CN210856068U - Intestinal flora nucleic acid extraction system - Google Patents
Intestinal flora nucleic acid extraction system Download PDFInfo
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- CN210856068U CN210856068U CN201920698022.8U CN201920698022U CN210856068U CN 210856068 U CN210856068 U CN 210856068U CN 201920698022 U CN201920698022 U CN 201920698022U CN 210856068 U CN210856068 U CN 210856068U
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Abstract
The utility model discloses a name is intestinal fungus crowd nucleic acid extraction system. Belongs to the technical field of medical and health clinical examination. The method mainly solves the problems that the traditional manual method is time-consuming and labor-consuming, low in working efficiency and incapable of ensuring experimental results and quality. It is mainly characterized in that: the device comprises a sample introduction module, an intelligent centrifugal module, a test tube sample introduction module, a manipulator module and a reagent sample introduction module; the intelligent centrifugal module is positioned in the middle of a machine bottom plate; the sample injection module and the reagent injection module are arranged on a middle-layer frame of the machine frame and are positioned above the intelligent centrifugal module; the test tube sample introduction module is movably arranged on a middle-layer rack of the machine rack and is positioned above the intelligent centrifugal module; the manipulator module is arranged on an upper layer frame of the machine frame. The utility model discloses the bacterial nucleic acid in the automatic extraction excrement and urine of mainly used.
Description
Technical Field
The utility model belongs to the technical field of medical health clinical examination, especially, relate to in the automatic inspection instrument, other biological sample can be extended to mainly used excrement and urine sample intestinal fungus crowd nucleic acid extraction and fungus crowd analysis automation instrument, like the nucleic acid extraction in biological samples such as whole blood, plasma, pharynx swab, tissue, sputum, cerebrospinal fluid.
Background
With the continuous development of modern biological technology, the research results of biological science are widely applied, nucleic acid is a biological macromolecular compound polymerized by a plurality of nucleotides, is one of the most basic substances of life, is a carrier of biological genetic information, widely exists in all animal and plant cells and microorganisms, plays an important role in the life process of organisms, and plays an irreplaceable role in the field of life science leader research. Nucleic acid extraction and purification are of particular importance as the first step in nucleic acid research.
The intestinal microecology is called the second largest genome of human, the research of the intestinal flora is paid much attention in the medical field in recent years, the nucleic acid extraction of the intestinal flora is mainly obtained by a stool specimen, and the traditional manual method adopted at present has the disadvantages of complicated steps, time and labor consumption, low working efficiency and uncertain experimental results and quality.
Disclosure of Invention
The utility model aims at the above-mentioned weak point and provide an intestinal flora nucleic acid extraction system, through the centrifugation method, including using supporting nucleic acid extraction reagent to accomplish the instrument of extracting the bacterium nucleic acid from excrement and urine automatically.
The technical solution of the utility model is that: an intestinal flora nucleic acid extraction system is characterized in that: the device comprises a sample introduction module, an intelligent centrifugal module, a test tube sample introduction module, a manipulator module and a reagent sample introduction module; the intelligent centrifugal module is positioned in the middle of a machine bottom plate; the sample injection module and the reagent injection module are arranged on a middle-layer frame of the machine frame and are positioned above the intelligent centrifugal module; the test tube sample introduction module is movably arranged on a middle-layer rack of the machine rack and is positioned above the intelligent centrifugal module; the manipulator module is arranged on an upper layer frame of the machine frame.
The utility model adopts the technical proposal that the sample feeding module comprises a sample feeding tray and a sample feeding motor; the sample injection motor and the sample injection synchronous belt are arranged on a middle-layer frame of the machine frame through a sample injection bracket and are positioned above one side of the intelligent centrifugal module; the sample introduction tray is arranged on the sample introduction bracket in a matching way and is connected with the sample introduction synchronous belt.
The intelligent centrifugal module in the technical solution of the utility model comprises a centrifugal rotor positioning device, a specimen holder and a centrifugal large disc; wherein, two opposite outer sides of the specimen rack are provided with longitudinal specimen rack fixing grooves, and the other two opposite sides are provided with mechanical finger clip fixing parts; the specimen rack is provided with a fixing lug matched with the specimen rack fixing groove; the centrifugal rotor positioning device comprises a centrifugal rotating shaft, a centrifugal motor, a centrifugal synchronous belt, a driven wheel and a centrifugal positioning piece, wherein the centrifugal rotating shaft is installed in a shell of the intelligent centrifugal module through a bearing and a support, the centrifugal motor is connected with the driven wheel on the centrifugal rotating shaft through the centrifugal synchronous belt, and the lower end of the centrifugal rotating shaft is connected with a centrifugal large disc through the centrifugal positioning piece.
The technical solution of the utility model is that the test tube sample feeding module comprises a test tube rack sample feeding tray, a centrifugal reagent feeding tray and a test tube sample feeding motor; the test tube sample injection motor and the test tube sample injection synchronous belt are arranged on a middle-layer frame of the machine frame through a test tube sample injection support and are positioned above the intelligent centrifugal module; the test tube rack sample introduction tray is arranged on the test tube sample introduction bracket in a matching way and is connected with the test tube sample introduction synchronous belt; the centrifugal reagent adding tray is arranged on the side part of the sample feeding tray of the test tube rack.
The technical solution of the utility model is that the manipulator module comprises a movable X/Y/Z manipulator and a specimen holder arranged on the manipulator for transferring finger clamps and a reagent needle tube.
The reagent sample introduction module in the technical proposal of the utility model comprises a reagent sample introduction tray and a reagent sample introduction motor; the reagent sample injection motor and the reagent sample injection synchronous belt are arranged on a middle-layer frame of the machine frame through a reagent sample injection bracket and are positioned above the other side of the intelligent centrifugal module; the reagent sample introduction tray is arranged on the reagent sample introduction bracket in a matching way and is connected with the reagent sample introduction synchronous belt.
The technical proposal of the utility model also comprises a disposable liquid-transferring head device which is combined with the manipulator module; the disposable liquid-transfering head device is formed from sampling needle and disposable liquid-transfering head. .
The manipulator capable of moving in the X/Y/Z direction in the technical scheme of the utility model comprises a Z-direction first lead screw motor, a Z-direction second lead screw motor, an X-direction slider, a Y-direction motor and a Y-direction slider; the X-direction motor and the X-direction sliding block are arranged on an upper layer frame of the machine frame; the Y-direction motor and the Y-direction sliding block are arranged on the X-direction sliding block; a Z-direction first lead screw motor and a Z-direction second lead screw motor are arranged on the Y-direction slide block; the specimen rack transferring finger is clamped on the Z-direction first screw rod motor; the reagent adding needle tube is arranged on the Z-direction second lead screw motor.
The center of the centrifugal large plate in the technical solution of the utility model is provided with a mounting hole matched with a centrifugal positioning piece, and four mounting groove positions of the specimen holder are symmetrically arranged around the centrifugal large plate; four specimen cup placing grooves are arranged in the specimen rack.
The technical solution of the utility model in the sample frame shift indicate press from both sides the straight-bar that includes two symmetries and set up, the lower extreme of straight-bar is equipped with inside circular hook.
The utility model has the advantages of it is following: (1) sample introduction module: bringing a sample rack into a module of the machine, and placing a specimen box to be processed in the sample rack; (2) a centrifugal module: compared with the common centrifugal machine, the centrifugal machine has more rotor positioning functions, and after the sample is placed in an instrument, automatic centrifugal treatment is carried out according to different samples; (3) the test tube sample introduction module: bringing a sample holder into a module of the machine, the test tube being placed in the sample holder; (4) a manipulator module: the device is used for completing corresponding work such as collecting samples and adding reagents in the instrument (X/Y/Z movement can be realized, X moves left and right along the bridge direction, Y moves front and back space, and Z moves up and down); (5) a reagent sample introduction module: the required reagents are placed into the reagent sample introduction zone as specified.
Drawings
Fig. 1 is a schematic structural diagram of the present invention.
Fig. 2 is the structure schematic diagram of the specimen sample feeding module of the utility model.
Fig. 3 is the utility model discloses the structural schematic diagram of intelligence centrifugation module.
Fig. 4 is a schematic view of the internal structure of fig. 3. The centrifugal module runs at a high speed to centrifuge the sample, and after the centrifugation, the centrifugal positioning piece returns to zero under the action of the motor and the driven wheel, so that the sample number is judged and the next operation is carried out.
Fig. 5 is a partial enlarged view of the specimen holder and the centrifugal module according to the present invention.
Fig. 6 is a schematic structural view of the specimen cup of the present invention.
Figure 7 is the utility model discloses the test tube advances kind module's structural schematic.
Fig. 8 is a schematic structural diagram of the manipulator module of the present invention.
Fig. 9 is a partial enlarged view of the specimen holder transfer finger clip of the present invention.
Fig. 10 is a dynamic diagram of the specimen rack transfer finger clip of the present invention.
Fig. 11 is the structure schematic diagram of the reagent sample introduction module of the present invention.
Fig. 12 is a schematic structural view of the disposable pipetting head device of the present invention.
In the figure: 1. a sample introduction module; 1-1, sample introduction tray; 1-2, sample injection motor; 2. an intelligent centrifuge module; 2-1, a centrifugal rotor positioning device; 2-2, placing a specimen rack; 2-3, specimen rack, or test tube rack; 2-4, mechanical finger clip fixing piece; 2-5, fixing grooves of the specimen rack; 2-6. a centrifugal motor; 2-7, centrifuging the synchronous belt; 2-8, centrifuging the large disc; 2-9. a driven wheel; 2-10, centrifugal positioning piece; 3. a test tube sample introduction module; 3-1, a sample introduction tray of the test tube rack; 3-2, centrifuging and adding a reagent plate; 4. a manipulator module; 4-1, transferring the finger clamp by the specimen rack; 4-2, adding a reagent needle tube; 4-3. a first screw motor in the Z direction; 4-4. Y-direction motor; 4-5. a Z-direction second screw rod motor; 4-6. X-direction sliding block; 4-7. an X-direction motor; 4-8, Y-direction slide block; 5. a reagent sample introduction module; 5-1, reagent sample injection tray; 6. a disposable pipetting head device; 6-1, a sampling needle; 6-2, disposable pipetting head.
Detailed Description
The following detailed description of the embodiments of the present invention will be made with reference to the accompanying drawings.
As shown in fig. 1-12. The utility model discloses intestinal fungus crowd nucleic acid extraction system includes that the sample advances kind module 1, intelligent centrifugal module 2, test tube advance kind module 3, manipulator module 4 and reagent advance kind module 5. Wherein, the intelligent centrifugal module 2 is positioned in the middle of the bottom plate of the machine. The sample injection module 1 and the reagent injection module 5 are arranged on a middle-layer frame of the machine frame and are positioned above the left side and the right side of the intelligent centrifugal module 2. The test tube sample injection module 3 is movably arranged on the middle layer frame of the machine frame and is positioned above the intelligent centrifugal module 2. The manipulator module 4 is arranged on the upper shelf of the machine frame.
The sample introduction module 1 comprises a sample introduction tray 1-1 and a sample introduction motor 1-2. The sample injection motor 1-2 and the sample injection synchronous belt are arranged on a middle layer frame of the machine frame through a sample injection bracket and are positioned above one side of the intelligent centrifugal module 2. The sample introduction tray 1-1 is arranged on the sample introduction bracket in a matching way and is connected with the sample introduction synchronous belt.
The intelligent centrifugal module 2 comprises a centrifugal rotor positioning device 2-1, a specimen holder 2-3 and a centrifugal large disc 2-8. Wherein, two opposite outer sides of the specimen shelf 2-3 are provided with longitudinal specimen shelf fixing grooves 2-5, and the other two opposite sides are provided with mechanical finger clip fixing parts 2-4. The specimen holder 2-3 is provided with a fixing lug matched with the specimen holder fixing groove 2-5. The centrifugal rotor positioning device 2-1 comprises a centrifugal rotating shaft, a centrifugal motor 2-6, a centrifugal synchronous belt 2-7, a driven wheel 2-9 and a centrifugal positioning piece 2-10, wherein the centrifugal rotating shaft is arranged in a shell of the intelligent centrifugal module 2 through a bearing and a support, the centrifugal motor 2-6 is connected with the driven wheel 2-9 on the centrifugal rotating shaft through the centrifugal synchronous belt 2-7, and the lower end of the centrifugal rotating shaft is connected with a centrifugal large disc 2-8 through the centrifugal positioning piece 2-10. The center of the centrifugal large plate 2-8 is provided with a mounting hole matched with the centrifugal positioning piece 2-10, and four mounting groove positions of the specimen rack 2-3 are symmetrically arranged on the periphery. Four specimen cup placing grooves are arranged in the specimen rack 2-3.
The test tube sample introduction module 3 comprises a test tube rack sample introduction tray 3-1, a centrifugal reagent adding tray 3-2 and a test tube sample introduction motor. The test tube advances a kind motor and test tube and advances a kind hold-in range and pass through the test tube and advance a kind support mounting on the well layer frame of machine frame, is located intelligent centrifuge module 2's top. The sample introduction tray 3-1 of the test tube rack is arranged on the sample introduction bracket of the test tube in a matching way and is connected with the sample introduction synchronous belt of the test tube. The centrifugal reagent adding tray 3-2 is arranged at the side part of the sample introduction tray 3-1 of the test tube rack.
The sample introduction bracket and sample introduction tray 1-1 of the sample introduction module 1 and the test tube sample introduction bracket and sample introduction tray 3-1 of the test tube frame are identical in appearance. The specimen holder 2-3 may be a test tube holder. The sample to be processed that puts in the sample appearance module 1, the test tube that the test tube appearance module 3 was put.
The manipulator module 4 comprises a manipulator capable of moving in the X/Y/Z direction, and a sample rack transfer finger clamp 4-1 and a reagent adding needle tube 4-2 which are arranged on the manipulator. The manipulator capable of moving in the X/Y/Z direction comprises a Z-direction first lead screw motor 4-3, a Z-direction second lead screw motor 4-5, an X-direction motor 4-7, an X-direction sliding block 4-6, a Y-direction motor 4-4 and a Y-direction sliding block 4-8. The X-direction motor 4-7 and the X-direction sliding block 4-6 are arranged on an upper layer frame of the machine frame. The Y-direction motor 4-4 and the Y-direction sliding block 4-8 are arranged on the X-direction sliding block 4-6. The Z-direction first screw rod motor 4-3 and the Z-direction second screw rod motor 4-5 are arranged on the Y-direction sliding block 4-8. The specimen rack transfer finger clamp 4-1 is arranged on a Z-direction first screw rod motor 4-3. The reagent adding needle tube 4-2 is arranged on a Z-direction second lead screw motor 4-5. The specimen rack transferring finger clamp 4-1 comprises two straight rods which are symmetrically arranged, and the lower ends of the straight rods are provided with inward circular hooks. The manipulator module 4 is combined with a disposable pipetting head device 6. The disposable liquid-transfering head device 6 is composed of a sampling needle 6-1 and a disposable liquid-transfering head 6-2.
The reagent sample introduction module 5 comprises a reagent sample introduction tray 5-1 and a reagent sample introduction motor. The reagent sample injection motor and the reagent sample injection synchronous belt are arranged on a middle layer frame of the machine frame through a reagent sample injection bracket and are positioned above the other side of the intelligent centrifugal module 2. The reagent sample introduction tray 5-1 is arranged on the reagent sample introduction bracket in a matching way and is connected with the reagent sample introduction synchronous belt.
The working process is as follows:
1. placing the test tube into a sample holder 2-3, and bringing the sample holder 2-3 into the instrument through a sample introduction tray 1-1; placing the specimen into a specimen rack;
2. the specimen rack transfer finger clamp 4-1 is combined with the manipulator finger clamp fixing part 2-4 (as shown in figure 10), so that the specimen rack is driven to be transferred and placed into a centrifugal module specimen rack placing position 2-2, and the specimen rack placing position 2-2 is matched and combined with a specimen rack fixing groove 2-5; the finger clamp of the mechanical arm is combined with the specimen rack, and the specimen rack is operated and combined with the centrifugal module;
3. under the control of a program, a centrifuge is used for rotating at a low speed to centrifuge the samples in the sample racks 2-3 (the same as a common centrifuge in the market), after the centrifugation is finished, a centrifugal rotor positioning device 2-1 rotates a centrifugal module to a fixed direction or position, and after a rotor is fixed, a manipulator module takes out the sample racks and puts the sample racks back to the original position of a sample injection module; a first step of centrifugal treatment (aiming at eliminating impurities in the fecal specimen, and the impurities are deposited below through the first step of centrifugal treatment);
4. the manipulator is combined with the disposable liquid-moving head 6-2, the sampling needle 6-1 pumps (sucks) supernatant fluid, then the supernatant fluid is injected into a test tube in the test tube sample injection module 3, and the disposable liquid-moving head 6-2 (a waste box is ready to be drawn) is thrown away; transferring a required sample;
5. the manipulator module puts the test tube rack in the test tube sample injection module 3 into the centrifugal module for high-speed centrifugation (the rotation speed is different, the operation steps are the same as the centrifugation steps above), and then the test tube rack is taken out and put back to the original position of the test tube sample injection module 3; a second step of centrifugal treatment (the purified specimen makes the shaped components more concentrated);
6. the manipulator is combined with the disposable liquid-moving head 6-2, the supernatant liquid is pumped (sucked) and thrown into a waste box (to be drawn) together with the disposable liquid-moving head 6-2, and about 1ml of sediment is left in the test tube;
7. a manipulator sampling needle 6-1 (for adding lysis solution) sucks about 20ml of lysis solution required by nucleic acid extraction from a reagent bottle in the reagent sampling module 5, and fills the lysis solution into the test tube in the previous step (namely, mixes the lysis solution with about 1ml of the precipitate left in the test tube); adding a lysis solution;
8. the manipulator module puts the test tube rack in the test tube sample injection module 3 into the centrifugal module for high-speed centrifugation for about 30min (the operation steps are the same as the centrifugation steps above with different rotating speeds), and after the rotor is fixed, the test tube rack is taken out and put back to the original position of the test tube sample injection module 3; a third step of centrifugation (lysis, cell wall and cytoplasm destruction to obtain the desired nucleic acid);
9. the manipulator is combined with the disposable liquid transfer head, and the supernatant liquid is pumped (sucked) and thrown into a waste box (to be drawn) together with the disposable liquid transfer head, and about 0.2g of sediment (namely the extracted macro basic group nucleic acid of the fecal bacteria) is left;
10. the finished sample injection module, the test tube injection module and the reagent injection module are all automatically withdrawn from the instrument, and nucleic acid extracting solution required by people is collected by a test tube in the test tube injection module 3; and (3) collecting the nucleic acid.
The manipulator is combined with the disposable liquid-transferring head to avoid cross contamination.
Claims (10)
1. An intestinal flora nucleic acid extraction system is characterized in that: comprises a sample injection module (1), an intelligent centrifugal module (2), a test tube sample injection module (3), a manipulator module (4) and a reagent sample injection module (5); wherein the intelligent centrifugal module (2) is positioned in the middle of a machine bottom plate; the sample injection module (1) and the reagent injection module (5) are arranged on a middle-layer frame of the machine frame and are positioned above the intelligent centrifugal module (2); the test tube sample introduction module (3) is movably arranged on a middle-layer rack of the machine frame and is positioned above the intelligent centrifugal module (2); the manipulator module (4) is arranged on an upper layer frame of the machine frame.
2. The system for extracting nucleic acid from intestinal flora according to claim 1, wherein: the sample injection module (1) comprises a sample injection tray (1-1) and a sample injection motor (1-2); the sample injection motor (1-2) and the sample injection synchronous belt are arranged on a middle-layer frame of the machine frame through a sample injection bracket and are positioned above one side of the intelligent centrifugal module (2); the sample introduction tray (1-1) is arranged on the sample introduction bracket in a matching way and is connected with the sample introduction synchronous belt.
3. An intestinal flora nucleic acid extraction system according to claim 1 or 2, wherein: the intelligent centrifugal module (2) comprises a centrifugal rotor positioning device (2-1), a specimen holder (2-3) and a centrifugal large disc (2-8); wherein, two opposite outer sides of the specimen rack (2-3) are provided with longitudinal specimen rack fixing grooves (2-5), and the other two opposite sides are provided with mechanical finger clip fixing parts (2-4); the specimen holder (2-3) is provided with a fixing bump matched with the specimen holder fixing groove (2-5); the centrifugal rotor positioning device (2-1) comprises a centrifugal rotating shaft, a centrifugal motor (2-6), a centrifugal synchronous belt (2-7), a driven wheel (2-9) and a centrifugal positioning piece (2-10), wherein the centrifugal rotating shaft is installed in a shell of the intelligent centrifugal module (2) through a bearing and a support, the centrifugal motor (2-6) is connected with the driven wheel (2-9) on the centrifugal rotating shaft through the centrifugal synchronous belt (2-7), and the lower end of the centrifugal rotating shaft is connected with a centrifugal large disc (2-8) through the centrifugal positioning piece (2-10).
4. The system for extracting nucleic acid from gut flora according to claim 1 or 2, wherein: the test tube sample introduction module (3) comprises a test tube rack sample introduction tray (3-1), a centrifugal reagent adding tray (3-2) and a test tube sample introduction motor; the test tube sample injection motor and the test tube sample injection synchronous belt are arranged on a middle-layer frame of the machine frame through a test tube sample injection support and are positioned above the intelligent centrifugal module (2); the sample introduction tray (3-1) of the test tube rack is arranged on the sample introduction bracket of the test tube in a matching way and is connected with the sample introduction synchronous belt of the test tube; the centrifugal reagent adding tray (3-2) is arranged at the side part of the sample introduction tray (3-1) of the test tube rack.
5. The system for extracting nucleic acid from gut flora according to claim 1 or 2, wherein: the manipulator module (4) comprises a manipulator capable of moving in the X/Y/Z direction, a specimen rack transfer finger clamp (4-1) and a reagent adding needle tube (4-2) arranged on the manipulator.
6. The system for extracting nucleic acid from gut flora according to claim 1 or 2, wherein: the reagent sample introduction module (5) comprises a reagent sample introduction tray (5-1) and a reagent sample introduction motor; the reagent sample injection motor and the reagent sample injection synchronous belt are arranged on a middle-layer frame of the machine frame through a reagent sample injection bracket and are positioned above the other side of the intelligent centrifugal module (2); the reagent sample introduction tray (5-1) is arranged on the reagent sample introduction bracket in a matching way and is connected with the reagent sample introduction synchronous belt.
7. The system for extracting nucleic acid from gut flora according to claim 1 or 2, wherein: the device also comprises a disposable pipetting head device (6) combined with the manipulator module (4); the disposable liquid transfer head device (6) is composed of a sampling needle (6-1) and a disposable liquid transfer head (6-2).
8. The intestinal flora nucleic acid extraction system of claim 5, wherein: the manipulator capable of moving in the X/Y/Z direction comprises a first Z-direction lead screw motor (4-3), a second Z-direction lead screw motor (4-5), an X-direction motor (4-7), an X-direction sliding block (4-6), a Y-direction motor (4-4) and a Y-direction sliding block (4-8); the X-direction motor (4-7) and the X-direction sliding block (4-6) are arranged on an upper layer frame of the machine frame; the Y-direction motor (4-4) and the Y-direction sliding block (4-8) are arranged on the X-direction sliding block (4-6); a Z-direction first screw rod motor (4-3) and a Z-direction second screw rod motor (4-5) are arranged on a Y-direction sliding block (4-8); the specimen rack transfer finger clamp (4-1) is arranged on a Z-direction first screw rod motor (4-3); the reagent adding needle tube (4-2) is arranged on the Z-direction second lead screw motor (4-5).
9. The system for extracting nucleic acid from gut flora according to claim 3, wherein: the center of the large centrifugal tray (2-8) is provided with a mounting hole matched with the centrifugal positioning piece (2-10), and the periphery of the large centrifugal tray is symmetrically provided with four mounting groove positions of the specimen rack (2-3); four specimen cup placing grooves are arranged in the specimen rack (2-3).
10. The intestinal flora nucleic acid extraction system of claim 5, wherein: the specimen rack transfer finger clamp (4-1) comprises two symmetrically arranged straight rods, and inward circular hooks are arranged at the lower ends of the straight rods.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110437970A (en) * | 2019-05-15 | 2019-11-12 | 湖北微伞医疗科技有限公司 | Intestinal flora nucleic acid extraction system |
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| CN110437970A (en) * | 2019-05-15 | 2019-11-12 | 湖北微伞医疗科技有限公司 | Intestinal flora nucleic acid extraction system |
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Effective date of registration: 20221228 Address after: 441004 Building 9, Xiangyang science and Technology City, Xijing 4th Road, high tech Zone, Xiangyang City, Hubei Province (No.37 Zhuhai Avenue, Shenzhen Industrial Park) Patentee after: Xiangyang Weisan Medical Laboratory Co.,Ltd. Address before: 441100 Building 9, Xiangyang Science and Technology City, Xijing 4th Road, High tech Zone, Xiangyang City, Hubei Province (No. 37, Zhuhai Avenue, Shenzhen Industrial Park) Patentee before: Hubei Weisan Medical Technology Co.,Ltd. |