CN103300937A - Acousto-optical-electric programmable random stimulator - Google Patents
Acousto-optical-electric programmable random stimulator Download PDFInfo
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- CN103300937A CN103300937A CN2012100641637A CN201210064163A CN103300937A CN 103300937 A CN103300937 A CN 103300937A CN 2012100641637 A CN2012100641637 A CN 2012100641637A CN 201210064163 A CN201210064163 A CN 201210064163A CN 103300937 A CN103300937 A CN 103300937A
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Abstract
The invention belongs to the technical field of experimental devices, relates to an experiment device for preparing an experimental animal model, in particular to an acousto-optical-electric programmable random stimulator, which consists of a singlechip, a display screen, an input keyboard, a voltage sampling unit, a voltage regulating transformer, an electric shock control unit, an acousto-optical control unit, an electric shock mouse cage and acousto-optical equipment, wherein the singlechip is connected with the display screen, the input keyboard, the voltage sampling unit, a motor control power supply and the acousto-optical control unit respectively; an external power supply is used for supplying power to the voltage sampling unit and the motor control power supply through the voltage regulating transformer; the motor control power supply is connected with the electric shock mouse cage; the acousto-optical control unit is connected with the acousto-optical equipment. As is proved by a using result, due to the adoption of the acousto-optical-electric programmable random stimulator, the learning and memorizing processes of the experimental animal model can be hindered, the formation of conditioned reflex is delayed, and the modeling efficiency is effectively increased; the stimulator can be applied to preparation of stress-induced hypertension animal models.
Description
Technical field
The invention belongs to the experimental provision technical field, relate to the experimental provision for the preparation of experimental animal model, be specifically related to a kind of sound, light, electrically programmable random stimulus device, this stimulator can be used for preparing the irritability hypertension animal model.
Background technology
Zoopery is current biomedicine, pharmaceutical field scientific research indispensable research means and method, particularly is widely used in the multiple subjects such as pharmacology, physiology, neurobiology, zoology.Laboratory animal is to carry out the essential condition of exploring biosis and essence thereof, important foundation and the supporting condition of life science, indirect research by means of animal model, can change consciously the factor that those can not or be difficult for eliminating under field conditions (factors), in order to observe more accurately the experimental result of model and compare research with human diseases, help more conveniently, more effectively be familiar with the regularity of occurrence and development of human diseases, the research prophylactico-therapeutic measures.Therefore the animal model function and significance that in biomedicine, has irreplaceable " exploration ".Those skilled in the art are known: animal model should possess with human diseases similarity, model should possess the characteristics such as repeatability, hypersensitivity, comparability and objective quantitative, prepares simultaneously model and also answers standardization and standardization.
Hypertension is the most general, the modal cardiovascular disease in the present whole world, there is statistics to show, China 18 years old and above prevalence of hypertension rate reach 18.8%, predict that whole world trouble hypertension number in 2025 will reach 1,500,000,000, account for 30% of world's total number of persons, therefore, set up hypertension animal model for the hypertensive generation of research, development mechanism, seek the hypertensive novel targets for the treatment of and labelled molecule, formulate New Policy, finding novel drugs and carrying out the treatment of individuation mutiple targets has extremely important realistic meaning.
The method that the device of the preparation hypertension animal model that uses in the prior art adopts the foot shock of Fixed Time Interval to stimulate in conjunction with noise mostly, have following defective in the described method: often occur the modeling animal produce the conditionality reflection and reduce it stress degree, make the defectives such as modeling time lengthening, modeling Efficiency Decreasing, so that affect the accuracy of experimental studies results.
The application is through long-term experimentation, a kind of sound, light, electrically programmable random stimulus apparatus have been worked out, this device can overcome the defective in the present preparation hypertension animal model technology, can obstruct the process of animal learning, memory, delay the time of formation condition reflection, effectively improve modeling efficient.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of device for preparing hypertension animal model, be specifically related to a kind of sound, light, electrically programmable random stimulus device, this stimulator can obstruct study, the Memory Process of animal in the modeling process, delay the time of formation condition reflection, effectively improve modeling efficient.This device can be used for preparing the irritability hypertension animal model.
Particularly, a kind of sound of the present invention, light, electrically programmable random stimulus device, it is characterized in that, formed by single-chip microcomputer 1, display screen 2, input keyboard 3, voltage sampling unit 4, adjustable transformer 5, electric shock control unit 6, controlled by sound and light unit 7, electric shock mouse cage 8 harmony light devices 9; Described single-chip microcomputer 1 connects respectively display screen 2, input keyboard 3, voltage sampling unit 4, Electric Machine Control power supply 6 harmony light control units 7, external power supply is powered to voltage sampling unit 4 and Electric Machine Control power supply 6 by adjustable transformer 5, Electric Machine Control power supply 6 connects electric shock mouse cage 8, and described controlled by sound and light unit 7 connects acousto-optic equipment 9.
Among the present invention, described single-chip microcomputer 1 is the control assembly of this stimulator, and it receives stimulus parameter and action command from input keyboard 3, and control electric shock control unit 6 harmony light control units 7 are implemented the stimulation of different mode; In one embodiment of the present of invention, control electric shock control unit 6 harmony light control units 7 are implemented the stimulation of 3 kinds of different modes to laboratory animal;
The program of described single-chip microcomputer 1 uses the C51 assembler language to write, and adopts intervalometer to start the ADC sampling, and produces interrupt requests by ADC sampling end signal, and in the interrupt response subprogram, CPU reads in sampled value; Stimulus intervals timing and total time timing are finished by intervalometer, and stimulus intervals and stimulation mode are finished by random number generation software module; In one embodiment of the present of invention, described single-chip microcomputer 1 is selected the C51F005 single-chip microcomputer;
Among the present invention, described display screen 2 shows the numerical value of keying in when the parameters state, shows stimulation time, stimulation voltage, stimulus intervals and stimulation mode in the time of in working order; In one embodiment of the present of invention, described display screen 2 adopts 480X64 lattice lcd screen;
Among the present invention, but described input keyboard 3 input stimulus parameters, and stimulus parameter comprises:
(1) stimulate total time,
(2) electric shock pulse width,
(3) stimulate largest interval and minimum interval,
(4) ratio between acousto-optic-electric complex stimulus, acousto-optic stimulation, three kinds of stimulation modes of electricity irritation;
Among the present invention, described voltage sampling unit 4 is comprised of 100: 1 step-down transformer L4, commutation diode D3 and capacitor C; The DC voltage of voltage sampling unit output is connected to the input pin ADC0 of the analog-digital converter of single-chip microcomputer 1, and program is calculated the actual output amplitude of adjustable transformer according to sampled value, and shows at display screen 2;
Among the present invention, described adjustable transformer 5 is regulated stimulation voltage, and its range of accommodation is to line voltage from 0V;
Among the present invention, described electric shock control unit 6 mainly is comprised of elements such as relay, resistance, audions; Wherein, D1 is discharge diode, and described relay L1 closure makes that loudspeaker pipe, the flash of light of red bulb, from the signal of the P3.0 port of single-chip microcomputer 1 open and-shut mode through the drive circuit control relay; Described drive circuit is comprised of pliotron Q1, resistance R 1 and potentiometer W1 among the NPN;
Among the present invention, described controlled by sound and light unit 7 mainly is comprised of elements such as relay, resistance, audions; Wherein, D2 is discharge diode, and relay L2 closure makes the electric shock mouse cage charged, from the signal of the P3.1 port of single-chip microcomputer 1 open and-shut mode through the drive circuit control relay; Described drive circuit is comprised of pliotron Q2, resistance R 2 and potentiometer W2 among the NPN;
Among the present invention, the bottom of described electric shock mouse cage 8 is comprised of two groups of exposed metal bars, two groups of metal bars connect respectively power supply the two poles of the earth, arrange by the both positive and negative polarity adjacent sequential, to improve the probability that animal gets shocked in the cage; In one embodiment of the present of invention, the overall dimensions of electric shock mouse cage 8 is 22*22*26cm
2
During use, experimental rat is put into the mouse attacking cage 8 that the bottom is covered with the copper grid, place one in each cage, logical discontinuity alternating current on the copper grid, electric shock voltage is 50-80V, be 50ms each conduction time; Following the intensity of being sent by buzzer in electric shock is that 90-100db, persistent period are the noise of 50ms, reflects in order to set up the condition; The blanking time of In The Rat Sole electric shock and noise stimulation and combination for noise adds the vola electric shock, only have noise to stimulate by computer random control sometimes sometimes; Stimulate twice every day, each 2h, the time, midfeather 4h continuously stress 14d.
Use is the result show, sound of the present invention, light, electrically programmable random stimulus device, the process of can obstruct experimental animal study, remembering delays the time that formation condition reflects, Effective Raise modeling efficient can be used for making chronic, the acute hypertension model of various laboratory animals.
This sound, light, electrically programmable random stimulus device have the following advantages:
(1) is a kind of device of simple in structure, easy to use, preparation irritability hypertension animal model that effect is superior;
(2) this stimulator adopts integral structure, and soft and hardware organically combines;
(3) stimulus intervals of original creation and the randomness characteristics of stimulation mode;
(4) arbitrariness of stimulus parameter setting is greatly widened application surface;
(5) adopt liquid crystal display screen to show many information, make man-machine interaction more convenient;
(6) stimulation power is large, can connect 10 electric shock mouse cages, Effective Raise molding speed.
For the ease of understanding, below will describe in detail sound of the present invention, light, electrically programmable random stimulus device by concrete the drawings and specific embodiments.It needs to be noted, these descriptions only are exemplary descriptions, do not consist of limitation of the scope of the invention.According to the discussion of this description, many variations of the present invention, change all are apparent concerning one of ordinary skill in the art.
Description of drawings
Fig. 1 is structured flowchart of the present invention,
Wherein, 1 be single-chip microcomputer, 2 for LCDs, 3 for input keyboard, 4 for the voltage sampling unit, 5 for adjustable transformer, 6 for the electric shock control unit, 7 for the controlled by sound and light unit, 8 for electric shock mouse cage, 9 for acousto-optic equipment.
Fig. 2 is electric principle sketch of the present invention,
Wherein, D1 is discharge diode, and D2 is discharge diode, and D3 is commutation diode.
Fig. 3 is software flow pattern of the present invention.
Specific embodiment
Embodiment 1
Shown in Fig. 1～3, this sound, light, electrically programmable random stimulus device are comprised of single-chip microcomputer 1, display screen 2, input keyboard 3, voltage sampling unit 4, adjustable transformer 5, electric shock control unit 6, controlled by sound and light unit 7, electric shock mouse cage 8 harmony light devices 9; Described single-chip microcomputer 1 connects respectively display screen 2, input keyboard 3, voltage sampling unit 4, Electric Machine Control power supply 6 harmony light control units 7, external power supply is powered to voltage sampling unit 4 and Electric Machine Control power supply 6 by adjustable transformer 5, Electric Machine Control power supply 6 connects electric shock mouse cage 8, and described controlled by sound and light unit 7 connects acousto-optic equipment 9;
Described single-chip microcomputer 1 is selected the C51F005 single-chip microcomputer, and it is the control assembly of this stimulator, receives stimulus parameter and action command from input keyboard 3, and control electric shock control unit 6 harmony light control units 7 are implemented the stimulation of different mode; The program of this single-chip microcomputer 1 uses the C51 assembler language to write, and adopts intervalometer to start the ADC sampling, and produces interrupt requests by ADC sampling end signal, and in the interrupt response subprogram, CPU reads in sampled value; Stimulus intervals timing and total time timing are finished by intervalometer, and stimulus intervals and stimulation mode are finished by random number generation software module;
Described display screen 2 adopts 480X64 lattice lcd screen, and it shows the numerical value of keying in when the parameters state, shows stimulation time, stimulation voltage, stimulus intervals and stimulation mode in the time of in working order;
But described input keyboard 3 input stimulus parameters, stimulus parameter comprises:
(1) stimulate total time, (2) electric shock pulse width, (3) stimulate largest interval and minimum interval, the ratio between (4) acousto-optic-electric complex stimulus, acousto-optic stimulation, three kinds of stimulation modes of electricity irritation;
Described voltage sampling unit 4 is comprised of 100: 1 step-down transformer L4, commutation diode D3 and capacitor C; The DC voltage of voltage sampling unit output is connected to the input pin ADC0 of the analog-digital converter of single-chip microcomputer 1, and program is calculated the actual output amplitude of adjustable transformer according to sampled value, and shows at display screen 2; Described adjustable transformer 5 is regulated stimulation voltage, and its range of accommodation is to line voltage from 0V; Described electric shock control unit 6 mainly is comprised of elements such as relay, resistance, audions; Wherein, D1 is discharge diode, and described relay L1 closure makes that loudspeaker pipe, the flash of light of red bulb, from the signal of the P3.0 port of single-chip microcomputer 1 open and-shut mode through the drive circuit control relay; Described drive circuit is comprised of pliotron Q1, resistance R 1 and potentiometer W1 among the NPN;
Described controlled by sound and light unit 7 mainly is comprised of elements such as relay, resistance, audions; Wherein, D2 is discharge diode, and relay L2 closure makes the electric shock mouse cage charged, from the signal of the P3.1 port of the C51F005 open and-shut mode through the drive circuit control relay; Described drive circuit is comprised of pliotron Q2, resistance R 2 and potentiometer W2 among the NPN;
The overall dimensions of described electric shock mouse cage 8 is 22*22*26cm
2, its bottom is comprised of two groups of exposed metal bars, and two groups of metal bars connect respectively the two poles of the earth of power supply, press the both positive and negative polarity adjacent sequential and arrange, to improve the probability that animal gets shocked in the cage.
During use, rat is put into the mouse attacking cage 8 that the bottom is covered with the copper grid, place one in each cage, logical discontinuity alternating current on the copper grid, electric shock voltage is 50-80V, be 50ms each conduction time; Following the intensity of being sent by buzzer in electric shock is that 90-100db, persistent period are the noise of 50ms, reflects in order to set up the condition; The blanking time of In The Rat Sole electric shock and noise stimulation and combination for noise adds the vola electric shock, only have noise to stimulate by computer random control sometimes sometimes; Stimulate twice every day, each 2h, the time, midfeather 4h continuously stress 14d.
Embodiment 2 preparation irritability hypertension animal models
In conjunction with noise stimulation set up the condition reflection preparation irritability hypertension animal model, 200-220g SD rat is put into the electric shock cage (each cage is placed) that the bottom is covered with the copper grid with foot shock; Electric shock cage size is 22*22*26cm2, passes to the discontinuity alternating current on the copper grid, and electric shock voltage is 50-80V, and be 50ms each conduction time; Following the intensity of being sent by buzzer in electric shock is that 90-100db, persistent period are the noise of 50ms, reflects in order to set up the condition; The blanking time of In The Rat Sole electric shock and noise stimulation and combination namely sometimes for noise adds the vola electric shock, only have noise to stimulate by computer random control sometimes.Stimulate twice every day, each 2h, the time is generally 8 a.m.-10 point, 2 pm-4 point, midfeather 4h continuously stress 14d.
Result's demonstration,
(1) change of irritability rat aspect behavior and body weight
The stress group rat is accepted every day 2 times, and each 2 hours foot shock adds noise, continuously 14d.Stress after rat behavior learn to change: after entering the electric shock cage, breathe and obviously deepen quickenings, chaeta settings, two rears, forelimb and seek connections with at electric shock cage sidewall, and show nervous frightened and escape behavior, Li Mao and wash one's face and move increase.Behind the stress stimulation of accepting a period of time, rat finds in the electric shock cage that not only trip for unusual, also shows great vigilance under rest state, easily enrages, and disturbance is uneasy.The 200-220g normal rat is after raising 14d, and body weight can reach 320-350g, stress rats stress before 6d, body weight rises to 230-250g gradually, along with stress continue carry out, the stress rats food-intake is without obvious minimizing, growth but is subject to obvious inhibition, and body weight is stuck in 260-280g.
(2) change of irritability rat aspect blood pressure and heart rate
The stress group rat is accepted every day 2 times, and each 2 hours foot shock adds noise, continuously 14d.Every other day, after 2h stress being finished for the second time, detect rat tail artery systolic pressure (SBP) and heart rate (HR) with the arteria caudalis tiretube process.Rat SBP in stress process rises gradually, stress the 4d blood pressure and heart rate obviously increase, later on along with increase that stress natural law, SBP continues soaring steadily, stress 10d, 110 ± 5.4mmHg rises to 142 ± 7.6mmHg by matched group, and after this SBP maintains more stable level.
Afterwards rat HR stress 6d in significantly accelerate, be increased to 445 ± 22beats/min by 372 ± 19beats/min, along with proceeding of stimulating, HR slows down before to some extent, to 14d, HR is 420 ± 22beats/min.
The result of above-described embodiment shows, sound of the present invention, light, electrically programmable random stimulus device can obstruct the process of animal learning, memory, delay the time of formation condition reflection, and Effective Raise modeling efficient can be used for preparing the irritability hypertension animal model.
Claims (9)
1. a sound, light, electrically programmable random stimulus device, it is characterized in that, formed by single-chip microcomputer (1), display screen (2), input keyboard (3), voltage sampling unit (4), adjustable transformer (5), electric shock control unit (6), controlled by sound and light unit (7), electric shock mouse cage (8) harmony light device (9); Described single-chip microcomputer (1) connects respectively display screen (2), input keyboard (3), voltage sampling unit (4), Electric Machine Control power supply (6) harmony light control unit (7), external power supply is powered to voltage sampling unit (4) and Electric Machine Control power supply (6) by adjustable transformer (5), Electric Machine Control power supply (6) connects electric shock mouse cage (8), and described controlled by sound and light unit (7) connects acousto-optic equipment (9).
2. by sound claimed in claim 1, light, electrically programmable random stimulus device, it is characterized in that, described single-chip microcomputer (1) is the C51F005 single-chip microcomputer, it receives stimulus parameter and action command from input keyboard (3), and control electric shock control unit (6) harmony light control unit (7) is implemented the stimulation of different mode;
The program of described single-chip microcomputer (1) uses the C51 assembler language to write, adopt intervalometer to start the ADC sampling, and by ADC sampling end signal generation interrupt requests, in the interrupt response subprogram, CPU reads in sampled value, stimulus intervals timing and total time timing are finished by intervalometer, and stimulus intervals and stimulation mode are finished by random number generation software module.
3. by sound claimed in claim 1, light, electrically programmable random stimulus device, it is characterized in that, described display screen (2) adopts 480X64 lattice lcd screen.
4. by sound claimed in claim 1, light, electrically programmable random stimulus device, it is characterized in that, described input keyboard (3) input stimulus parameter, stimulus parameter comprises: (1) stimulates total time, (2) electric shock pulse width, (3) stimulate largest interval and minimum interval, the ratio between (4) acousto-optic-electric complex stimulus, acousto-optic stimulation and electrical stimulus patterns.
5. by sound claimed in claim 1, light, electrically programmable random stimulus device, it is characterized in that, described voltage sampling unit (4) is comprised of 100: 1 step-down transformer L4, commutation diode D3 and capacitor C; The DC voltage of voltage sampling unit output is connected to the input pin ADC0 of the analog-digital converter of single-chip microcomputer (1), and program is calculated the actual output amplitude of adjustable transformer according to sampled value, and shows at display screen (2).
6. by sound claimed in claim 1, light, electrically programmable random stimulus device, it is characterized in that, described adjustable transformer (5) is regulated stimulation voltage, and its range of accommodation is to line voltage from 0V.
7. by sound claimed in claim 1, light, electrically programmable random stimulus device, it is characterized in that, described electric shock control unit (6) mainly is comprised of relay, resistance, triode; Wherein, D1 is discharge diode, and described relay L1 closure makes that loudspeaker pipe, the flash of light of red bulb, and the signal of the P3.0 port of single-chip microcomputer (1) is through the open and-shut mode of drive circuit control relay; Described drive circuit is comprised of pliotron Q1, resistance R 1 and potentiometer W1 among the NPN.
8. by sound claimed in claim 1, light, electrically programmable random stimulus device, it is characterized in that, described controlled by sound and light unit (7) mainly is comprised of relay, resistance, triode; Wherein, D2 is discharge diode, and described relay L2 closure makes the electric shock mouse cage charged, and the signal of the P3.1 port of single-chip microcomputer (1) is through the open and-shut mode of drive circuit control relay; Described drive circuit is comprised of pliotron Q2, resistance R 2 and potentiometer W2 among the NPN.
9. by sound claimed in claim 1, light, electrically programmable random stimulus device, it is characterized in that, the overall dimensions of described electric shock mouse cage (8) is 22*22*26cm
2, its bottom be metal bar, connect respectively power supply the two poles of the earth, arrange by the both positive and negative polarity adjacent sequential.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104224130A (en) * | 2014-09-25 | 2014-12-24 | 中国科学院生物物理研究所 | Stimulation device for rodent animals and various-sensing-mode program-controlled stimulation system |
| CN104756886A (en) * | 2014-01-07 | 2015-07-08 | 复旦大学 | Assembly type social stress cage |
| CN105379631A (en) * | 2015-12-17 | 2016-03-09 | 王俊杰 | Rat hypertension model preparation device |
| CN109106361A (en) * | 2017-06-23 | 2019-01-01 | 周厚荣 | A kind of monitoring device inducing animal ventricular fibrillation |
| CN109675171A (en) * | 2019-03-04 | 2019-04-26 | 中国科学院深圳先进技术研究院 | Animal stimulating method, device, equipment and storage medium |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1354405A (en) * | 2000-11-16 | 2002-06-19 | 深圳市中兴通讯股份有限公司 | Constant current control equipment and method |
| JP3704111B2 (en) * | 2002-08-20 | 2005-10-05 | 有限会社 秋田開発技研 | Bird and beast harm prevention device |
| CN1775323A (en) * | 2005-09-30 | 2006-05-24 | 东北大学 | Cranial nerve electrostimulating device capable of remotely controlling exercise behevior |
| CN1817323A (en) * | 2005-12-19 | 2006-08-16 | 中国人民解放军第四军医大学 | Automatic inspection of mouse exercising studying memory abilities after being stressed |
| CN101044977A (en) * | 2006-12-05 | 2007-10-03 | 徐容 | Electric defensive type motion conditioned response instrument |
| CN101313845A (en) * | 2008-04-23 | 2008-12-03 | 中国科学技术大学 | Data acquisition control device for ring flat base |
| CN102023248A (en) * | 2009-09-18 | 2011-04-20 | 哈尔滨九洲电气股份有限公司 | Direct current bus voltage sampling device of medium-voltage frequency converter |
| RU2432902C2 (en) * | 2009-11-17 | 2011-11-10 | Государственное Образовательное Учреждение Высшего Профессионального Образования Амурская Государственная Медицинская Академия Росздрава | Problem chamber for measurement of individual level of cognitive ability of rats |
| CN202589697U (en) * | 2012-03-12 | 2012-12-12 | 复旦大学 | Acousto-optic-electric programmable random stimulator |
-
2012
- 2012-03-12 CN CN2012100641637A patent/CN103300937A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1354405A (en) * | 2000-11-16 | 2002-06-19 | 深圳市中兴通讯股份有限公司 | Constant current control equipment and method |
| JP3704111B2 (en) * | 2002-08-20 | 2005-10-05 | 有限会社 秋田開発技研 | Bird and beast harm prevention device |
| CN1775323A (en) * | 2005-09-30 | 2006-05-24 | 东北大学 | Cranial nerve electrostimulating device capable of remotely controlling exercise behevior |
| CN1817323A (en) * | 2005-12-19 | 2006-08-16 | 中国人民解放军第四军医大学 | Automatic inspection of mouse exercising studying memory abilities after being stressed |
| CN101044977A (en) * | 2006-12-05 | 2007-10-03 | 徐容 | Electric defensive type motion conditioned response instrument |
| CN101313845A (en) * | 2008-04-23 | 2008-12-03 | 中国科学技术大学 | Data acquisition control device for ring flat base |
| CN102023248A (en) * | 2009-09-18 | 2011-04-20 | 哈尔滨九洲电气股份有限公司 | Direct current bus voltage sampling device of medium-voltage frequency converter |
| RU2432902C2 (en) * | 2009-11-17 | 2011-11-10 | Государственное Образовательное Учреждение Высшего Профессионального Образования Амурская Государственная Медицинская Академия Росздрава | Problem chamber for measurement of individual level of cognitive ability of rats |
| CN202589697U (en) * | 2012-03-12 | 2012-12-12 | 复旦大学 | Acousto-optic-electric programmable random stimulator |
Non-Patent Citations (1)
| Title |
|---|
| 王锦: ""血管紧张素-（1-7）在延髓腹外侧调节血压的机制"", 《中国博士学位论文全文数据库 医药卫生科技辑 》 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104756886A (en) * | 2014-01-07 | 2015-07-08 | 复旦大学 | Assembly type social stress cage |
| CN104756886B (en) * | 2014-01-07 | 2017-07-11 | 复旦大学 | Assembly type social stress cage |
| CN104224130A (en) * | 2014-09-25 | 2014-12-24 | 中国科学院生物物理研究所 | Stimulation device for rodent animals and various-sensing-mode program-controlled stimulation system |
| CN104224130B (en) * | 2014-09-25 | 2017-09-12 | 中国科学院生物物理研究所 | Stimulating apparatus and polyesthesia pattern programmed electrical stimulation system for rodent |
| CN105379631A (en) * | 2015-12-17 | 2016-03-09 | 王俊杰 | Rat hypertension model preparation device |
| CN109106361A (en) * | 2017-06-23 | 2019-01-01 | 周厚荣 | A kind of monitoring device inducing animal ventricular fibrillation |
| CN109675171A (en) * | 2019-03-04 | 2019-04-26 | 中国科学院深圳先进技术研究院 | Animal stimulating method, device, equipment and storage medium |
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Application publication date: 20130918 |