CN205196653U - Have a preference for case with conditionity position that free activity rat brain electrographic recording coupling allies oneself with - Google Patents
Have a preference for case with conditionity position that free activity rat brain electrographic recording coupling allies oneself with Download PDFInfo
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- CN205196653U CN205196653U CN201521070180.7U CN201521070180U CN205196653U CN 205196653 U CN205196653 U CN 205196653U CN 201521070180 U CN201521070180 U CN 201521070180U CN 205196653 U CN205196653 U CN 205196653U
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Abstract
The utility model provides a have a preference for case with conditionity position that free activity rat brain electrographic recording coupling allies oneself with, it is grey first baffle for black, opposite side to be equipped with one side between black box and the ash bin, it is white second baffle for ash, opposite side to be equipped with one side between ash bin and the white box, first baffle and second plate washer are all including the V -shaped plate, riser and the 2nd V -shaped plate that set gradually, a V -shaped plate and the 2nd V -shaped plate's the wideest punishment do not be according to the preceding lateral wall of the whole case of rectangle with the back lateral wall and set up, the riser is located between a V -shaped plate and the 2nd V -shaped plate, little door has been seted up to the bottom of riser, be equipped with a vertical opening on the riser. The utility model provides a have a preference for case with conditionity position that free activity rat brain electrographic recording coupling allies oneself with, its emergence of effectively avoiding among the prior art incident that experimental animals was impeded by the inspectors trunk to reduce in the experimentation various other factors and to the influence of experimental result, effectively improved the accuracy of experiment.
Description
Technical field
The utility model relates to technical field of medical instruments, particularly relates to a kind of conditioned place preference case be coupled with free moving rats eeg recording for synchronous recording free moving rats brain electricity.
Background technology
The experiment of environmental conditioned place preference is the Classic Experiments model evaluating Drug psychological dependence at present, is also the effective tool being widely used in finding anti-drug-seeking behavior.Laboratory animal (rat, mouse) is placed in the white observation area of the conditioned place preference case be coupled with free moving rats eeg recording by this experiment, and give psychic dependence medicine (such as morphine), then observation experiment animal is in the black region of conditioned place preference case be coupled with free moving rats eeg recording and the active situation of white area, has wicket to supply animal free shuttling between white area, black region and grey area wherein.Animal is in administration district at every turn will to the preference on generation position, black and white region under the effect of drug reward effect, and its degree is relevant to the psychic dependence of medicine.
But the current conditioned place preference case be coupled with free moving rats eeg recording cannot the EEG signals of the rat freely movable in case of synchronous recording, therefore effectively cannot record the EEG signals that habituation is relevant; Carrying out in the process of testing, mouse brain signal monitoring line with it cannot be normal freely movable in existing experimental box, can frequently impede by this monitoring line, be even wound around by it.
Utility model content
The conditioned place preference case be coupled with free moving rats eeg recording that the purpose of this utility model there is provided that a kind of and free moving rats eeg recording is coupled, it effectively avoids the generation of the event that the monitored line of laboratory animal is impeded in prior art, thus other factors various, on the impact of experimental result, effectively improve the accuracy of experiment in minimizing experimentation.
To achieve these goals, the technical scheme that the utility model is taked is: the conditioned place preference case that a kind of and free moving rats eeg recording is coupled, comprise black box, white box, ash bin three box body splicings become a rectangular experimental box, ash bin is between black box and white box;
To be provided with side between described black box and ash bin be black, opposite side is the first baffle plate of ash, is provided with that side is ash, opposite side is white second baffle between described ash bin and white box;
Described first baffle plate and second baffle include the first V-type plate, riser and the second V-type plate that set gradually;
The widest part of described first V-type plate and the second V-type plate is arranged according to the front side wall of the overall case of rectangle and rear wall respectively, and described riser is located between the first V-type plate and the second V-type plate;
The bottom of described riser offers wicket; Described riser is provided with a vertical opening, and described opening offers the middle part above wicket from the plan vertical of riser;
Also comprise a slideway, the top of described experimental box is located at by described slideway, its from left side wall until right side wall is horizontally set on described opening;
The upper end sidewall of described black box, white box and ash bin three casings is respectively equipped with infrared camera;
The bottom of described black box is roughening plane, and the bottom of white box is slickness plane.
The conditioned place preference case be coupled with free moving rats eeg recording as above, wherein, described first V-type plate and the second V-type plate are ganoid plate body;
Described first V-type plate, riser are identical with the width of the second V-type plate;
The thickness of its widest part is 5cm, and the thickness at the narrowest place is 1cm;
The thickness of described riser is 1cm.
The conditioned place preference case be coupled with free moving rats eeg recording as above, wherein, the base plate of described experimental box is the plate body with open-work, and be provided with below the base plate of described experimental box can the pumping board of pull.
The conditioned place preference case be coupled with free moving rats eeg recording as above, the shape of described open-work is circular or rectangular paliform.
The conditioned place preference case be coupled with free moving rats eeg recording as above, wherein, described white box is for placing the mouse of periodical injections morphine, and described black box is for placing the mouse of periodical injections physiological saline; Passing through of the brain signal monitoring line that described opening connects with it for mouse.
The conditioned place preference case be coupled with free moving rats eeg recording as above, wherein, described wicket is arch; Its size is 6*10cm.
The conditioned place preference case be coupled with free moving rats eeg recording as above, wherein, the width of described opening is 1cm.
The conditioned place preference case be coupled with free moving rats eeg recording as above, wherein, the length, width and height of described experimental box are 75*21*18cm.
The conditioned place preference case be coupled with free moving rats eeg recording as above, wherein, described experimental box adopts aluminum alloy frame and acrylic material to make.
Compared with prior art, the beneficial effect that the utility model produces is mainly reflected in:
1, the conditioned place preference case that is coupled of a kind of and free moving rats eeg recording of the present utility model, in this experimental box, arrange the first V-type plate, riser and the second V-type plate, the animal of convenient experiment is arbitrarily shuttled back and forth and impeding not by monitoring line in experimental box;
2, the conditioned place preference case that is coupled of a kind of and free moving rats eeg recording of the present utility model, the interference from the external world can be reduced as far as possible, animal can arbitrarily be shuttled back and forth effectively in black, grey, white three casings of experimental box, to ensure the effect of testing;
3, the conditioned place preference case that is coupled of a kind of and free moving rats eeg recording of the present utility model, it has simple, easy to use, the practical feature of structure.
Accompanying drawing explanation
Fig. 1 is the structural representation of the conditioned place preference case that a kind of and free moving rats eeg recording of the present utility model is coupled;
Description of reference numerals:
1, experimental box 2, black box 3, white box
4, ash bin 5, first baffle plate 6, second baffle
7, the first V-type plate 8, riser 9, second V-type plate
10, wicket 11, opening 12, slideway
13, infrared camera 14, open-work 15, pumping board
Embodiment
For the ease of understanding the purpose of this utility model, technical scheme and effect thereof, now will be elaborated further the utility model in conjunction with the embodiments.
As shown in Figure 1, the conditioned place preference case that a kind of and free moving rats eeg recording of the present utility model is coupled, comprise black box 2, white box 3, ash bin 4 three box body splicings become a rectangular experimental box 1, ash bin 4 is between black box 2 and white box 3; To be provided with side between described black box 2 and ash bin 4 be black, opposite side is the first baffle plate 5 of ash, is provided with that side is ash, opposite side is white second baffle 6 between described ash bin 4 and white box 3; Described first baffle plate 5 and second baffle include the first V-type plate 7, riser 8 and the second V-type plate 9 that set gradually; The widest part of described first V-type plate 7 and the second V-type plate 9 is arranged according to the front side wall of the overall case of rectangle and rear wall respectively, and described riser 8 is located between the first V-type plate 7 and the second V-type plate 9; The bottom of described riser 8 offers wicket 10; Described riser 8 is provided with a vertical opening 11, and described opening 11 offers the middle part above wicket 10 from the plan vertical of riser 8; Also comprise a slideway 12, the top of described experimental box 1 is located at by described slideway 12, its from left side wall until right side wall is horizontally set on described opening 11; The upper end sidewall of described black box 2, white box 3 and ash bin 4 three casings is respectively equipped with infrared camera 13; The bottom of described black box 2 is roughening plane, and the bottom of white box 3 is slickness plane.
The conditioned place preference case that a kind of and free moving rats eeg recording of the present utility model is coupled, first V-type plate 7, riser 8 and the second V-type plate 9 are set in this experimental box 1, this first V-type plate 7, riser 8 and the second V-type plate 9 are ganoid plate body, simultaneously, the top of described experimental box 1 is located at by described slideway 12, its from left side wall until right side wall is horizontally set on described opening 11; It is inner that monitoring line is placed to experimental box 1 from slideway 12; Thus ensure that laboratory animal in test can arbitrarily expeditely be shuttled back and forth in casing; Simultaneously infrared camera 13 is for information such as the event trace of acquisition and recording rat and times; Thus effectively avoid the generation of the event that the monitored line of laboratory animal is impeded in prior art, thus other factors various in experimentation that reduce, on the impact of experimental result, effectively improve the accuracy of experiment.
As shown in Figure 1, the conditioned place preference case that a kind of and free moving rats eeg recording of the present utility model is coupled, described first V-type plate 7 and the second V-type plate 9 are ganoid plate body; Described first V-type plate 7, riser 8 are identical with the width of the second V-type plate 9; The thickness of its widest part is 5cm, and the thickness at the narrowest place is 1cm; The thickness of described riser 8 is 1cm.
As shown in Figure 1, the conditioned place preference case that a kind of and free moving rats eeg recording of the present utility model is coupled, the base plate of described experimental box 1 is the plate body with open-work 14, and be provided with below the base plate of described experimental box 1 can the pumping board 15 of pull.
As shown in Figure 1, the conditioned place preference case that a kind of and free moving rats eeg recording of the present utility model is coupled, the shape of described open-work 14 is circular or rectangular paliform.
The conditioned place preference case that a kind of and free moving rats eeg recording of the present utility model is coupled, arranging this can pull pumping board 15, this pumping board 15 is provided with open-work 14 simultaneously, conveniently laboratory animal excreta is in test cleaned out chamber in time, also avoid those factors to affect experimental result to provide a clean environment simultaneously.
As shown in Figure 1, the conditioned place preference case that a kind of and free moving rats eeg recording of the present utility model is coupled, described white box 3 is for placing the mouse of periodical injections morphine, and described black box 2 is for placing the mouse of periodical injections physiological saline; Passing through of the brain signal monitoring line that described opening 11 connects with it for mouse.
As shown in Figure 1, the conditioned place preference case that a kind of and free moving rats eeg recording of the present utility model is coupled, described wicket 10 is arch; Its size is 6*10cm.
As shown in Figure 1, the conditioned place preference case that a kind of and free moving rats eeg recording of the present utility model is coupled, the width of described opening 11 is 1cm.
As shown in Figure 1, the conditioned place preference case that a kind of and free moving rats eeg recording of the present utility model is coupled, the length, width and height of described experimental box 1 are 75*21*18cm.
As shown in Figure 1, the conditioned place preference case that a kind of and free moving rats eeg recording of the present utility model is coupled, described experimental box 1 adopts aluminum alloy frame and acrylic material to make.
The conditioned place preference case that a kind of and free moving rats eeg recording of the present utility model is coupled, in experimental stage, for morphine model group rats carries out conditionity training, every morning injection morphine 10mgkg-1, namely puts into white box 3 after injection, leaves standstill 45min; The isopyknic physiological saline of P.M. injection, namely puts into black box 2 after injection, leaves standstill 45min.For physiology salt water model group rat carries out conditionity training, every morning injects isopyknic physiological saline, namely puts into white box 3 after injection, leaves standstill 45min; The isopyknic physiological saline of P.M. injection, namely puts into black box 2 after injection, leaves standstill 45min.At test phase, respectively morphine model group rats and physiological saline model group rats are put into ash bin 4, determined the chest that will go by rat, thus experimentally data result judges.
The utility model is done above in conjunction with the embodiments and further described, but the utility model is not limited to above-mentioned embodiment, in the ken that one skilled in the relevant art possesses, can also make a variety of changes under the prerequisite not departing from the utility model aim.
Claims (9)
1. the conditioned place preference case be coupled with free moving rats eeg recording, comprise black box, white box, ash bin three box body splicings become a rectangular experimental box, ash bin is between black box and white box; It is characterized in that:
To be provided with side between described black box and ash bin be black, opposite side is the first baffle plate of ash, is provided with that side is ash, opposite side is white second baffle between described ash bin and white box;
Described first baffle plate and second baffle include the first V-type plate, riser and the second V-type plate that set gradually;
The widest part of described first V-type plate and the second V-type plate is arranged according to the front side wall of the overall case of rectangle and rear wall respectively, and described riser is located between the first V-type plate and the second V-type plate;
The bottom of described riser offers wicket; Described riser is provided with a vertical opening, and described opening offers the middle part above wicket from the plan vertical of riser;
Also comprise a slideway, the top of described experimental box is located at by described slideway, its from left side wall until right side wall is horizontally set on described opening;
The upper end sidewall of described black box, white box and ash bin three casings is respectively equipped with infrared camera;
The bottom of described black box is roughening plane, and the bottom of white box is slickness plane.
2. the conditioned place preference case that is coupled of a kind of and free moving rats eeg recording according to claim 1, is characterized in that:
Described first V-type plate and the second V-type plate are ganoid plate body;
Described first V-type plate, riser are identical with the width of the second V-type plate;
The thickness of its widest part is 5cm, and the thickness at the narrowest place is 1cm;
The thickness of described riser is 1cm.
3. the conditioned place preference case that is coupled of a kind of and free moving rats eeg recording according to claim 2, is characterized in that:
The base plate of described experimental box is the plate body with open-work, and be provided with below the base plate of described experimental box can the pumping board of pull.
4. the conditioned place preference case that is coupled of a kind of and free moving rats eeg recording according to claim 3, is characterized in that:
The shape of described open-work is circular or rectangular paliform.
5. the conditioned place preference case that is coupled of a kind of and free moving rats eeg recording according to claim 4, is characterized in that:
Described white box is for placing the mouse of periodical injections morphine, and described black box is for placing the mouse of periodical injections physiological saline; Passing through of the brain signal monitoring line that described opening connects with it for mouse.
6. the conditioned place preference case that is coupled of a kind of and free moving rats eeg recording according to claim 5, is characterized in that:
Described wicket is arch; Its size is 6*10cm.
7. the conditioned place preference case that is coupled of a kind of and free moving rats eeg recording according to claim 6, is characterized in that:
The width of described opening is 1cm.
8. the conditioned place preference case that is coupled of a kind of and free moving rats eeg recording according to claim 7, is characterized in that:
The length, width and height of described experimental box are 75*21*18cm.
9. the conditioned place preference case that is coupled of a kind of and free moving rats eeg recording according to claim 8, is characterized in that:
Described experimental box adopts aluminum alloy frame and acrylic material to make.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201521070180.7U CN205196653U (en) | 2015-12-19 | 2015-12-19 | Have a preference for case with conditionity position that free activity rat brain electrographic recording coupling allies oneself with |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201521070180.7U CN205196653U (en) | 2015-12-19 | 2015-12-19 | Have a preference for case with conditionity position that free activity rat brain electrographic recording coupling allies oneself with |
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| Publication Number | Publication Date |
|---|---|
| CN205196653U true CN205196653U (en) | 2016-05-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201521070180.7U Expired - Fee Related CN205196653U (en) | 2015-12-19 | 2015-12-19 | Have a preference for case with conditionity position that free activity rat brain electrographic recording coupling allies oneself with |
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| CN (1) | CN205196653U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109350083A (en) * | 2018-11-20 | 2019-02-19 | 遵义医学院 | A kind of preference case of changeable colour |
| CN110301364A (en) * | 2019-08-02 | 2019-10-08 | 中国人民解放军军事科学院军事医学研究院 | Experimental box is used in a kind of research of mouse Social behaviors |
-
2015
- 2015-12-19 CN CN201521070180.7U patent/CN205196653U/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109350083A (en) * | 2018-11-20 | 2019-02-19 | 遵义医学院 | A kind of preference case of changeable colour |
| CN109350083B (en) * | 2018-11-20 | 2023-11-03 | 遵义医学院 | Color-changeable preference box |
| CN110301364A (en) * | 2019-08-02 | 2019-10-08 | 中国人民解放军军事科学院军事医学研究院 | Experimental box is used in a kind of research of mouse Social behaviors |
| CN110301364B (en) * | 2019-08-02 | 2021-09-24 | 中国人民解放军军事科学院军事医学研究院 | Experiment box for research on social behaviors of mice |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160504 Termination date: 20161219 |