CN110338784A - Test method, apparatus, computer equipment and the storage medium of sleep deprivation effect - Google Patents
Test method, apparatus, computer equipment and the storage medium of sleep deprivation effect Download PDFInfo
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Abstract
The embodiment of the invention discloses a kind of method, apparatus, computer equipment and storage mediums for testing sleep deprivation effect.The described method includes: carrying out sleep deprivation to test animal, and the physiological signal of the test animal is acquired, as the first physiological signal；According to first physiological signal, setting adjustment signal is issued to the test animal, and acquires the physiological signal after the test animal is regulated and controled, as the second physiological signal；According to first physiological signal and second physiological signal, the effect of sleep deprivation is determined.The embodiment of the present invention realizes the effect of evaluation sleep deprivation methods, provides data supporting for selection sleep deprivation methods, to improve the reliability of sleep deprivation test, improves the precision of test data.
Description
Technical field
The present embodiments relate to sleep deprivation technical field more particularly to it is a kind of test sleep deprivation effect method,
Device, computer equipment and storage medium.
Background technique
Sleep is the quiescent condition of the spontaneous reversible brain of one kind occurred in the higher vertebrate period, be body for
The reactivity of extraneous sensory perception stimulation reduces and the short interruption of consciousness.Existing research shows sleep and learning and memory, biological clock
Adjusting, metabolism, immune, hormone the secretion etc. of organism it is closely related.Sleep disturbance will affect human thinking, memory, feelings
The abnormal change such as thread, immune, and the generation of mental disease is closely related may also lead to nerve metabolism, nerve immunity, nerve
The relevant disease of endocrine.
Currently, in order to study influence of the sleep of biology to biology, researcher generally carries out sleep stripping to test organism
Take by force, acquire the status data of test organism, the influence slept to test organism is analyzed with this.Existing sleep deprivation device has by force
Compel the method for movement, physical stimulation method (pat cage, wooden stick stir or shock by electricity stimulate etc.), pier method or medicine irritation method.
Researcher is often directed to the limitation and test objective of each method, to select the side of suitable sleep deprivation
Method.The effect of sleep deprivation how is evaluated currently without specific standard.Meanwhile sleep deprivation device pair is used in researcher
When testing animal progress sleep deprivation, due to being difficult to accurately hold the effect of sleep deprivation, to be difficult to sleep deprivation device
Improve (such as the size for how improving the platform only stood for test animal in horizontal platform).
Summary of the invention
The embodiment of the present invention provides a kind of method, apparatus, computer equipment and storage medium for testing sleep deprivation effect,
It realizes the effect of evaluation sleep deprivation methods, provides data supporting for selection sleep deprivation methods, to improve sleep deprivation examination
The reliability tested improves the precision of test data.
In a first aspect, the embodiment of the invention provides a kind of methods for testing sleep deprivation effect, comprising:
Sleep deprivation is carried out to test animal, and acquires the physiological signal of the test animal, as the first physiological signal；
According to first physiological signal, setting adjustment signal is issued to the test animal, and it is dynamic to acquire the test
Object regulated and controled after physiological signal, as the second physiological signal；
According to first physiological signal and second physiological signal, the effect of sleep deprivation is determined.
Second aspect, the embodiment of the invention also provides a kind of devices for testing sleep deprivation effect, comprising:
First physiological signal collection module for carrying out sleep deprivation to test animal, and acquires the test animal
Physiological signal, as the first physiological signal；
Second physiological signal collection module, for issuing and setting to the test animal according to first physiological signal
Adjustment signal, and the physiological signal after the test animal is regulated and controled is acquired, as the second physiological signal；
Sleep deprivation effect determining module is used for according to first physiological signal and second physiological signal, really
Determine the effect of sleep deprivation.
The third aspect the embodiment of the invention also provides a kind of computer equipment, including memory, processor and is stored in
On memory and the computer program that can run on a processor, the processor realize that the present invention is implemented when executing described program
The method of any test sleep deprivation effect in example.
Fourth aspect, the embodiment of the invention also provides a kind of computer readable storage mediums, are stored thereon with computer
Program realizes the method for any test sleep deprivation effect in the embodiment of the present invention when program is executed by processor.
The technical solution of the present embodiment, by acquisition sleep deprivation after the first physiological signal, and to sleep deprivation after
Test animal regulated and controled after the second physiological signal, sleep deprivation is determined according to the first physiological signal and the second physiological signal
Effect solves the problems, such as that the effect of sleep deprivation can not be evaluated in the prior art, realizes the effect of evaluation sleep deprivation methods,
Data supporting is provided for selection sleep deprivation methods, to improve the reliability of sleep deprivation test, improves the essence of test data
Degree.
Detailed description of the invention
Fig. 1 is a kind of flow chart of the method for test sleep deprivation effect that the embodiment of the present invention one provides；
Fig. 2 is a kind of flow chart of method for testing sleep deprivation effect provided by Embodiment 2 of the present invention；
Fig. 3 is a kind of structural schematic diagram of the device for test sleep deprivation effect that the embodiment of the present invention three provides；
Fig. 4 is a kind of structural schematic diagram for computer equipment that the embodiment of the present invention four provides.
Specific embodiment
The present invention is described in further detail with reference to the accompanying drawings and examples.It is understood that this place is retouched
The specific embodiment stated is used only for explaining the present invention rather than limiting the invention.It also should be noted that in order to just
Only the parts related to the present invention are shown in description, attached drawing rather than entire infrastructure.
Embodiment one
Fig. 1 is a kind of flow chart of the method for test sleep deprivation effect that the embodiment of the present invention one provides, the present embodiment
It is applicable to carry out animal the situation of sleep deprivation, this method is executed by test sleep deprivation effects device, which can be with
It is realized, can be generally integrated in computer equipment, this method specifically comprises the following steps: by software and/or hardware
S110 carries out sleep deprivation to test animal, and acquires the physiological signal of the test animal, as the first physiology
Signal.
In the present embodiment, physiological signal may include EEG signals, such as Cortical ECoG signal, hippocampus electric signal, go back
It may include electrocardiogram, electromyogram, or can also include blood oxygen saturation.Sleep deprivation is carried out to test animal, can be adopted
With forced movement method, physical stimulation method, pier method or medicine irritation method etc..First physiological signal can be test is dynamic
Object is placed on after the shielded box for sleep deprivation, the physiological signal of the test animal of acquisition.Wherein, the frequency of acquisition can
To be one hour primary, it is also possible to be continued for acquisition until sleep deprivation terminates.
Optionally, physiological signal can be characterized using EEG signals, this is because, the brain cell moment is all carrying out certainly
Hair property, rhythmicity, comprehensive bioelectrical activity, so that the bioelectrical activity of brain cell embodies the state of test animal.It will
The spontaneous bioelectric of this brain cell group is recorded by electrode, and using current potential as the longitudinal axis, the time be horizontal axis by its
It is shown with the form of curve, as EEG signals.Specifically, Cortical ECoG can refer to electrocorticogram
(Electrocorticogram, ECoG), mainly brain are in activity, the synchronous postsynaptic potential warp occurred of a large amount of neurons
It is formed after summation, mainly there are prefrontal lobe, top and occipital lobe etc. in acquisition position；Hippocampus electricity may include hippocampus electrograph
(Electrohippocampogram, EHG) and hippocampus Evoked field potential (field evoked potentials, FEP)；Myoelectricity
It can be electrical activity when static muscle or contraction, it, can by myoelectricity data for checking nerve, muscle excitement and conduction function
To determine the functional status of peripheral nerve, neuron, neuromuscular junction and muscle itself.
In more detail, EEG signals can be generally divided into according to frequency characteristic be generally divided into delta frequency range (1-4Hz),
Theta frequency range (4-8Hz), alpha frequency range (8-13Hz), beta frequency range (13-30Hz), gamma frequency range (30-48Hz).It is sleeping
During dormancy, brain wave feature changes along with dormant different.Therefore, pass through the correlation of extraction sleep cerebral electricity signal
Characteristic (such as time domain specification, frequency domain characteristic) can carry out by stages sleep stage namely eeg signal can be used for characterizing
Sleep state.Under each period of sleeping, different characteristic is presented in brain wave, specifically, people in the state of awake close one's eyes,
Alpha wave gradually increases, and becomes the leading waveform of brain wave, and state at this time is referred to as lucid interval.When people will appear tired meaning,
Alpha wave is weak, and theta wave largely occurs, and indicates enter 1 phase of sleep at this time.Sleep Stage 2 is one and shallowly sleeps state,
Human eyeball's activity stops, and brain wave frequency further slows down, along with the appearance of K complex wave and sleep spindle.In sleep 2
Phase, brain wave voltage are in a median, and brain wave energy is concentrated mainly on theta wave band.With going deep into for sleep, human body
3 phases of sleep are entered, that is to say, that brain has entered slow wave sleep, occurs delta wave, and brain wave in brain at this time
Voltage value it is larger.When having entered 4 phases of sleep, delta wave energy is further enhanced in brain wave, and human body has entered depth
Sleep.In 3 phases of sleeping and 4 phases of sleep, human body is difficult to awaken.In conclusion 1 phase of sleep and Sleep Stage 2 are referred to as shallowly slept the phase, and sleep
Sleep 3 phases and 4 phases are then known as the sound sleep phase, are called slow wave sleep (Slow Wave Sleep, SWS), different sleep periods has
Different feature brain waves, alpha wave are lucid interval feature brain electricity, and theta wave is shallowly to sleep phase feature brain wave, and delta wave is
The feature brain wave of sound sleep phase.In addition, sleep cycle further includes the REM sleep deprivation phase, the brain wave of the REM sleep deprivation phase and clear
The state of waking up, the brain wave for 1 phase of sleeping are similar, and feature is low-voltage fast activity, is enhanced along with theta wave.
Specifically, can determine whether test animal enters sleep by the situation of change of each frequency range, and test dynamic
The sleep state of object, thus can also be according to the sleep deprivation effect of the situation of change evaluation test animal of each frequency range.
It should be noted that being slept when for a long time (as more than 48 hours) since there are compensation mechanism for sleep deprivation
After dormancy is deprived, the case where each frequency range of eeg signal (such as the power of each frequency range) and each frequency range before sleep deprivation
Situation is unanimous on the whole, so that the time of sleep deprivation is unsuitable too long.
S120 issues setting adjustment signal to the test animal, and acquire the survey according to first physiological signal
The physiological signal after animal is regulated and controled is tried, as the second physiological signal.
In the present embodiment, the second physiological signal can be after exporting adjustment signal, acquire (such as 20 points of setting time
Clock) in physiological signal.In addition, the physiological signal of acquisition can still act as after the setting time of output adjustment signal
First physiological signal.That is, in addition to being second exporting the physiological signal acquired in the setting time after adjustment signal
Physiological signal, furthermore the physiological signal of other times acquisition, is used as the first physiological signal.Wherein, adjustment signal may include
Electric signal, optical signal and drug injection signal.
Specifically, specifically can be electric current when adjustment signal is electric signal, setting adjustment signal, which can be, to be preset
Output period of electric current, in the duration of output or the parameters such as size of electric current at least one of；When adjustment signal is light
When signal, light beam specifically can be, setting adjustment signal can be the waveform of pre-set light beam, the wavelength of light beam, light beam
Intensity or output beam the parameters such as frequency at least one of；When adjustment signal is drug injection signal, setting regulation
Signal can be at least one in the parameters such as injection dosage or the injection cycle of pre-set drug.
In another optional embodiment of the invention, the adjustment signal is light adjustment signal.
Specifically, being regulated and controled using light adjustment signal, quickly the specific cell of real-time monitoring, realization test can be directed to
The standing state of animal carries out light stimulus, to obtain reaction of test animal in the state of current sleep deprivation, to stimulation
Ability (such as response time and response intensity).
Optionally, before issuing setting adjustment signal to the test animal, comprising: according to dynamic to the test in advance
The gene type that setting cell in object locus coeruleus brain area imports determines the optical parameter of light adjustment signal, wherein setting cell packet
Include the neuron for synthesizing norepinephrine.
Specifically, light regulation can refer to using the special eroticism of light genetic technique or inhibit target cell activity.?
Before carrying out carrying out light regulation to target animal, needs to import light responsive gene to target cell in advance, be imported into cell
The method of gene can be using the methods of viral vectors, physical method or chemical method.Encode light responsive gene or its functional sheet
The polynucleotide sequence of section is operably connected the promoter of a cell-specific, thus the table in setting cell of targeting
It reaches, makes non-photosensitivity sense cells switch photaesthesia cell that can cause the cell when photaesthesia cell is by light stimulation
Excited or inhibition carries out light regulation to implant site to realize.Wherein, locus coeruleus brain area can be nucleus ceruleus (Locus
Coeruleus), it is located at fourth ventricle bottom, pons antedorsal.Locus coeruleus brain area is that the main portion of norepinephrine is synthesized in brain
Position.Norepinephrine can be adrenaline and remove the substance formed after N- methyl, be both a kind of neurotransmitter and one
Kind hormone, locus coeruleus brain area can be by the synthesis and secretion of norepinephrine, to participate in waking up and guard against.Wherein, locus coeruleus brain
Projection of the area in central nervous system is very wide, and primary target area may include the relaying of spinal cord, cerebellum, hypothalamus, thalamus
Core group, amygdaloid nucleus, akrencephalon basal part and cerebral cortex etc..In general, the single neuron in locus coeruleus brain area can pass through
Its huge axiramificate activates almost entire cerebral cortex, but also the cognitive function of prefrontal lobe can be enhanced, and improves motivation
Level, and the hypothalamus-pituitary-adrenal axis heart is activated, and then improve sympathetic nerve activity and inhibit parasympathetic activity.This
It outside, can be related with REM sleep deprivation with the norepinephrine neuron synthesized in locus coeruleus brain area.
In more detail, light genetic technique is to combine optics and science of heredity, will be carried specifically by genetic engineering means
Property light responsive gene virus be transferred to cell type specific expression, as excited type channel protein gene be ion channel rhodopsin
2 (Channelrhodopsin-2, ChR2), suppressive channel protein gene be Halophiles rhodopsin (Helorhodopsin,
NpHR), light stimulation is carried out for specific cells, excitatory cells may be implemented or inhibits cellular activity.Due to photaesthesia base
Because ion channel is in different wave length, to need targetedly to go to stimulate different light responsive genes using the light of different wave length.
Wherein, ion channel is the access that various ions across membranes passively transport, if blue light wavelength λ=473nm can activate ChR2, thus
Selection allows cationic specificity to pass through, and causes cell depolarization to act on, thus excitatory cells；Yellow wavelengths λ=593nm can swash
NpHR living causes the hyperpolarization of cell, to inhibit cellular activity so that selection allows anion specificity to pass through.Wherein, it sets
Cell may include neuronal cell.
It should be noted that excited type channel protein gene can also include the rhodopsin extracted from volvox
(channelrhodopsin-1from Volvox carteri, VChR1), suppressive channel protein gene can also be ancient thin
Bacteriorhodopsin 3 (Archaerhodopsin-3, Arch), bacteria rhodopsin (bacteriorhodopsin, eBR) or visual purple
Red matter 3 (rhodopsin-3, GtR3) etc., the present embodiment is simultaneously not specifically limited.
It is to be regulated and controled using the method for light science of heredity by setting regulation method, can be adjusted for specific cells
Control, improves the precision and reliability of regulation；The region that regulation is arranged simultaneously is nucleus ceruleus for synthesizing norepinephrine
Neuron may be implemented excitement or inhibit the activity at other positions, even directly affect sleep state, it is thus possible to root
According to the respond that test animal is stimulated in sleep deprivation, the effect of sleep deprivation is determined, improve evaluation sleep deprivation effect
The reliability of fruit.
S130 determines the effect of sleep deprivation according to first physiological signal and second physiological signal.
In the present embodiment, the effect of sleep deprivation can be characterized using the variable quantity of the characteristic parameter of physiological signal,
It can also be characterized using the grade of preset sleep deprivation.For example, variable quantity can be test animal before and after regulation
EEG signals in delta wave power variable quantity, wherein the first physiological signal is to test brain telecommunications of the animal before regulation
Number, the second physiological signal is the EEG signals for testing animal after regulation.And the grade of sleep deprivation can be according to the first physiology
Signal and the second physiological signal and the inquiry of preset sleep deprivation table of grading determine.Wherein, sleep deprivation table of grading can
To include the corresponding relationship of the first physiological signal and the second physiological signal and sleep deprivation grade, for example, the first physiological signal pair
The power for the delta wave answered is 4, and the power of the corresponding delta wave of the second physiological signal is 6, then variable quantity is 2, sleep deprivation
The corresponding grade of variable quantity 2 is 1 in table of grading, then sleep deprivation grade is 1.
In the present embodiment, in a specific example, sleep stripping can be carried out to test animal using horizontal platform method
Take by force, and light stimulation is carried out to test animal using light regulation method.Specifically: test animal is placed on sleep deprivation cabinet
Carry out sleep deprivation test in, the cabinet include: hamper, drinking bottle, platform (only for test animal stand chain-wales) and
Pond.By light regulation device to test animal output light adjustment signal, wherein light regulation device may include waveform
Device, laser, optical fiber, lock pin etc..By acquiring the physiological signal of feedback device collecting test animal, and it is based on the physiological signal
It determines the optical parameter of light adjustment signal, and controls light regulation device output light adjustment signal, can specifically include, signal acquisition
Device, electrode, computer equipment for recording and analyzing physiological signal etc..Wherein, optical fiber and electrode are both needed to implantation test animal
In vivo, optical fiber is tested in animal body for testing the intracorporal setting cell output light adjustment signal of animal, and by the way that lock pin is fixed,
Electrode is for acquiring and transmitting the test intracorporal physiological signal of animal.
In another optional embodiment of the invention, described pair of test animal carries out sleep deprivation, comprising: will at least
Two test animals are placed under conditions of different sleep deprivations and carry out sleep deprivation respectively.
Correspondingly, it is described according to first physiological signal and second physiological signal, determine the effect of sleep deprivation
Fruit, comprising: according to corresponding first physiological signal of each test animal and second physiological signal, by each test
The corresponding sleep deprivation condition of animal is ranked up；Using the ranking results of the corresponding sleep deprivation condition of each test animal as
The corresponding sleep deprivation effect of corresponding with each test animal sleep deprivation condition.
Specifically, different sleep deprivation methods can be respectively adopted to multiple test animals simultaneously carries out sleep deprivation,
Compare the effect of sleep deprivation；It is also possible to the same sleep deprivation methods, but the specific setting condition of its sleep deprivation is different,
Size such as chain-wales in Horizontal Bridgman Method is different.The determination method of the effect of sleep deprivation specifically can be, by a test animal
It is placed in horizontal platform sleep deprivation device, another test animal is placed in rotor sleep deprivation device, point
Not Ji Suan sleep deprivation under the conditions of two kinds distinguishes data, be ranked up, specifically can be the biggish sleep of distinguishes data
Method is deprived as the preferable sleep deprivation methods of sleep deprivation effect, and by the conduct difference sleep deprivation methods of ranking results
Sleep deprivation effect.
By carrying out sleep deprivation respectively to multiple test animals, and the condition of sleep deprivation is different, according to each test
The corresponding physiological signal of animal carrys out the effect of more each sleep deprivation, and using comparison result as the effect of sleep deprivation, should
The test data for acquiring sleep deprivation simultaneously may be implemented in method, reduces the disturbing factor of sleep deprivation test, improves sleep stripping
Take the precision of test data by force, and only need the effect of qualitative relatively sleep deprivation, it is possible to reduce the mistake of evaluation sleep deprivation effect
Calculative data volume in journey improves the efficiency of sleep deprivation effect evaluation method.
Optionally, different sleep deprivation methods can also be respectively adopted in a test animal and carry out sleep deprivation, it will
For characterizing effect of the ranking results as sleep deprivation of the data of sleep deprivation effect.
Optionally, it can adopt the same method and sleep deprivation is carried out to multiple test animals, the animal of each test
The actual conditions of sleep deprivation are different, determine a kind of sleep deprivation methods it is each under the conditions of sleep deprivation effect.For example,
Multiple test animals are individually positioned on the various sizes of chain-wales in horizontal platform sleep deprivation device, it is more each small flat
The effect of sleep deprivation caused by platform is realized to select the chain-wales of optimum size and improves horizontal platform sleep deprivation device.
The technical solution of the present embodiment, by acquisition sleep deprivation after the first physiological signal, and to sleep deprivation after
Test animal regulated and controled after the second physiological signal, sleep deprivation is determined according to the first physiological signal and the second physiological signal
Effect solves the problems, such as that the effect of sleep deprivation can not be evaluated in the prior art, realizes the effect of evaluation sleep deprivation methods,
Data supporting is provided for selection sleep deprivation methods, to improve the reliability of sleep deprivation test, improves the essence of test data
Degree.
Embodiment two
Fig. 2 is a kind of flow chart of method for testing sleep deprivation effect provided by Embodiment 2 of the present invention, the present embodiment
It is embodied on the basis of the above embodiments, the physiological signal is embodied as Cortical ECoG signal, hippocampus electricity
Signal and electromyography signal.This method specifically comprises the following steps:
S210 carries out sleep deprivation to test animal, and acquires the physiological signal of the test animal, as the first physiology
Signal, wherein the physiological signal includes Cortical ECoG signal, hippocampus electric signal position and electromyography signal.
In the present embodiment, pass through the acquisition intracorporal electricity physiological signal of animal (including Cortical ECoG signal, hippocampus telecommunications
Number and electromyography signal) be used as physiological signal, due to the remote metachemistry signal of the time precision of electric signal, thus realize raising sleep shape
The precision of state judgement；Electric signal can carry out real-time multipoint recording simultaneously, human cost and time cost be reduced, moreover, electric
A large amount of information is contained in signal, is suitable for deep study and analysis, is conducive to researcher and extracts from a large amount of information
Multiple signals improve the reliability of sleep deprivation effect assessment to realize the effect according to multiple signal evaluation sleep deprivations.
S220 issues setting adjustment signal to the test animal, and acquire the survey according to first physiological signal
The physiological signal after animal is regulated and controled is tried, as the second physiological signal.
S230 determines the corresponding characteristic parameter of first physiological signal, as pure stripping according to first physiological signal
Take characteristic parameter by force, wherein characteristic parameter includes gravity frequency, power and complexity value.
In the present embodiment, power can be characterized by power spectrum, wherein power spectrum is electroencephalogram power as frequency becomes
The spectrogram of change can characterize the changed power situation of each frequency range in EEG signals.Gravity frequency can be the flat of each frequency range
Equal power can be obtained by spectra calculation.For example, reference characteristic parameter can be the power of alpha wave, can also be
The power ratio of alpha wave and delta wave.
In more detail, the brain wave figure for obtaining the first physiological signal and the second physiological signal, can be by amplitude at any time
The EEG signals of variation are converted to electroencephalogram power spectrogram varying with frequency, i.e. power spectrum, wherein the area that curve is covered is in number
It is equal to the general power (energy) of signal in value, so as to obtain the general power of each frequency range.
In general, EEG signals can be the synthesis of a large amount of neuron electric signals, can be the allusion quotation comprising certain rule
The Nonlinear Time Series of type, it is possible thereby to using nonlinear metric algorithm: algorithm complexity.It can be same by imbedded electrode
When detect the spontaneous potential of rat cerebral cortex and hippocampus, and analyzed using multiple methods of Complexity Measurement and compare two kinds
Current potential is being awakened and the variation characteristic for each phase of sleeping.Wherein, complexity value includes algorithm complexity (Algorithmic
Complexity, Kc), complexity C1, approximate entropy (Approximate entropy, ApEn) etc..
S240 determines the corresponding characteristic parameter of second physiological signal, as regulation according to second physiological signal
Deprive characteristic parameter.
S250, according to it is described it is pure deprive characteristic parameter and characteristic parameter is deprived in the regulation, obtain the test animal and sleep
The response data slept after depriving, wherein the response data includes response speed and response intensity.
Usually, the stress reaction ability of animal is tested as the increase of sleep deprivation time is first to rise to decline afterwards
's.Can according to response data assessment test animal stress reaction ability, such as the response time it is shorter, response intensity more
Greatly, show that stress reaction ability is stronger, wherein the response time can be from exporting adjustment signal, until the physiological signal of acquisition
Time experienced when significant changes occurs for (i.e. the second physiological signal), and whether be significant changes judgment criteria, can be
Physiological signal (i.e. the first physiological signal) before second physiological signal and output adjustment signal in setting time (such as 10 minutes)
Before whether difference is more than given threshold, and the threshold value can be according to the reception adjustment signal of test animal for not carrying out sleep deprivation
The variable quantity of physiological signal afterwards determines；The intensity of response can be the brain wave before and after test animal receives adjustment signal
Power variable quantity.
S260 determines the first sleep deprivation grade according to the response data.
In the present embodiment, sleep deprivation table of grading can be preset, is can recorde in table by response data and sleep
Deprive the corresponding relationship of grade, can data according to response specific value, inquired in the sleep deprivation table of grading, determination is slept
The grade that dormancy is deprived.For example, setting characteristic parameter is the power of eeg signal, can preset response data is brain in 1s
The power variation (taking absolute value) of electric wave signal, sleep deprivation table of grading may include, when response data (0,1] in range
When, the grade of sleep deprivation is 1；When response data (1,5] in range when, the grade of sleep deprivation is 2；When response data exists
(5,10] in range when, the grade of sleep deprivation is 3.
It optionally, include multiple characteristic parameters in sleep deprivation table of grading, meanwhile, in the catalogue of each characteristic parameter
Under, it is provided with the range of multiple response datas, the corresponding sleep deprivation level value of each range.In a specific example
In, characteristic parameter is the power ratio of beta wave Yu alpha wave, then pure to deprive characteristic parameter and regulate and control to deprive the sound of characteristic parameter
The corresponding range of data is answered to can be, when response data is not more than -0.1, corresponding sleep deprivation grade is 1；Work as number of responses
When according between -0.1 to 0.1, corresponding sleep deprivation grade is 2；When response data is not less than 0.1, corresponding sleep stripping
Taking grade by force is 3；And when characteristic parameter is power variation (the taking absolute value) of beta wave, sleep deprivation table of grading can wrap
Include, when response data (0,1] in range when, the grade of sleep deprivation is 1；When response data (1,5] in range when, sleep
The grade deprived is 2；When response data (5,10] in range when, the grade of sleep deprivation is 3.
Optionally, pure to deprive characteristic parameter and regulation deprives feature ginseng and may each comprise multiple characteristic parameters, it can be set
In the corresponding response data of each characteristic parameter, the different weighted value of the commensurate in scope of different response datas, according to each spy
The response data weighted value corresponding with its for levying parameter, determines sleep deprivation grade according to calculated weighted sum.
Optionally, it will can also be used to evaluate the numerical value of the specific data of sleep deprivation as sleep deprivation grade.For example,
When characteristic parameter is power variation (the taking absolute value) of beta wave, specific value 6, then sleep deprivation grade be can be
6。
It should be noted that there are also other factors for the mode of determining sleep deprivation grade, for example, sleep deprivation grade may be used also
To determine according to the duration of adjustment signal, the ratio for calculating the duration of response data and adjustment signal specifically can be
Value inquires sleep deprivation table of grading according to calculated result, determines the effect of sleep deprivation.Sleep deprivation effect also by other because
Element influences, and corresponding there are also other calculation methods, the embodiment of the present invention is not particularly limited this.
S270 determines the effect of sleep deprivation according to the first sleep deprivation grade.
In the present embodiment, first can also be can be set using the first sleep deprivation grade as the effect of sleep deprivation
The corresponding relationship of sleep deprivation grade and the effect of sleep deprivation, for example, when the first sleep deprivation grade is 100, sleep stripping
The effect taken by force is good；When the first sleep deprivation grade is 200, the effect of sleep deprivation is excellent.
It should be noted that determine that the effect of sleep deprivation can also be other modes according to the first sleep deprivation grade,
The embodiment of the present invention is not specifically limited.
In another optional embodiment of the invention, according to first physiological signal and second physiology
Signal, before the effect for determining sleep deprivation, further includes: when according to the non-sleep deprivation of the test animal obtained in advance
Physiological signal determines the corresponding characteristic parameter of the reference signal, as reference characteristic parameter as reference signal；In basis
First physiological signal determines the corresponding characteristic parameter of first physiological signal, as it is pure deprive characteristic parameter after, also
Include: according to it is described it is pure deprive characteristic parameter and the reference characteristic parameter, before and after obtaining the test animal sleep deprivation
Distinguishes data, wherein distinguishes data includes the change direction and variation of the characteristic parameter before and after the test animal sleep deprivation
Amount；According to the distinguishes data, the second sleep deprivation grade is determined；Sleep deprivation is determined according to the first sleep deprivation grade
Effect, further comprise: according to the first sleep deprivation grade and the second sleep deprivation grade, determining sleep deprivation
Effect.
Specifically, in advance obtain test animal not by sleep deprivation when reference signal, can be used for characterizing the test
The original normal state of animal, wherein the reference signal may include the physiological signal tested under animal waking state and sleep
Physiological signal under dormancy state.By obtaining the characteristic parameter of the reference signal of test animal, it is former that the test animal can be extracted
The feature of physiological signal under beginning normal condition, for the standard as evaluation sleep deprivation.Furthermore, it is possible to according to center of gravity frequency
Rate, power and complexity value divide reference signal, obtain awake stage corresponding reference signal and sleep stage is corresponding
Reference signal.
Wherein, pure characteristic parameter of depriving can be the general power of each frequency range in eeg signal.It can additionally calculate
Power ratio between each frequency range deprives characteristic parameter as pure, for embodying the change of test animal rest state and active state
Change trend, such as alpha wave and the power ratio of delta wave and the power ratio etc. of beta wave and theta wave.
Furthermore, it is possible to data determine according to response the first sleep deprivation grade and second be slept according to what distinguishes data determined
Grade is deprived in dormancy, calculates the weighted sum of two grades, the effect as final sleep deprivation grade namely sleep deprivation.Its
In, the weighted value of weighted sum can be preset.
It should be noted that can also be other according to the mode of the first sleep deprivation grade and the second sleep deprivation grade
Mode, for example, the first sleep deprivation grade and the second sleep deprivation grade can be preset, with total sleep deprivation grade
Corresponding relationship determines that total sleep deprivation grade, the embodiment of the present invention are not particularly limited this according to the corresponding relationship.
After according to the variation of the physiological signal before and after sleep deprivation and sleep deprivation, the response energy that is stimulated
Power increases the factor of evaluation of sleep deprivation effect collectively as the effect of evaluation sleep deprivation methods, and realization is more comprehensively commented
Valence sleep deprivation improves the reliability of the method for evaluation sleep deprivation effect.
Optionally, reference characteristic parameter may include multiple parameters, corresponding, and pure characteristic parameter of depriving includes and benchmark spy
Levy the corresponding characteristic parameter of parameter.Specifically, reference characteristic parameter includes the general power of theta wave, correspondingly, pure deprive feature
Parameter includes the general power of theta wave；Distinguishes data can be theta wave and the first physiology after sleep deprivation in reference signal
The ratio of the power of the theta wave of signal, the ratio characterize the variation feelings of frequency band energy of the theta wave before and after sleep deprivation
Condition.
Optionally, it is described according to it is described it is pure deprive characteristic parameter and the reference characteristic parameter, obtain the test animal
Distinguishes data before and after sleep deprivation, comprising: deprive the target in characteristic parameter described in acquisition and deprive parameter, and obtain the base
The corresponding target fiducials parameter of parameter is deprived with the target in quasi- characteristic parameter；It calculates the target and deprives parameter and institute
The relative difference of target fiducials parameter is stated, and using the relative difference as target distinguishes data；Number is distinguished according to the target
According to determining distinguishes data.
Specifically, depriving characteristic parameter and reference characteristic parameter may include multiple parameters, wherein from depriving characteristic parameter
It is middle to select a parameter as target and deprive parameter, it is corresponding, and selection with the target deprives parameter pair in reference characteristic parameter
The parameter answered is as target fiducials parameter.Calculate target deprive parameter and target fiducials parameter relative difference can use it is as follows
Formula:Wherein, E is relative difference；A is that target deprives parameter；R is target fiducials parameter.According to target
The method that distinguishes data determines distinguishes data, which can be, to be calculated the weighted sums of multiple target distinguishes datas (weighted value can be set in advance
It is fixed), as final distinguishes data.
In a specific example, deprives and the general power of theta wave is selected to deprive parameter as target in characteristic parameter,
It is corresponding, select the general power of theta wave as target fiducials parameter from reference characteristic parameter.Then about test animal sleep
The relative difference for depriving the general power of the theta wave of front and back can be calculated according to above-mentioned formula, if E < 0, then it represents that should
Theta wave frequency band energy reduces, i.e. generation Event-related desynchronization phenomenon；If E=0, then it represents that the theta wave frequency band energy
Absolutely not change；If E > 0, then it represents that the theta wave frequency band energy increases, and event-related design phenomenon occurs.
By using the relative difference before and after sleep deprivation as distinguishes data, realize according to the energy variation of frequency range (amount
Variation and the variation in direction) determine sleep deprivation grade, it can avoid making using the characteristic parameter before sleep deprivation as benchmark
Error in characteristic parameter brings subsequent calculating process into, to reduce the error of characteristic parameter, improves evaluation sleep deprivation side
The accuracy and reliability of method.
In embodiments of the present invention, by setting electric signal for physiological signal, and the external world is pierced according to after sleep deprivation
The responding ability of energizing signal determines the effect of sleep deprivation, improves the accuracy and reliability of evaluation sleep deprivation methods.
Embodiment three
Fig. 3 is a kind of schematic diagram of the device for test sleep deprivation effect that the embodiment of the present invention three provides.Embodiment three
It is the related device of the method for the test sleep deprivation effect for realizing that the above embodiment of the present invention provides.Described device includes:
First physiological signal collection module 310 for carrying out sleep deprivation to test animal, and acquires the test animal
Physiological signal, as the first physiological signal；
Second physiological signal collection module 320, for issuing and setting to the test animal according to first physiological signal
Determine adjustment signal, and acquire the physiological signal after the test animal is regulated and controled, as the second physiological signal；
Sleep deprivation effect determining module 330 is used for according to first physiological signal and second physiological signal,
Determine the effect of sleep deprivation.
The technical solution of the present embodiment, by acquisition sleep deprivation after the first physiological signal, and to sleep deprivation after
Test animal regulated and controled after the second physiological signal, sleep deprivation is determined according to the first physiological signal and the second physiological signal
Effect solves the problems, such as that the effect of sleep deprivation can not be evaluated in the prior art, realizes the effect of evaluation sleep deprivation methods,
Data supporting is provided for selection sleep deprivation methods, to improve the reliability of sleep deprivation test, improves the essence of test data
Degree.
Further, it includes Cortical ECoG signal, hippocampus electric signal and flesh that described device, which includes: the physiological signal,
Electric signal.
Further, the first physiological signal collection module 310, is used for: at least two test animals are placed in difference
Sleep deprivation under conditions of carry out sleep deprivation respectively.
Further, the sleep deprivation effect determining module 330, is used for: corresponding described according to each test animal
The corresponding sleep deprivation condition of each test animal is ranked up by the first physiological signal and second physiological signal；It will
Each ranking results for testing the corresponding sleep deprivation condition of animal are as sleep deprivation condition corresponding with each test animal
Corresponding sleep deprivation effect.
Further, the sleep deprivation effect determining module 330, comprising: it is pure to deprive characteristic parameter determining module, it is used for
According to first physiological signal, determines the corresponding characteristic parameter of first physiological signal, deprives characteristic parameter as pure,
In, characteristic parameter includes gravity frequency, power and complexity value；Characteristic parameter determining module is deprived in regulation, for according to
Second physiological signal determines the corresponding characteristic parameter of second physiological signal, deprives characteristic parameter as regulation；Response data
Determining module, for according to it is described it is pure deprive characteristic parameter and characteristic parameter is deprived in the regulation, obtain the test animal and sleep
The response data slept after depriving, wherein the response data includes response speed and response intensity；First sleep deprivation grade is true
Cover half block, for determining the first sleep deprivation grade according to the response data；Effect determining module, for according to described the
One sleep deprivation grade determines the effect of sleep deprivation.
Further, described device is also used to: life when according to the non-sleep deprivation of the test animal obtained in advance
Signal is managed as reference signal and the corresponding characteristic parameter of the reference signal is determined, as reference characteristic parameter.
Further, described device is also used to: according to it is described it is pure deprive characteristic parameter and the reference characteristic parameter, obtain
Distinguishes data before and after the test animal sleep deprivation, wherein distinguishes data includes the test animal sleep deprivation front and back
Characteristic parameter change direction and variable quantity；According to the distinguishes data, the second sleep deprivation grade is determined.
Further, the effect determining module, is used for: according to the first sleep deprivation grade and second sleep
Grade is deprived, determines the effect of sleep deprivation.
Further, it is light adjustment signal that described device, which includes: the adjustment signal,.
Further, described device is also used to: being led according to the setting cell in advance into the test animal locus coeruleus brain area
The gene type entered determines the optical parameter of light adjustment signal, wherein setting cell includes for synthesizing norepinephrine
Neuron.
The device of test sleep deprivation effect provided by the embodiment of the present invention can be performed any embodiment of that present invention and be mentioned
The method of the test sleep deprivation effect of confession, has the corresponding functional module of execution method and beneficial effect.
Example IV
Fig. 4 is a kind of structural schematic diagram for computer equipment that the embodiment of the present invention four provides.Fig. 4, which is shown, to be suitable for being used to
Realize the block diagram of the exemplary computer device 401 of embodiment of the present invention.The computer equipment 401 that Fig. 4 is shown is only one
A example, should not function to the embodiment of the present invention and use scope bring any restrictions.
As shown in figure 4, computer equipment 401 is showed in the form of universal computing device.The component of computer equipment 401 can
To include but is not limited to: one or more processor or processing unit 402, system storage 403 connect not homologous ray group
The bus 404 of part (including system storage 403 and processing unit 402).
Bus 404 indicates one of a few class bus structures or a variety of, including memory bus or Memory Controller,
Peripheral bus, graphics acceleration port, processor or the local bus using any bus structures in a variety of bus structures.It lifts
For example, these architectures include but is not limited to industry standard architecture (Industry Standard
Architecture, ISA) bus, microchannel architecture (Micro Channel Architecture, MCA) bus, enhancing
Type isa bus, Video Electronics Standards Association (Video Electronics Standards Association, VESA) local
Bus and peripheral component interconnection (Peripheral Component Interconnect, PCI) bus.
Computer equipment 401 typically comprises a variety of computer system readable media.These media can be it is any can
The usable medium accessed by computer equipment 401, including volatile and non-volatile media, moveable and immovable Jie
Matter.
System storage 403 may include the computer system readable media of form of volatile memory, such as deposit at random
Access to memory (Random Access Memory, RAM) 405 and/or cache memory 406.Computer equipment 401 can be with
It further comprise other removable/nonremovable, volatile/non-volatile computer system storage mediums.Only as an example,
Storage system 407 can be used for reading and writing immovable, non-volatile magnetic media, and (Fig. 4 do not show, commonly referred to as " hard drive
Device ").Although not shown in fig 4, the disk for reading and writing removable non-volatile magnetic disk (such as " floppy disk ") can be provided to drive
Dynamic device, and to removable anonvolatile optical disk (such as compact disc read-only memory (Compact Disc Read-Only
Memory, CD-ROM), digital video disk (Digital Video Disc-Read Only Memory, DVD-ROM) or other
Optical medium) read-write CD drive.In these cases, each driver can be connect by one or more data medium
Mouth is connected with bus 404.Memory 403 may include at least one program product, the program product have one group (for example, at least
One) program module, these program modules are configured to perform the function of various embodiments of the present invention.
Program/utility 409 with one group of (at least one) program module 408, can store in such as memory
In 403, such program module 408 includes --- but being not limited to --- operating system, one or more application program, other
It may include the realization of network environment in program module and program data, each of these examples or certain combination.Journey
Sequence module 408 usually executes function and/or method in embodiment described in the invention.
Computer equipment 401 can also be with one or more external equipments 410 (such as keyboard, sensing equipment, display
411 etc.) it communicates, the equipment interacted with the computer equipment 401 communication can be also enabled a user to one or more, and/or
(such as network interface card is adjusted with any equipment for enabling the computer equipment 401 to be communicated with one or more of the other calculating equipment
Modulator-demodulator etc.) communication.This communication can be carried out by input/output (Input/Output, I/O) interface 412.And
And computer equipment 401 can also pass through network adapter 413 and one or more network (such as local area network (Local
Area Network, LAN), wide area network (Wide Area Network, WAN) and/or public network, such as internet) communication.
As shown, network adapter 413 is communicated by bus 404 with other modules of computer equipment 401.Although should be understood that
It is not shown in Fig. 4, other hardware and/or software module can be used in conjunction with computer equipment 401, including but not limited to: micro- generation
Code, device driver, redundant processing unit, external disk drive array, disk array (Redundant Arrays of
Inexpensive Disks, RAID) system, tape drive and data backup storage system etc..
Processing unit 402 by the program that is stored in system storage 403 of operation, thereby executing various function application with
And data processing, such as realize a kind of method for testing sleep deprivation effect provided by the embodiment of the present invention.
That is, the processing unit is realized when executing described program: carrying out sleep deprivation to test animal, and described in acquisition
The physiological signal for testing animal, as the first physiological signal；According to first physiological signal, issues and set to the test animal
Determine adjustment signal, and acquire the physiological signal after the test animal is regulated and controled, as the second physiological signal；According to described
One physiological signal and second physiological signal, determine the effect of sleep deprivation.
Embodiment five
The embodiment of the present invention five provides a kind of computer readable storage medium, is stored thereon with computer program, the journey
The method of the test sleep deprivation effect provided such as all inventive embodiments of the application is provided when sequence is executed by processor:
That is, realization when the program is executed by processor: carrying out sleep deprivation to test animal, and it is dynamic to acquire the test
The physiological signal of object, as the first physiological signal；According to first physiological signal, setting regulation is issued to the test animal
Signal, and the physiological signal after the test animal is regulated and controled is acquired, as the second physiological signal；According to first physiology
Signal and second physiological signal, determine the effect of sleep deprivation.
The computer storage medium of the embodiment of the present invention, can be using any of one or more computer-readable media
Combination.Computer-readable medium can be computer-readable signal media or computer readable storage medium.It is computer-readable
Storage medium for example may be-but not limited to-the system of electricity, magnetic, optical, electromagnetic, infrared ray or semiconductor, device or
Device, or any above combination.The more specific example (non exhaustive list) of computer readable storage medium includes: tool
There are electrical connection, the portable computer diskette, hard disk, RAM, read-only memory (Read Only of one or more conducting wires
Memory, ROM), erasable programmable read only memory (Erasable Programmable Read Only Memory,
EPROM), flash memory, optical fiber, portable CD-ROM, light storage device, magnetic memory device or above-mentioned any appropriate combination.
In this document, it includes or the tangible medium of storage program that the program can be by that computer readable storage medium, which can be any,
Instruction execution system, device or device use or in connection.
Computer-readable signal media may include in a base band or as carrier wave a part propagate data-signal,
Wherein carry computer-readable program code.The data-signal of this propagation can take various forms, including --- but
It is not limited to --- electromagnetic signal, optical signal or above-mentioned any appropriate combination.Computer-readable signal media can also be
Any computer-readable medium other than computer readable storage medium, which can send, propagate or
Transmission is for by the use of instruction execution system, device or device or program in connection.
The program code for including on computer-readable medium can transmit with any suitable medium, including --- but it is unlimited
In --- wireless, electric wire, optical cable, radio frequency (RadioFrequency, RF) etc. or above-mentioned any appropriate group
It closes.
The computer for executing operation of the present invention can be write with one or more programming languages or combinations thereof
Program code, described program design language include object oriented program language-such as Java, Smalltalk, C++,
It further include conventional procedural programming language-such as " C " language or similar programming language.Program code can be with
It fully executes, partly execute on the user computer on the user computer, being executed as an independent software package, portion
Divide and partially executes or executed on a remote computer or server completely on the remote computer on the user computer.?
It is related in the situation of remote computer, remote computer can pass through the network of any kind --- including LAN or WAN --- even
It is connected to subscriber computer, or, it may be connected to outer computer (such as pass through internet using ISP
Connection).
Note that the above is only a better embodiment of the present invention and the applied technical principle.It will be appreciated by those skilled in the art that
The invention is not limited to the specific embodiments described herein, be able to carry out for a person skilled in the art it is various it is apparent variation,
It readjusts and substitutes without departing from protection scope of the present invention.Therefore, although being carried out by above embodiments to the present invention
It is described in further detail, but the present invention is not limited to the above embodiments only, without departing from the inventive concept, also
It may include more other equivalent embodiments, and the scope of the invention is determined by the scope of the appended claims.
Claims (10)
1. a kind of method for testing sleep deprivation effect characterized by comprising
Sleep deprivation is carried out to test animal, and acquires the physiological signal of the test animal, as the first physiological signal；
According to first physiological signal, issue setting adjustment signal to the test animal, and acquire the test animal by
Physiological signal after to regulation, as the second physiological signal；
According to first physiological signal and second physiological signal, the effect of sleep deprivation is determined.
2. the method according to claim 1, wherein the physiological signal includes Cortical ECoG signal, hippocampus
Electric signal and electromyography signal.
3. according to the method described in claim 2, it is characterized in that, described according to first physiological signal and described second
Physiological signal determines the effect of sleep deprivation, comprising:
According to first physiological signal, the corresponding characteristic parameter of first physiological signal is determined, deprive feature ginseng as pure
Number, wherein characteristic parameter includes gravity frequency, power and complexity value；
According to second physiological signal, determines the corresponding characteristic parameter of second physiological signal, deprive feature as regulation
Parameter；
According to it is described it is pure deprive characteristic parameter and characteristic parameter is deprived in the regulation, after obtaining the test animal sleep deprivation
Response data, wherein the response data includes response speed and response intensity；
According to the response data, the first sleep deprivation grade is determined；
The effect of sleep deprivation is determined according to the first sleep deprivation grade.
4. according to the method described in claim 3, it is characterized in that, according to first physiological signal and second life
Signal is managed, before the effect for determining sleep deprivation, further includes:
Physiological signal when according to the non-sleep deprivation of the test animal obtained in advance, as reference signal, determine described in
The corresponding characteristic parameter of reference signal, as reference characteristic parameter；
According to first physiological signal, determines the corresponding characteristic parameter of first physiological signal, deprive feature as pure
After parameter, further includes:
According to the pure area for depriving characteristic parameter and the reference characteristic parameter, obtaining before and after the test animal sleep deprivation
Other data, wherein distinguishes data includes the change direction and variable quantity of the characteristic parameter before and after the test animal sleep deprivation；
According to the distinguishes data, the second sleep deprivation grade is determined；
The effect that sleep deprivation is determined according to the first sleep deprivation grade further comprises:
According to the first sleep deprivation grade and the second sleep deprivation grade, the effect of sleep deprivation is determined.
5. the method according to claim 1, wherein the adjustment signal is light adjustment signal.
6. according to the method described in claim 5, it is characterized in that, to the test animal issue setting adjustment signal it
Before, comprising:
Light adjustment signal is determined according to the gene type that the setting cell in advance into the test animal locus coeruleus brain area imports
Optical parameter, wherein setting cell includes the neuron for synthesizing norepinephrine.
7. the method according to claim 1, wherein described pair of test animal carries out sleep deprivation, comprising:
At least two test animals are placed under conditions of different sleep deprivations and carry out sleep deprivation respectively；
It is described according to first physiological signal and second physiological signal, determine the effect of sleep deprivation, comprising:
According to corresponding first physiological signal of each test animal and second physiological signal, by each test animal
Corresponding sleep deprivation condition is ranked up；
The ranking results of the corresponding sleep deprivation condition of each test animal are shelled as sleep corresponding with each test animal
Take the corresponding sleep deprivation effect of condition by force.
8. a kind of device for testing sleep deprivation effect characterized by comprising
First physiological signal collection module for carrying out sleep deprivation to test animal, and acquires the physiology of the test animal
Signal, as the first physiological signal；
Second physiological signal collection module, for issuing setting regulation to the test animal according to first physiological signal
Signal, and the physiological signal after the test animal is regulated and controled is acquired, as the second physiological signal；
Sleep deprivation effect determining module, for according to first physiological signal and second physiological signal, determination to be slept
The effect that dormancy is deprived.
9. a kind of computer equipment including memory, processor and stores the meter that can be run on a memory and on a processor
Calculation machine program, which is characterized in that the processor realizes the test as described in any in claim 1-7 when executing described program
The method of sleep deprivation effect.
10. a kind of computer readable storage medium, is stored thereon with computer program, which is characterized in that the program is by processor
The method of the test sleep deprivation effect as described in any in claim 1-7 is realized when execution.
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