CN103623491A - Animal sleep deprivation device and application thereof - Google Patents
Animal sleep deprivation device and application thereof Download PDFInfo
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- CN103623491A CN103623491A CN201310545829.5A CN201310545829A CN103623491A CN 103623491 A CN103623491 A CN 103623491A CN 201310545829 A CN201310545829 A CN 201310545829A CN 103623491 A CN103623491 A CN 103623491A
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Abstract
The invention relates to an animal sleep deprivation device and application of the animal sleep deprivation device. The animal sleep deprivation device is provided with a stimulation occurrence base plate and a multi-lead program control instrument. The stimulation occurrence base plate is sequentially provided with a sieve plate, a stimulation plate and a supporting plate from top to bottom. The sieve plate is provided with sieve holes. The upper end face of the stimulation plate is provided with stimulation columns which correspond to the sieve holes in position and can penetrate through the sieve holes. A mechanical power device is arranged between the stimulation plate and the supporting plate, and is connected with the multi-lead program control instrument through a guide line. The multi-lead program control instrument is provided with a switch key, a guide line interface and a parameter adjusting panel. When the animal sleep deprivation device is used for building an insomnic animal model, no harmful stimulation is produced on experimental animals, experimental results are more accurate and reliable, the repeatability is good, multiple insomnia models can be obtained, and operation is convenient. The animal sleep deprivation device is simple in structure and low in cost.
Description
Technical field
The present invention relates to a kind of animal experiment device capable, specifically, is that a kind of animal sleep is deprived device and application thereof.
Background technology
Insomnia is puzzlement modern's clinical common disease and problem, it is reported, the adult in the whole world approximately 30% suffers from insomnia, and China is 20%-30%, and wherein 1/3 genus severe insomnia, so insomnia's research and preventing and controlling are extremely urgent.
In biomedical research, we usually depend on animal model and come confirmatory experiment hypothesis and clinical hypothesis, to be more effectively familiar with generation, law of development and the research prophylactico-therapeutic measures of human diseases.Therefore, use animal model to become in modern biomedical research a very important experimental technique and means, and rat and mice are current the most frequently used laboratory animals, account for laboratory animal utilization rate more than 90%.
At present insomnia animal model constructing method mainly contains four large classes: 1) water environment platform method, and this device is that animal is placed on relatively little platform, circumfusion is slightly lower than the water of platform.Its principle is to utilize rat to enter the sleep of fast quick-action eye, and holotonia declines, and face is stained with or is dipped into the water surface and wakes up with a start suddenly, and this behavior can occur repeatedly.This device distinct disadvantage is to make a series of stimulations such as animal is isolated, braking, immersion, and can only be for depriving REM sleep; 2) forced movement method, the common feature of this method is to force rat ceaselessly to move by power set, and it cannot be fallen asleep, what have the meaning of representing is that horizontal rotating disc sleep deprivation method and interruption treadmill are deprived method.This device shortcoming is that experimental provision is complicated, and animal is subject to the series reaction that prolonged exercise causes body; 3) drug model, reaches insomnia object by administration, and shortcoming is that poisonous side effect of medicine is obvious, and long term administration labor workload is large; 4) stimulus method, utilizes sense of touch, sound or light to stimulate, and makes animal cannot enter sleep, can be by patting gently rat cage or utilizing sonic stimulation to promote rat to keep clear-headed.Such device shortcoming is the parallel poor repeatability of experiment, and labor workload super large, is difficult to build chronic model.
In sum, need the suffered pessimal stimulation of a kind of animal body badly few, can obtain sleep deprivation model more accurately, little on experimental result impact, and can build multiple insomnia animal model, simple in structure, the device and method of convenient operation, but about these class apparatus and method, have not been reported at present.
Summary of the invention
The object of the invention is for deficiency of the prior art, provide a kind of animal sleep to deprive device.
One object more of the present invention is to provide above-mentioned animal sleep to deprive the purposes of device.
Another object of the present invention is that a kind of method that builds insomnia animal model is provided.
For achieving the above object, the technical scheme that the present invention takes is:
Animal sleep is deprived a device, and it comprises stimulates generation backing plate and lead program control instrument more; Described stimulation generation backing plate is provided with sieve plate, stimulus board and supporting plate from top to bottom successively, described sieve plate is provided with sieve aperture, it is corresponding with described sieve aperture position and can be through the stimulation post of sieve aperture that described stimulus board upper surface is provided with, between described stimulus board and supporting plate, be provided with mechanical driver unit, described mechanical driver unit by wire with lead program control instrument more and be connected.
Preferably, the described program control instrument of leading is provided with on & off switch, conductor interface and parameter adjusting panel more.
Preferably, described mechanical driver unit is provided with sleeve pipe, power transmission shaft, engine and holder, described sleeve pipe is fixed on the upper surface of supporting plate, and described engine is fixed on the lower surface of stimulus board by holder, and described power transmission shaft lower end is socketed in engine, upper end is socketed in sleeve pipe.
Preferably, described sieve aperture is circular, and described stimulation post is provided with columniform stimulation bar and conical stimulation head, and described sieve aperture and stimulation post are all array way and arrange.
Preferably, between described sieve plate and supporting plate, be provided with support bar.
Preferably, described animal sleep is deprived device and is also provided with cage for animal, and described stimulation generation backing plate is placed in the inside of cage for animal, described leads the outside that program control instrument is placed in cage for animal more.
Preferably, an edge of described supporting plate is provided with the wire column that hollow and upper end extend to cage for animal top, and described wire is through in wire column.
For realizing above-mentioned second object, the technical scheme that the present invention takes is:
As above arbitrary described animal sleep is deprived the application of device in building insomnia animal model.
Described insomnia animal model can be acute sleep deprivation model, subacute sleep deprivation model, chronic sleep deprivation model, complete sleep deprivation model or partial sleep deprivation model.
For realizing above-mentioned the 3rd object, the technical scheme that the present invention takes is:
Build a method for insomnia animal model, utilize as above arbitrary described animal sleep to deprive device and give animal and stimulate.Its concrete steps can comprise:
1) for cage for animal is selected the stimulation generation backing plate matching, and wire is connected to and leads program control instrument more;
2) lead program control instrument more connect power supply, experiment parameter is set;
3) press on & off switch, laboratory animal is stimulated, according to experimental program, determine duration of experiment.
In experiment, can access according to actual needs one or more stimulates generation backing plate.
The present invention takes to stimulate post to give laboratory animal external force to be stimulated, and the intensity, the frequency that by many helical pitches control instrument control system, stimulate and hold time, thereby obtains insomnia animal model.Its advantage is:
1, this kind of stimulation mode can not produce pessimal stimulation to laboratory animal, do not affect laboratory technician's administration and changes water and change the water inlet and movable of normally taking food of food and laboratory animal, and the insomnia animal model of acquisition is close to true wakefulness state, and experimental result more accurately and reliably;
2, by the adjustment to stimulus intensity, frequency, can build multiple insomnia model, as acute sleep deprivation model, subacute sleep deprivation model, chronic sleep deprivation model, by the adjustment that stimulation is held time, can build complete sleep deprivation model and partial sleep deprivation model, more convenient insomnia be carried out to deep research;
3, by leading program control instrument, can regulate each parameter, experimental result is parallel reproducible, and experimental implementation is easy, time saving and energy saving more;
4, overall structure is simple, and without setting up special experiment porch, the stimulation generation backing plate that the laboratory animal cage of main flow is equipped with respective model gets final product work, has significantly improved conventional efficient, has reduced experimental cost.
Accompanying drawing explanation
Accompanying drawing 1 is that animal sleep of the present invention is deprived apparatus structure schematic diagram.
Accompanying drawing 2 is mechanical driver unit structural representations.
The specific embodiment
Below in conjunction with accompanying drawing, the specific embodiment provided by the invention is elaborated.
The Reference numeral and the ingredient that in accompanying drawing, relate to are as follows:
1. cage for animal 2. stimulates generation backing plate
21. sieve plate 211. sieve apertures
22. stimulus boards 221. stimulate post
2211. stimulate bar 2212. to stimulate head
23. supporting plate 24. support bars
25. wire column 26. mechanical driver units
261. sleeve pipe 262. power transmission shafts
263. engine 264. holders
27. wires more than 3. are led program control instrument
31. on & off switch 32. conductor interfaces
33. display lamps 34. regulate panel
341. stimulate post ascensional range to regulate panel 342. stimulus durations to regulate panel
343. stimulate the intermittent time
Please refer to Fig. 1, Fig. 1 is that animal sleep of the present invention is deprived apparatus structure schematic diagram.Described animal sleep is deprived device and is provided with cage for animal 1, stimulates generation backing plate 2 and lead program control instrument 3 more.Described cage for animal 1 is cuboid cage.Described stimulation generation backing plate 2 is placed in cage for animal 1.Stimulate generation backing plate 2 to be provided with successively sieve plate 21, stimulus board 22 and supporting plate 23 from top to bottom.Described sieve plate 21 is rectangle, is provided with some sieve apertures 211 above, and described sieve aperture 211 is circular, is array mode and arranges.Described stimulus board 22 is also rectangle, and upper surface is provided with some stimulation posts 221, and described stimulation post 221 is also array mode to be arranged, corresponding one by one with sieve aperture 211 positions.Stimulate post 221 to be provided with and stimulate bar 2211, described stimulation bar 2211 be cylinder, and top is provided with cone shape stimulation 2212, and the bottom surface diameter of described stimulation 2212 and the bottom surface diameter of stimulation bar 2211 are all less than the diameter of sieve aperture 211.Described supporting plate 23 is also rectangle, is placed on cage for animal 1 bottom surface.Three corners corresponding with sieve plate 21, three corners of supporting plate 23 are connected by support bar 24, and described support bar 24 is solid.The 4th edge of described supporting plate 23 is provided with wire column 25, described wire column 25 inner hollow, and upper end extends to the top of cage for animal 1.Between described stimulus board 22 and supporting plate 23, be provided with mechanical driver unit 26(not shown), described mechanical driver unit 26 connects wire 27, described wire 27, through the inside of wire column 25, passes in cage for animal 1, is connected with the program control instrument 3 of leading of cage for animal 1 outside more.The described program control instrument 3 of leading is provided with on & off switch 31, conductor interface 32, display lamp 33, regulates panel 34 more.Described conductor interface 32 is for connecting wire 27, and each conductor interface 32 correspondence arranges a display lamp 33, and described adjusting panel 34 comprises stimulates post ascensional range to regulate panel 341, stimulus duration regulate panel 342 and stimulate the intermittent time 343.
Please refer to Fig. 2, Fig. 2 is mechanical driver unit structural representation.Described mechanical driver unit 26 comprises sleeve pipe 261, power transmission shaft 262, engine 263 and holder 264.Described sleeve pipe 261 is fixed on the upper surface of supporting plate 23, and described engine 263 is fixed on the lower surface of stimulus board 22 by holder 264, and described power transmission shaft 262 lower ends are socketed in engine 263, upper end is socketed in sleeve pipe 261.
It should be noted that, the rearging cage for zoopery that described cage for animal 1 is main flow, is not limited only to rectangular shape; Described stimulation generation backing plate 2 and lead program control instrument 3 more and can realize deprivation experiment animal sleep, described stimulation generation backing plate 2 is placed in suitable cage for animal 1 and gets final product work, without setting up special experiment porch, not affecting laboratory technician's administration changes water and changes the water inlet and movable of normally taking food of food and laboratory animal, the insomnia model obtaining is more close to real wakefulness state, and result more accurately and reliably; Described sieve plate 21 directly contacts with laboratory animal or directly contacts with laboratory animal by bedding and padding; The specification of described sieve aperture 211 can be definite according to laboratory animal build, and if laboratory animal is SD rat, described sieve aperture 211 apertures can be set to 1cm, pitch-row 5cm.Described sieve aperture 211 can be circular other shape in addition, guarantees to stimulate post 221 to pass; The shape of described stimulation post 221 is also not limited only to cylinder to stimulate bar 2211 to add cone to stimulate 2212, can be also other shape, as long as can produce and stimulate for laboratory animal, reach the object of disturbing sleep; It is undue sharp-pointed that described stimulation 2212 should be avoided, in order to avoid stab laboratory animal; Described support bar 24 is for supporting screening plate 21 and supporting plate 23; Described wire column 25, for holding wire 27, plays a protective role; Described mechanical driver unit 26 can be realized moving up and down of stimulus board 22, and its structure is not limited only to the present embodiment, as long as can realize the machinery of height transmission, all can; Described leads program control instrument 3 for controlling the motion of mechanical driver unit 26 more, and then the indirect state that stimulates post 221 of controlling, giving laboratory animal stimulates, described stimulation post ascensional range regulates panel 341, stimulus duration to regulate panel 342, stimulates the intermittent time 343 to be respectively used to regulate and arrange the parameters such as stimulus intensity, stimulus frequency and intermittent time, be convenient to experiment condition accurately to control, experimental result is parallel reproducible; Described conductor interface 32 can arrange a plurality of, for connecting and controlling many, stimulates generation backing plate 2, expands experiment sample.Described program control instrument 3 power supplys of leading are common 220V alternating current more.Animal sleep of the present invention is deprived device can be by isoparametric setting of stimulus intensity, stimulus frequency and intermittent time built to acute sleep deprivation model, subacute sleep deprivation model and chronic sleep deprivation model, and sleep deprivation model and partial sleep deprivation model completely.
1) according to cage for animal 1, select the stimulation generation backing plate 2 matching, backing plate 2 is occurred in stimulation and put into cage for animal 1, wire 27 is passed from cage for animal 1 through after wire column 25, connect and lead program control instrument 3 more;
2) will lead program control instrument 3 more be connected with power supply, the state of viewing lamp 33 determines that wire 27 successfully connects, then by regulating panel 34 that each experiment parameter is set;
3) press on & off switch 31, starting provides stimulation to laboratory animal, according to experimental program, determines duration of experiment.
In experiment, can access according to actual needs one or more stimulates generation panel 2.
1) buy some of 6-8 week SD rats, with Morris water maze, screen out the animal of learning and memory poor ability, retain 12.Be divided at random each 6 of experimental group (giving stimulating group) and matched groups (not giving stimulating group), be divided into 2 mouse cages.Use normal size Mus group support cage M-5 type (specification 475 * 350 * 200mm), select the stimulation generation backing plate that supporting plate specification is 46.5 * 34 * 19cm.
2) many helical pitches control instrument parameter is set: explore and adjust stimulation amplitude 1-3cm, stimulate/intermittence, parameter was as 3s on/12s off, 1min on/4min off or 15min on/60 min off, every day sleep deprivation 18h(16:00-every day 10:00 next day), rear recovery sleep 6h(10:00-16:00 on the same day).Backing plate is occurred in stimulation and be placed in mouse cage, switch on power and get final product work, normal feeding is fed water.
3) experiment the 1st day, the 3rd day, the 1st week, the 4th week and the 12nd week, with electroencephalogram, electromyogram etc., measure SD Sleep in Rats pattern and time, record rat awakening time (Wake), total sleep time (Total sleep), REM sleep time (REM sleep) and non rapid eye movement sleep, NREMS (NREM sleep) time in 8 hours.
4) analytic record parameters, records complete sleep deprivation and partial sleep and deprives relevant parameter.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, do not departing under the prerequisite of the inventive method; can also make some improvement and supplement, these improvement and supplement and also should be considered as protection scope of the present invention.
Claims (10)
1. animal sleep is deprived a device, it is characterized in that, it comprises stimulates generation backing plate and lead program control instrument more; Described stimulation generation backing plate is provided with sieve plate, stimulus board and supporting plate from top to bottom successively, described sieve plate is provided with sieve aperture, it is corresponding with described sieve aperture position and can be through the stimulation post of sieve aperture that described stimulus board upper surface is provided with, between described stimulus board and supporting plate, be provided with mechanical driver unit, described mechanical driver unit by wire with lead program control instrument more and be connected.
2. animal sleep according to claim 1 is deprived device, it is characterized in that, the described program control instrument of leading is provided with on & off switch, conductor interface and parameter adjusting panel more.
3. animal sleep according to claim 1 is deprived device, it is characterized in that, described mechanical driver unit is provided with sleeve pipe, power transmission shaft, engine and holder, described sleeve pipe is fixed on the upper surface of supporting plate, described engine is fixed on the lower surface of stimulus board by holder, described power transmission shaft lower end is socketed in engine, upper end is socketed in sleeve pipe.
4. animal sleep according to claim 1 is deprived device, it is characterized in that, described sieve aperture is circular, and described stimulation post is provided with columniform stimulation bar and conical stimulation head, and described sieve aperture and stimulation post are all array way and arrange.
5. animal sleep according to claim 1 is deprived device, it is characterized in that, between described sieve plate and supporting plate, is provided with support bar.
6. animal sleep according to claim 1 is deprived device, it is characterized in that, described animal sleep is deprived device and is also provided with cage for animal, and described stimulation generation backing plate is placed in the inside of cage for animal, described leads the outside that program control instrument is placed in cage for animal more.
7. animal sleep according to claim 6 is deprived device, it is characterized in that, described edge of supporting plate is provided with the wire column that hollow and upper end extend to cage for animal top, and described wire is through in wire column.
8. the arbitrary described animal sleep of claim 1-7 is deprived the application of device in building insomnia animal model.
9. application according to claim 8, is characterized in that, described insomnia animal model is acute sleep deprivation model, subacute sleep deprivation model, chronic sleep deprivation model, complete sleep deprivation model or partial sleep deprivation model.
10. a method that builds insomnia animal model, is characterized in that, utilizes the arbitrary described animal sleep of claim 1-7 to deprive device and gives animal stimulation.
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| CN201310545829.5A CN103623491B (en) | 2013-11-07 | 2013-11-07 | A kind of animal sleep deprivation device and application thereof |
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| CN109699506A (en) * | 2019-01-23 | 2019-05-03 | 浙江中医药大学 | A kind of rats and mice sleep deprivation equipment |
| CN110338784A (en) * | 2018-04-02 | 2019-10-18 | 中国科学院深圳先进技术研究院 | Test method, apparatus, computer equipment and the storage medium of sleep deprivation effect |
| CN110338780A (en) * | 2018-04-02 | 2019-10-18 | 中国科学院深圳先进技术研究院 | Wireless feedback regulator control system and method |
| CN110338789A (en) * | 2018-04-02 | 2019-10-18 | 中国科学院深圳先进技术研究院 | Biofeedback regulator control system and method |
| WO2020042655A1 (en) * | 2018-08-29 | 2020-03-05 | 中山大学 | Method for constructing sleep deprivation-based yin-deficiency fire-excess type oral ulcer animal model |
| CN114698558A (en) * | 2022-03-09 | 2022-07-05 | 河南中医药大学 | Sleep deprivation squirrel cage device for electric shock rats and mice |
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| CN110338789A (en) * | 2018-04-02 | 2019-10-18 | 中国科学院深圳先进技术研究院 | Biofeedback regulator control system and method |
| WO2020042655A1 (en) * | 2018-08-29 | 2020-03-05 | 中山大学 | Method for constructing sleep deprivation-based yin-deficiency fire-excess type oral ulcer animal model |
| CN109699506A (en) * | 2019-01-23 | 2019-05-03 | 浙江中医药大学 | A kind of rats and mice sleep deprivation equipment |
| CN114698558A (en) * | 2022-03-09 | 2022-07-05 | 河南中医药大学 | Sleep deprivation squirrel cage device for electric shock rats and mice |
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