symmetry is equipped with in the lower end of rotating shaft, there is the fixedly rubber tip of usefulness each fixed support end, rubber tip places in the smooth draw-in groove of depression, loam cake and sidewall all around are fixed together, the animal that prevents from shocking by electricity escapes electric shock, on the sidewall aperture is arranged around 9 locellus, the bottom that exchanges case is contained on the base of reassembling type, conductive plate is installed in and exchanges the case bottom, and fixes by the two row's apertures that exchange the case bottom, and conductive plate links to each other with placing the pressure regulator that exchanges the outer bottom of case.
This utility model novel structure is unique, easy to use, can be effective to the zoopery of shocking by electricity, mould as the chronic simple feared state of mind stress tests animal model of preparation, by acoustoelectric combined mode, can make and look on Mus and directly produce fear memory by foot shock on the one hand, effectively control the adaptability of laboratory animal to stimulating, hide the body injury by climbing simultaneously; On the other hand, make it can not escape foot shock to the restriction of electric shock Mus, the frightened information exchange small holes that produces is passed to look on Mus, make and look on Mus and produce indirect fear memory.This mould is intuitively effective, can effectively solve the mould of chronic simple feared state of mind stress tests animal model, realizes the difficult problem to chronic simple feared state of mind stress tests animal preparation and observation, is the innovation on the zoopery equipment.
Description of drawings
Fig. 1 is three-dimensional structure diagram of the present utility model.
Fig. 2 is pressure regulator structure line graph of the present utility model.
Fig. 3 is electric shock Animal Lab. superstructure upward view of the present utility model.
Fig. 4 is lucite spacer structural front view of the present utility model (part).
Fig. 5 is that lucite spacer A-A of the present utility model is to sectional view.
The specific embodiment
Below in conjunction with accompanying drawing the specific embodiment of the present utility model is elaborated.
Shown in Fig. 1-5, this utility model comprises the interchange case, conductive plate, base and pressure regulator, exchange the hollow cuboid that case 1 is comprised of lucite, hollow cuboid is interior by 9 identical locellus of lucite spacer 6 one-tenth sizes placed separately, wherein, locellus at center and four jiaos locellus are the electric shock Animal Lab., on each electric shock Animal Lab. loam cake 2 is arranged, look on Animal Lab. 4 for what do not establish loam cake for all the other 4, the up and down smooth draw-in groove 10 of depression of multilamellar symmetry is arranged on the sidewall around the electric shock Animal Lab., to regulate the height of loam cake, the rotating shaft 13 that is connected with handle 3 is equipped with at the center of each loam cake, it is indoor that the electric shock zoopery is stretched in the rotating shaft bottom, the fixed support 12 of cross symmetry is equipped with in the lower end of rotating shaft, there is the fixedly rubber tip 15 of usefulness each fixed support end, rubber tip places in the smooth draw-in groove 10 of depression, loam cake and sidewall all around are fixed together, the animal that prevents from shocking by electricity escapes electric shock, on the sidewall aperture 11 is arranged around 9 locellus, the bottom that exchanges case 1 is contained on the base 14 of reassembling type, conductive plate is installed in and exchanges case 1 bottom, and fixes by the two row's apertures that exchange the case bottom, and conductive plate links to each other with placing the pressure regulator 5 that exchanges the outer bottom of case.
Described conductive plate is mutually to be intersected by positive conductive plate 7, negative conductive plate 9, and the plane conduction web plate that is fixed together and consists of through insulation fixing head 8; Consist of the animal wastes apotheca between conductive plate and base internal upper part; Exchanging the case bottom has fixedly two rounds of conductive plate, in the conductive electrode load hole of conductive plate;
The smooth draw-in groove that some row's apertures and depression are arranged on the lucite spacer of each locellus, the diameter of aperture both can initiatively be climbed for looking on animal, effectively to avoid looking on the body injury of animal, can not allow again animal limb touch next door cell animal by aperture, aperture can make looks on animal by initiatively climbing the escape foot shock, can make again it obtain to close on the frightened information that produced by the foot shock animal by vision, audition, olfactory sensation, make it produce the indirect fear memory.
The electric shock Animal Lab. of described interchange case top is useful on and regulates height, prevents that laboratory animal from hiding the removable lid of electric shock.
Central authorities' locellus and four jiaos of locellus are electric shock animal cell, and all the other four for looking on electric shock animal cell.There is a loam cake that conforms to the cell size each electric shock cell top.The electric shock cell has its size of smooth draw-in groove (can according to the height of the different adjustment loam cake of laboratory animal) of four depressions of some rows to conform to loam cake pointer rubber tip size around wall.The lucite spacer top has a cross indicator knob to rotate, and has the leader can pick up loam cake, and both are connected by a screw.The cross pointer is long to be the length of organic dividing plate, and the front end of pointer is a rubber tip.When reversing pointer, front end rubber tip and four draw-in grooves are matched, with fixing top dividing plate, make in its card and the draw-in groove to be unlikely to skid off.
Regulate loam cake at the height of locellus, the activity of restriction electric shock animal makes its inevitability foot shock, and the animal that can prevent from again shocking by electricity escapes from, and looks on animal thereby the frightened information that will produce passes to.Can at the differing heights of electric shock locellus wall draw-in groove be set according to the size of laboratory animal, make the loam cake can be according to animal body size adjustment height.
Exchanging the relative organic plates two sides of certain altitude, case bottom has row's aperture of conductive plate, two electric conductors is intersected be fixed in the bottom.The diameter of aperture is consistent with the conductive filament diameter that forms wire guide plate, and its interval not to be namely to allow the animal foot leak down, and does not also allow the foot of animal step down in simultaneously two adjacent conductive filaments and is advisable.
Exchange on the wire guide plate of case bottom all naked plates, make and look on animal and also accept foot shock, produce direct fear memory.
3, conductive plate is comprised of two demountable electric conductors intersections.Electric conductor is formed by connecting by electric conductor by some conductive filaments, and wherein conductive filament one end is fixed in the fixing hole of poly (methyl methacrylate) plate, and the other end is connected with electric conductor.The interval is consistent with the fixing hole interval of poly (methyl methacrylate) plate between the conductive plate adjacent conductive silk.An electric conductor links to each other with the positive pole of pressure regulator, and another conductive plate links to each other with the negative pole of pressure regulator, thereby conductive plate forms an energising plate, and animal can get shocked as long as contacted simultaneously positive and negative electric conductor.
According to varying in size of laboratory animal, mould and conductive plate size are also different.For larger conductive plate, it is fixing to add a plastic body (such as the insulation fixing plate 8 among the figure) in the middle of conductive plate, and row's aperture is arranged in the middle of it, and diameter is consistent with conductive filament, and conductive filament penetrates in the hole, to prevent the contact of cross-conduction silk both positive and negative polarity.
4, the base size is for just in time putting into the interchange case.Surrounded by the lucite face.Length is decided according to exchanging case with width, and its floor space size is for just in time putting into exchanging case, and height can be according to deciding with the distance of conductive plate.
This base is used for collecting and removing the feces of experimentation animal, in order to avoid the laboratory table of making dirty.
5, pressure regulator is the voltage output device that can export 0-250V, has wire that it is connected with conductive plate, can be used for the laboratory animal that shocks by electricity.
This utility model is to utilize the conditioned fear reaction principle, and stimulating with indirect sound by direct electric shock stimulates, and sets up acoustoelectric combined trained reflex psychological stress, in order to prepare chronic simple feared state of mind stress animal model.Make and look on animal and directly accept electricity irritation, make it produce direct fear memory, avoid its adaptability; In the time of electric shock, by the some apertures on the dividing plate, for the laboratory animal climbing, make it escape electric shock, reduce the body injury; Also can accept the frightened information of electric shock Mus because sent by foot shock by looking, smell, listening, produce the indirect fear memory; The dividing plate of electric shock cell top makes electric shock animal inevitability; Can according to the size of laboratory animal build, adjust the height of electric shock cell dividing plate.This utility model is cheap, can reuse, and is applied to scientific research and is applicable to different laboratory animals, is a kind of novel animal model mould.
Can be found out that by above-mentioned this utility model is with traditional interchange case of looking on the electric shocking method employing and the cleverly combination of shuttle box of shuttle box laboratory method employing.At first, removed and exchanged the insulation board that case is looked on the cell bottom, made and look on animal and can directly accept electricity irritation, made it produce direct fear memory; Secondly, add some apertures at interchange case central dividing plate, not only can pass through initiatively climbing to escape foot shock for looking on animal, look on animal by looking, smell, listen the frightened information of acceptance electric shock Mus because sent by foot shock but also can make, make it produce the indirect fear memory; Simultaneously above the electric shock cell that exchanges case, add an active clapboard, regulate it and highly make electric shock animal inevitability foot shock, make the electric shock animal produce frightened information and pass to and look on animal.And do not establish dividing plate above looking on cell, and escape foot shock for looking on the animal climbing, avoid causing the body injury of animal.Therefore adopt the animal model of this mould preparation can avoid the body injury, can effectively control again the adaptability of laboratory animal to stimulating, by the chronic simple feared state of mind stress animal model of acoustoelectric combined preparation.Through practical probation, effective, easy to use, efficiently solve the experiment of chronic simple feared state of mind stressed animal in the zoopery, the injury that can avoid again laboratory animal directly perceived, accurate, the reliability of assurance experiment are the innovations on the chronic simple feared state of mind stress tests animal model mould.
Claims (6)
1. the mould of a chronic simple feared state of mind stress tests animal model, comprise the interchange case, conductive plate, base and pressure regulator, it is characterized in that, exchange the hollow cuboid that case (1) is comprised of lucite, hollow cuboid is interior by 9 identical locellus of lucite spacer (6) one-tenth size placed separately, wherein, locellus at center and four jiaos locellus are the electric shock Animal Lab., on each electric shock Animal Lab. loam cake (2) is arranged, look on Animal Lab. (4) for what do not establish loam cake for all the other 4, the up and down smooth draw-in groove of depression (10) of multilamellar symmetry is arranged on the sidewall around the electric shock Animal Lab., the rotating shaft (13) that is connected with handle (3) is equipped with at the center of each loam cake, it is indoor that the electric shock zoopery is stretched in the rotating shaft bottom, the fixed support (12) of cross symmetry is equipped with in the lower end of rotating shaft, there is the fixedly rubber tip of usefulness (15) each fixed support end, rubber tip places in the smooth draw-in groove of depression (10), loam cake and sidewall all around are fixed together, on the sidewall aperture (11) is arranged around 9 locellus, the bottom that exchanges case (1) is contained on the base (14) of reassembling type, conductive plate is installed in and exchanges case (1) bottom, and arrange apertures by two of interchange case bottom and fix, conductive plate links to each other with placing the pressure regulator (5) that exchanges the outer bottom of case.
2. the mould of chronic simple feared state of mind stress tests animal model according to claim 1, it is characterized in that, described conductive plate is mutually to be intersected by positive conductive plate (7), negative conductive plate (9), and the plane conduction web plate that is fixed together and consists of through insulation fixing head (8).
3. the mould of chronic simple feared state of mind stress tests animal model according to claim 1 is characterized in that, consists of the animal wastes apotheca between described conductive plate and base internal upper part.
4. the mould of chronic simple feared state of mind stress tests animal model according to claim 1 is characterized in that, fixedly two rounds of conductive plate are arranged at described interchange case bottom, in the conductive electrode load hole of conductive plate.
5. the mould of chronic simple feared state of mind stress tests animal model according to claim 1 is characterized in that, the smooth draw-in groove of some row's apertures and depression is arranged on the lucite spacer of described each locellus.
6. the mould of chronic simple feared state of mind stress tests animal model according to claim 1 is characterized in that, the electric shock Animal Lab. of described interchange case top is useful on and regulates height, prevents that laboratory animal from hiding the removable lid of electric shock.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012204505463U CN202776557U (en) | 2012-09-06 | 2012-09-06 | Mold for animal model for chronic simple psychological fear stress experiment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012204505463U CN202776557U (en) | 2012-09-06 | 2012-09-06 | Mold for animal model for chronic simple psychological fear stress experiment |
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| Publication Number | Publication Date |
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| CN202776557U true CN202776557U (en) | 2013-03-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2012204505463U Expired - Fee Related CN202776557U (en) | 2012-09-06 | 2012-09-06 | Mold for animal model for chronic simple psychological fear stress experiment |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104622584B (en) * | 2015-03-13 | 2016-08-24 | 河南中医学院 | Animal chronic dinosaur egg fossil instrument based on desperate situation method |
| CN106448405A (en) * | 2016-11-18 | 2017-02-22 | 中国科学院深圳先进技术研究院 | Rodent animal height fear test experiment device and experiment method |
| CN106614335A (en) * | 2016-12-15 | 2017-05-10 | 南阳师范学院 | Method for building mouse depression model |
| CN109566428A (en) * | 2018-11-19 | 2019-04-05 | 中国科学院深圳先进技术研究院 | A kind of experimental provision and experimental method of the behavior of animal instinct fear |
| CN114223574A (en) * | 2021-12-16 | 2022-03-25 | 中国科学院深圳先进技术研究院 | Animal selective behavior output detection device and experimental method |
| CN114451326A (en) * | 2022-02-10 | 2022-05-10 | 河南中医药大学 | Animal fear stress response detection system |
| CN114514881A (en) * | 2021-12-16 | 2022-05-20 | 中国科学院深圳先进技术研究院 | Experimental equipment |
-
2012
- 2012-09-06 CN CN2012204505463U patent/CN202776557U/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104622584B (en) * | 2015-03-13 | 2016-08-24 | 河南中医学院 | Animal chronic dinosaur egg fossil instrument based on desperate situation method |
| CN106448405A (en) * | 2016-11-18 | 2017-02-22 | 中国科学院深圳先进技术研究院 | Rodent animal height fear test experiment device and experiment method |
| CN106614335A (en) * | 2016-12-15 | 2017-05-10 | 南阳师范学院 | Method for building mouse depression model |
| CN109566428A (en) * | 2018-11-19 | 2019-04-05 | 中国科学院深圳先进技术研究院 | A kind of experimental provision and experimental method of the behavior of animal instinct fear |
| WO2020103261A1 (en) * | 2018-11-19 | 2020-05-28 | 中国科学院深圳先进技术研究院 | Experiment device and experiment method for animal instinct fear behavior |
| CN114223574A (en) * | 2021-12-16 | 2022-03-25 | 中国科学院深圳先进技术研究院 | Animal selective behavior output detection device and experimental method |
| CN114514881A (en) * | 2021-12-16 | 2022-05-20 | 中国科学院深圳先进技术研究院 | Experimental equipment |
| CN114451326A (en) * | 2022-02-10 | 2022-05-10 | 河南中医药大学 | Animal fear stress response detection system |
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Legal Events
| Date | Code | Title | Description |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130313 Termination date: 20140906 |
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| EXPY | Termination of patent right or utility model |