CN209656722U

CN209656722U - A kind of device for collecting liquid sample

Info

Publication number: CN209656722U
Application number: CN201821040943.7U
Authority: CN
Inventors: 吴志强; 洪亮; 朱杨煜; 科恩·罗玲; 吴淑江
Original assignee: Hangzhou Biotest Biotech Co Ltd
Current assignee: Hangzhou Biotest Biotech Co Ltd
Priority date: 2018-02-13
Filing date: 2018-06-29
Publication date: 2019-11-19
Anticipated expiration: 2028-06-29
Also published as: CN209148707U; CN110161268A; CN110161266A; CN209014587U; CN209014584U; CN209014586U; CN110161265A; CN110161264A; CN208721694U; CN208953548U; CN110161267A; CN209559909U; CN209559910U; CN110161266B; CN209014585U; CN209656723U

Abstract

The utility model provides the device of a kind of collection and detection liquid sample, which includes the first chamber and the second chamber, and the first chamber is used to collect liquid sample and carries out initial detecting, and the second chamber is used to collect liquid sample in case secondary-confirmation detection is used.The first chamber and the second chamber of the device are detachable combination.When needing to carry out secondary-confirmation detection, the second chamber can be separated with the first chamber, be sent to confirmation testing agency and carried out confirmation detection.The pollution that the detection reagent item and liquid sample that can avoid conventional apparatus may generate sample when contacting；Space needed for effectively reducing storage liquid sample, greatly reduces the risk of transportational process liquid sample leakage.

Description

A kind of device for collecting liquid sample

This application claims Chinese earlier application, application number 201810150485.0, the priority of applying date 2018-02-13.

Technical field

The utility model relates to a kind of device for collecting liquid sample, the especially collections and detection in quick diagnosis field The device of analyte in liquid sample, such as urine collecting and detection device.

Background technique

Currently, for detect in sample whether the detection device containing analyte, be largely used to hospital or family In, these detection devices for being applied to quick diagnosis include one or more detection reagent items, for example early pregnancy detects, drug abuse Detection etc..The detection device of this quick diagnosis is very convenient, can be at one minute, or at most ten minutes or so are detecting Testing result is obtained on reagent strip.

Illicit drugs inspection is widely used, be usually used in prohibition of drug department, public security bureau, narcotic house, medical center, country conscription physical examination at Etc. mechanisms.Illicit drugs inspection wide variety, number is frequent, can be automatically separated the illicit drugs inspection urine cup of remaining sample Yu detected sample With the huge market demand, after detection is completed, sample in urine cup will be by for illicit drugs inspection urine cup currently on the market To detection reagent pollution and cannot continue on for second of confirmation detection, such as United States Patent (USP) 7300633 describe as.

Although detected sample in the conventional technology, can be allowed to be isolated with the sample of collection, cost Height, and do not allow easy to operate.Such as United States Patent (USP), the piston urine cup that the patent No. 7,300,633 describes advance when promotion piston In the process, it allows liquid sample in collecting chamber, such as urine, is transferred to test chamber from collecting chamber, there is detection sample in test chamber The testing element of analyte in product, and the liquid sample of collecting chamber is kept apart by piston, thus two local samples It will not obscure, be detected so as to be used to later confirmation.Although can isolate out the sample of detection and the sample of collection in this way, But the urine cup of this piston is at high cost, and operation is not easy, and pushes piston to need bigger strength after all, this is because Piston needs to reach transfer sample, is necessarily required to play the effect of hydraulic seal with the wall of piston, achievees the effect that sealing needs Piston and plunger shaft is allowed closely to combine, in addition, when carrying out secondary detection, it is necessary to which whole device is transplanted on inspection body It carries out.

For another example United States Patent (USP) 8,992,855 describes a kind of device for collecting liquid sample, which includes and lid The piston structure for being linked together and moving together with lid separates although can detecte sample and the sample of collection, when inspection Test sample this enter test chamber after, need to overcome very big pressure just to can enter, and need the ruler of sophisticated design lid and rim of a cup Very little, the piston being linked together in this way with lid can accurately be just inserted into disengagement chamber.

In addition, carrying out confirmation inspection if necessary to subsequent after the completion of the preliminary tests such as these traditional collections and detection device It surveys, needing an entire collection and detection device to be transported to, the progress of confirmation testing agency is further to confirm detection, this just brings Many problems, at least have a problem in that first, and major part liquid is collected at present and detection device is provided only with Preliminary detection Chamber.When if necessary to subsequent confirmation detection, the whole device containing urine and detection reagent item can only be sent to confirmation detection machine Structure is detected.In this way, the sample in urine cup is possible to the pollution by detection reagent.Second, whole device is sent to really When recognizing testing agency, since rim of a cup is larger, liquid has the risk of leakage during transportation, this is just needed more at allowing originally Device has better seal effect, to reduce the risk of leakage to the greatest extent；Third, confirmation testing agency need huge low temperature bin Entire detection device is stored in library, prevents liquid sample rotten, in order to it is subsequent it is possible further confirm that detection is prepared, in this way Confirmation testing agency (being properly termed as secondary detection mechanism) cost is caused to be sharply increased.

It for above-mentioned some technical problems, therefore needs to make improvements, other approach is provided and solves existing traditional skill The deficiency of art.

Summary of the invention

For above situation, to overcome the shortcomings of existing technologies, can be separated the purpose of this utility model is to provide a kind of The detection device of initial detecting sample and confirmation detection sample (secondary detection), the device is after having collected liquid sample, In Before being detected or after detection, initial detecting sample and confirmation detection sample can be allowed to enter in two cavitys, such as the One chamber and second intracavitary, then after the completion of initial detecting or before completing, the second chamber can be with initial collection chamber (the first chamber) It is separated, to realize the detachable separation of the chamber of the second chamber and initial collection sample.It is separated with initial collection chamber Second cavity can be used to carry out subsequent second of detection or subsequent confirmation detection.Initial detecting sample is collected to reach This and subsequent possible confirmation detection sample (second of detection) are efficiently separated, finally primary to collect, at least two inspections That surveys witnesses.

It can also be expected that when collection device includes two cavitys, the two cavitys receive simultaneously or with sequencing Same liquid sample, such as urine, one of cavity, such as the first chamber are used to collection part liquid sample, in addition Cavity, such as the second chamber are used to collect the liquid sample of other part.After gathering or while collection, the liquid of the first chamber Body can be used to contact completion test for the first time with testing element, and the second chamber can be separated with the first chamber, secondary for carrying out Detection.

The utility model in a first aspect, the utility model provides a kind of for collecting the device of liquid sample, the device It include: the first chamber for collecting liquid sample；Be used to collect for confirm detect liquid sample the second chamber；Wherein, One chamber and the second cavity removably combine, and combine or connect.

In some preferred modes, before the second chamber is not separated with the first chamber, the first chamber and the second chamber are in liquid company Logical state；Alternatively, the first chamber and the second chamber are in liquid communication state when the first chamber and the second chamber are combined. In this way, no matter the first chamber or the second chamber are collected or receptive liquid sample, liquid can be allowed to flow in two cavitys, this Sample flowing is the flowing of active or passively flows.

In some preferred modes, the flowing of active is exactly that liquid can not naturally be flowed to from the first chamber by external force Second chamber flow to the first chamber from the second chamber.In some preferred modes, passively flowing is to allow liquid by external force From flowing to the second chamber from the first chamber or flow to the first chamber from the second chamber.Here external force can refer to negative pressure, pressure, compressing Liquid, so that liquid be allowed to be flowed.

In some preferred modes, after the second chamber is separated with the first chamber or before will be to be separated, the first chamber and the second chamber It is not at fluid connection, in this way, liquid is allowed not flow between two cavitys.In some preferred modes, the second chamber and Before the separation of one chamber or before will be to be separated, the first chamber and the second chamber be not at fluid connection.Alternatively, in some preferred sides In formula, while the second chamber is separated with the first chamber, the first chamber and the second chamber are not at fluid connection.In some preferred modes In, after the second chamber is separated with the first chamber, the liquid sample in the first chamber is stored in the second chamber.In some preferred modes In, when the first chamber collects liquid sample or after having collected, the second chamber also collects the liquid having in the first chamber Sample.In some preferred modes, while the first chamber collects liquid sample, the second chamber, which is also collected, to be had from the first cavity In liquid sample.

In some other embodiments, the first chamber and the second chamber, which are removably combined, can pass through combination bit It sets and is combined together, separated by combining position.Here combination is that two cavitys are separated, use before use When combination be assembled together, after the completion of use, it is allowed to be separated.Alternatively, the first chamber and the second chamber can be combined directly Together, it can also be combined indirectly by a certain structure.Combination position can be the first chamber and the physical contact of the second chamber Place.So the first chamber and the second chamber are assembled together at the beginning in the other side of the utility model, collect After good liquid sample, the second chamber is allowed to separate with the first chamber.First chamber can be used to carry out first time detection, and the second chamber is used to carry out Secondary detection or confirmation detection.In optional mode, the first chamber is separated at the beginning with the second chamber and is not assembled together, is received After having collected liquid sample, the second chamber is allowed to combine with the first chamber, so that partially liq be allowed to be handed between the first chamber and the second chamber Stream or flowing allow two cavitys to separate when needing secondary detection.First chamber can be used to carry out first time detection, Second chamber is used to carry out secondary detection or confirmation detection.

The second aspect of the utility model, the utility model provide a kind of for collecting the device of liquid sample, the device It include: the first chamber for collecting liquid sample；Be used to collect for confirm detect liquid sample the second chamber；Wherein, Perhaps direct dismountable combine combines or links together indirectly by combination position for one chamber and the second cavity.

In some preferred modes, the second chamber and the first chamber pass through an interface channel and are in fluid connection.Some In preferred mode, before the second chamber is not separated with the first chamber, the first chamber and the second chamber are in liquid by the interface channel and connect It is logical.In some preferred modes, while after the second chamber is separated with the first chamber or separation, the first chamber and the second chamber are not at Fluid connection, while the channel is sealed.In some preferred modes, after the second chamber is separated with the first chamber, stored up in the second chamber There is the liquid sample in the first chamber.In some preferred modes, the first chamber collect liquid sample when or After having collected, the second chamber has the liquid sample in the first chamber also by interface channel collection.In some preferred sides In formula, while the first chamber collects liquid sample, the second chamber has in the first cavity also by interface channel collection Liquid sample.

In one of one of aforementioned all modes embodiment, the first chamber includes for collecting opening for liquid sample Mouthful, liquid sample is entered in the first chamber by the opening.In some preferred modes, the first chamber of interface channel fluid connection With the second chamber, liquid sample can carry out fluid exchange by interface channel between the first chamber and the second chamber.Some preferred Mode in, liquid sample can be flowed in the second chamber from the first chamber by the interface channel.In some preferred modes, even Connecting road has the first opening and the second opening, wherein described first opening and the first chamber fluid connection, the second opening and the Two chamber fluid connections.In some preferred modes, interface channel is located on the first chamber or first is intracavitary.Second chamber passes through company Connect road removably connect with the first chamber, in conjunction with or combine.So interface channel can allow the first chamber and the second chamber to be in Indirectly detachable combination, in conjunction with or link together.

In some preferred modes, interface channel includes connecting the structure of the first chamber and the second chamber and allowing the first chamber and the The structure that two chambers separate, wherein the structure of the first and second chambers of connection is exactly space or the pipeline for forming channel.Other one In some preferred modes, alternatively, the interface channel has two states of sealing or non-tight, when in non-tight State, liquid can flow to the second chamber from the first chamber.Preferably, when interface channel is in the state of sealing, the liquid of the first chamber It is intracavitary second cannot to be flowed to from interface channel.So the sealing or blow-by of interface channel limit the first chamber and the second chamber Between the state of fluid exchange can be with fluid exchange, when interface channel seals between two cavitys if interface channel blow-by When, there is no the exchange of liquid between two cavitys.

The third aspect of the utility model, the utility model provide a kind of sealing element, which can the company of sealing Road is connected, interface channel is allowed to be in the shape body of sealing.In a preferred manner, interface channel is connected with the first chamber and the second chamber, To allow the second chamber and the first chamber to be in the state that liquid does not circulate by the sealing of sealing element.In some preferred modes In, which further includes the sealing element for being tightly connected channel.In some preferred modes, sealing element is in sealed passage When while perhaps seal or after sealing, exclude the liquid sample of the second inside cavity point.Preferably, the liquid of exclusion Body sample is into the first chamber.Alternatively, partially liq sample of sealing element while being tightly connected channel, in interface channel (if there is) is just rejected in the place except interface channel, such as the first chamber or other places.In some preferred sides In formula, be the sealing element can also include elastic seal ring, the sealing ring by sealing element and interface channel inner wall Contact, so that sealing element be allowed more to seal.In the preferred mode of other, sealing element comes relative to interface channel It says, it is more flexible, so that deformation or extruding has occurred in any one by contact between the two, to allow sealing element It is closely contacted with the inner wall of interface channel, to play the effect of sealing.For example, sealing element is elastic, interface channel To be rigid, in this way when external force forces sealing element to enter connection circulation passage, elastic element is extruded and deformation, from And it is tightly connected channel.

In other modes, sealing element and connection are sealed by way of screw thread.Such as sealing element has External screw thread, interface channel have internal screw thread, and sealing element is tightly connected channel by way of relative rotation.It is excellent at other In the mode of choosing, sealing element is the structure of a similar lid, has internal screw thread, and the first of interface channel the opening outer has There is external screw thread, such sealing element and interface channel can play the role of sealing.

The fourth aspect of the utility model, the device of the utility model can also include draining element, sealing element sealing Before first opening of interface channel, part draining element is entered in the second chamber.In some preferred modes, sealing element It is tightly connected after the opening in channel, part draining element enters in the second chamber.Alternatively, sealing element is tightly connected channel Before first opening, part draining element is entered in the second chamber by interface channel.

So the fourth aspect of the utility model, the device of the utility model provides a kind of draining element, which is used for It excludes outside the partially liq to the second chamber in the second chamber.Preferably, sealing element is tightly connected before first opening in channel, portion Draining element is divided to enter in the second chamber.In some preferred modes, sealing element is tightly connected after the opening in channel, portion Draining element is divided to enter in the second chamber.Optionally, draining element is entered in the second chamber by interface channel, thus exclusion portion Outside liquid separation body to the second chamber.In some preferred modes, draining element and sealing element are linked together structure.In some modes In, draining element enters fluidic connection channels prior to sealing element.Preferably, the second chamber passes through the second of fluidic connection channels Opening and the detachable combination of the first chamber, combine or link together.Or it is optional, draining element is prior to sealing element Close to the first opening of interface channel, wherein first, which is opened on the first chamber, is in fluid connection.In some preferred modes, The structure that sealing element and draining element is linked together perhaps removably combines or in some mode, and sealing element can be with Serve as two functions, sealing and drain carry out simultaneously, and optionally, draining element can also play two functions, drain it is same When sealing link channel.Here the difference of title is only the difference of function, certain two functions can by an element come It realizes.

5th aspect of the utility model, the device of the utility model can also include lyophoby channel, by draining element or The liquid that person's sealing element excludes is rejected to except interface channel and/or the second chamber by lyophoby channel.Except so-called Including in the first chamber or other places, such as in accommodating chamber.It include liquid in sealing element in some preferred modes Accommodate cavity, it is described from the second chamber exclude liquid sample sealing element is entered by lyophoby channel receiving cavity in. Here " accommodating chamber " refers to the surplus liquid collected and excluded by draining element or sealing element, so, accommodating chamber can be First chamber, can also be with other places, such as the space in sealing element or draining element.In this way, the liquid excluded is logical It crosses lyophoby channel and enters accommodating chamber.In some preferred modes, lyophoby channel has one or more inlet, allows liquid Body is entered in accommodating chamber by inlet.In some preferred modes, the inlet is located at the first of interface channel The downstream of opening.Alternatively, lyophoby channel has one or more inlet, which is located on sealing element, wherein allows The inlet enters in interface channel prior to sealing element.In some preferred modes, sealing element is tightly connected channel Afterwards, lyophoby channel inlet opening is located in the second chamber.In some preferred modes, the accommodating chamber is located at close It seals in element.In some preferred modes, the inlet in the lyophoby channel is located on the wall of sealing element.Some excellent In the mode of choosing, the inlet in the lyophoby channel is located at the end of sealing element.

In some preferred modes, sealing element and draining element are linked together structure, wherein draining element is prior to close Envelope element enters in interface channel.In some preferred modes, part draining element is entered in the second chamber, sealing element Seal interface channel, it is preferred that sealing element is located in interface channel.In some modes, the inlet position in lyophoby channel Between sealing element and draining element, alternatively, being located under sealing element, or it is located on draining element.In some modes In, the end of draining element is arranged in the inlet in lyophoby channel, perhaps enter in interface channel prior to draining element or It is entered in the second chamber prior to draining element.

6th aspect of the utility model, the utility model provide a kind of for covering the collection liquid sample for closing first chamber Be open the first lid, wherein the sealing element for being tightly connected channel is connect with lid, alternatively, sealing element is in conjunction with lid It has been integrated structure.In this way, it is logical that sealing element also enters connection during the opening that the first cover cap closes the first chamber Road is tightly connected channel.In some preferred modes, first lid includes sealing element.In some preferred sides In formula, the of sealing element sealed connection channel connect while the first cover cap closes the first chamber opening with the first lid One opening.The first opening that first cover cap closes the process of the opening of the first chamber and sealing element is tightly connected channel is almost substantive It is synchronous to carry out.Alternatively, being provided with sealing element when sealing element and draining element are linked together or on the first lid And draining element, three components can be linked together the dismountable combination being also possible to.In this way, cover cap closes opening for the first chamber Mouthful, the process completed to lid conjunction is closed from lid and sealing element is tightly connected the opening in channel, and draining element excludes in the second chamber Partially liq (if there is), the liquid of extra exclusion entered in accommodating chamber by lyophoby channel.

In some preferred modes, the central axes of the sealing element on lid and the central axes essence of interface channel are same On one line, when allowing the first cover cap to close the first chamber opening in this way, sealing element can be allowed also to be tightly connected channel.One In a little preferred modes, the sealing element is removably connect with lid.In some modes, the sealing Element is connect by way of screw thread with lid.In some modes, sealing element is connect by connecting rod with lid, is allowed in this way First chamber has certain depth, and when cover cap closes the first chamber opening, sealing element is located at or close to interface channel Opening, when closing the first chamber with cover cap, the sealing element of connecting rod connection is open from close to the first of interface channel It enters in interface channel, to be tightly connected channel.

It is understood that sealing element is connected to one end of connecting rod, and the other end of connecting rod is connect with lid, lid Body movement band moving sealing element move synchronously, such as lid rotation the rotation with moving sealing element or lid on to Under movement, the also movement with moving sealing element from top to bottom.More it is understood that understanding, when sealing element passes through piston type Can be tightly connected channel to move synchronously when being tightly connected channel.Certainly, if sealing element and connection are logical By way of screw thread, synchronous rotary can also allow sealing element to be tightly connected channel in road.

In some modes, the utility model mentions a kind of lid of opening first for covering the collection liquid sample for closing the first chamber Body, wherein first lid includes sealing element and draining element or the sealing element and draining element and lid Body connection, or structure is linked together with lid.In some preferred modes, when the first cover cap closes the same of the first chamber opening When the sealing element that is connected with the first lid be tightly connected first opening in channel, draining element enters in the second chamber.It can be with Understand, the movement band moving sealing element and draining element of the first lid move together.

7th aspect of the utility model, in some preferred modes, the device of the utility model can also include using Come seal the second chamber opening the second lid.In some modes, the second lid is arranged on the second lid, close when needing When sealing the opening of the second chamber, the second lid is removed from the first lid to seal the opening of the second chamber.So in some sides In formula, the second lid is located on the first lid, is arranged on the first lid by modes such as screw thread, piston, bolts.Another In some preferred modes, the second lid is removably located on the first lid, can be easy to remove the in this way from the first lid Two lids.

In some preferred modes in aforementioned all modes, second chamber, which has, collects opening for liquid sample Mouthful.In some preferred modes, the opening of second chamber and the second opening fluid connection of interface channel.Some excellent It selects in mode, the second chamber is removably connect by screw thread with interface channel.In some preferred embodiments, described The opening of two chambers has internal screw thread and external screw thread, wherein the external screw thread of the internal screw thread and interface channel is cooperatively connected.It is described The second chamber opening external screw thread and lid close the second chamber opening the second lid be cooperatively connected.Optionally, the second chamber and connection are logical Second opening in road can not also be by way of screw thread, and the mode that can be clamping is removably attachable to together.

In some preferred modes, the device further includes testing element, at the testing element and the first chamber In fluid connection.In some preferred modes, the device further includes test chamber, and the testing element is located at test chamber In.

The eighth aspect of the utility model, the utility model provide a kind of method for collecting liquid sample, provide such as preceding institute The device for the collection liquid sample stated, which includes the first chamber for collecting liquid sample；Be used to collect liquid sample Be used to carry out confirmation detection the second chamber；Wherein, the first chamber and the second cavity removably combine, and combine or connect；It allows Liquid sample is entered in the first chamber by the opening of the first chamber, and liquid sample is allowed to enter in the second chamber from the first chamber.

In some preferred modes, which includes allowing the interface channel of the first chamber and the second chamber fluid connection.

In some preferred modes, this method provides a sealing element, and after waiting liquid to enter in the second cavity, use is close Seal component seal interface channel.

In some preferred modes, after sealing element is tightly connected channel, the second chamber is allowed to separate with the first chamber.

In some preferred modes, after the second chamber is separated with the first chamber, the opening of the second chamber is closed with cover cap.

In some preferred modes, this method includes allowing the first chamber and the second chamber after allowing the second chamber to separate with the first chamber It is not at fluid connection.In some preferred modes, it is used to store after allowing the second chamber to separate with the first chamber, in the second chamber and Liquid sample from the first chamber.In some preferred modes, when allowing the first chamber to collect liquid sample or collect Later, the second chamber is allowed also to collect the liquid sample having in the first chamber.In some preferred modes, in the first chamber collection liquid While body sample, the second chamber also collects the liquid sample having in the first cavity.

In some preferred modes, this method includes allowing the first chamber and the second chamber to pass through an interface channel to be in liquid Body connection.In some preferred modes, before allowing the second chamber not separate with the first chamber, make the first chamber and the second chamber logical by this Road is in fluid connection.It in some preferred modes, allows the second chamber after separating with the first chamber or while separate, allows first Chamber and the second chamber are not at fluid connection, while the interface channel is sealed.In some preferred modes, the second chamber and are allowed After the separation of one chamber, allows in the second chamber and store the liquid sample in the first chamber.In some preferred modes, in the first chamber When collecting liquid sample or after having collected, the second chamber has the liquid in the first chamber also by interface channel collection Body sample.In some preferred modes, while the first chamber collects liquid sample, the second chamber is collected also by interface channel There is the liquid sample in the first cavity.

In some preferred modes, the first chamber includes the opening for collecting liquid sample, allows liquid sample by being somebody's turn to do Opening enters in the first chamber.In some preferred modes, interface channel is allowed to be connected to the first chamber and the second chamber, thus, allow liquid Body sample can carry out fluid exchange by interface channel between the first chamber and the second chamber.In some preferred modes, liquid Body sample can be flowed in the second chamber by the fluid passage from the first chamber.In some preferred modes, interface channel has The first opening and the second opening, wherein allow described first to be open and the first chamber fluid connection, allow the second opening and the second chamber liquid Body connection.In some preferred modes, allows interface channel to be located on the first chamber or first is intracavitary.The second chamber is allowed to pass through liquid Channel is removably connect with the first chamber, in conjunction with or combination.

In some preferred modes, interface channel has the structure of the first chamber of connection and the second chamber and allows the first chamber and the The structure that two chambers separate, wherein the structure of the first and second chambers of connection is exactly to form the space in channel.Alternatively, the connection Channel has two states of sealing or non-tight, when the state for being in non-tight, allows liquid that can flow to the from the first chamber Two chambers；When state of the interface channel in sealing, allow the liquid of the first chamber that cannot flow to second from interface channel intracavitary.

In some preferred modes, this method comprises: the device includes the collection liquid sample for closing the first chamber for covering The first lid of opening, wherein sealing element is connect with lid, in conjunction with.In some preferred modes, first lid Including sealing element.In some preferred modes, when the first cover cap close the first chamber opening while or in the process or Later, the sealing element for allowing the first lid to connect is tightly connected the second chamber opening in channel.In some preferred modes, lid On include the second lid for sealing the opening of the second chamber.In some preferred modes, the sealing element and lid Removably connect.In some modes, the sealing element is connect by way of screw thread with lid.

In some preferred modes, second chamber has the opening for collecting liquid sample.In some preferred sides In formula, the opening of second chamber and the second chamber opening fluid connection of interface channel.In some preferred embodiments, the second chamber It is removably connect by screw thread with interface channel.In some preferred embodiments, the opening of second chamber has Internal screw thread and external screw thread, wherein the external screw thread of the internal screw thread and interface channel is cooperatively connected.The second chamber opening The second lid that external screw thread and lid close the second chamber opening is cooperatively connected.

Dismountable connection type of above the first chamber and the second chamber, is set by the structure of interface channel and the second chamber It counts and is detachably connected to, this dismountable connection is directly to connect.In some preferred modes, the second chamber can It is detachably connected to, combines or is combined together with the first chamber with the connection type of channel screw thread, in the second chamber and chamber Between when directly carry out dismountable mode and combine, the first chamber and the second chamber are in fluid connection.Preferably, First chamber and the second chamber carry out fluid connection by interface channel.In some preferred modes, the second chamber is opened on connection Second opening in channel is in fluid connection.In some preferred modes, the second chamber is arranged on a pedestal, the pedestal with First chamber forms dismountable combination.Optionally, the second chamber is also formed with pedestal and is removably combined.In this way, when pedestal and the When one chamber is directly combined, the interface channel of the opening of the second chamber, which is formed, to be in fluid communication.When pedestal and the first chamber point From when, the second chamber on pedestal is separated with the second chamber together in company with pedestal.Preferably, when pedestal is separated with the first chamber When, the second chamber on pedestal is separated with interface channel together in company with pedestal.In some preferred modes, work as pedestal And after the second chamber being located on pedestal is separated with the first chamber, the second chamber is separated with pedestal.In some preferred modes, when After second chamber is separated with pedestal, the opening of the second chamber is closed with the second cover cap.

6th aspect of the utility model, the utility model also provide the method for collecting liquid sample, and this method includes mentioning For the device of collection liquid sample above-mentioned, which includes the first chamber and the second chamber, wherein the second chamber and the first chamber are can The mode of disassembly connects, and collects liquid sample with the first chamber, and liquid sample is allowed to be flowed into the second chamber.

In some preferred modes, when waiting the collection of the second cavity to have liquid sample, the second chamber and the first chamber is allowed to divide From to close the opening of the second chamber with the second cover cap.

In some preferred modes, the first chamber and the second chamber is allowed to link together by interface channel, wherein allowing connection First opening in channel and the first chamber fluid connection allow the second of interface channel to be open and the second chamber fluid connection.

In some preferred modes, which further includes sealing element, before the second chamber is separated with the first chamber, is allowed close Seal component seal interface channel.

In some preferred modes, which further includes lid, and lid and sealing element are linked together structure, allows lid When lid closes the first chamber opening, while lid is tightly connected second opening in channel with moving sealing element.

In some preferred modes, lid band moving sealing element is allowed to enter in interface channel.In some preferred sides In formula, after allowing sealing element to be tightly connected channel, the second chamber is allowed to separate with the first chamber.

In some preferred modes, the draining element for excluding partially liq in the second chamber is also set up on lid, Allow lid that draining element is driven to enter in the second chamber.In some preferred modes, sealing element and drain are set on lid Element allows draining element to enter in the second chamber prior to sealing element.

In some preferred modes, which further includes lyophoby channel, and the liquid sample for allowing draining element to be discharged is logical The lyophoby channel is crossed to be rejected to outside the second chamber.In some preferred modes, sealing element is allowed to enter in interface channel, The liquid that sealing element is discharged is rejected to outside interface channel by lyophoby channel.

In some preferred modes, the liquid for allowing sealing element or draining element to exclude is discharged to by lyophoby channel In first chamber.In some preferred modes, accommodating chamber is set on lid, the accommodating chamber and lyophoby channel are in liquid Connection, wherein the liquid for allowing sealing element or draining element to exclude is discharged in accommodating chamber by lyophoby channel.

9th aspect of the utility model, the utility model, which provides, whether there is analyte in a kind of detection liquid sample The method of matter, the method include the fluid collection device of any one above-mentioned mode, and the collection of the first chamber is waited to have liquid-like After this, the liquid sample from the first chamber is detected with testing element.After obtaining testing result, the second chamber and first are allowed Chamber separation, is separated according to above-mentioned arbitrary mode.

In some specific modes, device further includes the test chamber for accommodating testing element, in test chamber and first Chamber is in flow communication, and after the collection of the first chamber has liquid sample, liquid is flowed into test chamber.When test chamber includes test When element, after waiting testing elements to complete detection, the second chamber is allowed to separate with the first chamber.In some preferred modes, liquid is allowed Body sample from first it is intracavitary be introduced into test chamber, then enter back into the second chamber.Such structure is as described earlier Structure design, so that the liquid for avoiding enter into test chamber also enters the second chamber, thus the liquid sample of the second chamber of pollution.

At the tenth aspect of the utility model, the utility model provides a lid, and setting is used to the company of sealing on the lid Connect the sealing element in road.In some preferred modes, sealing ring is set on sealing element.In some preferred modes, Sealing element with the material of interface channel be as or be different.In some preferred modes, sealing element is soft Property material, interface channel be rigidity material.In some preferred modes, sealing element passes through connecting rod and the first lid It is linked together structure.It further include the opening in lyophoby channel on sealing element in some preferred modes.In some preferred sides In formula, the opening in lyophoby channel is located under sealing element, alternatively, the opening in lyophoby channel enters connection prior to sealing element In channel.It further include accommodating chamber on lid in some preferred modes, the accommodating chamber and lyophoby channel are in fluid connection. The opening in communication of the accommodating chamber and lyophoby channel.In some preferred modes, accommodating chamber is located in sealing element.

In other preferred modes, draining element is also set up on the first lid, which compares sealing element Further from the first lid.Alternatively, draining element is arranged under sealing element, alternatively, sealing element and draining element are set in this way It sets, draining element is allowed to enter in the second chamber prior to sealing element, alternatively, draining element is allowed to enter connection prior to sealing element In channel.Alternatively, working as connecting rod is set to connect the first lid and sealing element, while sealing element connected drainage member on lid Part.Alternatively, connecting rod and sealing element and draining element are structure as a whole.

Beneficial effect

Using the above structure, have the characteristics that simple and reasonable, use lower cost for material, function admirable；Convenient for two Secondary detection.Particularly, when needing to carry out subsequent confirmation detection, entire detection device is not needed to be sent to mechanism for testing It is detected, and is only to remove the second chamber from device, be sent to detection structure, so not only safety, but also saving sky Between, save the cost is more environmentally-friendly.

Detailed description of the invention

Fig. 1 is the STRUCTURE DECOMPOSITION structural schematic diagram of the collection device in a specific embodiment of the utility model.

Fig. 2 is the schematic perspective view of the lid in a specific embodiment of the utility model.

Fig. 3 is the vertical section structure schematic diagram of lid shown in Fig. 2 in a specific embodiment of the utility model.

Fig. 4 is that the vertical section of the first chamber in a specific embodiment of the utility model shows that structure is intended to (without containing inspection Survey chamber).

Fig. 5 is that the vertical section of the second chamber in one specific embodiment of the utility model shows that structure is intended to.

Fig. 6 is the schematic perspective view without the first lid in one specific embodiment of the utility model.

Fig. 7 is that the vertical section of device shown in fig. 6 in the utility model shows that structure is intended to, wherein the first chamber and the first chamber group The structural schematic diagram being combined.

Fig. 8 is that the part enlarged structure of the first chamber and the combination of the second chamber in one specific embodiment of the utility model is shown It is intended to.

Fig. 9 is the stereochemical structure signal of the first chamber and the combination of the second chamber in one specific embodiment of the utility model Figure.

Figure 10 is the operating process knot that the first cover cap closes the first chamber opening in one specific embodiment of the utility model Structure is three-dimensional.

Figure 11 is the stereochemical structure that the first cover cap closes after the first chamber opening in one specific embodiment of the utility model Schematic diagram.

Figure 12 is the schematic diagram of the section structure of device shown in Figure 11 in a specific embodiment of the utility model.

Figure 13 is in one specific embodiment of the utility model, and the second chamber is detached from the first chamber, and the second lid is detached from first The schematic perspective view of lid.

Figure 14 is the schematic perspective view that the second cover cap closes the second chamber in one specific embodiment of the utility model.

Figure 15 is the schematic perspective view of the device in the another embodiment of the utility model.

Figure 16 is the schematic perspective view of the first chamber in a specific embodiment of the utility model.

Figure 17 is the schematic perspective view of the testing element carrier in a specific embodiment of the utility model.

Figure 18 is the three-dimensional knot of the first lid with sealing element in a specific embodiment of the utility model Structure schematic diagram.

Figure 19 is the schematic perspective view of the first chamber in one specific embodiment of the utility model (without second Chamber).

Figure 20 is the schematic diagram of the section structure (that in one specific embodiment of the utility model and the second chamber combines The part-structure enlarged diagram that one chamber is detachably combined with the second chamber).

Figure 21 is that the first lid starts standing after lid the first chamber of conjunction is open in the utility model another embodiment Body structural schematic diagram (operating process).

Figure 22 is the schematic diagram of the section structure of device shown in Figure 21 in a specific embodiment of the utility model (sealing element unsealing interface channel starts close to opening).

Figure 23 be the utility model a specific embodiment in, shown in device the schematic diagram of the section structure (sealing Element enters interface channel).

Figure 24 is in one specific embodiment of the utility model, and the second chamber is detached from the first chamber, and the second lid is detached from first The schematic perspective view of lid.

Figure 25 is the second chamber and first in detection or collection device in the another embodiment of the utility model The schematic perspective view of chamber anabolic process (the second chamber is located in support holder structure).

Figure 26 is the structural schematic diagram in the detection or collection device of the utility model, after the first chamber and tray combination.

Figure 27 is the schematic diagram of the section structure of structure shown in Figure 26 in the detection or collection device of the utility model.

Figure 28 is the structural representation of the second lid the second chamber of sealing in the another embodiment of the utility model Figure.

Figure 29 is the structural schematic diagram that the second chamber leaves pallet.

Figure 30 is often to have schematic perspective view of the trays of the second chamber to the first chamber.

Figure 31 is the solid of the first lid with sealing element in the another embodiment of the utility model Structural schematic diagram.

Figure 32 is first with sealing element in another embodiment shown in Figure 31 of the utility model The schematic diagram of the section structure of lid.

Figure 33 is to have sealing element schematic perspective view in the another embodiment of the utility model.

Figure 34 is the schematic diagram of the section structure of structure shown in Figure 33.

Figure 35 A and Figure 35 B be sealing element, sealing element shown in draining element or Figure 33 exchange or it is default wherein The structural schematic diagram of one component.

Figure 36 is the first chamber and the separation of the second chamber and combined principle knot in other specific embodiments of the utility model Structure schematic diagram.

Figure 37 is the structural schematic diagram of the first chamber and the combination of the second chamber in the utility model another embodiment.

Figure 38 A and Figure 38 B are the first chamber shown in 37 and the separation of the second chamber, use the first chamber as secondary-confirmation detection Structural schematic diagram.

The stereochemical structure theory structure of the first chamber and the second chamber shows in other specific embodiments of Figure 39 the utility model It is intended to.

First chamber and the separation of the second chamber and combined stereochemical structure in other specific embodiments of Figure 40 the utility model Theory structure schematic diagram.

It is described in detail

Below to the utility model relates to structure or technical term used in these be described further, if do not had There is spy is standby to indicate, is understood and explained according to the general general terms of this field.

Detection

Detection indicates chemical examination or tests a kind of substance or material to whether there is, for example, but it is not limited to this, chemical substance, Organic compound, inorganic compound, metabolism product, drug or drug metabolite, organic organization or organic organization generation Thank object, nucleic acid, protein or polymer.In addition, detection indicates the quantity of test substances or material.Furtherly, table is gone back in chemical examination Show immune detection, chemical detection, enzyme detection etc..

Sample

The detection device of the utility model or the sample of collection include biofluid (such as casing fluids or clinical sample Product).Fluid sample or fluid sample can from the sample of solid-state or semisolid, including excreta, biological tissue and Food samples.The sample of solid-state or semisolid can be converted to fluid sample using any method appropriate, such as mix, smash It is broken, macerate, be incubated for, dissolution or in a suitable solution (such as water, phosphate solution or other buffer solutions) using enzymatic hydrolysis make With digestion of solid sample." biological sample " includes deriving from animal, plant and food samples, for example including from human or animal Urine, saliva, blood and its ingredient, spinal fluid, vaginal fluid, sperm, excrement, sweat, secretion, tissue, organ, tumor, The culture of tissue and organ, cell culture and medium.It is preferred that biological sample is urine.Food samples include the object of food processing Matter, final products, meat, cheese, wine, milk and reference water.Plant sample includes being derived from any plant, plant tissue, and plant is thin Born of the same parents' culture and medium." environmental sample " from environment (for example, from lake or the fluid sample of other water bodys, sewage Sample, soil property sample, underground water, seawater and waste liquid sample).Environmental sample may also include sewage or other waste water.

Using the suitable detecting element of the utility model, any analyte can detecte.Preferably by the utility model Drugs small molecule in detection saliva, urine.Certainly, any of the above form can be collected using the collection device of the utility model Sample, no matter be initially solid or liquid, if after these liquid or liquid sample are flowed into the first chamber, this A little liquid samples can flow into simultaneously or later the second chamber, since the second chamber can removably be combined with the first chamber, combination Or connection allows the second chamber to separate with the first chamber when needing to carry out subsequent confirmation detection, thus, the second chamber can carry out two Secondary detection, and the liquid of the first chamber can carry out primary detection.Optionally, the liquid of the second chamber can carry out primary detection, and The liquid of first chamber can carry out secondary detection.

Alternatively, these liquid samples or processed sample are after liquid is collected into the first chamber, to need It carries out using the second chamber before chemically examining for the first time or after chemical examination to extract the partially liq sample in the first chamber as subsequent confirmation and chemically examine Only use.First chamber can be combined with the second chamber at the beginning, be also possible to combine when in use, then again It separates.

Downstream and upstream

Downstream or upstream are that liquid flow direction is divided, and general liquid flows from upstream to downstream area.Position Receive the liquid from upstream region in downstream area, liquid can also flow to downstream area along upstream region.Here general It is also to be divided according to the direction of liquid flowing, for example, liquid can be on some materials for promoting liquid to flow using capillary force Gravity and flowed to the opposite direction of gravity, divide upstream and downstream also according to the flow direction of liquid this when.Example Such as, in the collection device of the utility model, in some preferred modes, chamber of first chamber as collection liquid sample, and Second chamber and the first chamber are in fluid connection, and the liquid into the first chamber is flowed into the second chamber, the first chamber can be referred to as on Trip, and the second chamber can be referred to as downstream.Certainly, this flowing is the natural flowing under the gravity of liquid.Optionally, This natural flowing is that liquid is flow in the second chamber from the first chamber.Certainly, liquid can also passively be flow to from upstream Downstream, such as in the case that liquid is reacted power, force liquid to flow from upstream to downstream, or flow to height from low position Position, this row reaction can be the effect of capillary or forcing for ambient pressure, so that liquid be allowed to flow to height from low level Position, the division of upstream and downstream here, which is not necessarily meant that, centainly needs liquid presence, and referring to has the existing of liquid In the case of, it is to be flowed according to the sequence of flowing.

Gas connection or fluid connection

Gas connection or fluid connection refer to that liquid or gas can flow to another place from a place, stream In dynamic process guiding function may be played by the structure of some physics.The so-called structure by physics generally refers to liquid warp Cross the space on the surface of the structure of these physics or the inside of these structures and passive or with actively flowing to another Side, passive is usually the flowing received under flowing caused by external force, such as capillarity.Here flowing is also possible to liquid Either gas is also possible to passively flow because of self-acting (gravity or pressure).Here connection is not offered as centainly Needing liquid, perhaps there is the connection relationship or state only shown in some cases between two objects in gas, if It, can be from a material flows to another object with the presence of liquid.This refers to the states of two objects connection, on the contrary, If do not have between two objects fluid connection perhaps gas connection state if there is liquid in an object or on, liquid Body cannot flow in another object or on, such state be non-interconnected, the state of on-liquid or gas connection.

Dismountable combination

Detachable combination refers to that the connection relationship between two components is in several different states or position is closed System, such as when being two physical significance upper-parts, can be at the beginning it is separated, when connecting at suitable first It connects or combines, at suitable second, two components can be allowed to separate, this is separately in physical significance Space separate without contact.Alternatively, two components are combined at the beginning, when in a suitable case, can allowing two The space that a component is formed in physical significance separates.Again alternatively, two objects be at the beginning it is separated, when needs combination exist Certain function is completed together, is then separated again, or combine again again for certain purpose later.In short, the two Separating between combining or both is readily to carry out, this to combine or be separately that repeat Repeatedly circulation, it is of course also possible to be disposably to combine and separate.Furthermore it is possible to removably combined between two components, Three or three be can also be with dismountable combination two-by-two between upper-part.For example, there is the first, second, and third component, The first component and second component removably combine, and second component and third member are also possible to detachable combination, and first Component and third member removably can also be combined or be separated.In addition, combined mode can be two objects itself Detachably, it can also indirectly be combined by other object.

Testing element

Here so-called " testing element " refers to that can detecte sample or sample is whether containing interested analyzed The element of substance can be referred to as testing element, and this detection is either based on which kind of technical principle, immunology, chemistry, electricity It learns, optics, molecules, nucleic acid, physics etc. are ok.Testing element can select the test strip of lateral flow, it can Detect a variety of analytes.Certainly, other suitable testing elements can also be used in the utility model,

Various testing elements can be grouped together and apply in the utility model.A kind of form is Test paper.With The Test paper of analyte (such as drugs or showing the metabolin of physical condition) in analysis sample can be various forms, Such as immunoassays or the form of chemical analysis.Test paper can be using non-competing method or the analytical model of competition law.Detection examination Paper bag is containing a water-absorbent material with sample application zone, reagent area and test section.Sample-adding passes through capillary originally to sample application zone Effect flows to reagent area.In reagent area, if there is analyte, sample is in conjunction with reagent.Then sample continues to flow to inspection Survey area.Other reagents, such as molecule with analyte specific binding are fixed on detection zone.In these reagents and sample Analyte (if present) reacts and analyte is incorporated in the area, or in conjunction with some reagent of reagent area.With Exist and reagent area or isolated mark zone in the marker of display detection signal.

Typical non-competing method analytical model is if containing analyte in sample, and signal will generate, if do not wrapped Containing analyte, signal is not just generated.In competition law, if analyte is not present in sample, signal is generated, if deposited In analyte, then signal is not generated.

Testing element can be Test paper, the material that can be selected water suction or not absorb water.Test paper may include a variety of Material is transmitted for liquid sample.The material of one of Test paper can cover on another material, as filter paper is covered on On nitrocellulose filter.One area of Test paper can select one or more materials, and another area selects other different One or more materials.Test paper can be attached on certain support or hard surface and be affectedly bashful Test paper for improving Intensity.

Analyte is detected by signal generating system, such as utilizes one with this analyte generation specific reaction Kind or a variety of enzymes, are fixed on the method on Test paper for specific combinating substance using such as aforementioned, one or more signals are sent out The composition of raw system is fixed on the analyte detection zone of Test paper.Generate signal substance can in sample application zone, reagent area, Or on detection zone, or entire Test paper, which can be full of on one or more materials of Test paper.Signal will be contained The solution of object is added to the surface of test paper or one or more materials of test paper is immersed in the solution of the object containing signal.Make to be added and contain The test paper of signal object solution is dry.

Each area of Test paper can arrange in the following manner: sample application zone, reagent area, detection zone, control zone determine sample This whether adulterated area, liquid sample uptake zone.Control zone is located at after detection zone.All areas can be arranged at only with a kind of On one test paper of material.It can also be not same district and use different materials.Each area can directly be contacted with liquid sample, or not Direction arrangement of the same area according to liquid sample flowing, the end in each area is connected and is overlapped with the front end in another area.Used Material can be the preferable material of water imbibition such as filter paper, glass or nitrocellulose filter etc..Test paper can also use it His form.

General common reagent strip is nitrocellulose assay strip, i.e. detection zone includes nitrocellulose filter, in nitre Specific binding molecule is fixed on acid cellulose film to show the result of detection；It can also be cellulose acetate film or nylon membrane etc. Deng.Such as the description of the following patent reagent strip or device containing reagent strip: US 4857453；US 5073484；US 5119831；US 5185127；US 5275785；US 5416000；US 5504013；US 5602040；US 5622871；US 5654162；US 5656503； US 5686315；US 5766961；US 5770460；US 5916815；US 5976895；US 6248598； US 6140136；US 6187269；US 6187598；US 6228660；US 6235241；US 6306642； US 6352862；US 6372515；US 6379620；With US 6403383.Test-strips disclosed in patent documents above and Similar device with test-strips can be applied in the testing element or detection device of the utility model and divided Analyse substance detection, such as in sample analyte detection.

Apply to the lateral effluent reagent strip (Lateral that the detection reagent item of the utility model can be known as Flow test strip), the specific structure and testing principle of these detection reagent items are the general skill in this field in the prior art Technology well known to art personnel.Common detection reagent item, including sample collection region, marked region, detection zone and suction zones Domain, sample collection region include sample receiving pad, and marked region includes label pad, and suction zone may include water absorption pad, wherein It include that can detect whether the necessary chemical substance containing analyte, such as immunoreagent or enzymology are tried in detection zone Agent.General common detection reagent item is nitrocellulose assay strip, i.e. detection zone includes nitrocellulose filter, in nitric acid Specific binding molecule is fixed on cellulose membrane to show the result of detection；It can also be cellulose acetate film or nylon membrane etc., It certainly, can also include testing result control area in the downstream of detection zone, in general, with cross in control area and detection zone The form of line occurs, and is detection line or control line.Such detection reagent item is that traditional reagent strip can also be it certainly The other types of reagent strip that he is detected using capillarity.In addition, having dry chemistry reagent on general detection reagent item Ingredient, such as fixed antibody or other reagents, after encountering liquid, liquid is flowed with capillarity along reagent strip, With flowing, dry agent formulations is allowed to be dissolved in liquid, so that the dry reagent to next regional processing in the area reacts, To carry out necessary detection.Liquid flowing mainly carries out through capillary action.These testing elements are shown in retouching for following file It states and records: " regeneration treatment of nitrocellulose filter and its research of adhesion protein ability " of Li Fugang；Ma Hongyan, Li Qiang etc. The analysis of membrane material characteristic " in colloidal gold diagnosis kit chromatograph "；Wang Yong, Wang Luhai etc. " a kind of new colloidal gold is immune Chromatograph test strip ".Can be applied in the detection device of the utility model herein, or be arranged in test chamber with Liquid sample contact either whether there is or existing for detecting analyte in the liquid sample entered in test chamber Quantity.

Carry out test fluid in addition to above-mentioned test-strips or lateral flow test strip itself are used to contact with the liquid of the first chamber Whether containing outside analyte in body sample.In some preferred modes, testing element can also be arranged on some loads On body, such as 106 on some cards, there are many grooves, in the grooves, entire test card is set testing element on card In test chamber 105, contact liq sample is carried out in the bottom 1051 for allowing the sample applying zone of testing element to be located at test chamber.In this way Liquid sample may come from the first chamber 103, such as liquid sample passes through through-hole between test chamber 105 and the first chamber 1038 phase fluid connections (such as shown in Fig. 9 and Fig. 1).It is also possible that the sample for allowing the sample application zone of testing element to be located at test chamber converges Contact liq sample is carried out in collection region, to complete the detection of analyte.

In other mode, such as shown in Figure 16 and 17, a kind of carrier 206 is provided, has a plurality of one end to seal on carrier 2062, one or more of test-strips, the sample applying zone of test-strips is arranged in the channel of another end opening 2063 in the channel Positioned at one end of opening 2063, there are one or more channels for accommodating test-strips in carrier 206, each channel is arranged one The testing element of different analysis substances can be arranged when with multiple channels in testing element in each channel, this Sample can detect multiple analytes using the same sample.This carrier 206 is placed in the first chamber 203, There are two positive stop strips 2032 and 2033 on the wall of chamber 203, carrier 206 is inserted into or is snapped fit onto two limiting slots, allowed The one end 2065 in the channel with opening is close to the bottom of the first chamber, the opening close to the first chamber of one end 2064 with sealed passage 2031 (Figure 16) of mouth.When liquid sample is flowed into the first chamber by the opening 2031 of the first chamber, liquid sample is just and test-strips Sample applying zone contact, to complete to detect.The U.S. Patent application that such carrier is applied in the applicant, application number 15/644,148 and Chinese Patent Application No. 2016106132817,2016106079834 have specific description.Certainly, In addition to the carrier of the above patent disclosure, carrier in addition can also be applied to the load in the utility model as bearing test item Body.

For example, the first chamber can first collect liquid sample in some modes, then with individually carrying out with testing element The detection of analyte in liquid sample in one chamber.With test-strips or the card with test-strips or carrier are inserted into It is detected in one chamber.Those of ordinary skill in the art are appreciated that according to documented by the utility model, these test-strips It can be not provided on carrier, but be individually present, the test chamber 105 of the utility model is also in some cases can be with Lack, test-strips are also that can lack in some cases.It will do it explanation in elaborating below.

Analyte

It can include some small-molecule substances with the example of the analyte involved in the utility model, these small molecule packets Include drugs (such as drug abuse)." drug abuse " (DOA) refers to that the work of paralysis nerve (is usually played using drug in non-medical destination With).It abuses these drugs and will lead to body & mind and be damaged, generate dependence, addicted and/or dead.Drug is indiscriminate Example includes cocaine；Amphetamine AMP is (for example, black beauty, white amphetamine tablet, dextroamphetamine, dextrorotation Amphetamine tablet, Beans)；Crystal methamphetamine MET (crank, meth, crystal, speed)；Barbiturate BAR (such as Valium, Roche Pharmaceuticals, Nutley, New Jersey)；Sedative (i.e. sleep adjuvant Product)；Lysergic acid diethylamide (LSD)；Inhibitor (downers, goofballs, barbs, blue devils, yellow Jackets, methaqualone)；The anti-antidepressant of tricyclic antidepressants (TCA, i.e. imipramine, amitriptyline and doxepin)；Two methylenedioxy groups Methylaniline MDMA；Phencyclidine (PCP)；Tetrahydrocannabinol (THC, pot, dope, hash, weed, etc..)；Opiate (i.e. morphine MOP or opium, cocaine COC；, heroin, hydroxyl dihydrocodeinone)；Anxiolytic and hypnotic sedative agent resist Anxiety medicine is that one kind is mainly used for anxiety reduction, anxiety, fear, sets the mind at rest, has the drug of hypnosis sedation, including benzene concurrently Diazepine BZO (benzodiazepines), atypia BZ class, fusion phenodiazine NB23C class, benzene nitrogen Zhuo class, BZ receptor are matched Body class, open loop BZ class, diphenylmethane derivatives, piperazine carboxylic acid salt, piperidine carboxylic acid salt, Kui oxazoline ketone, thiazine and thiazole Derivative, other heterocyclics, imidazole type calmness/anodyne (such as hydroxyl dihydrocodeinone OXY, methadone MTD), propylene glycol are derivative Object-carbamates, aliphatic compound, anthracene derivative etc..It can be used for examining using the detection device of the utility model The detection for belonging to medical usage but being easy overdose is surveyed, such as tricyclic antidepressant (imipramine or the like) and acetyl ammonia Base phenol etc..These drugs can be metabolized to small-molecule substance after being absorbed by the body, these small-molecule substances be present in blood, urine, In the body fluid such as saliva, sweat or part body fluid there are above-mentioned small-molecule substances.

For example, with the utility model detect analyte include but is not limited to, creatinine, bilirubin, nitrite, Albumen (non-specificity), hormone (for example, human chorionic promotes sex hormone, luteinizing hormone, follicular stimulating hormone etc.), blood, white blood Ball, sugar, heavy metal or toxin, bacterial components (albumen or glucide as being directed to specific bacterial, such as such as Escherichia coli 0157:H7, staphylococcus, salmonella, fusobacterium, Campylobacter, L.monocytogenes, vibrio or cactus bar Bacterium) and urine sample in substance relevant to physiological characteristic, such as pH and specific gravity.Other any Clinical Urinary chemical analyses are all using lateral Flow test format cooperation utility model device is detected.

The flowing of liquid

The flowing of liquid typically refers to flow to another place, under normal circumstances, the liquid of nature from a place The flowing of body is most of to flow to lower from eminence by the effect of gravity, and flowing here is also by external force, i.e., external weight Flowing in the case of power can become the flowing of natural gravity.In addition to gravity, the flowing of liquid can also with customer service gravity, Carry out the movement that eminence is flow to from lower.For example, the extraction of liquid or the compressing of liquid or liquid receive pressure, and Go out to flow to eminence the bottom of from, also or the care of pressure and the gravity of client's liquid itself and the flowing that carries out.For example, Fig. 9, In 19,22,27, the first chamber is located on the second chamber, and the second chamber is located under the first chamber, when thering is liquid to enter the second chamber, liquid Body relies on the gravity of itself, can naturally rely on gravity flowing into the second chamber from the first chamber, can also be from upstream certainly So it flow to downstream position.

Detection device or collection device

Detection device refer to for detect in sample whether the device containing analyte.Collection device refers to carry out liquid The collection and storage of body sample.Detection device may include collection device, and collection device also may include detection device, Huo Zheshou Acquisition means are separated with detection device, when detection, are combined to collection device and detection device, to complete to examine It surveys.It is also possible to collection device and device that detection device is structure as a whole, after collecting liquid sample, so that it may at once It is detected, obtains test result, while carried out detection sample and collecting the separation of sample, so as to carry out secondary detection (if necessary).Here the meaning of detection device or test chamber can be interchanged, and collection device and collection chamber can also be with It exchanges, only plays the role of exchange that is different and carrying out function.For example, when the utility model mentions collection device, it can With do not include test chamber do not include perhaps testing element but collection device may include have testing element or containing test member The carrier of part, the collection device containing testing element can also be referred to as detection device.Certainly, collection device may include for The space of testing element is set, but is not necessarily required to containing testing element, testing element can be subsequent any suitable When and collection device be combined and become detection device.For example, collection device may include for accommodating testing element Space, such as there is suitable position to set containing test chamber 105 (Fig. 7), or in the chamber of the collection liquid of collection device Testing element or the carrier (Figure 16) containing testing element are set, so, the utility model can be just for the sake of collection liquid Sample and the device designed are also possible to when collecting, while the detection device detected.

First chamber and the second chamber removably combine, combination or cooperation

First chamber and the second chamber of the utility model can form detachable pair of combination, when needing to carry out liquid collection Before, the first chamber and the second chamber have been combined, and after the completion of collecting liquid sample, the second chamber can be with the first chamber point From.Alternatively, the first chamber and the second chamber be it is separated, when needing to be collected liquid sample, recombinant together, collect After the completion, the first chamber and the second chamber are separated.In some specific embodiments in the present invention, as represented in figures 1 through 14 A concrete mode in, the utility model provide it is a kind of detection liquid sample in whether containing analyte detection dress It sets, or the collection device for collecting liquid sample comprising the first chamber 103 and the second chamber 104, the first chamber 103 can be made Come for collecting chamber using that is, for collecting liquid sample, wherein the first chamber and the second chamber are removably combined, even It connects or assembles.

Here " combination, connection or assembling " actually indicates the same meaning, and only word used is different, all It can indicate to be combined together, this combination is corresponding with " separation ".In conjunction with and separation all can it is any under the conditions of, It can be with unrestricted choice.In some modes, when the first chamber and the second chamber are combined, the first chamber and the second chamber are in The state of liquid communication.In other modes, when perhaps being separated before separating before the first chamber and second or after separation, First chamber and the second chamber are not at the state of liquid communication.

In some preferred modes, which further includes interface channel, the first chamber removably engages with interface channel, In conjunction with or assembling.To realize and removably the organizing of the second chamber, combination or assembling.Shown in Fig. 9, the first chamber 103 Come as collecting chamber using it has the opening 1031 collected or receive liquid sample, and liquid sample is flowed by opening In first chamber 103, there is interface channel 109 in the bottom of the first chamber, interface channel has the first opening 1091, and the other end has Second opening 1092.The opening 1091 of interface channel 109 first and the first chamber 103 are in liquid communication, the liquid sample of the first chamber It can be flow by opening 1091 in interface channel 109 come then by 1092 outflow of the second opening of the other end.So The utility model provides a kind of cavity for collecting fluid sample, and the cavity includes that an opening 1031 allows fluid sample to enter chamber In 103, the bottom of collecting chamber include a channel, the channel have the first opening and the second opening, partially liq sample can To enter interface channel by the first opening 1091 of interface channel, by 1090 outflow of the second opening of interface channel.Outflow Refer to and flows out to 103 outside of the first chamber.Preferably, it is entered in 104 in the second chamber from the liquid that interface channel flows out.So The collection collection device can also include the second chamber, and generally, there is the first chamber opening and side wall and bottom to surround a cavity. Interface channel is normally on the bottom of the first chamber.In this specific embodiment, interface channel is located on the region of bottom. But, it is not limited to the position of interface channel can be located on side wall, can also be located at the intersection of bottom and side wall.Only Will enter collecting chamber 103 liquid sample can enter interface channel can any position.

The meaning of " interface channel " herein is usually to connect a structure of the first chamber and the second chamber, when needs It waits, the first chamber and the second chamber is allowed to connect or be combined together, when the second chamber and the first chamber in some cases, can be allowed to carry out Separation.In fact, herein, interface channel plays two functions simultaneously, one is to make the first chamber and the second chamber dismountable Mode links together, and in addition structure plays the role of the first cavity and the second cavity fluid connection simultaneously, can pass through the knot Structure liquid between two cavitys flows mutually, such as pipe, groove or other modes, so, use " interface channel " to be One preferred embodiment of the utility model.It is appreciated that herein, being allowed than in more preferably scheme, connecting and having The channel of first chamber and the second chamber fluid connection is that the same structure forms two different functions, such as the utility model Interface channel shown by the structure of tubular shape, Fig. 9 or Fig. 9 and Fig. 4 has simultaneously on connection the second chamber to the first chamber, The structure of the state of fluid connection is also functioned to simultaneously.It is appreciated that interface channel mechanism can with defect, behind in other reality It applies in mode and is discussed in detail.Certainly, the understanding of " interface channel " here can also function only as the effect of connection, allow the Two chambers and the dismountable mode of the first chamber are attached or combine, and and do not have the second chamber and the first chamber allowed to carry out liquid company Logical function；Optionally, here " interface channel " is it can be appreciated that function only as that the second chamber and the first chamber is allowed to carry out liquid The function of connection, without the please function with the second chamber of connection first.Optionally, here " interface channel " it also will be understood that As described above, that is, have connection it is total can, also have the function of allowing fluid connection simultaneously.

In some preferred modes, there is external screw thread in the outside of the second opening of interface channel.Second chamber is provided 104, the second chamber 104 have opening 1042, second opening 1042 and interface channel outer diameter quite or less times greater than even The outer diameter for connecting road has internal screw thread in the opening inner side of the second chamber 104, in this way, passing through the external screw thread and second of interface channel The externally threaded cooperation of chamber can allow the second chamber and the first chamber to be in and be detachably matched, combine or connect.That is, carrying out group When conjunction, directly the second chamber is connect by way of screw thread with interface channel；When needing to dismantle, the shape of derotation screw thread Formula allows the second chamber 104 to separate with interface channel, to separate with collecting chamber 103.Alternatively, in the second opening 1092 of interface channel Interior setting internal screw thread, is arranged external screw thread on the outside of the opening 1042 of the second chamber 104, the internal screw thread of access portal and the second chamber it is outer It is threadedly engaged, assembles or connect so that the first chamber and the second chamber be allowed to be in off-loadable mode.When the second chamber divides from the first chamber From rear, the opening 1042 of the second chamber is closed using the second cover cap, thus the second chamber of sealing.

Certainly, optionally, as shown in figure 9, the outer wall of the second opening 1092 of interface channel does not have screw thread, but connecting A long and narrow space 1098 is arranged in second 1092 outer walls of opening in channel 109, which just can be with the second chamber 104 Opening cooperated, i.e., with the thickness of the opening of the second chamber cooperate.For example, long and narrow space is by the second of interface channel The outer wall 1905 and corresponding wall 110 of opening 1092 form (such as shown in Fig. 8), helicitic texture are arranged on wall 110, the screw thread External screw thread at the opening 1042 of structure and the second chamber 104 cooperates, so as to allow the second chamber external screw thread and wall 110 on It is threadedly engaged, to realize the combination of the first chamber and the second chamber, this combination is also the inner wall being open by the second chamber and company Connect road one end 1092 outer wall cooperation and complete.Second chamber 104 and the first chamber 103, which are in, to be detachably matched, and is combined Or connection.In order to allow there is better seal matching relationship before the first chamber and second, can have in the opening inner side of the second chamber Have the second sealing ring 107, it allow the second chamber opening inner wall and interface channel the closer cooperation of outer wall, thus prevent into Enter the liquid sample leakage (as shown in FIG. 8 and 9) in the second chamber 104.Those of ordinary skill in the art are it should be understood that institute here " detachable " of meaning refer to two objects when needed and can be grouped together into an overall structure, when needing to allow two A object separate when, they can readily separate, it is this separately be mainly physical significance on space structure on not Contact.

This dismountable mode is other than the connection of the form of screw thread, and there are also other any modes, such as the shape of buckle Formula, the form of piston, the mode of grafting, snap close mode etc. can groups as long as allowing the first chamber and the second chamber when needed Conjunction links together, to obtain partially liq sample from the first chamber, when both needing to separate, allows the first chamber and second Chamber separation.For example, the form of screw thread, is exactly to rotate in opposite directions, to isolate from the first chamber；Or with other sides Formula, such as the mode of extraction, the mode of unlock allow the second chamber 104 after obtaining liquid sample in the first chamber, it may be convenient to from Separating on second chamber can.This mode for obtaining liquid, can allow the first chamber 103 and the second chamber 104 connecting When, keep fluid connection can.

Certainly, in a particular embodiment, and in preferred mode, interface channel 109 and the first chamber 103 are one Secondary property injection molding, and the second chamber 104 be other injection molding, the second chamber by with interface channel it is dismountable combine, Engagement or combination.It should be understood that interface channel 109 and the second chamber 104 are one-time injection molding, and interface channel 109 It is also feasible for removably combining, engage or combine with the first chamber 103 together with the second chamber 104.

So the function itself of can also be so-called " connection " allows an individual structure to complete, have allow the first chamber and Second chamber fluid connection state is completed by another structure.Such mode is also readily comprehensible, such as by connecting machine Structure allows the first chamber and the second chamber removably to link together, and the liquid cannot be by the bindiny mechanism itself It is flowed between two chambers and the first chamber, but by other structure, such as channel, allow liquid to flow to the second chamber from the first chamber.Institute With, it will be understood that, in some preferred modes, which further includes connection structure, the first chamber and the second chamber by being somebody's turn to do Connection structure forms dismountable engagement, combination or assembling, when connecting by the connection structure, allows the first chamber and the Two chambers are in liquid communication state.Here liquid communication can be by other structure, such as pipe, channel, groove allow two Chamber is in liquid communication state.

Those of ordinary skill in the art are appreciated that interface channel 109 here is dispensed.As long as allowing first When chamber collects liquid sample, it can allow liquid sample for example in the second chamber to link together with the first chamber , when needing the second chamber to separate with the first chamber, be easy to allow the second chamber separated with the first chamber can, such mode Can be those of ordinary skill in the art see the utility model marrow it is conceivable that other suitable modes.For example, Shown in Figure 36, the first chamber 903 side wall have a hole 903, the hole be at the beginning the diaphragm seal for being easy to puncture or from The silica gel of sealing, rubber, flexible plastic sealing collect sample with the first chamber 903, collect liquid when needing to collect sample After sample is good, the second chamber 904 (not at the beginning being to link together with the first chamber) is provided, allows the opening position of the second chamber The sealing film (not shown) on the first chamber is punctured, thus, allow the liquid of the first chamber to be flowed into the second chamber, then again with One cavity is separated, to carry out secondary detection with the liquid of the second chamber.For another example as Figure 37-38 is illustrated, first Chamber and the second chamber are also not detachably to be combined by interface channel, but the first chamber and the second chamber pass through it is mutually matched Helicitic texture progress can open the combination unloaded.Such as Figure 25-27 is illustrated again, is carried out by support holder structure detachable Combination, is described in detail below.

Selectable, referring to Fig. 8, the utility model designs interface channel 109, it is allowed to connect the opening of the second chamber 104 1042, it is of course possible to interface channel 109 is not needed, but the opening position 1042 of the second chamber 104 is allowed to be used as interface channel, The opening 1042 of second chamber is directly connect with the inside of the first chamber, being clamped of this connection, the form of piston type, lock, There is a hole to allow liquid that can lead to the first chamber as long as the opening 1042 of the second chamber is corresponding with hole for the bottom of this when, the first chamber Flowing to the second chamber can.Preferably, the first chamber and the second chamber are just connected to before the first chamber is collected sample Together, when needing that the second chamber and the first chamber point is allowed, facilitate realization separation just feasible.

In other preferred modes, dismountable connection, combination or the combination of the first chamber and the second chamber are not Direct dismountable connection of first chamber and the second chamber as shown in figure 33 is without by other structure, also unlike such as Fig. 8-9, As shown in 1,22-23, the first chamber and the second chamber carry out indirectly detachable connection by interface channel, but such as figure It removably connects or combines shown in 25-30.It illustrates in detail below.

So the other side of the utility model, providing a kind of collection or detection device, the device includes for receiving Collect the first chamber of liquid sample；With the second chamber for carrying out confirmation secondary detection, wherein device further includes a pallet knot Structure, which removably combines with the first chamber, combination or assembling.In some modes, the second chamber is located on pallet, That is the second chamber is between the first chamber in conjunction with dismountable mode or to combine be dismountable mode by pallet and the first chamber In conjunction with or combination come what is realized indirectly, i.e. support holder structure and the second chamber is carried out by way of linkage, and linkage here is general Be that the movement of pallet drives the movement of the second chamber, thus realize with the separation of the first chamber, then and after linkage, may be implemented with The separation of support holder structure or not.

This when, interface channel can have, and can also not have, so, connectivity structure it is not necessary to.Example Such as, as shown in figs. 25-30, the second cavity is located on a understructure or support holder structure 1004, and the opening of the second chamber is still With interface channel fluid connection (have interface channel), yet it is not desirable to rely on the second cavity and interface channel as described above It is directly connected to reach the conducting of liquid by the structure of itself like that, and in this embodiment, it is thus only necessary to second The opening of chamber and the second outlet of interface channel are bonded together, and the bottom of understructure 1004 and the first chamber 103 is by matching It closes structure to be bonded together (Figure 27), the form of this fit structure such as screw thread.In this way, understructure has screw thread, such as outer Screw thread, and the bottom of the first chamber has internal screw thread, the two is combined by way of screw thread, is allowed by the binding force of screw thread Second chamber closely cooperates with interface channel.Specifically, such as under type: for example, second chamber 304 is located at as shown in Figure 25-28 In one base tray 1004, and base tray 1004 and the first chamber be removably connect, and the second chamber 304 also with the pedestal The detachable combination of pallet 1004.Specifically, support holder structure 1004 has internal screw thread, the bottom of the internal screw thread and the first chamber 303 The external screw thread 3031 that portion extends cooperates, to realize the detachable combination of support holder structure 1004 and the first chamber 303.In this way, if There is also interface channels, and as shown in figure 27, interface channel 309, which still can have, is in the first of liquid flowing with the first chamber Opening 3091 and the second opening 3092 that liquid flowing is in the second chamber, and interface channel has one section of extended segment 3098, The extended segment is deep into 3052 the inside of opening of the second chamber, contacts, can be connected together, it may be assumed that prolong with the inner wall of opening 3041 Stretch the outer diameter in region and the internal diameter matching of opening 3041.Although the second chamber and the first chamber can also be by interface channels 109 as schemed 27 are clamped connection like that, but this connection does not need firmly to connect very much, does not need closely to connect as Fig. 8-9 It connects (by modes such as screw threads), this is because outer spiral shell of the support holder structure 1004 by the extended segment of screw thread 10041 and the first chamber 103 Line 3031 cooperates, and no matter the second chamber 304 collects how much liquid sample is measured in this way, not will cause interface channel 109 and the second chamber Leakage problem between opening 1042.So the internal diameter of interface channel 109 can less than the internal diameter of the opening 1042 of the second chamber, Interface channel can be allowed to be inserted into the opening 3042 of the second chamber in this way, the mode of this insertion can be easily plugged into (Figure 27 institute Show).And (such as Figure 27) only is closed in lid of the opening outer setting screw thread of opening 3042 for the second lid.This when, even As long as the connection for connecting the opening of road and the second chamber guarantees not leak when collecting liquid sample, can allow Liquid enter the second chamber can, without more structures limit.Can being clamped of this connection, piston type, lock The form of button is ok.In fact, allow the first chamber removably to combine with the second chamber, in conjunction with or engagement be indirect mode come It completes.

After the completion of equal collections, the sealing in channel or the row of the second cavity are attached according to the method described below After liquid function, if necessary to carry out second of confirmation chemical examination, subiculum dish structure 1004 is separated from the first chamber 103, such as pass through Derotation pallet and the first bottom of chamber portion cooperate volume helicitic texture, this when, the second chamber 104 on pallet is also with pallet knot Structure is separated with the first chamber 103 together, and such as Figure 27, this when takes down the second lid 101 lid and closes the opening 3042. of the second chamber so After allow the second chamber to separate 1004 (such as Figure 29) with pallet, this is because the bottom of the second chamber and the bottom of pallet have clamping Structure 10042, so, pallet and the second chamber can be separated with the first chamber 103 together.Then lower tray is dismantled from the second chamber 304 After 1004, then individually pallet 1004 is connect with the first chamber 103 again, is combined.Still maintain the first chamber this when Integrality, and the second chamber can be sent to confirmation chemical examination mechanism carry out secondary-confirmation chemical examination.In order to allow the second chamber 304 with support The movement of disk and be detached from the first chamber, on pallet have clamping ring 10042, the cavity of the shape of the clamping ring and the second chamber 304 Shape adapts to, such as the cavity of the second chamber is U-shaped, and being clamped ring 10042 also is U-shaped, in this way, support holder structure 1004 is rotating When, drive the second chamber 304 also to rotate together, since the second chamber and clamping ring slightly can closely cooperate, natural second Chamber 304 is detached from the first chamber 303 together with support holder structure 1004 together.Certainly in some modes, the second chamber is similar square Structure, pallet be arranged 4 buckle structures, allow the second chamber and buckle structure to be connected together, to realize the movement of pallet The movement of the second chamber is driven, and then realizes the separation of the second chamber and the first chamber.

It during this time, can be in the second chamber in order to guarantee the security property after the second cavity is closed by the second cover cap On stick strip of paper used for sealing, which covers the second lid and the second cavity of part.Guarantee that the sample in second cavity is not replaced maliciously It changes, the liquid in the second cavity is allowed to keep consistent with the original sample in the first chamber.Certainly optional, it can allow 1004 He of pallet Second cavity is packaged transport together, allows strip of paper used for sealing to cover the lid of the second cavity and pallet and the second cavity of sealing, thus shape Integral structure is transported.Understandable, it is primary that understructure 1004 and the second cavity 104, which are structure as a whole, Property injection molding structure, in this way, when pedestal 1004 is combined with the first chamber 104, the second cavity 104 also together with connect it is logical Road 109 combines.

Optionally, here interface channel and extended segment 3098 can omit, this is because, it is only necessary in the first chamber A hole is opened in 103 bottom, and allows the size in hole less than or equal to the opening 3042 of the second chamber 304, without interface channel With extended segment (such as Figure 27), the opening of interface channel first 3091 can play the part of the function of base apertures, in this way, when being allowed by pallet When second chamber is incorporated on the first chamber, bottom opening (the similar diagram 3091 of the opening 1042 of the second chamber and the first chamber 103 Position) place it is corresponding, by the cooperation of pallet 1004 and the first chamber 303, allow the second chamber 304 opening and hole around Region forms close cooperation, or forms closely contact, so that the second chamber and the first chamber is allowed to form liquid communication state, when When the collection of first chamber has liquid, liquid can also be flowed in the second chamber.The first chamber 103 and the second chamber is allowed to separate if necessary, The hole (similar Figure 27 shows 3091 position) for sealing up the second bottom of chamber portion, so that pallet 1004 be allowed to separate with the first chamber 103, drives Second chamber 103 is also separated with the first chamber together.Also achieve identical function.Optionally, which is to be easy to puncture at the beginning Sealing material sealing, collection have liquid after, or starting detection after, puncture the sealing material, liquid allowed to be flowed into the second chamber In, the mode of sealing element, behind can be specifically described.

Deng the first chamber liquid collect after, the second chamber can be allowed to separate with the first chamber, thus the second chamber can store or Person is shipped for testing agency and carries out secondary-confirmation detection, and the liquid in the first chamber can be used as the first time or primary detection, alternatively, After collecting Deng the first chamber liquid, the second chamber can be allowed to separate with the first chamber, after separation, the liquid of the first chamber be carried out first Detection waits after obtaining testing result, the second chamber of separation can be stored or is routed directly to detection structure and carry out second Secondary confirmation detection, then alternatively, detect after liquid sample collection to the liquid sample of the first cavity, wait acquisitions first After testing result, the second chamber is being allowed to separate with the first chamber, the second chamber of separation is examined for storing or confirming for subsequent second It surveys.

Certainly, the liquid in the first chamber can store, and the needs suitable time is waited to carry out primary detection.Some excellent In the mode of choosing, it is desirable to after the liquid in the first chamber gathers, while carry out corresponding first or detect for the first time, detections is waited to tie After fruit, for the result of some primary detections, if it is desired, carry out secondary-confirmation detection.Once primary detection is only Whether there are also analyte in preliminary detection sample, the sensitivity of detection do not need generally it is very high, sometimes, when in sample Analyte when be in threshold limit value, the result of primary detection cannot provide certainly or negative as a result, this When wish to same part sample carry out secondary-confirmation detection.

After the first chamber and the separation of the second chamber, if it is used to confirm secondary detection with the second chamber or the first chamber, such as It can be used to carry out secondary detection with the first chamber, and the liquid sample of the second chamber carries out primary detection, is possible to.Institute With the first chamber and the second chamber can only have the second chamber just there is no restriction and can be carried out confirmation detection.In some modes, such as Figure 37 Shown in 38, the utility model provides a kind of the first chamber 603 for collecting liquid sample and for carrying out primary detection Two chambers 604, the second chamber have test chamber 605, and test chamber and the second chamber have fluid connection through-hole 6038.First chamber has opening 6031, there is interface channel 609 in the bottom of chamber, which has the first opening 6091 and the first chamber fluid connection, With the second opening 6092, wherein the first opening is sealed by sealing element, which is the sealing element that shell punctures, example Such as film, double-sided adhesive, aluminium foil sealing.In this way, liquid will not be at the beginning when using the first chamber to collect liquid sample Just pass through the first opening outflow of interface channel.After the collection of the first chamber has liquid sample, combined with the second chamber, such as utilize the The external screw thread 6031 of one chamber and the internal screw thread of the second chamber are combined, alternatively, the first chamber and the second chamber pass through screw thread at the beginning Mode has been combined, and directly collects liquid sample with the first chamber 603.After the completion of receipts, with 6028 Hes of sealing Puncturing elements 6029 are tightly connected the sealing element of the opening of channel first to puncture, and release liquid carries out just to the second chamber 604 Secondary detection, the liquid enter test chamber 605 and carry out chemically examining detection for the first time, when needing to carry out second of confirmation detection, Lower first chamber is dismantled from the second chamber, the opening of the first chamber is sealed with lid, so that the liquid sample of the first chamber is carried out second Confirmation detection.Optional mode is to include the sealing element 6028 on the lid for sealing the first chamber and puncture member Part 6029, the channels 610 with an extension corresponding with the first opening 6091 of interface channel 609, the channel in the first chamber To the first intracavitary extension, in this way, when cover cap closes the first chamber, 6029 shape of lid and sealing element 6028 and puncturing elements At the relationship of linkage, band moving sealing element and puncturing elements in this way move together, are tightly connected chamber first when puncturing elements puncture Be open 6091 when, sealing element pushes the liquid in channel 610 to be flowed into the second chamber and is chemically examined for the first time, this when covers Body seals the opening of the first chamber.As shown in the figure of the upper surface of Figure 38.When carrying out the second chemical examination of confirmation, from the second chamber 604 are detached from the first chambers 603, and be then tightly connected channel with the second lid second is open, such as the mode of screw thread, then the One chamber 603 is sent to testing agency and carries out secondary-confirmation detection, as shown in the figure under Figure 38.

Certainly, puncturing elements can also have the function of excluding the second cavity segment liquid, this when, on puncturing elements It can have lyophoby channel and inlet and accommodating chamber.It is open after 7091, punctures in this way, puncturing and being tightly connected the first of channel Element direct part is inserted into the second chamber, in order to which liquid can exclude the feed liquor that liquid can be allowed to pass through lyophoby channel outside Mouth is flowed into accommodating chamber, such as accommodating chamber is located in puncturing elements, this combines subsequent detailed description that can clearly manage Solution and combination.

In some optional modes, when as detection device, the collection device also packet testing element can be right The sample of collection is tested.Such as collection device includes test chamber, wherein test chamber and the first collecting chamber are in liquid communication, It can be flowed in test chamber positioned at the liquid sample of the first chamber.Certainly, detection device here includes that test chamber is only excellent The embodiment of choosing, when as collection device, can lack test chamber or the detection device includes test chamber, but It is and without testing element that when waiting to need to detect, detecting element is inserted into test chamber.In some specific embodiment party In formula, test chamber 105 is set outside the side wall of the first chamber, the first chamber 103 and test chamber 105 are in fluid connection (such as Fig. 9), such as There is liquid sample in the first chamber of fruit 103, liquid can be carried out by the through-hole 1038 that test chamber 105 and collecting chamber 103 are arranged Fluid connection, hence into carrying out necessary first chemical examination or detection into test chamber.

Generally, the sensitivity (for the first time or primary detection) of the detection of the liquid sample in the first chamber 103 is not secondary Confirm the high sensitivity of detection, either for the first time or the specificity of the primary detection specificity that does not have secondary-confirmation to detect is accurate. Carry out secondary detection in this way can be confirmed whether primary detection is just very accurate substantially.For example, primary detection is by immune, chemistry Method carry out, and secondary-confirmation detection be generally adopted by mass spectrum (GS), gas phase or liquid chromatographic detection.This secondary inspection Survey is generally carried out with the liquid sample in the second chamber separated with the first chamber, this is because the first chamber and the second chamber both for It is with a sample, their property is only to be divided into different parts all, and second of detection can be to first Confirmation is played the role of in detection.

In some preferred modes, wait the first chamber 103 collect liquid sample while or collect after it is very short In time, the liquid in the first chamber is detected at once.So in the utility model one preferred mode, the first chamber 103 and test chamber 105 be in fluid connection, include testing element in test chamber.In some preferred modes, these test members Part is arranged on carrier.In a preferred manner, test chamber includes test carrier 106, and testing on carrier has many card slots 1061, testing element is provided in each card slot.For example, as shown in figure 9, when the first 103 inner collection liquid sample of chamber It waits, liquid sample a part is flowed into test chamber 105 by through-hole 1038, the liquid sample being flowed into test chamber and test Element contact, to complete the detection of analyte；The liquid sample of another part passes through the opening 1091 of interface channel 109 It is flowed into the second chamber 104.After the testing element being located in test chamber terminates detection, the reading of first test result is carried out, After reading, when feeling it is necessary to carry out confirmation secondary detection, the second chamber 104 is separated from the first chamber 103, is then used Second lid 101 seals the opening 1042 of the second chamber 104, and the second chamber 104 is stored or be routed directly to exact p-value It chemically examines structure and carries out further confirmation chemical examination.And the liquid in the first chamber 103 and test chamber 105 detected for the first time can be with It abandons or is handled.

By the way of detection for the first time and secondary-confirmation detection separation, some disadvantages of conventional detection devices are thus overcome End.In conventional detection devices, after the completion of test, secondary chemical examination is carried out if necessary, is required entire detection device (band Have the first chamber as the cavity for collecting liquid and/or with test chamber, alternatively, the testing element in test chamber) it saves, Entire detection device packed and transported (automobile land, sea-freight or air transportion) is either carried out confirmation chemical examination to secondary chemical examination mechanism, This just needs to guarantee or ensure any structure of entire detection device, cannot Anywhere there is leakage liquid sample, because one Denier causes the leakage of sample to will result in extraneous pollution, and sample also can mutually pollute, to confirmation or secondary detection inspection Measuring tape carrys out uncertain result.This structure that certainly will just may cause leakage to each is sealed encapsulation, this, which gives, manufactures this Kind detection device increases a large amount of cost and design difficulty, because these primary detection devices are usually plastic products, and Be it is disposable, will cause to reach this device in no instance liquid leakage be it is relatively difficult, just Calculation can guarantee not leak, but manufacturing cost really need it is very high.Ideally, cost is on the one hand reduced as far as possible, together When, and need to guarantee that liquid sample does not leak, biggish challenge is brought to producer.For example, this is just needed to sealing first First lid 102 of the opening 1031 of cavity carries out complicated design, it is ensured that liquid cannot be let out by opening 1031.Such as Fruit device further includes testing element, this just need to carry out the cavity (if there is) for accommodating testing element more accurate processing or Person's design, it is ensured that liquid sample cannot be let out by test chamber, and particularly, these devices generally require carry out air transportion, In It is not leaked in the case where negative pressure or high pressure, brings bigger challenge to manufacture and design.In tradition, leakage is avoided always Using sealing ring or change component of the silicagel pad as sealing, but device storage time is once long, these silica gel or Plastics have oxidation or aging, cause the leakage of liquid when in use.Second, if necessary to primary detection result Sample is saved, it is also desirable to which more storage spaces accommodate the detection device of large volume；This is also necessarily increased more Space, special standby for profession chemically examines mechanism, the sample size of detection is very huge, this just needs enough spaces to store These samples Jing Guo primary detection, these samples Jing Guo primary detection are accommodated in bigger detection device, to storage Hide space requirement bigger area or volume.Third, to these primary detections complete device due to volume it is big, dramatically increase Transportation and packing are caused the raising of cost, traditional detection device volume is huge after all, and is all individually to wrap by transportation cost Dress and transport.4th, if detection device has a testing element at the beginning, in transportational process, the liquid of collection is always and test What element contacted, and contain chemical substance on testing element, these chemical substances are not to deposit in itself in liquid sample , it allows liquid sample to contact with testing element for a long time, causes the pollution to liquid sample, it may be to subsequent secondary detection Cause negative impact.In short, whatsoever reason, traditional detection device or collection device have one described above Or several defects.

And the device of the utility model is used, volume of the volume of the second chamber generally than the first chamber is small, or even only passes The either part of 1/10th of test chamber of uniting.Second chamber generally only needs 1-50 milliliters of sample secondary with regard to carrying out enough Chemical examination, such as 0.1 milliliter is needed, 0.2 milliliter, 0.3 milliliter, 0.4 milliliter, 0.5 milliliter, 0.6 milliliter, 0.7 milliliter, 0.8 milliliter, 0.9 milliliter, 1 milliliter, or it is only necessary to 1.2 milliliters, 1.4 milliliters, 1.6 milliliters, 1.8 milliliters, 2 milliliters, or it is only necessary to 3 milliliters, 4 milliliters, 5 milliliters, 6 milliliters are sufficient, and 7 milliliters, 8 milliliters, 9 milliliters, 10 milliliters, 11 milliliters, 12 milliliters, 15 millis It rises, 25 milliliters, 30 milliliters.The volume of first chamber is usually 5-500 milliliters of volume, for example, 8 milliliters, 10 milliliters, 12 millis It rises, 14 milliliters, 16 milliliters, 18 milliliters, 20 milliliters, 22 milliliters, 24 milliliters, 26 milliliters, 28 milliliters, 30 milliliters, 32 milliliters, 34 millis It rises, 36 milliliters, 38 milliliters, 40 milliliters, 42 milliliters, 44 milliliters, 46 milliliters, 48 milliliters, 50 milliliters, 60 milliliters, 70 milliliters, 80 millis It rises, 100 milliliters, 150 milliliters, 200 milliliters, 250 milliliters, 500 milliliters.Moreover, general, only one opening 1042 of the second chamber, As long as 1042 confirmatory sample of the second opening is sealed to be not leaked.On the one hand, the second chamber is small in size, light-weight, this Sample transportation and packing cost significantly reduces, storage space very little.On the other hand, it does not need to the first chamber and/or containing test chamber Component has seal request high as conventional apparatus, such as the sealing for sealing the opening 1031 of the first chamber to the first lid is wanted Ask just much lower, and also more much lower than traditional for the seal request of the test chamber of testing element setting, it might even be possible to no Consider the first lid whether to the sealing effect of the opening of the first chamber 103, also different sealing effects for considering test chambers itself, this Be because Yi Dan complete primary detection after, the first chamber 103 with or the first chamber with test chamber 105 or even the first lid 102 It can carry out discard processing.Disposable detection device as tradition relatively, has saved a large amount of cost, and it is safer can It leans on.In addition, the property due to the liquid in the second chamber is consistent with the property of the first cavity, to ensure that the effect of secondary detection Property.Third, it is small in size due to the second chamber, it does not need special appendix and considers storage space, the place of very little can store largely The second cavity, reduce confirmation chemical examination laboratory pressure, decrease transportation cost, at the same can guarantee transport safety Property.Because not needing the risk for worrying very much liquid leakage.

In some preferred modes, when need to the first chamber 103 collect liquid sample detected and collected it is secondary It is when completion under the same time in confirmatory sample to the second chamber 104, it is desirable to be flowed into test chamber (if having detection When chamber) sample the liquid sample that enter the second chamber 104 will not be caused potentially to pollute, allow interface channel 109 Opening 1091 position be higher than through-hole 1038 height (such as shown in Fig. 7 and Fig. 6, shown in Fig. 9), in this way, flow into test chamber Liquid would not or can hardly enter in the second cavity, thus ensure that liquid in the second chamber 104 and without and survey The liquid sample essence for trying element contact is the same.It after all may be containing on testing element with the liquid sample of testing element contact It, may if perhaps the such reagent of other ingredients or ingredient enter in the second cavity processed some chemical reagent Second of test result is had adverse effect on.It is appreciated that the opening 1091 with interface channel is higher than through-hole 1038, or As the method previously described, the opening that the liquid of the second chamber of inflow passes through is higher than the position for flowing into the through-hole of test chamber (before such as to person The base apertures of examples of implementation are stated, are not had this when to connect), it can enter to avoid the liquid sample contacted with test-strips Into the second chamber, when testing element is included in device and contacts with liquid sample.

In some preferred modes, the first cavity contains the collection region 1035 or 1036 for collecting liquid, these remittances Collection region is located at the bottom of the first chamber 103, and around interface channel 109 or interface channel first is open for 1091 week It encloses.In some preferred modes, the position of these collection regions is lower than the position of interface channel opening 1091, in this way, working as liquid Body enters in the first chamber, first collect in collection region, then by through-hole 1038 enter in test chamber with testing element Contact.So the sequence reached according to liquid, collection region first has reaching for liquid, is then flowed into through-hole 1038 and enters inspection Chamber (if present) is surveyed, the position of the first opening 1091 of interface channel is then just reached.

In some preferred modes, for example, Figure 12, raised in the bottom middle position of the first chamber shown in 4,5 The main structure of the second cavity of accommodating portion 104 is carried out in region, the formed space of the elevated regions.It is arranged on the region of protrusion and connects Connect road or hole, raised region also forms collection region u (shown in Figure 4 and 5) and (such as schemes in terms of the bottom of the first cavity 4), to 103 sunken inside of the first chamber, the opening 1042 that the region of this recess is just used to the second cavity of accommodating portion 104 exists for bottom Interior partial region will not additionally increase the material of detection device, will not seem lofty, such as Fig. 7-in this way, seeing on the whole Described in 11, the opening portion of the second chamber is set under the bottom of the first chamber 103, is seen on the whole, is still to be filled with traditional detection Set difference only.In some preferred modes, the position of collection region 1036 and 1035 is lower than the position of through-hole 1038, allows in this way The liquid sample collected passes through through-hole 1038 first and enters in test chamber (if present) 105, if fill full test chamber or After liquid closes through-hole 1038, extra liquid will enter the second chamber by the first opening 1091 of interface channel 109 In 104.It thus avoids to be flowed into the liquid of test chamber and come out from test chamber as far as possible and enter in the second chamber.Alternatively, For sequence according to liquid flowing, liquid usually first reaches collection region and is collected, and waits after being pooled to certain altitude, In Be flowed into test chamber by through-hole 1038 and carry out test assay, etc. after test chambers collect liquid sample, through-hole 1038 can by liquid Body sealing, with increasing for liquid, the position that liquid level can reach interface channel opening 1091 is filled out hence into the second chamber Enter full of the second chamber or partially liq sample and is used as subsequent progress secondary-confirmation detection in the second chamber.

In other mode, detection device does not individually contain test chamber (as illustrated in Figure 1), such as schemed 15-17 is such, includes a region on the side wall in the first chamber 203, for example, including in the first chamber 203 as shown in Figure 16 Two vertical strips 2032 and 2033, two strips limit such a region, carrier as shown in figure 17 are allowed to be inserted into In the region, the structure with test function is formed.For example, carrier structure as described in Figure 17, multiple appearances are set on the carrier Receive the channel 2063 of testing element, the one end of the channel 2062 closing, another end opening 2061, each channel is according to such phase The direction of appearance is arranged on carrier, and the detection zone and suction zone on testing element are located in channel, and on testing element Sample applying zone is located at one end of access portal 2063, and the testing element in each channel is in this way, in this way, each The sample applying zone of testing element in channel is all located at the end 2065 of carrier, corresponding, the detection zone of testing element It is all located at close to one end of channel sealing, positioned at the top of carrier 2064.It is combined in the first chamber 103, allows carrier assembly The end 2065 of carrier allows the top 2064 of carrier close to the opening 2031 of the first chamber close to the bottom of the first chamber 2034.This Sample, the part sample of the liquid sample entered from the opening of the first chamber 203 is just and near the 2034 of the bottom of the first chamber 203 Testing element the contact of sample applying zone, to complete to the test assay of analyte in liquid sample.In addition Some preferred modes in, such as shown in Figure 25-30, the combination of dismountable mode of the second chamber 304 and the first chamber 303 Form can be with previously described such as his Fig. 1, and the mode of 6-13 is realized or aforementioned any mode carries out, after also including Continue any mode to be sealed or separate.

In some preferred modes, the bottom 2034 of the first chamber has 2035 structure of groove, and groove structure 2035 can be with Liquid template is allowed to collect this in the first chamber, as depicted in figures 22 and 23.In some preferred modes, the of interface channel 209 The height of one opening 2091 is higher than the height of groove, the i.e. opening 2091 of interface channel 2091 upstream that is in groove 2035, this What sample can prevent from contacting with testing element, the liquid sample near groove passes through the opening of interface channel 209 first 2091 It is flowed into the second chamber 204.Equally, when the testing element in the carrier being located in the first chamber is completed to test for the first time or for the first time Afterwards, it is believed that when it is necessary to carry out the detection of subsequent secondary-confirmation, the second chamber can be directly separated from the first chamber, after separation, It is individually stored with the opening 2041 that the second lid 201 seals the second chamber 204, or individually packaging is transported to second really Recognize detection structure and carries out confirmation detection.It is corresponding, complete primary detection carrier 206 and with carrier suffer a chamber 203 with And 2,031 first lid 202 of opening with the first chamber 203 of sealing is abandoned or is handled together.The volume of first chamber is general It is greater than the volume of the second chamber, the difference that they are also possible to volume as elucidated before is designed, certainly, the body of the first chamber Product can also be equal with the volume of the second chamber, and optionally, the volume of the first cavity might be less that the volume of the second chamber.

In some modes, the shape of shape and the second chamber for the first chamber is not particularly limited, for example, in general, The shape of first cavity is cylinder, and the shape of the second chamber is cylinder, and certainly, the shape of the first chamber can be cuboid, Square, ellipsoid or cone, correspondingly, the shape of the second chamber can be cuboid, square, ellipsoid or cone.

Front teaches dismountable mode of the first chamber and second, general second cavity be located at the first inside cavity or Bottom generally after collecting liquid, carries out the first chamber and second alternatively, at the beginning, the first chamber and the first chamber are just combined The separation of chamber.Certainly, it is not intended to limit the specific location of the second cavity, the second cavity can also be otherwise.

Sealing element

In some preferred modes, after the first chamber is separated with the second cavity or before will separating or by stages before, Original the first chamber in liquid communication state and the second chamber is allowed to be not at liquid flowing, to prevent liquid in the first chamber and the It circulates between two chambers.Alternatively, whether liquid, which is connected to, between the first chamber and the second chamber has following several states: first state It is that liquid is not connected to, the second state is fluid connection,；Alternatively, first state is fluid connection, the second state is that liquid does not connect It is logical.As for the different conditions of the second chamber and the second chamber in different purposes or operating process, be in fluid connection or It is not connected to, it can arbitrarily devised and selection.For example, when the first chamber collects fluid sample or liquid sample, the first chamber Liquid communication state is at second；When need separate before or separation when, allow the second chamber not with the first chamber be in liquid Circulation status.Alternatively, the first chamber and second is just not at liquid when the first chamber collects fluid sample or liquid sample Circulation status；Before needing to separate or when separation, allow the second chamber not with the first chamber be in liquid communication state, to allow the Two chambers collect the liquid from the first chamber, and the first chamber and second is then allowed just to be not at liquid communication state again, thus separation the Two chambers are simultaneously detached from the first chamber.

So a sealing element is provided in some modes, if the first chamber 103 passes through interface channel 109 and second When chamber 104 removably combines, which is tightly connected channel, and the liquid of the first chamber cannot be allowed to enter back into second Chamber, or the liquid of the first chamber cannot be allowed to flow out in the channel by the liquid for entering the second chamber.It is so-called not allow liquid logical It crosses interface channel to flow out, is exactly tightly connected the place of the first chamber of sealing and the second chamber connection of channel either essence, this Kind connection can be indirectly connected with by interface channel, can not also be connected by interface channel, anyway, in these embodiment party In formula, while allowing the second chamber perhaps to separate after separating with the first chamber or before point separation, the ground of the first chamber and the connection of the second chamber Side is in hydraulic seal, so that liquid sample will not lead to after not allowing liquid in entering the second chamber or the separation of the second cavity Junction is crossed to leak into the outside environment of the first chamber.In some preferred modes, liquid cannot be leaked by junction In the external environment of the first chamber containing test chamber, alternatively, liquid cannot leak into containing testing element by junction In the external environment of one chamber.It is readily understood that connection and liquid communication are not by the " connection of the preferred mode of the utility model When channel " is realized, but connected by connection structure with two independent structures of circulation passage, once the first chamber and second After chamber is separated by connection structure, as long as being achieved that the flowing of liquid with sealing element sealing circulation passage.So sealing member The function of part is exactly the state for allowing the first chamber and the second chamber to be not at liquid communication, from liquid flow state change to liquid not The state of flowing.

In some preferred modes, when the second chamber is removably connect by interface channel with the first chamber, when the second chamber Before separating with the first chamber, while later or separation, the interface channel is sealed by sealing element.The sealing member Part can be tightly connected first opening 1091 in channel, as described in Figure 12.Herein, sealing element is blocked up as a plug The firmly opening 1091 of interface channel so that liquid be prevented to enter in the second chamber, or does not allow liquid first from interface channel Opening 1091 flows out to except the first cavity.Here sealing element can be match with the shape of the opening of interface channel or Person is adapted, to be tightly connected channel.Here adaptable refer to sealing element and interface channel by it is suitably sized, close One of suitable material, suitable shape or combination cooperate and play the role of liquid sealing.For example, the first of interface channel Opening be it is round, sealing element be also it is circular, alternatively, interface channel is plastics, sealing element is also plastics, by material The mechanical elasticity of matter having in itself and seal, alternatively, sealing element is rigid, interface channel is elastic, then alternatively, close Envelope element is rigid, the rigidity of interface channel, these modes can achieve the effect that sealing, to realize foregoing description Function.For example, sealing element be it is elastically-deformable, and interface channel be it is rigid, sealing element is packed into interface channel, from And seal the opening of interface channel.This sealing means are can be optional.Sealing element can individually be used to close It seals interface channel or seals the place of the first chamber and the second chamber liquid communication, allow the first chamber and the second chamber fluid connection.

It include the sealing element in the described sealed connection channel in some preferred modes, on the first lid 102, the While one cover cap closes the opening of the first chamber, the sealing element is tightly connected the opening in channel.In fact, sealing element Joint-action mechanism is formed with lid, the movement of lid is with the movement of moving sealing element.The movement of first lid seals the first chamber Opening, if the first lid move, can also allow sealing element simultaneously be tightly connected channel, in this way operate on more It is convenient.It will be appreciated, of course, that it is not linkage that the first cover cap, which closes the first cavity and sealing element sealed connection channel, it can It completes to be also to belong to the scope of the utility model to be divided into two steps.Preferably, sealing element is tightly connected the of channel One opening.It is also possible that say, the movement of the first lid and the change of the state of the first chamber and the second chamber fluid connection is allowed to be connection It is dynamic to complete together.For example, the movement of the first lid, in the process of movement, the first chamber and second in fluid connection is allowed Chamber changes into the first chamber and the second chamber is not at the state of fluid connection.Alternatively, the movement of the first lid, the first chamber and second are allowed The state that chamber is not at fluid connection becomes the first chamber and the second chamber is in fluid connection state, with movement, and allows first Chamber and the second chamber are not at the state of fluid connection.

Here lid closes the lid that can refer to the first lid and the cooperation of the first cavity and cover the opening 1031 of the first chamber, It is of course also possible to be the opening 1031 that lid seals the first chamber 103, sealing here can be only general sealing, alternatively, Be also possible to the state of blow-by, spill in the first chamber simply against liquid sample and, for example, mobile first chamber when It waits, liquid is avoided to overflow to come from the opening 1031 of the first cavity.As set forth above, the opening of the first lid and the first cavity Lid close there is no need to the sealing effects as conventional detection devices because not needing to transport entire detection device Or transportational process under some extreme conditions.Sealing element waits the first cavity to collect the liquid of sufficient amount on lid When, the opening that cover cap closes the first chamber is generally required, while cover cap closes opening 1031 of the first chamber, is connected to lid On sealing element be tightly connected the opening or interface channel in channel simultaneously, so that liquid not allowed to enter in the second chamber, when After second cavity is separated with the first chamber, liquid cannot be leaked into the external world by interface channel.Allow operation more convenient in this way, Easily and quickly, two functions are completed while operating a step.Here sealing element is tightly connected the sealing effect in channel Fruit, which only can be, does not temporarily allow liquid to leak into the external world by interface channel, without close as conventional detection devices Effect is sealed, guarantees under extreme traffic condition to leak under (such as high pressure or vacuum).This also in that, the sample of the second chamber This carries out secondary-confirmation detection as transport agent, and the liquid in the first chamber need not be transported or be stored, and can be carried out Subsequent discard processing.So here to the close of opening 1031 and interface channel or the interface channel opening 1091 of the first chamber Envelope is only general sealing, without needing the sealing state under negative pressure, vacuum state as conventional apparatus.Mainly Because not needing the laboratory for the first chamber of fluid connection in the first chamber being transported to profession or chemical examination mechanism carrying out secondaryization It tests.

For convenience and production cost it is cheap, the first chamber and the second chamber are all plastic materials, these all be injection molding once Property is molding, and sealing element and the first lid are also injection molding, can be reached by the physical property between plastic material Sealing element is allowed to seal the junction of the first chamber and the second chamber, it is preferred that be tightly connected the interface channel of the first chamber and the second chamber. In order to reach better seal effect, elastic seal ring 108, such as " O " type sealing ring can be set on sealing element, such as The material relative to sealing element of silica gel sealing ring, these sealing rings can have flexibility, thus, connect when sealing element seals When connecting first opening 1091 in road, increase its sealing effect.It is appreciated that when needing lid and sealing element to link When, the opening of usual first lid and the first chamber is joined together by screw thread, first this be rotation mode lid The opening of first chamber, and the opening that sealing element is also the mode of rotation to enter interface channel or be tightly connected channel, or Person seals the hole (if in the case that interface channel omits) of the first chamber and the second chamber fluid connection.

It is appreciated that " O " type sealing ring and sealing element are used cooperatively, then " O " type sealing ring, which can individually produce, to be filled It is fitted on sealing element, has Packed function in this way, certainly, the structure of " O " type sealing ring can be with installation " O " type sealing ring Position be but disposably to be completed by injection molding with the same material, in this way, facilitate production and processing technology.Certainly, In other cases, " O " type sealing ring be also can be default, it is only different by the material of interface channel and sealing element And it can realize sealing.

It, can be by once at injection molding when sealing element and the connection of the first lid in some preferred modes Molding, can also be connect by dismountable mode with lid.Such as shown in Figures 2 and 3, sealing member is connected on the first lid Sealing ring 108 is arranged on sealing element for part 1028, and sealing element is structure as a whole with lid 102.In order to preferably solid Determine sealing ring, a groove structure is set on sealing element, allows sealing element is elastic to be fixed on groove.General first chamber Need to accommodate the liquid sample of certain volume, so there is certain volume, so, 1031 the first chamber of distance of opening of the first chamber Bottom interface channel the first opening 1091 with one section of distance, so, sealing element passes through 1023 He of connection structure Lid 102 links together, and becomes one structure.As shown in figure 12, when lid is in such a way that lid closes, such as the side of rotation When formula lid is closed to opening 1031 of the first chamber and sealing element 1028 that lid the is linked together also company of being rotated into together It connects in road 109, the lid of lid closes process therewith, and sealing element enters in interface channel, so that sealing element 1028 seals One opening 1091 of interface channel, to prevent liquid sample to enter the first chamber, when the second chamber is separated with the first chamber Wait, positioned at the liquid sample of the first chamber will not be leaked by interface channel it is extraneous come.

For example, as shown in figure 22, connection structure 2023 is connected on the first lid 202, connection structure 2023 extends one Duan Zuowei sealing element 2028 is tightly connected channel；State shown by Figure 22, sealing element 2028 (is exactly to have at this time 208) there are no when close opening 2091, the first chamber and the second chamber are in liquid flowing state in the place of sealing ring.With The seat of lid changes, and sealing element is close to the position of opening 2091, and with movement, sealing element seals up opening 2091, Sealing effect is reached at this time, the liquid in the first chamber would not flow in the second chamber.

It carries out being preferred mode by the way of lid and sealing element linkage, the first chamber and the second chamber is allowed not to be located in this way In fluid connection state.No doubt, lid and sealing element can disposably be molded completion, can also be assemblied in one with Multi-step injection molding It rises.For example, lid is that disposable injection molding is completed, connecting rod 2023 and sealing element 2028 are that disposable injection molding is completed；Then lead to It crosses any optional grafting, screw thread or other way to combine, the movement band moving sealing element of lid is allowed to move together, Referred to as " link ".In other mode, sealing element, connecting rod and lid are molded respectively, and then fitting together is also Can with.

So sealing element is also that dismountable mode is connect with lid in some preferred modes.For example, as schemed Shown in 31-35, lid 402 includes sealing element 4028, the shape matching of the shape of the sealing element and interface channel or and First opening, 1091,3091 matching, such as the shape of piston.This mode, a part of connection structure 4023 is as sealing member Part 4028 uses, and this when does not have sealing ring.But material can be different, the material of general sealing element is generally more High resilience, even if in this way, flexible sealing element is easier to be tightly connected channel, or sealing connects without sealing ring Connect first opening in road.For example, sealing element can be latex, silica gel or other flexible materials, alternatively, close Envelope element is made of two parts, and inside is the material composition for comparing hard, and one layer is covered on the material surface of hard rich in bullet Property the materials such as silica gel, rubber, latex come enhance sealing element and interface channel or be open 1091 opening sealing effect. Meanwhile first lid of lid 402 when close the opening of the first chamber 103,203, spend smaller strength that can allow sealing element 4028 are tightly connected channel or opening, such as allow sealing element to enter in interface channel and be tightly connected channel.Alternatively, close It is to be threadedly attached in one that element 5029 (when the structure using 5029 is as sealing element), which is sealed, with connecting rod 5023 It rises, such as Figure 33-34, in this embodiment example, external screw thread is arranged in one end 5030 of sealing element 5029, in connection structure Internal screw thread is arranged in one end on 5023, and sealing element is linked together structure by thread forms and lid, in this way, sealing element can To have different materials with lid and from connection structure, there is sealing element more design forms and mode to meet not Same sealing needs,.

Here sealing may be an individual component or be arranged on the place connected in the second chamber and the first chamber, The liquid flowing before the second chamber and the first chamber can be obstructed.Here flowing is usually the flowing of active.In fact, working as liquid When passively flowing to the first chamber from the second chamber, sealing element it is not necessary to.

In addition, as being talked about above in conjunction with Figure 27, when the structure for being not provided with interface channel in the first chamber and the second chamber When, only actually has a hole, such as 3091 similar holes, and lacks the part 3098 of interface channel extension, this When a, sealing element it is only necessary to sealed openings 3091 can, it is not necessary to allow sealing element to enter in interface channel Come.Such as sealing element such as a rubbery stopper, the rubbery stopper are arranged in the connecting rod 3023 of lid, the linkage of lid Dynamic plug clogs opening 3091, realizes the change of the liquid communication state between the first chamber and the second chamber.

In addition, sealing element can seal the first opening of interface channel at the very start, when the first chamber 103 has collected After liquid sample, alternatively, being pierced before or after carrying out the first chamber liquid sample progress primary detection using puncturing elements It breaks the sealing element or cancels sealing element, liquid sample is allowed to be flowed into interface channel, enter second by the second opening In chamber 104, moreover, the second chamber is removably to combine with the first chamber, so that the second chamber be allowed to separate with the first chamber, progress is subsequent can Test is chemically examined in the confirmation of energy.So sealing element here can be the knot that can be punctured when puncturing sealing element Structure, for example, this sealing element can be adhesive sticker, double-sided adhesive, plastic sheet etc..Generally, which is at the beginning Liquid will not be allowed to enter in interface channel, but just entered after being punctured.The mode being punctured has many kinds, for example, Sharp thing punctures.In some modes, puncturing elements can be arranged on the first lid 102, and linkage punctures in lid Structure, when the first cover cap closes the opening of the first chamber 103, puncturing elements sealing element, to allow liquid from first The second chamber that chamber flows to.It allows the first chamber and the second chamber to separate if necessary, before separation, another sealing element sealing is allowed to puncture Place, to realize the change of the liquid communication state between the first cavity and the second chamber.

For example, the figure anticipated as shown in figs. 39-40, the first chamber 702 includes the opening 7031 of receptive liquid sample, in the first chamber In there is hole, which is the first opening 7091 of interface channel, sealing element which can be punctured seals 70281 and the The test chamber 705 of one chamber fluid connection carries out fluid connection by channel 7038.It is not both first with shown by Figure 37-38 Chamber of the chamber as the collection liquid sample of primary detection, and connection detachable at the second opening 7092 of interface channel There is the second chamber 704.When collection has liquid sample, the liquid portion of the first chamber is flowed into test chamber and carries out first chemical examination Then detection closes the opening of the first chamber with the first cover cap, the second lid is had on lid, sealing member is provided on the first lid Part 7028 and puncturing elements 7029.Lid and sealing element 7028 and puncturing elements 7029 in this way form joint-action mechanism, and such the When one cover cap closes the first chamber, band moving sealing element and puncturing elements link, and puncturing elements are existing to puncture sealing company The sealing element that road first is open is connected, liquid is then discharged into the second chamber, the opening of the second chamber is then sealed up with sealing element. Certainly, puncturing elements can also have the function of excluding the second cavity segment liquid, also can have on puncturing elements this when Lyophoby channel and inlet and accommodating chamber.It is open after 7091 in this way, puncturing and being tightly connected the first of channel, puncturing elements are direct It is inserted partially into the second chamber, in order to which liquid can exclude outside, liquid can be allowed to be flowed by the inlet in lyophoby channel In accommodating chamber, such as accommodating chamber is located in puncturing elements, this combines subsequent detailed description that can be clearly understood from and combine. Such as shown in Figure 40 draw above.When needing to carry out secondary-confirmation detection, the second chamber is removed from the first chamber, such as Rotation screw thread is removed, and the opening 7041 of the second chamber 704 is then sealed with the second lid, carries out subsequent secondary-confirmation detection.

To sum up see, allow liquid from the first chamber flow to the second chamber can be allow liquid to enter the first chamber when, also together When can flow to the second chamber, liquid simultaneously or is not immediately entered to the after perhaps allowing liquid sample to flow into the second chamber Two chambers, this be should be the second chamber and the first chamber be not in fluid connection, but it is subsequent whenever, allow the second chamber with First chamber is in fluid connection.It is not at fluid connection and the mode in fluid connection is exactly the control opportunity to sealing element Problem, such as puncturing the sealing element being tightly connected in the opening of channel first 1091 or the second opening 1092 is exactly to allow two The mode of chamber connection.Certainly, in order to allow the second chamber to separate it is unlikely to that the first chamber liquid is allowed to proceed to the second chamber, while after puncturing It also needs to seal.

So in some modes, the second chamber and first when collecting liquid sample, are not allowed with the first chamber 104 Chamber is in fluid connection, waits when collecting liquid or after collecting liquid sample, the second chamber is allowed to be not at the first chamber Fluid connection.Certainly, optionally, the second chamber and the first chamber when collecting liquid sample, is not allowed not to be located with the first chamber 104 It in fluid connection, waits when collecting liquid or after collecting liquid sample, the second chamber and the first chamber is allowed to be in liquid company It is logical, when allowing liquid sample to enter in the second chamber or later, before needing that the first chamber and the second chamber is allowed to separate, again The second chamber and the first chamber is allowed to be not at fluid connection.In the above mode, sealing element plays the part of difference with the different time Function.When seal, when blow-by, can be selected according to suitable opportunity.

In the example for needing sealing element above, liquid sample always be free to flow to second from the first chamber 103 Chamber (such as under the action of gravity, liquid always flow to low level from a high position) continues to flow, just after avoiding two cavitys of separation Use sealing element；But in fact, sealing is first when liquid sample passively overcomes gravity to flow to a high position from low level Part is not necessary.Such as the example in design 3, do not need individual sealing element.

Lyophoby channel

Described " lyophoby channel " is exactly the channel of similar drain herein, liquid dredge by the channel or Discharge, it is also assumed that being the channel for allowing liquid to flow to another place from a place by the channel.In addition to this, this In " lyophoby channel " extra gas can also be excluded, thus the effect relieved stress；Gas is dredged by the channel Logical or discharge, it is also assumed that being the channel for allowing gas to flow to another place from a place by the channel.So Here " lyophoby channel " can exclude extra liquid, can also exclude the mixing of extra gaseous state or gas and liquid State.So-called " channel " ordinary meaning is, such as the shape of pipe, such as all round closure, and is open including two, an opening It can be used as inlet, another opening can be used as liquid outlet；Alternatively, an opening can be used as air inlet, another is opened Mouth can be used as gas outlet；Alternatively, an opening can be used as into liquid and gaseous mixed state mouth, another opening can be made For the mouth for excluding liquid and gaseous mixed state.Here a import and an outlet is only a kind of embodiment, when One or more import can so be contained, also may include one or more outlet.Here to the length in channel itself There is no any limitation, can be long, can also be shorter, this carrys out those of ordinary skill in the art, and being all can be with It is easy according to the actual situation to realize.

In some more preferably modes, if only the hole between the first chamber of sealing and the second chamber can four realizations Sealing, still, if it is desired to the sealing for reaching more preferable effect, for example, by using interface channel connect the first chamber and the second chamber when It waits, interface channel generally has extended segment 3094, which extends into Figure 27 in the opening of the second chamber, certainly, It can be at interface channel 3091 to first intracavitary extension one end distance or length.In order to preferably reach sealing effect, fill in Sealing element as son, which generally requires, to be inserted partially into interface channel to be tightly connected channel, generally, logical being tightly connected Before road, liquid sample, the liquid sample also filled in the second chamber are contained in interface channel.This is because the liquid-like collected Originally to meet secondary-confirmation detection and the primary detection for testing element, liquid sample still need enough volumes.So In some preferred modes, the height of the liquid level of the liquid sample in the first chamber is higher than the position of the first opening of interface channel It sets, i.e. the first opening of interface channel is located under liquid level, in such interface channel and has been filled with liquid in the second chamber.At this It in the case where sample, to allow sealing element part to enter in interface channel and reach better seal effect, the sealing of this liquid allows liquid Body sample will not be unlikely to liquid and leak into the external world in the first chamber after subsequent second chamber is separated with the first chamber again.Such In the case of, sealing element enters interface channel with certain difficulty, although because the size of sealing element and interface channel Quite, inevitable when being tightly connected channel 109, it needs to overcome the reaction for acting on certain liquid on sealing element Power.This is because in order to reach preferable sealing effect need that sealing element is allowed to enter in interface channel a part, thus Obtain better seal.In order to obtain better seal, in the presence of interface channel, seal process is one dynamic Process, close to the first opening (first state) of interface channel since sealing element, to sealing element, all obstruction connection is logical First opening (the second state, this when are possible, and can play the role of sealing) in road, then arrives sealing element entrance Interface channel (third state, it is exactly to obtain better seal effect that this, which reaches the third state), during this, when need from When second state becomes the third state, actually need to overcome the liquid-like contacted in interface channel with sealing element This reaction force, especially sealing element enters in interface channel, needs to oppress the liquid in interface channel, if liquid Body cannot be excluded, then be difficult that sealing element is allowed to become the third state from the second state.From the first opening for being tightly connected channel It can be 0.1-10 millimeters or farther distance to the distance for entering interface channel, to guarantee preferable sealing effect, example Distance as sealing element enters interface channel is 0.1 millimeter, and 0.2 millimeter, 0.3 millimeter, 0.4 millimeter, 0.5 millimeter, 0.6 in the least Rice, 0.7 millimeter, 0.8 millimeter, 0.9 millimeter, 1 millimeter, 2 millimeters, 3 millimeters, 4 millimeters, 5 millimeters, 6 millimeters or 7-10 millimeters. In order to mitigate the reaction force of this liquid, this reaction force is exactly the pressure that liquid is applied to sealing element, needs to allow close The liquid volume that envelope element excludes smoothly is rejected to other place, could mitigate the reaction that sealing element is born in this way Pressure, entered in interface channel so that sealing element be allowed to be relatively easy to.So, it is necessary to enter connection in sealing element When channel, the partially liq volume in interface channel is excluded, allows sealing element can smoothly enter into interface channel, thus smoothly The opening for being tightly connected channel or interface channel.This is just similar to the reason one with the opening for filling in bottle with the plug of bottle Sample, if filling water in bottle, plug is difficult to fill in equally, needs to allow the water of bottle or liquid to outwell a part, in this way Plug can just fill in bottleneck to the opening of closed bottle.However, being also filled with liquid in interface channel when the second chamber is hydraulically full Body, sometimes the first opening of interface channel is located under the liquid level of the first chamber, needs sealing element entrance or sealing element The opening in channel is tightly connected in the form of piston, this just needs to exclude the partially liq in interface channel to other ground Side, conveniently allows sealing element to enter in interface channel, and best mode is when entering, exclusive segment liquid, sealing element Entrance be to receive forcing for external force and enter in interface channel.

So the device further includes lyophoby channel in some preferred modes, it can be sealing by the lyophoby channel Except the fluid removal to interface channel for the extruding that the interface channel that element enters generates, so that sealing element be allowed to smoothly enter Interface channel.For example, the inlet in lyophoby channel is located on sealing element, with sealing element in some preferred modes Into interface channel, extra liquid is entered in lyophoby channel by inlet, to be rejected to outside interface channel.Here Generally can be not except described lyophoby channel includes that interface channel and the second chamber being detachably connected with interface channel exist Perhaps in test chamber or other places in place except interior, such as accommodating chamber, such as the first chamber.So the present apparatus It further include accommodating chamber, the accommodating chamber is for receiving liquid or gas in lyophoby channel.Generally, sealing element sealing connects It connects road or the first chamber of barrier and the second chamber carries out liquid flowing or flowing, be generally divided into two states, first, sealing is first Before being tightly connected channel, the first chamber and the second chamber communicate part, this when, liquid can be swapped in two chambers, Liquid can be usually allowed naturally to flow in the second chamber from the first chamber.Second, when sealing element starts to be tightly connected channel, Such as the opening of interface channel, the first chamber and the second chamber are not communicated with, due to the interface channel that goes successively to of sealing element, even The pressure for connecting road and the second cavity will increase, and due to the effect of pressure, the liquid of interface channel and the second cavity will be by dredging The inlet in liquid channel enters to reduce the former pressure in accommodating chamber, so that sealing element be allowed smoothly to be tightly connected channel.When So, lyophoby channel here can be arbitrarily arranged, and general lyophoby channel and accommodating chamber are in fluid connection.In this way, if sealing The liquid that element goes successively to be discharged in interface channel is entered in accommodating chamber by lyophoby channel.

In some modes, such as shown in Fig. 3 and 2, sealing element 1028 is used to be tightly connected the opening in channel 109 1091, and accommodating chamber can be located in sealing element, such as sealing element is hollow structure, the liquid excluded in this way can be into Enter into accommodating chamber, hollow structure 1029 can be used as accommodating chamber come using.For example, as shown in figure 3, on sealing element 1028 It further include an accommodating chamber 1029, when sealing element enters interface channel, extra liquid passes through lyophoby channel 1025 enter in accommodating chamber 1029, to alleviate pressure, lyophoby channel 1025 certainly here is very short, this is because sealing Element is thin-wall construction or sealing element is hollow structure.It will of course be readily appreciated that accommodating chamber is not necessarily located at sealing member On part, when connection rod structure 1023 is hollow structure 1030, hollow structure 1030 and accommodating chamber 1029 communicate composition one big Accommodating chamber come accommodate sealing element exclusion liquid volume or hollow structure 1030 just as accommodating chamber come use, tool There is equivalent effect.In some preferred modes, such as such as Fig. 2-3, shown in 12, the sealed connection of sealing element 1028 channel 1091 opening simultaneously enters in interface channel 109, and extra liquid enters accommodating chamber 1029 by lyophoby channel 1025 In.In such an embodiment, the liquid communication in (inlet) open at one end Yu interface channel in lyophoby channel, and it is another The liquid and accommodating chamber fluid connection of end opening (liquid outlet), thus can just liquid be allowed to enter in accommodating chamber, herein, by It is arranged on hollow sealing element in lyophoby channel, so, lyophoby channel is very short, and it is no matter how short, always there are liquid-inlet and liquid Body outlet.In fact, inlet and liquid outlet do not have in fact when accommodating chamber is located in sealing element or in subsequent draining element Have stringent division, only arrive lyophoby channel it is long when, just have the division of inlet and liquid outlet position, this be because Hollow structure for, sealing element or draining element, and wall be also it is very thin, a hole is actually opened on wall, should Hole just plays the effect for allowing liquid to enter accommodating chamber, this when, for the not no inevitable position of inlet or liquid outlet Division is set, which can also be referred to as inlet, can also be referred to as liquid outlet, in short, it is not clearly that position, which divides,.

In some preferred modes, as shown in figure 12, the inlet in lyophoby channel is located at below sealing element.One In a little preferred modes, the inlet in lyophoby channel is located on sealing element, enters interface channel earlier than sealing element In, thus could be outside extra fluid removal to interface channel, to reduce the reaction for the liquid level that sealing element is born Resistance.Lyophoby channel is exactly that can refer to the through-hole on accommodating chamber 1029 herein.Such lyophoby channel can be one or Person is multiple.

In one preferred embodiment, the inlet in lyophoby channel enters in interface channel prior to sealing element. So in some modes, if lyophoby channel is long, and when the first chamber is used as accommodating chamber, lyophoby channel Inlet is located on sealing element, but enters in interface channel earlier than sealing element, in this way, as sealing element enters During interface channel, the liquid of exclusion enters lyophoby channel by the inlet in lyophoby channel, then passes through lyophoby channel Liquid outlet into the first chamber, or enter in accommodating chamber.Here, the first chamber is a specific mode of accommodating chamber, the One chamber can also become a cavity with the total energy of accommodating chamber.So accommodating chamber is not necessarily located on sealing element, it is best Mode be located at sealing element on or in the connecting rod for allowing sealing element to connect with lid.In this way, with sealing member Part enters in interface channel, and extra liquid is rejected to except interface channel by the inlet in lyophoby channel.This row Except being the liquid for entering interface channel due to sealing element and the pressure to liquid level that generates and being forced to exclude.Certainly, accommodating chamber Size it is related with the liquid of exclusion.As long as suitable volume capacity is arranged to accommodate the liquid of exclusion.

The positional relationship of " inlet in lyophoby channel " can oppress if sealing element needs to enter in interface channel Liquid sample in interface channel, in this case, the position of inlet should be located at below sealing element, so-called " under For face " is only relative position, it is not necessarily located on sealing element.For example, can be located on the wall of interface channel, when close When envelope element enters interface channel, position below sealing element is located relatively at into liquid port on interface channel wall at this time It sets, as sealing element continues into interface channel, forces partially liq to enter inlet and be excluded, to smoothly allow Sealing element enters.In one case, sealing element can go successively to interface channel until sealing element and interface channel Wall on inlet overlapping, liquid cannot just be entered in lyophoby channel by inlet, to be rejected to outside interface channel. So inlet is located under sealing element, such as shown in Fig. 2-3, sealing element 1028 in some preferred modes Inlet 1032, the inlet in the inlet lyophoby channel 1025 are set under position.

For another example Figure 15, illustrated in 18,22,23,27.Such as shown in Figure 15-24, sealing element 2024 It is structure as a whole with connection structure 2023, the extension of the connection structure entire connection structure and is prolonged as sealing element Stretching structure is hollow structure 2030,2029, the hollow structure accommodating chamber big as one use, and lyophoby channel enters liquid Mouth 2025 is the opening positioned at extended structure side wall, which is the inlet in lyophoby channel, also is located under sealing element. For another example as shown in figure 23, during waiting sealing elements 2028 to enter interface channel, the lyophoby under sealing element is logical The entrance 2025 in road extra fluid removal to outer, to reduce the resistance of sealing element entrance.In some preferred sides In formula, the difference is that, lack the sealing element 3028 of sealing ring 208 with structure shown in Figure 31, it is connection structure 3024 a part as sealing element, meanwhile, the top of connection structure extended structure have opening 3025, the opening 3025 It is connected to the hollow accommodating chamber 2039 being located in sealing element, it is extra when sealing element enters interface channel Liquid sample is entered in accommodating chamber by lyophoby feeder connection 3025, such as shown in Figure 33-35B, although sealing element 4029 It is removably combined with connecting rod 4024, inlet 4038 is set on the top of sealing element, exclusion surplus liquid can be played Function.It is appreciated that sealing element is for better seal interface channel, shape or size preferably with interface channel Match, such as interface channel is circular hollow structure, sealing element is also circular structure, and convenient sealing between the two is matched It closes.

With continued reference to Figure 33-35, connecting rod 5023 is set on the first lid 502, there is sealing element in the connecting rod 5028, which can be used to be tightly connected channel, if logical to be tightly connected with sealing element 4028 described above When road, the inlet 4038 in lyophoby channel is set in the place on its top 4029, and in sealing element 5028 includes receiving Chamber 5030 enters the liquid that interface channel excludes to collect sealing element.It is of course also possible to be set below sealing element 5028 Inlet 5025 is set, sealing element 5028 enters interface channel come when being tightly connected channel, extra liquid passes through feed liquor Mouth 5025 enters in accommodating chamber, i.e., hollow structure is as accommodating chamber 5030.This when, component 4029 be not play it is close The effect of envelope, but the effect of drain, and the effect sealed is the place of the extending end 4028 of connecting rod 4024.

Certainly, if the part-structure 5028 for not having to connecting rod 5022 is used as sealing element, but knot shown in 5035 Sealing element 5029 is set on structure, and as shown in Figure 33-35, which can removably connect with connecting rod, example As the mode of grafting, screw thread or clamping links together.Such as element 5035 includes having externally threaded one end 5030, it should End and the internal screw thread 5027 of connecting rod cooperate.And the cooperation of the inner wall of sealing element 5029 and interface channel is tightly connected channel.And The top 5038 of element 5035 is then arranged in the inlet in lyophoby channel, more when sealing element 5029 enters in interface channel Remaining liquid head is entered in the accommodating chamber 4029 in sealing element by inlet 4038, this when, inlet 5025 could To lack or omit.

In some preferred modes, in order to facilitate liquid exclusion also easily and effectively allow feed liquor body to enter inlet, It the perpendicular position of the position of the inlet in lyophoby channel will be lower than the vertical position in the outermost face of sealing element, in other words It says, the floor projection region of the position of the inlet in lyophoby channel is not completely the same with the floor projection region of sealing element, excellent Choosing, the region of the floor projection of the position of the inlet in lyophoby channel is located within the floor projection region of sealing element.From In addition the meaning understands, is exactly the inner wall contact of sealing element needs and interface channel, and the position of the inlet in lyophoby channel It is not contacted with the inner wall of interface channel preferably, because contact can seal inlet；Liquid is facilitated to enter lyophoby channel in this way Except inlet is to exclude.Such as Fig. 2 and 3 is as can be seen that the diameter of position of the sealing element with sealing ring 108 is greater than The diameter of position where inlet 1025, the position where thus being avoided that inlet 1025 contacted with the inner wall of interface channel and Influencing liquid can smoothly enter into lyophoby channel, to reach in accommodating chamber.In Fig. 2, the region 1055 of dotted line is sealing The region A-A ' of projection of elements, and view field's point of inlet 1025 or region are removed in B, the view field be located at A-A ' it Between.So according to such principle, in some schemes, sealing element can one inverted circular cone of band structure (below The function that can illustrate the structure, that is, have the function of drain), and the inlet 1025 in lyophoby channel is located at the surface of circular cone, this The inlet of sample, lyophoby channel will not be contacted with the inner surface of interface channel, and the liquid of exclusion is facilitated to enter lyophoby channel Inlet and be excluded.For Figure 18 it is also to be understood that the position of sealing element 2028 is since there are sealing rings 208, so position In the projection of the inlet 2025 of sealing element 2028 be within projection positioned at sealing ring.Similar Figure 27 can also be easy to manage Solution has an inverted cone shape, and the inlet in the surface of circular cone setting lyophoby channel is easy liquid is allowed to enter thin In liquid channel, to exclude extra liquid sample.In such as Figure 31-32, top is arranged in the inlet in lyophoby channel Position does not take into account that the case where interface channel side wall seals the inlet in lyophoby channel, but appoints and so meet inlet position Projection be positioned at sealing element floor projection region principle.Figure 33-34 is seen again, when no matter prolonging using connecting rod 5023 Stretch end 5028 as sealing element, or using shown in 5029 partially as sealing element might as well, and lyophoby channel into The projection of liquid mouth 5025 or 5027 is still located within the floor projection of sealing element, this is because recess be arranged into Perhaps 5027 inlets will not be connected the side wall sealing in channel or stop up, the inner wall of general interface channel liquid mouth 5025 Be it is flat and smooth, in this way be easy sealed, such structure facilitates the exclusion of liquid.

In short, preferred mode is exactly that sealing element is allowed to enter connection when sealing element is tightly connected channel Channel, and the pressure of sealing element entrance is alleviated, it needs to be arranged lyophoby channel, sealing element is entered interface channel and is excluded Liquid be discharged to other place.Concrete mode as described above, the inlet setting lyophoby channel are first in sealing Under part, one end inlet ratio sealing element in the lyophoby channel will enter in interface channel in advance, so that extra liquid could allow Body enters lyophoby channel.Also as described above, when accommodating chamber in sealing element or positioned at other positions, lyophoby Another outlet (liquid outlet) in channel is connected to accommodating chamber, to accommodate the extra liquid in interface channel.

In other some optional schemes, the first chamber can also be used as accommodating chamber come using, allow sealing element even The liquid sample that road excludes is connected to be discharged in the first chamber by lyophoby channel.In above embodiment, the entrance in lyophoby channel It is linked together in the connection structure of structure or under sealing element on sealing element or positioned at lid.Certainly optional , lyophoby channel is not on sealing element, can be located on interface channel, for example, lyophoby channel is located at interface channel On side wall, the entrance (inlet) in lyophoby channel is located on the side wall of interface channel, and liquid outlet is connected with the first chamber, when close Envelope element is when enter interface channel, because of sealing element entrance and the extra liquid that is discharged by lyophoby channel into Liquid mouth enters in the first chamber, until the inlet port in sealing element sealing lyophoby channel.Those of ordinary skill in the art Read the embodiments of the present invention, it is envisaged that obtain, no matter how lyophoby channel is arranged, such as inlet and liquid out The setting of mouth position, as long as can exclude because sealing element enters the liquid sample of the exclusion of interface channel, to reduce close Seal element liquid to the resistance of sealing element can, for example, the inlet in lyophoby channel be located on sealing element or Person's other positions are all possible.

In other mode, the size of inlet can carry out it is arbitrarily devised, for example, liquid can enter, still Liquid cannot be flowed out freely from inlet.Because it is often the compressing because of liquid that liquid, which enters lyophoby channel by inlet, And enter in lyophoby channel, after liquid enters lyophoby channel, liquid because inlet surface tension without from into The outflow of liquid mouth.Such benefit is exactly, because inlet is normally at sealing element in the following, when the second chamber and interface channel separate Mouthful, inlet is exposed to outside, if the liquid of accommodating chamber can be flowed out by inlet, also results in liquid sample dirt The risk of environment is contaminated, therefore, it is desirable to which inlet can only be that liquid is allowed to enter and liquid cannot be allowed to flow out.Generally, inlet is set Size, such as 0.1-1-2 millimeters, the liquid in accommodating chamber is since surface tension from inlet without flowing out.

It in some modes, after sealing element is tightly connected channel, can be separated with the first lid, if sealing member Part is arranged when on lid.In a mode, sealing element is linked together or combines with lid, sealing Channel is connected and sealed as the first cover cap closes the opening of the first chamber in element.After the completion of sealing, if necessary to open First lid, thus the first lid of reverse rotation and expose the opening of the first chamber, allow sealing element to remain in this when Channel is tightly connected in interface channel, and in addition removing the first lid can carry out from the first intracavitary partially liq sample of taking away Detection or chemical examination.For example, sealing element 5029 is removably combined with lid by connecting rod 5023 as shown in Figure 33-35 Together, this when, sealing element 5029 are located on element 5035.And the connecting rod 5023 of element 5035 and lid is detachable Combine, this dismountable mode not instead of helicitic texture as shown in Figure 33-35, the mode of grafting is that is, first One end 5030 of part 5035 is inserted into one end of connecting rod.When the first lid 502 is tightly connected with moving sealing element 5029 After channel, the second chamber can be allowed to separate with the first chamber this when, thus the opening of the second chamber of sealing, such as with second Lid seals the opening of the second chamber, comes using the sample in the second chamber as second of test.This when, the first lid 502 have covered and have got togather the first chamber, such as the opening 1031 of the first chamber 103 shown in Fig. 9；If also need this when from First intracavitary taking-up liquid sample, inverts the first lid this when, when reversion, this when, sealing element with connect There is relatively closely cooperation in channel, and element 5035 is only the mode of grafting with connecting rod, the first lid can again with First chamber 103 separates, and element 5035 is allowed to rest in interface channel.The advantage designed in this way is, if the first chamber is only After gathering sample, to seal interface channel for collecting sample, carried out liquid sample separation processing, this when Time can open the first lid, take out part sample as chemical examination, if result of laboratory test needs further confirm that inspection from the first chamber It surveys, the second chamber can be removed from the first chamber, carry out secondary chemical examination.In fact, intracavitary can repeatedly take out sample from first Carry out the detection or chemical examination that do not have to index repeatedly.

The liquid for needing to exclude above is usually interface channel and when the second chamber all fills liquid sample.It can manage Solution, when the liquid sample of the second chamber is not filled up with the second chamber, will not generally contain liquid sample in interface channel, such as When fruit sealing element enters interface channel sealed connection channel, this when of lyophoby channel can play exclusion and be oppressed Portion gas to the second chamber outside, the resistance that sealing element enters interface channel can also be mitigated, the resistance of this when is The reaction force for hindering sealing element to enter is generated because of gas urges.

So in both cases, when interface channel has liquid, lyophoby is logical in some preferred modes Play the role of being exactly the effect for excluding liquid in road；When the second chamber is not liquid filled, in order to preferably allow sealing Component seal interface channel, the lyophoby channel of this when play the role of being exactly the effect being vented.So lyophoby channel is in function Two kinds or any of them effect can be gone up while play the role of, so, it can also claim lyophoby channel that can be called discharge stream The channel of body, fluid here refers to the mixing of liquid or gas or the two, corresponding, the liquid inlet in lyophoby channel It can be referred to as air intake, liquid outlet can also be referred to as gas outlet, or be referred to as mouth and the mouth of fluid out into fluid.It can To understand, when if necessary to exclude the gas being oppressed, it may not be necessary to exhaust passage be specially set, can use lyophoby Exhaust is realized in channel, can also not have to it is special design such channel because sealing element is when having liquid, as long as reaching To liquid seal degree can, if there is gas, actually also only reach liquid sealing can.So working as needs When excluding gas, the function of excluding gas may be selected in small gap between sealing element and interface channel element just It can be with these small gaps can be the error between mechanical structure, can also be the structure being deliberately designed, these cracks Gap can allow gas by that liquid cannot be allowed to pass through, and thus have the function that exclude gas.Certainly, exhaust passage here Or the structure of exhaust nor is it necessary that, because sealing element is tightly connected channel it is desirable that liquid sealing effect, rather than Hermetic seal effect.In contrast, when not necessarily reaching hermetic seal when reaching liquid sealing, but reached hermetic seal, The effect of hydraulic seal also reaches.

" lyophoby channel " is also a preferred mode of the utility model, is because sealing element better seal connects Channel allows portion sealing element to enter interface channel and preferably reach sealing effect.If it is other way, sealing element It is only tightly connected first opening in channel, needs to enter interface channel one end distance without sealed opening, and Feasible, this when, lyophoby channel can be default.If second is intracavitary also other, it is not filled by liquid completely, Lyophoby channel is also can be default, is not important because the effect of sealed opening or interface channel just seems, because not Have the leakage of liquid.

In addition, in other situations, it is also not necessary to which the structure in similar lyophoby channel is arranged, such as shown in the figure (design 2 does not need lyophoby channel when being tightly connected the opening in channel with lid)

Draining element

In some preferred modes, the device of the utility model can also include draining element, for excluding the second chamber In partially liq sample.Here so-called " draining element " is when an object enters in liquid sample, since the object has There is certain volume, which can occupy the certain space of liquid, to exclude the liquid of certain volume, object enters liquid Volume is exactly to exclude the volume of liquid, which can be referred to as draining element.It is to be understood that being similar Steamer in water, due to steamer weight reasons and need to exclude the water of certain volume, steamer can occupy occupied by original water Space.Certainly, as being said above, if do not contain liquid in space, and contain gas, draining element enters Behind space containing gas, exclusion is exactly gas and on-liquid.

In other mode, for example, when the second chamber fills liquid sample, even if sealing element seals connection Channel, still, the liquid of the second chamber are that complete complete essence fills out and is filled with liquid sample, under needing the second chamber to dismantle from the first chamber When coming, due to being all mechanically actuated, the liquid in the second chamber filled with can be overflowed due to mechanically actuated to be come, and causes to operate Unfriendly property, also will cause the pollution to extraneous or operator.Even if in addition, carefully filling with the of liquid sample Two chambers are taken off or are disassembled from the first chamber, with the second lid seal the second chamber opening be also it is very difficult, in this way Second chamber, which fills liquid during transportation, can also cause the risk of some leakages.So in more some preferred modes In, it needs while sealing element is tightly connected channel perhaps later or before, it is also desirable to exclude the part in the second chamber Outside liquid sample to the second chamber.To allow the liquid of the second chamber to be not that filling is full, thus, second separated from the first chamber Liquid sample in chamber, which does not overflow, to be come, and the safety and friendly of operation are increased, while it is secondary to also reduce subsequent progress The risk of leakage in transportational process is detected, the friendly and safety of the operation of subsequent second of detection are also increased.

When the second chamber is disassembled from device, such as shown in Figure 13, there is certain space in the second chamber It reserves and, liquid is not just to fill with the second chamber, and in this way when disassembly, liquid sample would not be overflowed from the second chamber Come, reduces the extraneous risk of pollution.

In some preferred modes, device further includes that the liquid sample of the second chamber of exclusion is first to the drain outside the second chamber Part.It is appreciated that draining element can be any structure or method for reducing by the second chamber liquid sample.In some preferred sides In formula, draining element is the extension of sealing element and is formed or draining element is located on sealing element.For example, scheming In 2-3, Figure 18, the structure of meaning shown in 23,27,31,33.Such as in Fig. 2-3, sealing element 1028 and draining element 1027 It is structure as a whole, drainage structure 1017 and 1028 shape of sealing element are about the same, and only longitudinal size is first less times greater than sealing Part is laterally less than the size of sealing element.This when, the floor projection for being also possible to draining element are located at sealing element Alternatively, the floor projection of partial draining element is located within the floor projection of sealing element within floor projection.This when, It is that draining element 1027 enters in interface channel first, due to draining element when sealing element enters interface channel 1027 diameter is smaller than the diameter of interface channel 109, owns, and extra liquid sample is led to by the surface of draining element with connecting Space or gap 809 between the surface in road 109 are rejected to outside the second chamber 104 or the first chamber of interface channel outer 109 In 103, (such as Figure 22,12) is entered further into the second chamber with draining element 1027, this when, sealing element is just opened Begin the opening 1091 for being tightly connected channel 109, to as described above, carry out the sealing of hydraulic seal interface channel.By It is entered in the second chamber in draining element 1027, eliminates the partially liq sample in the second chamber.It is opened in sealing element 1028 Begin the opening 1091 for being tightly connected channel, at this point, the liquid sample being located under interface channel opening 1091 cannot pass through row Space between the surface of liquid element 1027 and the surface of interface channel 109 excludes, at this time if sealing element also needs downwards Movement, this when, draining element continue the liquid sample that the liquid sample excluded and sealing element itself exclude and just pass through The entrance in lyophoby channel enters in lyophoby channel, hence into accommodating chamber.So lyophoby is logical in some preferred modes The entrance in road is located on draining element.More preferably, accommodating chamber is located in draining element.It is readily understood that sealing element It can be with one-time injection molding with draining element.When injection molding, it is molded into hollow structure, to form accommodating chamber to receive Hold the liquid of discharge.

As front is said, it is discharged to outside in order to smoothly allow liquid to enter the entrance in lyophoby channel, drain member The trans D of part is less than the interior diameter of interface channel.For example, draining element can be the shape of back taper, and the row such as Figure 18 Liquid element, i.e. pyramidal structure where the entrance 3025 in lyophoby channel.Such as the draining element 3027 in Figure 27 is back taper Structure.Pyramidal structure 4027 under sealing element 4029 shown in shown in Figure 31 and 32, the drainage structure as shown in Figure 33-35 435 are formed by pyramidal structure.In fact, drainage structure does not need individual structure, and if sealing element long enough, sealing Element can be deep into the second chamber, this when, sealing element can play dual effect, that is, realize the second chamber and The change of liquid communication state between one chamber, while also eliminating the second intracavitary partially liq.So draining element is only It is restriction functionally, and non-individual needs other structure to realize.In fact, these pyramidal structures can also be used as drain Element uses, this is discussed in detail subsequent.

In other modes, for example, Figure 15,18,22-23, shown in 27, draining element 2027,3027 and sealing element 2028,3028 connection and sealing element extension and formed.Sealing ring 208 is set outside sealing element 2024, in this way, sealing Circle 208 is arranged on the surface of sealing element, slightly above the outer surface of sealing element 2014.Even if in this way, draining element 2017 diameter as the diameter 2024 of sealing element, when draining element 2027 enters interface channel 209 (such as Such as Figure 22), this when, sealing element and draining element enter in interface channel together, since draining element is located at end, And sealing element is located at the upper surface of draining element, so, draining element is first into interface channel, if in interface channel There is liquid, the liquid that draining element enters interface channel and is discharged just passes through the surface of draining element and the inner surface of interface channel Gap 809 before enters in the first chamber 103.With the further movement of sealing element and draining element, draining element 2027 enter in the first chamber, this when, sealing ring may be tightly connected the opening 2091 in channel 209 not yet, with row Liquid element 2027 further enters in the second chamber 204, and liquid still can be rejected to the first chamber 203 by gap 809 In.When the sealing ring 2023 on sealing element 2024 is tightly connected opening 2091 in channel 209, liquid cannot lead to Gap 900 is crossed to be rejected in the first chamber.This when, sealing element and sealing ring continue to move in interface channel needs, reach To stable sealing effect.Continue movement need continue exclude liquid sample, this when the extra liquid-like removed by drain Originally it is rejected to outside interface channel and the second chamber by the inlet 2025 in lyophoby channel.Such as the import by lyophoby channel 2025 enter in lyophoby channel, are then entered in accommodating chamber 2029 or in the first chamber by the liquid outlet in lyophoby channel. It allows the second chamber 204 and device to separate this when, such as Figure 24, shown in 28, is separated with interface channel, due to drain member Part 2027 is located in the second chamber, eliminates the partially liq sample in the second chamber.When what the second chamber was disassembled from device When, such as shown in Figure 28, in the second chamber there is certain space to be preserved to come out, liquid is not just to fill with the second chamber, in this way When disassembly, liquid sample would not be overflowed from the second chamber to be come, and reduces the extraneous risk of pollution.

It is appreciated that draining element, as the size of sealing element, sealing element is tightly connected before channel, connection is logical Liquid in road can not be excluded from gap, but by the liquid inlet in lyophoby channel be rejected to two interface channels it is outer or Outside second chamber.

In other some modes, sealing element and draining element are not divided significantly, such as such as Figure 31-32 institute Show there is no sealing ring, the extended segment of 5028 connection structures 5023 of draining element 5027 and sealing element on sealing element 5028 On, 5023 one end of connection structure connect with the first lid 502, the other end and the connection of sealing element 5028 either connection structure End.Sealing element 5028 is connected with draining element 5027 again.And the feed liquor body 5025 in lyophoby channel is located at the end of draining element On end, accommodating chamber, which is located in draining element, to be perhaps located in sealing element or is located in connection structure.Work as connection structure, it is close When envelope element and draining element are hollow structure, the liquid outlet in lyophoby channel is communicated with accommodating chamber.With reference to above description, When such draining element 5027 is entered in interface channel, the liquid of exclusion passes through the feed liquor positioned at draining element end Mouth 5038 enters in lyophoby channel, is then entered in accommodating chamber by the liquid outlet in lyophoby channel.Inlet can be set Such size, allows liquid to pass through, but is into the liquid of accommodating chamber due to the liquid surface at the place of inlet Tension from inlet without leaking out.This is because draining element once pass through the opening 2091,1091 of interface channel into Entering into interface channel 109,209, the surface of draining element 5027 is also sealed with the inner surface formation of interface channel 209, this When, draining element and sealing structure are exactly the same structure, and draining element plays simultaneously is tightly connected channel and exclusion liquid Double action.With movement of the draining element in interface channel, can there are a pressure, the pressure to the liquid in interface channel Force reaction is to draining element, to increase the difficulty that draining element 4027 enters interface channel.In order to reduce liquid Reaction force allows extra liquid to enter the inlet 4025 in lyophoby channel, hence into positioned at drain solution structure 4027 In accommodating chamber in 4029.

After allowing the second chamber to separate with device, since draining element 1027 is located in the second chamber, eliminate in the second chamber Partially liq sample.When the second chamber is disassembled from device, such as shown in Figure 13, have centainly in the second chamber Space to be preserved comes out, and liquid is not just to fill with the second chamber, and in this way when disassembly, liquid sample would not be from the second chamber It overflows and, reduce the extraneous risk of pollution.In addition, the liquid due to the surface tension at inlet 3025, in accommodating chamber Body sample will not be leaked out by inlet 3025.

In some modes, such as shown in Figure 33-35, original part 5035 can be used and sealed member as draining element Part 5028 is located in connecting rod 5024, this when, the connection of draining element and sealing element for detachable, draining element 5035 Whole lateral dimension be less than sealing element 5028 size, such as draining element diameter be less than sealing element 5028 ruler Very little (as shown in figure 33), the connection of draining element and sealing element is the connection of the mode of screw thread, such as such as Figure 35 A and 35B institute Show, sealing element 5028 is hollow structure, and internal screw thread is arranged in inner surface, and there is draining element 5035 one end to upwardly extend section 5030, external screw thread is set on extended segment, passes through the cooperation of internal and external threads in this way, so that it may allow draining element and sealing element 5028 link together.When allowing sealing element and draining element to enter in interface channel 209, due to draining element Size be less than interface channel size, so, draining element be easily accessible interface channel come, extra liquid passes through drain Gap between element and interface channel enters in the first chamber.As sealing element is tightly connected the opening 2091 in channel 209 Afterwards, liquid cannot be entered in the first chamber by gap, enter interface channel with sealing element, extra liquid just leads to The inlet 4025 for crossing lyophoby channel is entered in accommodating chamber or is entered in the first chamber.

In some preferred modes, referring again to Figure 33 and 35, the size of draining element 5035 and sealing element 5028 Diameter is suitable or the size of draining element is less than the diameter of sealing element, and just setting is extending the inlet 5025 in lyophoby channel In section 5030, by Figure 34 as can be seen that the diameter in the place with inlet 5025 is less than the diameter of sealing element 5028, Again smaller than the diameter of draining element 5029, a sunk area is formed at inlet 5025.In this way, working as draining element 5035 When entering interface channel 209, it is excluded the feed liquor that the liquid that structure 5029 excludes just passes through the lyophoby channel of recess Mouth 4025 is excluded.Same reason finally enters second with the interface channel that enters further into of draining element The space of chamber is come, and sealing element is tightly connected the opening 2091 in channel, finally enters in interface channel, one of both or The liquid that the two excludes can be excluded by the inlet 5025 in lyophoby channel, such as be rejected to accommodating chamber or first In chamber.It is appreciated that draining element is also preferred mode herein, it is not the necessary mode for completing the utility model.

The movement of sealing element or draining element

It talks about in front, sealing element is tightly connected channel, and draining element can also enter interface channel or enter In second chamber.These are all the processes of a movement, and the movement for starting these sealing elements and draining element is needed by certain External force or allow sealing element and/or draining element to be moved by other mechanical structure.So sealing element and The mode that draining element can link carries out, such as the movement for moving drive draining element of sealing element；For example, drain is first Movement of the movement of part with moving sealing element.

Here so-called " linkage " refers to that the movement an of object can directly or indirectly drive the movement of another object, In general, the motion mode of two objects is consistent, such as an object rotary motion, the object driven is also rotation fortune It is dynamic；Such as a plug-type movement of object, another object of drive are also plug-type movement.For another example, an object The position of end is moved to from initial position, in this motion process, another substance is driven also to move to knot from initial position Beam position.Rotary motion can play the movement that end position is moved to from initial seat, and certainly, rotation and insertion can mix Using or be used alone.Here it moves and movement means the understanding that can be interchanged.

First lid is moved by the way of linkage with sealing element or draining element, i.e. the movement of the first lid drives The movement of sealing element, to drive the movement of draining element.Alternatively, the first lid and person's draining element are by the way of linkage Movement, i.e. the movement of the first lid drives the movement of draining element, thus the movement with moving sealing element.In some preferred sides In formula, sealing element is located on the first lid, when lid, which carries out lid, closes the opening of the first chamber, lid band moving sealing element It is attached the sealing in channel, forms sealing state.As noted-above, sealing element is general to the sealing of interface channel Three states are divided into, first state is that sealing element will not be contacted with the opening of interface channel.For example, shown in Figure 22, the Sealing element 2028 is had on one lid 202, when lid, which carries out lid, closes the first chamber 203 opening 2031, band dynamic sealing member Part 2028 enters in the first chamber, and sealing element does not connect first 2091 (Figure 22) of opening in channel at this time, connects at this time It connects road and connects the first chamber and the second chamber, meanwhile, the first chamber and the second chamber carry out fluid connection by channel.As cover cap closes Onto the opening 2031 of the first chamber, lid moves from the top down along the y direction of the first chamber, and band moving sealing element gradually leans on The opening 2091 of nearly interface channel.At this point, as the first lid further builds conjunction, sealing element 2028 and interface channel 209 First opening 2091 contact, to seal the opening (Figure 23).It may be considered at this time and seal interface channel 209.But, In order to guarantee more stable sealed connection channel, it is desirable to which sealing element enters 209 a distance of interface channel, thus more Stable sealed connection channel, at this point, there is still a need for the conjunctions of the lid of lid, so that sealing element 2028 be pushed to enter interface channel In.Similar process, the process shown in such as Figure 27.The either sealing element of what type or form, these are close It is a preferred mode that envelope element and lid carry out movement simultaneously.Certainly, the movement of lid and the movement of sealing element can also It is separated movement, such as the first lid is used to cover the opening for closing the first chamber, to complete the process that lid closes.Sealing element but The sealing that interface channel is completed additionally by individual movement is not to complete with the collaboration of the first lid.

As for draining element, effect is exactly the partially liq excluded in the second chamber, as front is said, when the second chamber In it is hydraulically full when, need draining element carry out liquid exclusion, still, if do not have in the second chamber it is hydraulically full, this It may there is no need to draining elements when a.So draining element is a preferred mode of the utility model, being not must The mode of palpus.When needing draining element, draining element and lid can be allowed to be connected as one, in this way, lid Movement drives the movement of draining element, to be inserted into the exclusion for carrying out liquid in the second chamber.Certainly, as front is said, Sealing element and draining element are two different elements, moreover, draining element enters in the second chamber prior to sealing element.It is excellent In the mode of choosing, draining element enters in interface channel prior to sealing element, hence into the second chamber.In order to such Design, draining element is located at the end of sealing element, further from the first lid, to reach such Functional Design.

So the utility model provides a lid in some preferred modes of the utility model, it is arranged on the lid For being tightly connected the sealing element in channel.In some preferred modes, sealing ring is set on sealing element.Some preferred Mode in, sealing element with the material of interface channel be as or be different.In some preferred modes, sealing Element is material flexible, and interface channel is the material of rigidity.In some preferred modes, sealing element by connecting rod and First lid is linked together structure.It further include the opening in lyophoby channel on sealing element in some preferred modes.Some In preferred mode, the opening in lyophoby channel is located under sealing element, alternatively, the opening in lyophoby channel prior to sealing element into Enter into interface channel.It further include accommodating chamber on lid in some preferred modes, the accommodating chamber and lyophoby channel are in liquid Body connection.The accommodating chamber is connected with the liquid outlet in lyophoby channel.In some preferred modes, accommodating chamber is located at sealing element In.

In other preferred modes, draining element is also set up on the first lid, which compares sealing element Further from the first lid.Alternatively, draining element is arranged under sealing element, alternatively, sealing element and drain are in this way, allow Draining element enters in the second chamber prior to sealing element, alternatively, draining element is allowed to enter interface channel prior to sealing element In.Alternatively, working as connecting rod is set to connect the first lid and sealing element, while sealing element connected drainage element on lid. Alternatively, connecting rod and sealing element and draining element are structure as a whole.

In other mode, if the first chamber and the second chamber be not at the beginning for liquid communication state, but After the collection of first chamber has liquid sample, need to allow the first chamber and the second chamber to be in liquid flowing state, this when, lid can be with With allowing the first chamber and the second chamber to be in the first element of flow regime and the first chamber and the second chamber allowed to be not at fluid state Second element.For example, the first chamber and the second chamber be not at the beginning for liquid communication state realization be having sealing member Part sealed at the very start interface channel first opening 1091, if the lid moon first element and second linkage if, First element is allowed to contact with sealing element first, such as when sealing element is the structure for being easy to puncture, first element is sharp Puncture structure, after puncturing, the liquid of the first chamber is advanced in the second chamber.Then, second element is allowed to seal the first opening again, To realize the change of liquid flowing state.It is thus possible to which the second chamber is allowed to separate with the first chamber.Those skilled in the art can manage Solution, it also may include draining element that second element, which can be the alternative of any sealing element described above, can also be with The setting etc. in lyophoby channel.Such as in specific embodiment shown in prior figures 37-40.

First lid and the second lid

First lid is the lid for covering the first chamber of conjunction herein, and the second lid is to close opening for the second chamber for covering Mouthful.The specific example of lid can lid as shown in figures 1-28 shape.Certainly, lid plays the role of being exactly that lid closes in fact The opening of first chamber, the first lid are not necessarily required to the opening of the first chamber of sealing.But the main function of the second lid be for The opening for sealing the second chamber allows it not lead to the leakage of liquid sample.So the second lid is located at first in some modes On lid, the second lid is removably combined with the first lid.For example, the second lid is by way of screw thread or other grafting It combines, when needing to be sealed the usually opening of the second chamber of liquid sealing with the second lid, from the first lid The second lid is removed to seal the second chamber.

Liquid Sample Method is collected in detection

The utility model also provides the method for collecting liquid sample, and this method includes providing collection liquid sample above-mentioned Device, the device include the first chamber and the second chamber, wherein the second chamber and the first chamber connect for dismountable mode, with the first chamber Liquid sample is collected, allows the liquid sample to be flowed into the second chamber.In some preferred modes, the collection of the second cavity is waited to have liquid When body sample, the second chamber and the first chamber is allowed to separate, to close the opening of the second chamber with the second cover cap.Some preferred In mode, before allowing the first chamber and chamber to separate, the first chamber is allowed not to be in the state being in fluid communication with the second chamber.Some preferred Mode in, allow sealing element that the first chamber and the second chamber is isolated, so that the first chamber and the second chamber be allowed to be not at circulation status.

In some preferred modes, the first chamber and the second chamber is allowed to link together by interface channel, wherein allowing connection First opening in channel and the first chamber fluid connection allow the second of interface channel to be open and the second chamber fluid connection.By allowing Two chambers are separated with interface channel, so that the second chamber be allowed to separate with the first chamber；Alternatively, allowing the second chamber and interface channel with dismountable Mode connects, and interface channel is not connect removably with the first chamber；Alternatively, allowing the second chamber and interface channel with removable The mode unloaded connects, and interface channel is allowed also removably to connect with the first chamber.

In some modes, when the second chamber is removably connect with the first chamber by interface channel, make sealing first Part is tightly connected channel.So the device further includes sealing element in some preferred modes, when in the second chamber and first Before chamber separation, sealing element is allowed to be tightly connected channel.In some preferred modes, which further includes lid, lid and close Envelope element is linked together structure, and when allowing cover cap to close the first chamber opening, while lid band moving sealing element sealed connection is logical First opening in road.In some preferred modes, lid band moving sealing element is allowed to enter in interface channel.Some preferred Mode in, allow sealing element be tightly connected channel after, allow the second chamber to separate with the first chamber.In some preferred modes, In The draining element for excluding partially liq in the second chamber is also set up on lid, allows lid that draining element is driven to enter the second chamber In.In some preferred modes, sealing element and draining element are set on lid, draining element is allowed to enter prior to sealing element Into the second chamber.In some preferred modes, which further includes lyophoby channel, the liquid sample for allowing draining element to be discharged It is rejected to outside the second chamber by the lyophoby channel.In some preferred modes, sealing element is allowed to enter interface channel In, the liquid that sealing element is discharged is rejected to outside interface channel by lyophoby channel.In some preferred modes, sealing is allowed The liquid that element or draining element exclude is discharged in the first chamber by lyophoby channel.In some preferred modes, covering Accommodating chamber is set, and the accommodating chamber and lyophoby channel are in fluid connection, wherein allow sealing element or/and drain on body The liquid that element excludes is discharged in accommodating chamber by lyophoby channel.

In some modes, lyophoby channel have liquid inlet and liquid outlet, allow sealing element and draining element exclude Liquid enter liquid inlet, then enter accommodating chamber by the liquid outlet in lyophoby channel.

In other mode, sealing element is provided on lid, when by lid lid close the first chamber opening, from And channel is tightly connected with moving sealing element.In some modes, if the first lid leave again the opening of the first chamber when It waits, sealing element simultaneously stays in interface channel, and the latter, sealing element is separated with lid.

On the other hand, the utility model provides a kind of method for detecting and whether there is analyte in liquid sample, institute The method stated includes the fluid collection device of any one above-mentioned mode, after waiting the collection of the first chamber to have liquid sample, with test Element detects the liquid sample from the first chamber.After obtaining testing result, the second chamber is allowed to separate with the first chamber, according to Above-mentioned arbitrary mode is separated.In some specific modes, device further includes the test chamber for accommodating testing element, It is in flow communication in test chamber and the first chamber, after the collection of the first chamber has liquid sample, liquid is flowed into test chamber.Work as inspection When survey chamber includes testing element, after waiting testing elements to complete detection, the second chamber is allowed to separate with the first chamber.Some preferred Mode in, allow liquid sample from first it is intracavitary be introduced into test chamber, then enter back into the second chamber.Such structure is just Structure design as previously described, so that the liquid for avoiding enter into test chamber also enters the second chamber, thus the second chamber of pollution Liquid sample.

Test chamber

Test chamber is for carrying out whether there is for analysis test to the liquid sample from the first chamber in the utility model Analyte.It can include testing element, the testing element in test chamber without detection device, generally in test chamber It carries out contacting the chemical examination or test carried out to liquid sample with liquid sample.In traditional product, generally had in manufacture When the device of test chamber, typically first make testing element or allow testing element be arranged on carrier, then again Testing element is inserted into test chamber, then sealing detection chamber again.In this case, generally there is test chamber an opening to allow Testing element can enter and leave into test chamber.Such as illustrated in figs 1 and 9, test chamber 105 is in the opening close to the first chamber 103 1031 position has an opening 1051, and the testing element (not shown) being placed on test carrier 106 is located at test carrier Card slot in 1061, then allow carrier 106 to be inserted into test chamber by the opening of test chamber.Under normal conditions, it is inserted into inspection After surveying chamber, need to be sealed the opening 1051 of test chamber, this sealing effect and quality requirement are very high, as front institute It illustrates, entire detection device or collection device require to carry out transportation and packaging together, in order to avoid being located at test chamber The liquid of liquid or the first chamber is unlikely to leak, and needs strictly to seal any place there may be leakage, and Each product requires the detection of being sealed property, increases production cost in this way.But use the tool of this utility model After having the second chamber of secondary-confirmation, these were considered with the place for needing sealing effect good can not have to deliberately go to consider in the past, This sealing only needs temporary sealing with regard to much of that, and does not need to require persistent sealing.Such as shown in figure 9, for The sealing of the opening 1051 of detection limit just using conventional sealing can, such as heat-sealing sealing is carried out with film, as long as protecting Card when detection, the diaphragm seal is airtight or no leakage can, after completing detection, allow the second chamber and first After chamber separation, the first chamber and test chamber can be used as discard processing, without entire detection device is stored and transported.

Specific embodiment

Examples of implementation 1

How the detection device for being illustrated the utility model presently in connection with specific implementation example assembles, and how to operate.

Such as device shown in such as Fig. 1-3,6-14, the device include the first chamber 103 and the second cavity 104, the first chamber 103 In be used to import the opening 1031 of liquid sample.As shown in Figure 1, the first chamber is surrounded by side wall and bottom, in the bottom of the first chamber With an elevated regions, such as shown in figure 9, elevated regions are located at the center of entire bottom, it is arranged one in elevated regions and opens Mouthfuls 1091, there is one section of interface channel 109, the interface channel 109 first opening 1091 with communicated in the first chamber 103, Ling Yikai Mouth 1092 is communicated with the opening 1042 of the second chamber.Groove is formed around the elevated regions in the first intracavitary portion, which forms liquid Body sample pooling region 1035,1036 (such as Fig. 7).In the wall of the outside opposition close to the second opening 1092 of interface channel 109 Helicitic texture 1101 is set in upper setting 110, helicitic texture 1041, the spiral shell are set in the outer wall of the opening 1042 of the second chamber 104 Screw thread 1101 on line and wall 110 forms rotatable engagement, so that the second chamber 104 be allowed to be formed by interface channel 109 and the first chamber Detachable cooperation.Meanwhile further including test chamber 105, which forms fluid connection by through-hole 1038 and the first chamber. It include testing element in test chamber.Testing element is arranged in 1061 in the card slot of test carrier 106.Generally, testing element Sample applying zone is located at test carrier and examines the region in nearly second bottom of chamber portion, or examines the place of nearly test chamber bottom 1051, and The other end of the suction zone of testing element close to test chamber (close to one end of the first chamber opening 1031).

Lid 102 is also provided, is connected with connecting rod 1023 in the center of lid, the end of connecting rod is provided with sealing member Sealing ring 108 is arranged on sealing element for part 1028.Meanwhile draining element 1027, the draining element are set under sealing element 1027 and sealing element and connecting rod 1023 be formed as one, the only division of unused functional area.Generally, connecting rod 1023 and the length of sealing element 1038 and draining element 1027 will be less times greater than the opening 1031 to the second with the first chamber 103 The distance of the opening 1042 of chamber 104, in this way, draining element 1027 can be allowed to enter in the second chamber 104, to play exclusion Two intracavitary partially liq samples.Meanwhile the lower section of sealing element 1028 setting lyophoby channel inlet 1025 (Fig. 2 and 3).The inlet 1025 can be between draining element 1027 and sealing element 1028.Meanwhile sealing element, draining element And connecting rod is hollow structure, inside includes accommodating chamber 1029 to collect extra liquid sample.When in use, first It allows the opening of the first chamber to collect liquid sample to collect in the bottom of the first chamber, then pass through with the entrance of liquid sample Through-hole 1038 enters in test chamber, contacts into the liquid sample in test chamber with the sample reagent region of testing element, from And it is chemically examined and is detected.With the increase of liquid, liquid sample passes through the second chamber that the opening 1091 of interface channel enters In, then, liquid sample is gradually filled with the second chamber 104, then floods the first opening 1091 of interface channel, final liquid level is higher than First opening 1091 of interface channel 109.This stops collecting liquid sample in time.Then, the first lid 102 is carried out Gai He The opening 1031 of one chamber 103.As cover cap runs mouth 1031 jointly, the rotation lid of lid is closed, band moving sealing element 1028, drain member Part 1027 and the inlet in lyophoby channel 1025 close to interface channel 109 opening (such as Figure 10,11 and 12).With the rotation of lid Turn, draining element 1027 is first into interface channel 109, and the sealing ring of sealing element is logical close to connection not yet at this time First opening 1091 in road.Liquid can enter the first chamber by the gap between draining element 1027 and interface channel 109 In 103.With entering in interface channel 109 for sealing element, the liquid excluded at this time passes through the inlet 1025 in lyophoby channel It enters in accommodating chamber 1029, to exclude extra liquid sample, also mitigates the pressure that sealing element enters interface channel Power, to be easier to obtain preferable sealing.After equal draining elements enter in the second chamber, at this point, sealing element also seals Interface channel 109.This when, the testing element of test chamber complete for the first time by detection, it is believed that it is necessary to retain remaining sample After carrying out secondary-confirmation chemical examination, by rotating the second chamber, the second chamber is allowed to separate with the first chamber, since sealing element seals Interface channel, so, it does not leak out to come positioned at the liquid sample of the first chamber.Then with the be arranged on the first lid 102 Two lids 101 seal the opening 1042 of the second chamber 104 (as shown in Figure 14 and 13).In this way can individually the second lid into Row storage or packed and transported to chemical examination mechanism progress secondary-confirmation chemical examination.

Examples of implementation 2

Such as such as Figure 15-18, shown in 23-28, shown in device, which includes the first chamber 203 and the second cavity 204, It is used to import the opening 2031 of liquid sample in first chamber 203.As shown in figure 16, the first chamber is surrounded by side wall and bottom, The bottom of one chamber has an elevated regions, such as shown in figure 24, elevated regions are located at the center of entire bottom, in elevated regions One opening 2091 is set, there is one section of interface channel 209, the interface channel 209 first opening 2091 and phase in the first chamber 203 Logical, another opening 2092 is communicated with the opening 2042 of the second chamber.Groove is formed around the elevated regions in the first intracavitary portion, this is recessed Slot forms liquid sample collection region 2035,2034 (such as Figure 24).In the outside close to the second opening 2092 of interface channel 209 Helicitic texture 2101 is set in setting 210 on the wall of opposition, helicitic texture is set in the outer wall of the opening 2042 of the second chamber 204 2043, the screw thread 2101 on the screw thread and wall 210 forms rotatable engagement, thus allow the second chamber 204 by interface channel 209 with First chamber forms detachable cooperation.Meanwhile a kind of carrier 206 being provided, there are a plurality of one end sealing 2062, the other end on carrier The channel of opening 2063, is arranged one or more of test-strips in the channel, and the sample applying zone of test-strips is located at opening 2063 one end, has one or more channels for accommodating test-strips in carrier 206, and a test member is arranged in each channel When with multiple channels the testing element of different analysis substances can be arranged, in this way, utilizing in part in each channel The same sample can detect multiple analytes.This carrier 206 is placed in the first chamber 203, in chamber 203 Wall on there are two positive stop strips 2032 and 2033, carrier 206 is inserted into or snapped fit onto two limiting slots, and allowing has opening Channel one end 2065 close to the bottom of the first chamber, opening 2031 of the one end 2064 with sealed passage close to the first chamber (Figure 16).When liquid sample is flowed into the first chamber by the opening 2031 of the first chamber, liquid sample is just and the sample of test-strips Applying zone contact, to complete to detect.

Lid 202 is also provided, is connected with connecting rod 2023 in the center of lid, the end of connecting rod is provided with sealing member Sealing ring 208 is arranged on sealing element for part 2028.Meanwhile draining element 2027, the draining element are set under sealing element 2027 and sealing element 2028 and connecting rod 2023 be formed as one, the only division of unused functional area.Generally, even The length of extension bar 2023 and sealing element 2028 and draining element 2027 will be less times greater than the opening 2031 with the first chamber 203 To the distance of the opening 2042 of the second chamber 204, in this way, draining element 2027 can be allowed to enter in the second chamber 204, to play Exclude the second intracavitary partially liq sample.Meanwhile the inlet 2025 in the lower section of sealing element 2028 setting lyophoby channel (Figure 18 and 26).The inlet 2025 can be between draining element 2027 and sealing element 2028.

Meanwhile sealing element, draining element and connecting rod are hollow structure, inside includes accommodating chamber 2029 to receive Collect extra liquid sample.When in use, the opening of the first chamber is first allowed to collect liquid sample, with liquid sample into Enter, collects in the bottom of the first chamber, contacted immediately with the applying zone of the testing element on carrier, chemically examined and examined It surveys.With the increase of liquid, in the second chamber that the opening 2091 that liquid sample passes through interface channel enters, then, liquid-like Originally it is gradually filled with the second chamber 204, then floods the first opening 2091 of interface channel, final liquid level is higher than interface channel 209 First opening 2091.Again once adding with liquid, the position of setting is reached, receptive liquid sample is stopped, this stops receiving in time Collect liquid sample.Then, the first lid 202 is covered the opening 2031 for closing the first chamber 203.As cover cap runs mouth 2031 jointly, The rotation lid of lid closes, band moving sealing element 2028, and the inlet 2025 in draining element 2027 and lyophoby channel is logical close to connection The opening (such as Figure 22, shown) in road 209.With the rotation of lid, draining element 2027 is first into interface channel 209, The sealing ring of sealing element is not tightly connected the first of channel not yet close to the first opening 2091 of interface channel at this time Opening 2091.Liquid can be entered in the first chamber 203 by the gap 809 between draining element 2027 and interface channel 209. As sealing element is into the sealing in interface channel 209 to interface channel, sealing element or draining element are excluded at this time Liquid entered in accommodating chamber 2029 by the inlet 2025 in lyophoby channel, to exclude extra liquid sample, also subtract Light sealing element enters the pressure of interface channel, to be easier to obtain preferable sealing.Equal draining elements enter the After in two chambers, at this point, sealing element also seals interface channel 209.This when, the testing element of test chamber for the first time or Person's primary detection is completed, it is believed that it is necessary to retain after remaining sample carries out secondary-confirmation chemical examination, by rotating the second chamber, allows second Chamber is separated with the first chamber, since sealing element seals interface channel, so, the liquid sample positioned at the first chamber will not be let out It spills.Then the opening 2042 of the second chamber 204 is sealed with the second lid 201 being arranged on the first lid 202 (as schemed 24).The second cavity individually can be carried out storage or packed and transported in this way and carry out secondary-confirmation chemical examination to chemical examination mechanism.

Examples of implementation 3

Such as device as shown in figs. 25-30, which includes the first chamber 303 and the second cavity 304, in the first chamber 303 For importing the opening 3031 of liquid sample.As shown in figure 27, the first chamber is surrounded by side wall and bottom, is had in the bottom of the first chamber There are an elevated regions, such as shown in figure 27, elevated regions are located at the center of entire bottom, and an opening is arranged in elevated regions 3091, have one section of interface channel 309, the interface channel 309 first opening 3091 with communicated in the first chamber 303, another opening 3092 communicate with the opening 3042 of the second chamber.Groove is formed around the elevated regions in the first intracavitary portion, which forms liquid Sample pooling region 3035,3036 (such as Figure 27).In interface channel 309 close to the second opening 3092 for smooth outer wall and Inner wall.With a support holder structure 1004, which has an internal screw thread 10041, the bottom of the internal screw thread and the first chamber External screw thread is threadedly engaged.

Second chamber 304 is located in a base tray 1004, and base tray 1004 is removably to connect with the first chamber, And the second chamber 304 also combination detachable with the base tray 1004.Specifically, support holder structure 1004 has internal screw thread, should The external screw thread 3031 that the bottom of internal screw thread and the first chamber 303 extends cooperates, to realize support holder structure 1004 and the first chamber 303 Detachable combination.In this way, if as shown in figure 27, interface channel 309 still can have and the first chamber there is also interface channel The first opening 3091 in liquid flowing and be in the second of liquid flowing with the second chamber and be open 3092, and interface channel With one section of extended segment 3098, which is deep into 3052 the inside of opening of the second chamber, contacts with the inner wall of opening 3041, It can be connected together, it may be assumed that the outer diameter of elongated area and the internal diameter matching of opening 3041.Although the second chamber and the first chamber can also be with By the clamping connection as shown in Figure 27 of interface channel 109, but this connection does not need firmly to connect very much, does not need It is closely connected as Fig. 8-9 (by modes such as screw threads), this is because support holder structure 1004 passes through screw thread 10041 and first The external screw thread 3031 of the extended segment of chamber 103 cooperates, and no matter the second chamber 304 collects how much liquid sample is measured in this way, not will cause Leakage problem between interface channel 109 and the second chamber opening 1042.So the internal diameter of interface channel 109 can be less than second The internal diameter of the opening 1042 of chamber can allow interface channel to be inserted into the opening 3042 of the second chamber in this way, and the mode of this insertion can To be easily plugged into (shown in Figure 27).And it is only closed in lid of the opening outer setting screw thread of opening 3042 for the second lid (such as Figure 27).This when, as long as the connection of the opening of interface channel and the second chamber guarantees when collecting liquid sample not Leakage can, can allow liquid enter the second chamber can, without more structures limit.This connection Can be clamped, the form of piston type, lock is ok.In fact, allow the first chamber removably to combine with the second chamber, in conjunction with or Person's engagement is indirect mode to complete.

Lid 302 is also provided, is connected with connecting rod 3023 in the center of lid, the end of connecting rod is provided with sealing member Sealing ring is arranged on sealing element for part 3028, and sealing ring and sealing element are same material, and are single injection-moldeds. Meanwhile it is one that draining element 3027, the draining element 3027 and sealing element and connecting rod 3023 are arranged under sealing element Body is formed, only the division of unused functional area.Generally, connecting rod 3023 and sealing element 3038 and draining element 3027 length will be less times greater than at a distance from the opening 3042 of the 3031 to the second chamber of opening 304 of the first chamber 303, in this way, can To allow draining element 3027 to enter in the second chamber 304, the second intracavitary partially liq sample is excluded to play.Meanwhile In The inlet 3025 (Figure 27) in the lower section setting lyophoby channel of sealing element 3028.The inlet 3025 can be located at drain member Between part 3027 and sealing element 3028, or it is located on draining element.Meanwhile sealing element, draining element and connecting rod For hollow structure, inside includes accommodating chamber 3029 to collect extra liquid sample.When in use, the first chamber is first allowed Opening is collected liquid sample and is collected with the entrance of liquid sample in the bottom of the first chamber.With the increase of liquid, liquid In the second chamber that the opening 1091 that body sample passes through interface channel enters, then, liquid sample is gradually filled with the second chamber 304, Then the first opening 3091 of interface channel is flooded, final liquid level is higher than the first opening 3091 of interface channel 309.This is in time Stop collecting liquid sample.Then, the first lid 302 is covered the opening 3031 for closing the first chamber 303.As cover cap runs mouth jointly 3031, the rotation lid of lid closes, band moving sealing element 3028, and the inlet 3025 in draining element 3027 and lyophoby channel is close to even Connect the opening in road 309.With the rotation of lid, draining element 3027 is first into interface channel 309, at this time sealing member The sealing ring of part is not yet close to the first opening 3091 of interface channel.Liquid can by draining element 3027 with connect it is logical Gap between road 309 enters in the first chamber 303.With entering in interface channel 309 for sealing element, exclude at this time Liquid is entered in accommodating chamber 3029 by the inlet 3025 in lyophoby channel, to exclude extra liquid sample, is also mitigated Sealing element enters the pressure of interface channel, to be easier to obtain preferable sealing.Equal draining elements enter second After in chamber, at this point, sealing element also seals interface channel 309.

The liquid of the first chamber can be allowed to do subsequent primary detection to use, it is believed that it is necessary to retain remaining sample this when After this progress secondary-confirmation chemical examination, by rotary-tray structure, support holder structure is allowed to be detached from the first chamber, to drive the second chamber and the The separation of one chamber allows the second chamber to separate with the first chamber, since sealing element seals interface channel, so, it is located at first The liquid sample of chamber, which does not leak out, to be come.Then the second chamber is sealed with the second lid 301 being arranged on the first lid 302 304 opening 3042 (such as Figure 28).Support holder structure and the second chamber can be encapsulated this when together and be sent to the progress of chemical examination mechanism Secondary chemical examination.Alternatively, removing the second chamber from pallet, it is packaged and is used as secondary-confirmation chemical examination with (Figure 29).This when It waits, pallet continues again to be gone on the first chamber, and the structure (Figure 30) of completion is formed.

The utility model content below is also a part as technical solutions of the utility model.

1. a kind of device for receiving liquid sample includes: the first chamber for collecting liquid sample；It is used for really with being used to collect Recognize the second chamber of detection liquid sample；Wherein, the first chamber and the second cavity removably combine, and combine or connect.

2. according to above-mentioned device, wherein the first chamber and the second chamber are in the state of liquid communication.

3. according to above-mentioned device, wherein when the second chamber does not leave the first chamber, the first chamber and the second chamber are in Liquid communication state.

4. according to above-mentioned device, wherein before the second chamber leaves the first chamber, or will leave the first chamber it Before, the first chamber and the second chamber are not at liquid flowing state.

5. according to above-mentioned device, wherein first chamber and the second chamber is fitted together by detachable mode.

6. according to above-mentioned device, wherein second chamber is located at below the first chamber, alternatively, when collecting liquid When, liquid is introduced into the first chamber, the second chamber is then entered back into, alternatively, the second chamber is in the downstream of the first chamber；Alternatively, when receiving When collecting liquid, liquid enters the first and second chambers simultaneously；Alternatively, partially liq sample enters the first chamber, another part liquid Body sample enters the second chamber.

7. according to above-mentioned device, wherein the fluid communication between the first chamber and the second chamber includes in following state One or several kinds: fluid circulation, fluid not circulation status.

8. according to above-mentioned device, wherein the first chamber and the second chamber are first in the state that liquid does not circulate, and are then being in Liquid communication state again finally is at liquid not circulation status.

9. according to above-mentioned device, wherein the first chamber and the second chamber are first in liquid communication state, again then are at liquid Not circulation status.

10. according to above-mentioned device, wherein when the first chamber and the second chamber are in liquid communication state, the first chamber It is removably combined with the second chamber, alternatively, when the first chamber and the second chamber are in liquid not circulation status；First Chamber and the second chamber can be separated or be had been separated from.

11. according to above-mentioned device, wherein when the first chamber and the second chamber are in the state that liquid does not circulate, the first chamber and Second chamber is removably combined.

12. according to above-mentioned device, wherein the device further includes sealing element, which can change the first chamber And the second liquid communication state between chamber；Alternatively, the device further includes puncturing elements, which can be allowed in liquid The state not circulated changes into the state of liquid flowing；Alternatively, the device further includes sealing element and puncturing elements, first allows and puncture Element allows the first chamber and the second chamber to be in liquid communication state, is then in the state not circulated by liquid by sealing element.

13. according to above-mentioned device, wherein the sealing element before the second chamber leaves the first chamber or the second chamber with Before the separation of first chamber or before will separating, the first chamber and the second chamber is allowed to be not at liquid communication state.

14. the device further includes an interface channel according to above-mentioned device, second chamber is logical by connection Road is removably combined, combines or is assembled with the first chamber, or/and, second chamber and the first chamber pass through the company Road is connected to be in fluid connection or be not at fluid connection state.

15. according to above-mentioned device, wherein the device further includes an interface channel；Second chamber and One chamber is in fluid connection by the interface channel.

16. according to above-mentioned device, wherein when the second chamber does not leave the first chamber, interface channel is not close Envelope；Alternatively, interface channel is sealed before or after the second chamber leaves the first chamber.

17. according to above-mentioned device, wherein interface channel, which is sealed, to be sealed by sealing element.

18. according to above-mentioned device, wherein the device further includes sealing element, the sealing element for sealed passage from And it allows between the first chamber and the second chamber and is not at liquid communication state.

19. according to above-mentioned device, wherein the device further includes lyophoby channel, and lyophoby channel has inlet.

20. according to above-mentioned device alternatively, the inlet is located under sealing element, alternatively, working as sealing element When carrying out sealed passage, the inlet prior to sealing element close to interface channel, alternatively, entering connection when sealing element When channel, the inlet is located under the horizontal position of sealing element；Alternatively, when sealing element enters interface channel When, the inlet enters interface channel prior to sealing element.

21. according to above-mentioned device, wherein the inlet is located on sealing element.

22. according to above-mentioned device, wherein the inlet is located on the side wall of interface channel.

23. according to above-mentioned device, wherein the lyophoby channel also has liquid outlet, and the liquid outlet and one receive Cavity fluid connection.

24. according to above-mentioned device, wherein the accommodating chamber is located on sealing element.

25. according to above-mentioned device, wherein the lyophoby channel also has liquid outlet, the liquid outlet and first Chamber is in fluid communication.

26. according to above-mentioned device, wherein the device further includes for excluding partially liq sample in the second chamber Draining element.

27. according to above-mentioned device, wherein before the second chamber and the separation of the first chamber, the draining element is located at institute In the second chamber stated or part is located in the second chamber.

28. according to above-mentioned device, wherein after the second chamber and the first chamber separate, do not contained in second chamber Draining element does not contain part draining element.

29. according to above-mentioned device, wherein the device further includes for excluding partially liq sample in the second chamber Draining element；The draining element is located on sealing element or is linked together with sealing element；.

30. according to above-mentioned device, wherein the draining element enters in interface channel prior to sealing element, or Person's draining element enters in the second chamber prior to sealing element；Alternatively, when sealing element is located in interface channel, drain Element is located in the second chamber.

31. according to above-mentioned device, wherein the device further includes lyophoby channel, and lyophoby channel has inlet, institute The inlet stated is located on draining element；Alternatively, the device includes accommodating chamber, the accommodating chamber is located at draining element On.

32. according to above-mentioned device, wherein the inlet and an accommodating chamber fluid connection, the accommodating chamber position In draining element.

33. according to above-mentioned device, wherein the partial region of the sealing element is as the second intracavitary part liquid of exclusion The draining element of body uses.

34. according to above-mentioned device, wherein the portion sealing element seals member for being tightly connected channel, part Part is used to exclude the partially liq of the second chamber.

35. according to above-mentioned device, wherein the portion sealing element seals member for being tightly connected channel, part Part is located in the second chamber.

36. according to above-mentioned device, wherein the vertical projection region of the draining element is located at sealing element and throws vertically In the domain of shadow zone.

37. according to above-mentioned device, wherein the device further includes lyophoby channel, and lyophoby channel has inlet, institute The vertical projection for the inlet stated is located in the vertical view field of sealing element.

38. according to above-mentioned device, wherein the device further includes the first and second sealing elements, first sealing or the Two sealing elements can change the liquid communication state between the first chamber and the second chamber.

39. according to above-mentioned device, wherein described is used to be tightly connected channel, the second sealing with the first sealing element Part is used to seal the opening of the second chamber, alternatively, sealing the opening of the second chamber with the first sealing element, second seal is used to close Seal the first opening of interface channel.

40. according to above-mentioned device, wherein when with the first sealing element seal the second chamber opening while or sealing Afterwards, the seat of the second chamber is allowed to change from first position to the second position；Or the second chamber is allowed to be detached from the second chamber.

41. according to above-mentioned device, wherein the sealing element or draining element, which is linked, to be moved.

42. according to above-mentioned device, wherein the linkage be used to cover conjunction the first chamber opening lid and be moved.

43. according to above-mentioned device, wherein the movement is rotational motion.

44. a kind of method for collecting liquid sample, the method includes: to provide a kind of collection device, which includes For collecting the first chamber of liquid sample and collecting the second chamber of liquid sample, wherein first chamber and the second chamber is detachable Mode combine, combination or assembling；Before collecting liquid sample, the first chamber and the second chamber is allowed to be in fluid connection state, from And the liquid into the first chamber can be allowed to flow in the second chamber.

45. according to above-mentioned method, wherein after the first chamber has collected liquid sample, the first chamber and the second chamber is allowed not to locate In liquid communication state.

46. according to above-mentioned method, wherein when the first chamber and the second chamber are not at liquid communication state, from The second chamber is separated on one chamber, or the first chamber is allowed to separate with the second chamber.

47. according to above-mentioned method, wherein the liquid sample of the second chamber of entrance is allowed to derive from the liquid-like in the first chamber This；It allows and liquid while entering the first and second chambers；Alternatively, allow partially liq sample enter first, another part liquid sample into Enter the second chamber.

48. according to above-mentioned method, first chamber and the second chamber pass through interface channel and connect, wherein the second chamber with Interface channel removably combines, combination or assembling；Alternatively, allowing the first chamber and the second chamber to be in liquid by the interface channel Body circulation status.

49. according to above-mentioned method, allowing the first chamber and the second chamber to be not at liquid communication state is by with sealing element The channel is sealed to realize.

50. according to above-mentioned method, the channel have is in fluid communication with the first chamber first be open and with the second chamber The second opening being in fluid communication allows sealing element to be tightly connected first opening in channel.

51. according to above-mentioned method, wherein after allowing sealing element to be tightly connected first opening in channel, part is allowed to seal Element enters in channel.

52. according to above-mentioned method, wherein in a device further include lyophoby channel, which includes inlet.

53. according to above-mentioned method, wherein when allowing portion sealing element to enter in channel, sealing element is excluded Liquid sample by inlet be rejected to that interface channel is outer or the second chamber outside, if, in the presence of liquid sample.

54. according to above-mentioned method, wherein the liquid sample that sealing element excludes is rejected to accommodating chamber by lyophoby channel In.

55. according to above-mentioned method, wherein in a device further include lyophoby channel, which includes inlet, is allowed Inlet enters in interface channel prior to sealing element.

56. according to above-mentioned method, wherein in a device further include the drain for excluding the partially liq in the second chamber Element.

57. according to above-mentioned method, wherein when with sealing element, allow draining element prior to sealing element into Enter or examines closely into interface channel.

58. according to above-mentioned method, wherein allow draining element to enter in the second chamber, or allow part draining element into Enter in the second chamber.

59. according to above-mentioned method, wherein after the second chamber is separated with the first chamber, the draining element is allowed not to be located at In second chamber.

60. according to above-mentioned method, wherein when allowing sealing element to be tightly connected first opening in channel, allow drain Element enters in the second chamber, alternatively, sealing element is allowed to enter interface channel, draining element is allowed to enter in the second chamber.

61. according to above-mentioned method, sealing element and draining element ganged movement are allowed.

62. the linkage is that the lid for closing the first chamber by lid links according to above-mentioned method.

1. a kind of device for receiving liquid sample includes: the first chamber for collecting liquid sample；It is used for really with being used to collect Recognize the second chamber of detection liquid sample；Wherein, first chamber has the opening for receiving liquid sample, and the second chamber, which has, to be received The opening of liquid sample in the first chamber.

2. according to above-mentioned device, wherein the device further includes support holder structure, and second chamber is set by detachable It sets on support holder structure, the support holder structure and the detachable combination of first chamber.

3. according to above-mentioned device, wherein when support holder structure and the first chamber are combined, the second chamber and second Chamber is in liquid communication state.

4. wherein first chamber includes a hole according to above-mentioned device, the hole and the opening of the second chamber are in liquid communication State；Alternatively, the liquid sample of the first chamber can be flowed into the second chamber by the gravity that liquid itself is subject to.

5. according to above-mentioned device, wherein the hole is the first opening of interface channel, and second chamber passes through connection Realize the fluid communication between the first chamber in channel；Or the hole has the channel extended, second chamber is by being somebody's turn to do Realize the fluid communication between the first chamber in the channel of extension.

6. according to above-mentioned device, wherein the channel of the interface channel or extension has the first opening and second Opening, first opening are in fluid communication with the first chamber, and the second opening is in fluid communication with the second chamber.

7. according to above-mentioned device, wherein the device further include channel for being tightly connected channel, extension or The sealing element in hole.

8. according to above-mentioned device, wherein the sealing element can be by being tightly connected the logical of channel or extension First opening or portion sealing element in road enter the channel of interface channel or extension to seal.

9. according to above-mentioned device, wherein the device further includes lyophoby channel.

10. according to above-mentioned device, wherein lyophoby channel includes inlet, and the inlet is located at sealing element Under, alternatively, the inlet is prior to sealing element when sealing element is to be tightly connected channel or extend channel Close to interface channel perhaps extends channel alternatively, when sealing element enter interface channel or extension channel when, institute The inlet stated is located under the horizontal position of sealing element；Alternatively, when sealing element enters interface channel, it is described Inlet enters interface channel prior to sealing element.

11. according to above-mentioned device, wherein the device further includes lyophoby channel, the lyophoby channel include into The view field of liquid mouth, the liquid inlet is located within sealing element view field.

12. according to above-mentioned device, wherein the inlet is located on sealing element.

13. according to above-mentioned device, wherein the inlet is located on the side wall of interface channel.

14. according to above-mentioned device, wherein the inlet is lower than the position of interface channel opening

15. according to above-mentioned device, wherein the lyophoby channel also has liquid outlet, and the liquid outlet and one receive Cavity fluid connection.

16. according to above-mentioned device, wherein the accommodating chamber is located on sealing element.

17. according to above-mentioned device, wherein the lyophoby channel also has liquid outlet, the liquid outlet and first Chamber is in fluid communication

18. according to above-mentioned device, wherein the device further includes lyophoby channel, the lyophoby channel include into Liquid mouth, the partially liq forced by sealing element enter lyophoby channel by liquid inlet, thus be rejected to channel and/or Except the second chamber of person.

19. according to above-mentioned device, wherein the device includes the row for excluding partially liq sample in the second chamber Liquid element.

20. according to above-mentioned device, wherein the device further includes lyophoby channel, the lyophoby channel include into Liquid mouth, the liquid inlet are located on draining element.

21. according to above-mentioned device, wherein the draining element and sealing element is linked together structure, when with close When sealing element.

22. according to above-mentioned device, wherein when with sealing element come sealed passage, draining element is prior to sealing Element enters in the second chamber.

23. according to above-mentioned device, wherein the lyophoby channel includes liquid outlet, the liquid outlet and a receiving Chamber fluid connection.

24. according to above-mentioned device, wherein when the portion sealing element enters interface channel, the receipts Cavity, which is used to receive sealing element, enters the liquid sample that interface channel is discharged.

25. according to above-mentioned device, wherein the accommodating chamber is located in sealing element or in draining element.

26. according to above-mentioned device, wherein the view field of the draining element is located at the vertical projection of sealing element Within region.

27. according to above-mentioned device, wherein the trans D of the draining element is less than the laterally straight of sealing element Diameter.

28. according to above-mentioned device, wherein the interface channel be it is cylindrical, the sealing element is also round It is cylindrical.

29. according to above-mentioned device, wherein the device further includes for covering the first lid for closing the first chamber opening.

30. according to above-mentioned device, wherein the lid and sealing element ganged movement, the latter's lid and drain member Part ganged movement, alternatively, lid and sealing element and draining element ganged movement.

31. according to above-mentioned device, wherein when the first cover cap closes the first chamber opening, the sealing element It enters in interface channel as the lid of lid closes and to seal the first of the interface channel the opening or subelement.

32. according to above-mentioned device, wherein the device further includes draining element, the draining element and sealing Element connection.

33. according to above-mentioned device, wherein the draining element is than sealing element far from first lid.

34. according to above-mentioned device, wherein the sealing element is connect by connecting rod with the first lid.

35. according to above-mentioned device, wherein the sealing element is removably connect with connecting rod.

36. according to above-mentioned device, wherein the device further includes lyophoby channel, the lyophoby channel include into The view field of liquid mouth, the liquid inlet is located within sealing element view field.

37. according to above-mentioned device, wherein the liquid inlet is than sealing element far from the first lid.

38. according to above-mentioned device, wherein the liquid inlet is located on draining element.

39. according to above-mentioned device, wherein when the sealing element is tightly connected channel, the drain Element or part draining element are located in the second chamber.

1. a kind of method for collecting liquid: this method comprises:

A kind of device for collecting liquid sample is provided, wherein the device includes: the first chamber for collecting liquid sample, In, first chamber has the opening for receiving liquid sample；With

For collecting the second chamber for confirming detection liquid sample, the second chamber, which has, to be received from liquid-like in the first chamber This opening；

Support holder structure, the support holder structure include the second chamber, wherein support holder structure and the detachable combination of the first chamber are tied It closes or combines；

Liquid sample is collected with the first chamber, liquid sample is allowed to enter in a chamber by the opening of the first chamber.

2. according to above-mentioned method, wherein the first chamber has a hole, and the hole and the second chamber form liquid communication.

3. according to above-mentioned method, wherein before carrying out liquid collection, the first chamber and the second chamber is allowed to pass through the hole Form fluid connection state.

4. according to above-mentioned method, wherein when collecting liquid, allow liquid to enter the first chamber, then allow liquid Automatically it is flowed into the second chamber from the first chamber by the hole；Liquid while the first chamber and the second chamber are entered alternatively, allowing；Alternatively, It allows partially liq to enter the first chamber, another liquid is allowed to enter in the second chamber.

5. according to above-mentioned method, wherein the hole has the extension channel extended, and the part extends channel position In the second chamber, alternatively, the opening of second chamber of part is located in the passage portion, to form fluid connection.

6. according to above-mentioned method, wherein after the completion of liquid sample collection, the hole that makes sealing element sealing described or Person extends channel, thus, it is possible to which the second chamber and the first chamber is allowed to be not at fluid communication.

7. according to above-mentioned method, wherein after the second chamber and the first chamber are not at fluid communication, pallet is allowed to leave first Cavity, so that the second chamber be driven to leave the first chamber.

8. according to above-mentioned method, wherein the second chamber is allowed to be detached from the pallet.

9. according to above-mentioned method, wherein before allowing the second chamber to be detached from the pallet after the latter, with the second cover cap The opening for closing second chamber, to form the second chamber of sealing.

10. according to above-mentioned method, wherein provide the first lid that lid closes the first chamber opening, be arranged on the lid The sealing element allows lid and sealing element to carry out ganged movement.

11. according to above-mentioned method, wherein during the opening for closing the first chamber with lid, lid band moving sealing element The liquid formed between the first chamber and the second chamber does not circulate.

12. according to above-mentioned method, wherein lid seals the hole between the first chamber and the second chamber with moving sealing element Or extend channel.

13. according to above-mentioned method, wherein lid band moving sealing element allows portion sealing element to enter and extends channel In.

14. according to above-mentioned method, wherein the lid further includes draining element, and the draining element is than sealing Element is far from lid.

15. according to above-mentioned method, wherein further include lyophoby channel in the lid, the lyophoby channel includes Liquid inlet allows the position of liquid inlet than sealing element further from lid；Alternatively, liquid inlet is allowed to enter extension prior to sealing element In channel.

16. according to above-mentioned method, wherein the view field of the liquid inlet be located at sealing element view field it It is interior.

17. according to above-mentioned method, wherein enter lyophoby by liquid inlet by the partially liq that sealing element forces Channel, to be rejected to except channel and/or the second chamber.

18. according to above-mentioned method, wherein the lyophoby channel includes liquid outlet, the liquid outlet and a receiving Chamber fluid connection.

19. according to above-mentioned method, wherein the accommodating chamber is located in sealing element or in draining element or covers In body.

20. according to above-mentioned method, wherein when the portion sealing element enters interface channel, the receipts Cavity, which is used to receive sealing element, enters the liquid sample that interface channel is discharged.

21. according to above-mentioned method, wherein when draining element enters in the second chamber, the portion that the draining element excludes Point also sample enters in accommodating chamber.

1. the detection device of analyte includes: the first chamber for collecting liquid sample in a kind of detection sample；With For collecting the second chamber for confirming detection liquid sample, wherein first chamber has the opening for receiving liquid sample, Second chamber has the opening for receiving the liquid sample in the first chamber, wherein the device further includes testing element.

2. according to above-mentioned device, wherein the device further includes support holder structure, and the support holder structure and the first chamber can The connection of disassembly, wherein second chamber is arranged on pallet, second chamber by the pallet with first Dismountable combination of chamber, combination or connection.

3. according to above-mentioned device, wherein second chamber realizes the fluid stream between the first chamber by a channel Logical state.

4. according to above-mentioned device, wherein the channel has the first opening and the second opening, first opening It is in fluid communication with the first chamber, the second opening is in fluid communication with the second chamber.

5. according to above-mentioned device, wherein the device further includes the sealing element for being tightly connected channel.

6. according to above-mentioned device, wherein the sealing element in the sealed connection channel can pass through sealed passage First opening or portion sealing element enter interface channel to seal.

7. according to above-mentioned device, wherein the device further includes lyophoby channel, and the lyophoby channel includes into liquid Mouth and liquid outlet, the liquid inlet are located at the region under sealing element.

8. according to above-mentioned device, wherein the device further includes lyophoby channel, and the lyophoby channel includes into liquid Mouth and liquid outlet, the view field of the liquid inlet are located within sealing element view field.

9. according to above-mentioned device, wherein the device further includes the drain for excluding partially liq in the second chamber Element, the draining element and sealing element link together.

10. according to above-mentioned device, wherein the device further includes lyophoby channel, the lyophoby channel include into Liquid mouth, the liquid inlet are located on draining element.

11. according to above-mentioned device, wherein the lyophoby channel includes liquid outlet, the liquid outlet and accommodating chamber Fluid connection, the accommodating chamber are used to the liquid that structure draining element excludes.

12. according to above-mentioned device, wherein when the portion sealing element enters, channel is next, the accommodating chamber Enter the liquid sample that interface channel is discharged for receiving sealing element.

13. according to above-mentioned device, wherein the accommodating chamber is located in sealing element or in draining element.

14. according to above-mentioned device, wherein the view field of the draining element is located at the vertical projection of sealing element Within region.

15. according to above-mentioned device, wherein the trans D of the draining element is less than the laterally straight of sealing element Diameter.

16. according to above-mentioned device, wherein the interface channel be it is cylindrical, the sealing element is also round It is cylindrical.

17. according to above-mentioned device, wherein the device further includes the first lid for covering conjunction the first chamber opening, The sealing element is provided on the lid, so that described is close when the first cover cap closes the first chamber opening Envelope element enters connection and leads to as the lid of lid closes to seal the first of the interface channel the opening or subelement In road.

18. according to above-mentioned device, wherein the device further includes draining element, the draining element and sealing Element connection.

19. according to above-mentioned device, wherein the draining element is than sealing element far from first lid.

20. according to above-mentioned device, wherein the sealing element is connect by connecting rod with the first lid.

21. according to above-mentioned device, wherein the sealing element is removably connect with connecting rod.

22. according to above-mentioned device, wherein the device further includes lyophoby channel, the lyophoby channel include into The view field of liquid mouth, the liquid inlet is located within sealing element view field.

23. according to above-mentioned device, wherein the liquid inlet is than sealing element far from the first lid.

24. according to above-mentioned device, wherein the liquid inlet is located on draining element.

25. according to above-mentioned device, wherein when the sealing element sealed passage, the draining element Or part draining element is located in the second chamber.

26. according to above-mentioned device, wherein the device further includes test chamber, and the test chamber and the first chamber are in fluid communication, institute The testing element stated is located in test chamber.

27. according to above-mentioned device, wherein the device further includes a carrier, includes that multiple receivings are tested on carrier The channel of element, it is intracavitary that the carrier is located at first.

28. according to above-mentioned device, wherein the sample applying zone of the testing element is located at the bottom of the first chamber.

1. a kind of cavity for collecting liquid sample, which is characterized in that the cavity includes: side wall；Bottom；And it is used for Receive the opening of liquid, wherein the bottom allows with one and flows to the hole outside cavity into the liquid sample in cavity.

2. according to above-mentioned cavity, which is characterized in that have in the cavity bottom to the region of cavity internal projection, it should The region of protrusion and side wall form liquid sample collection region.

3. according to above-mentioned cavity, which is characterized in that the sample pooling region is configured to receive test carrier.

4. according to above-mentioned cavity, which is characterized in that include testing element on the test carrier.

5. according to above-mentioned cavity, which is characterized in that include the hole on the elevated regions.

6. according to above-mentioned cavity, which is characterized in that the hole has the channel extended.

7. according to above-mentioned cavity, which is characterized in that the channel extends into cavity and/or to cavity extension It stretches.

8. according to above-mentioned cavity, which is characterized in that the channel extends to outside cavity.

9. according to above-mentioned cavity, which is characterized in that the elevated regions have a platform structure in the cavity, described Platform structure on include the hole.

10. according to above-mentioned cavity, which is characterized in that the cavity further include in the elongated area of bottom, it is described The length of elongated area exceeds or equal to the length for extending channel.

11. according to above-mentioned cavity, which is characterized in that the position in the hole is higher than the position of pooling zone bottom, alternatively, When collecting liquid, liquid is allowed to arrive first pooling zone, then in inflow hole.

1. a kind of lid, which is characterized in that the lid includes sealing element.

2. according to above-mentioned lid, which is characterized in that the lid is for covering the lid for closing cavity hatch.

3. according to above-mentioned lid, which is characterized in that the lid further includes connection rod structure, the connecting rod one End connection lid, the other end connection sealing element.

4. according to above-mentioned lid, which is characterized in that the sealing element is the end of part connecting rod, or sealing Element is structure as a whole with connecting rod.

5. according to above-mentioned lid, which is characterized in that the sealing element is elastic material.

6. according to above-mentioned lid, which is characterized in that the sealing element and connecting rod is dismountable connection.

7. according to above-mentioned lid, which is characterized in that the sealing element and connecting rod grafting, the side of screw thread, buckle Formula connection.

8. according to above-mentioned lid, which is characterized in that the sealing element and connecting rod is hollow structure.

9. according to above-mentioned lid, which is characterized in that the sealing element and connection should be one-time injection molding.

10. according to above-mentioned lid, which is characterized in that the sealing element includes sealing ring.

11. according to above-mentioned lid, which is characterized in that as the sealing ring and the material of sealing element be, or Sealing element containing sealing ring is one-time injection molding.

1. a kind of lid, which is characterized in that the lid includes sealing element and draining element.

3. according to above-mentioned lid, which is characterized in that the lid further includes connection rod structure, the connecting rod one End connection lid ontology, the other end connection sealing element and draining element.

6. according to above-mentioned lid, which is characterized in that the sealing element is connect with draining element.

7. according to above-mentioned lid, which is characterized in that the draining element is than sealing element far from the lid Ontology.

8. according to above-mentioned lid, which is characterized in that the vertical projection of the draining element is located at the perpendicular of sealing element Within straight view field or it is overlapped.

9. according to above-mentioned lid, which is characterized in that the trans D of the draining element is less than the cross of sealing element To diameter.

10. according to above-mentioned lid, which is characterized in that the cone shape of the draining element.

11. according to above-mentioned lid, which is characterized in that during one of the sealing element, connecting rod, draining element include Empty cavity, alternatively, sealing element, connecting rod, draining element are all hollow structure.

1. a kind of lid, which is characterized in that the lid includes sealing element and draining element and accommodating chamber.

2. according to above-mentioned lid, which is characterized in that the lid further includes connection rod structure, the connecting rod one End connection lid ontology, the other end connection sealing element and draining element.

3. according to above-mentioned lid, which is characterized in that the sealing element is the end of part connecting rod, or sealing Element is structure as a whole with connecting rod.

4. according to above-mentioned lid, which is characterized in that the sealing element is elastic material.

5. according to above-mentioned lid, which is characterized in that the sealing element is connect with draining element.

6. according to above-mentioned lid, which is characterized in that the draining element is than sealing element far from the lid Ontology.

7. according to above-mentioned lid, which is characterized in that during one of the sealing element, connecting rod, draining element include Empty cavity, alternatively, the structure that sealing element, connecting rod, draining element multidigit are hollow, the accommodating chamber is the hollow of part Cavity or hollow structure.

8. according to above-mentioned lid, which is characterized in that the trans D of the draining element is less than the cross of sealing element To diameter.

9. according to above-mentioned lid, which is characterized in that the cone shape of the draining element.

10. according to above-mentioned lid, which is characterized in that the accommodating chamber is located at connecting rod, sealing element or drain In element.

1. a kind of lid, which is characterized in that the lid includes sealing element and lyophoby channel, the lyophoby channel Including liquid inlet and liquid outlet.

2. according to above-mentioned lid, which is characterized in that the lid further includes connection rod structure, the connecting rod one End connection lid ontology, the other end connection sealing element.

3. according to above-mentioned lid, which is characterized in that the liquid inlet in the lyophoby channel is than sealing element far from lid Ontology.

4. according to above-mentioned lid, which is characterized in that the sealing element is connect with draining element.

5. according to above-mentioned lid, which is characterized in that the liquid inlet in the lyophoby channel is located on draining element.

6. according to above-mentioned lid, which is characterized in that the sealing element includes sealing ring, the lyophoby channel Ontology of the liquid inlet than sealing ring far from lid.

7. according to above-mentioned lid, which is characterized in that further include accommodating chamber on the lid, wherein the lyophoby The liquid outlet and accommodating chamber in channel are in fluid communication.

8. according to above-mentioned lid, which is characterized in that during one of the sealing element, connecting rod, draining element include Empty cavity, alternatively, the structure that sealing element, connecting rod, draining element multidigit are hollow, the liquid outlet in the lyophoby channel with The hollow cavity or the connection of hollow structural fluid.

9. according to above-mentioned lid, which is characterized in that the liquid outlet in the lyophoby channel is than sealing element far from lid Ontology.

10. according to above-mentioned lid, which is characterized in that the vertical projection of the draining element is in the vertical of sealing element In view field or it is overlapped.

1. a kind of device for collecting liquid sample, which is characterized in that it includes the first cavity and the second cavity, wherein In The cavity bottom has to the region of cavity internal projection, and the elevated regions form the sky relative to the first chamber protrusion Between, to form the space relative to bottom notch, second chamber of part is located in the sunk area.

2. intracavitary described first includes hole, the opening in the hole and the second chamber according to above-mentioned sample collection device Form liquid communication state.

3. the device further includes interface channel according to above-mentioned sample collection device, second chamber by with Interface channel forms detachable combination, combination or assembling.

4. the opening of second chamber includes external screw thread according to above-mentioned sample collection device, interface channel includes interior Screw thread, the external screw thread of second chamber and the internal screw thread of interface channel pass through screw thread combination, combination or assembling.

5. the hole has one section of extension channel according to above-mentioned sample collection device, the extended segment is connection The a part in channel, wherein the extension channel is located in the dented space.

6. it is intracavitary positioned at second that the part extends channel according to above-mentioned sample collection device.

7. the outer diameter that the part extends channel is equal to or less than the second chamber and opens according to above-mentioned sample collection device The internal diameter of mouth.

8. described extends in channel insertion second chamber according to above-mentioned sample collection device.

9. the device further includes interface channel according to above-mentioned sample collection device, the hole is interface channel The first opening, which is to be in fluid communication with the first chamber, and the second opening of second chamber and interface channel is stream Body connection.

10. device further includes support holder structure according to above-mentioned sample collection device, second chamber is by detachable It is arranged on support holder structure, the support holder structure and the detachable combination of first chamber.

1. a kind of cavity for collecting fluid sample, which is characterized in that the cavity includes:

Side wall；

Bottom；And the opening for receiving liquid, wherein the bottom has one to allow into the liquid-like in cavity Originally the opening outside cavity is flowed to, wherein the device further includes the test chamber for placing testing element, the test chamber Fluid connection state is in by through-hole with cavity.

2. according to above-mentioned cavity, the position of the opening be higher than through-hole position or aperture efficiency through-hole closer to The opening of cavity；Or through-hole is than being open closer to the bottom of cavity.

3. when cavity collects liquid sample, liquid is introduced into through-hole, then enters back into out according to above-mentioned cavity Mouthful, alternatively, partially liq sample enters into through-hole, partially liq sample enters opening.

4. the opening includes the channel extended outside bottom according to above-mentioned cavity.

5. being had in the cavity bottom to the region of cavity internal projection, the region of the protrusion according to above-mentioned cavity Liquid sample collection region is formed with side wall.

6. the collection region includes bottom according to above-mentioned cavity, the opening is higher than the bottom position of pooling zone It sets.

7. the bottom of the collection region is the bottom section of part cavity according to above-mentioned cavity.

8. according to above-mentioned cavity, which is characterized in that the test chamber includes testing element.

9. according to above-mentioned cavity, which is characterized in that the testing element is located on carrier, and the carrier is located at institute In the test chamber stated.

10. according to above-mentioned cavity, which is characterized in that the testing element includes for contacting the liquid in detection limit The sample applying zone of sample.

1. a kind of device for collecting liquid sample, which is characterized in that the device includes: first for collecting liquid sample Chamber and the second chamber, second chamber further includes the test chamber for primary detection being in fluid communication with the second chamber, wherein first The bottom of chamber has opening, and the opening is sealed by a sealing element.

2. according to above-mentioned device, which is characterized in that the detachable combination of first chamber and the second chamber, in conjunction with or Person's assembling.

3. according to above-mentioned device, which is characterized in that the sealing element is the sealing element that can be punctured.

4. according to above-mentioned device, which is characterized in that the sealing element plastic film, double faced adhesive tape, one-faced tapes, One of aluminium foil is several.

5. according to above-mentioned device, which is characterized in that the opening has the outer channel extended outward, the channel Including the second opening with the second chamber for fluid communi.

6. according to above-mentioned device, which is characterized in that the device further includes puncturing member for puncture sealing element Part and/or another sealing element.

7. according to above-mentioned device, which is characterized in that also another sealing element of the device, another sealing member Part is used to seal opening described in the sealing after puncturing elements puncture sealing element.

8. according to above-mentioned device, which is characterized in that the puncturing elements and another sealing element are arranged on first On lid, first lid is used to cover the opening for closing the first chamber.

9. according to above-mentioned device, which is characterized in that the puncturing elements are relative to another sealing element far from lid Ontology.

10. according to above-mentioned device, which is characterized in that the puncturing elements and another sealing element are in this way, allow Puncturing elements first puncture the sealing element of sealed opening, then discharge partially liq into the second chamber, then allow another sealing first The part sealing opening.

11. according to above-mentioned device, which is characterized in that the device further includes the second opening for sealed passage Second lid.

The all patents and publications mentioned in the utility model specification all indicates that these are the public technologies of this field, The utility model can be used.All patents referred to herein and publication are all equally listed in bibliography, with each A publication is specifically individually referenced the same.The utility model described here can lack any element or Multiple element realizes that this limitation is not particularly illustrated here in the case where a kind of limitation or a variety of limitations.Such as it is each here Term "comprising" in a example, " essence by ... form " and " by ... form " remaining 2 term of one of both can be used Instead of.Here it is so-called "one" be merely representative of the meaning of " one ", and be not excluded for only only include one, can also indicate Including 2 or more.Here describing mode carried out by the terms and expressions mode used, and be not limited except as, it is also not any here It is intended to eliminate any equivalent feature come these terms for indicating the description of this book and explanation, but it is recognised that can be at this Any suitable be altered or modified is done in utility model and the scope of the claims.It is appreciated that described in the utility model Examples of implementation are all some preferred embodiment and feature, and any those of ordinary skill in the art can be practical according to this Some changes and variation are done under the marrow of novel description, these change and variation be recognized as belong to the scope of the utility model and In the range of independent claims and appended claims limit.

Claims

1. a kind of device for receiving liquid sample, which is characterized in that described device includes: the first chamber for collecting liquid sample； Be used to collect for confirm detect liquid sample the second chamber；Wherein, first chamber, which has, receives opening for liquid sample Mouthful, the second chamber has the opening for receiving the liquid sample in the first chamber.

2. the apparatus according to claim 1, wherein the device further includes support holder structure, and second chamber is detachable The setting of formula is on support holder structure, the support holder structure and the detachable combination of first chamber.

3. the apparatus of claim 2, wherein when support holder structure and the first chamber are combined, the second chamber Liquid communication state is in the second chamber.

4. the device according to shown in claim 3, wherein first chamber includes a hole, and the hole and the opening of the second chamber are in liquid Circulation status；Alternatively, the liquid sample of the first chamber can be flowed into the second chamber by the gravity that liquid itself is subject to.

5. device according to claim 4, wherein the hole is the first opening of interface channel, and second chamber is logical Cross the fluid communication between interface channel realization and the first chamber；Or the hole has the channel extended, second chamber The fluid communication between the first chamber is realized by the channel of the extension.

6. device according to claim 5, wherein the channel of the interface channel or extension have first opening and Second opening, first opening are in fluid communication with the first chamber, and the second opening is in fluid communication with the second chamber.

7. according to device described in claim 5 or 6, wherein the device further includes for being tightly connected channel, extending Channel or hole sealing element.

8. device according to claim 7, wherein the sealing element can be by being tightly connected channel or extension Channel first opening or portion sealing element enter the channel of interface channel or extension to seal.

9. device described in one of -6 or 8 according to claim 1, wherein the device further includes lyophoby channel.

10. device according to claim 7, wherein the device further includes lyophoby channel.

11. device according to claim 9, wherein lyophoby channel includes inlet, and the inlet is located at sealing member Under part, alternatively, the inlet is prior to sealing when sealing element is to be tightly connected channel or extend channel Element close to interface channel perhaps extends channel alternatively, when sealing element enters interface channel or when extending channel It waits, the inlet is located under the horizontal position of sealing element；Alternatively, when sealing element enters interface channel, The inlet enters interface channel prior to sealing element.

12. device according to claim 10, wherein lyophoby channel includes inlet, and the inlet is located at sealing Under element, alternatively, the inlet is prior to close when sealing element is to be tightly connected channel or extend channel It seals element and close to interface channel perhaps extends channel alternatively, when sealing element enters interface channel or extension channel When, the inlet is located under the horizontal position of sealing element；Alternatively, when sealing element enters interface channel It waits, the inlet enters interface channel prior to sealing element.

13. device described in one of -6 according to claim 1, wherein the device further includes lyophoby channel, the lyophoby Channel includes liquid inlet, and the view field of the liquid inlet is located within sealing element view field.

14. device according to claim 7, wherein the device further includes lyophoby channel, the lyophoby channel packet Liquid inlet is included, the view field of the liquid inlet is located within sealing element view field.

15. device described in one of 1-12 according to claim 1, wherein the inlet is located on sealing element.

16. device described in 1 or 12 according to claim 1, wherein the inlet is located on the side wall of interface channel.

17. device according to claim 16, wherein the inlet is lower than the position of interface channel opening.

18. device according to claim 9, wherein the lyophoby channel also has a liquid outlet, the liquid outlet with One accommodating chamber fluid connection.

19. device described in one of 0-12 or 14 or 17 according to claim 1, wherein the lyophoby channel also has out Liquid mouth, the liquid outlet and an accommodating chamber fluid connection.

20. device according to claim 13, wherein the lyophoby channel also has liquid outlet, the liquid outlet With an accommodating chamber fluid connection.

21. device according to claim 15, wherein the lyophoby channel also has liquid outlet, the liquid outlet With an accommodating chamber fluid connection.

22. device according to claim 16, wherein the lyophoby channel also has liquid outlet, the liquid outlet With an accommodating chamber fluid connection.

23. device described in one of 8 or 20-22 according to claim 1, wherein the accommodating chamber is located on sealing element.

24. device according to claim 19, wherein the accommodating chamber is located on sealing element.

25. device according to claim 9, wherein the lyophoby channel also has a liquid outlet, the liquid outlet with First chamber is in fluid communication.

26. device described in one of 0-12 or 14 or 17 according to claim 1, wherein the lyophoby channel also has out Liquid mouth, the liquid outlet and the first chamber are in fluid communication.

27. device according to claim 13, wherein the lyophoby channel also has liquid outlet, the liquid outlet It is in fluid communication with the first chamber.

28. device according to claim 15, wherein the lyophoby channel also has liquid outlet, the liquid outlet It is in fluid communication with the first chamber.

29. device according to claim 16, wherein the lyophoby channel also has liquid outlet, the liquid outlet It is in fluid communication with the first chamber.

30. device according to claim 7, wherein the device further includes lyophoby channel, the lyophoby channel packet Liquid inlet is included, the partially liq forced by sealing element enters lyophoby channel by liquid inlet, to be rejected to channel With or the second chamber except.

31. according to claim 1 one of -6 or one of 8 or 10-12 or one of 14 or 17-18 or one of 20-22 or 24- Device described in one of 25 or one of 27-30, wherein the device includes for excluding partially liq sample in the second chamber Draining element.

32. device according to claim 7, wherein the device includes for excluding partially liq sample in the second chamber This draining element.

33. device according to claim 9, wherein the device includes for excluding partially liq sample in the second chamber This draining element.

34. device according to claim 13, wherein the device includes for excluding partially liq sample in the second chamber This draining element.

35. device according to claim 15, wherein the device includes for excluding partially liq sample in the second chamber This draining element.

36. device according to claim 16, wherein the device includes for excluding partially liq sample in the second chamber This draining element.

37. device according to claim 19, wherein the device includes for excluding partially liq sample in the second chamber This draining element.

38. device according to claim 23, wherein the device includes for excluding partially liq sample in the second chamber This draining element.

39. device according to claim 26, wherein the device includes for excluding partially liq sample in the second chamber This draining element.

40. device according to claim 31, wherein the draining element and sealing element is linked together structure, when When with sealing element.

41. the device according to one of claim 32-39, wherein the draining element and sealing element is linked together Structure, when with sealing element.

42. device according to claim 40, wherein when with sealing element come sealed passage, draining element is first It is entered in the second chamber in sealing element.

43. device according to claim 41, wherein when with sealing element come sealed passage, draining element is first It is entered in the second chamber in sealing element.

44. according to claim 1 one of -6 or one of 8 or 10-12 or one of 14 or 17-18 or one of 20-22 or 24- Device described in one of one of 25,27-30 or one of 32-39 or one of 40 or 42-43, wherein the lyophoby channel packet Include liquid outlet, the liquid outlet and an accommodating chamber fluid connection.

45. device according to claim 9, wherein the lyophoby channel includes liquid outlet, the liquid outlet and one Accommodating chamber fluid connection.

46. device according to claim 13, wherein the lyophoby channel includes liquid outlet, the liquid outlet and One accommodating chamber fluid connection.

47. device according to claim 15, wherein the lyophoby channel includes liquid outlet, the liquid outlet and One accommodating chamber fluid connection.

48. device according to claim 16, wherein the lyophoby channel includes liquid outlet, the liquid outlet and One accommodating chamber fluid connection.

49. device according to claim 19, wherein the lyophoby channel includes liquid outlet, the liquid outlet and One accommodating chamber fluid connection.

50. device according to claim 23, wherein the lyophoby channel includes liquid outlet, the liquid outlet and One accommodating chamber fluid connection.

51. device according to claim 26, wherein the lyophoby channel includes liquid outlet, the liquid outlet and One accommodating chamber fluid connection.

52. device according to claim 40, wherein the view field of the draining element is located at the perpendicular of sealing element Within straight view field.

53. device according to claim 41, wherein the view field of the draining element is located at the perpendicular of sealing element Within straight view field.

54. the device according to claim 52 or 53, wherein the trans D of the draining element is less than sealing element Trans D.

55. according to claim 1 one of -6 or one of 8 or 10-12 or one of 14 or 17-18 or one of 20-22 or 24- Described in one of 25 or one of 27-30 or one of 32-39 or one of 40 or 42-43 or one of 45-51 or one of 52-53 Device, wherein the device further includes for covering the first lid for closing the first chamber opening.

56. device according to claim 7, wherein the device further includes closing the first of the first chamber opening for covering Lid.

57. device according to claim 9, wherein the device further includes closing the first of the first chamber opening for covering Lid.

58. device according to claim 13, wherein the device further includes closing the first of the first chamber opening for covering Lid.

59. device according to claim 15, wherein the device further includes closing the first of the first chamber opening for covering Lid.

60. device according to claim 16, wherein the device further includes closing the first of the first chamber opening for covering Lid.

61. device according to claim 19, wherein the device further includes closing the first of the first chamber opening for covering Lid.

62. device according to claim 23, wherein the device further includes closing the first of the first chamber opening for covering Lid.

63. device according to claim 26, wherein the device further includes closing the first of the first chamber opening for covering Lid.

64. device according to claim 31, wherein the device further includes closing the first of the first chamber opening for covering Lid.

65. device according to claim 41, wherein the device further includes closing the first of the first chamber opening for covering Lid.

66. device according to claim 44, wherein the device further includes closing the first of the first chamber opening for covering Lid.

67. device according to claim 54, wherein the device further includes closing the first of the first chamber opening for covering Lid.

68. device according to claim 55, wherein the lid and sealing element ganged movement, the latter's lid with Draining element ganged movement, alternatively, lid and sealing element and draining element ganged movement.

69. the device according to one of claim 56-67, wherein the lid and sealing element ganged movement, the latter Lid and draining element ganged movement, alternatively, lid and sealing element and draining element ganged movement.

70. device according to claim 68, wherein the device further includes draining element, the draining element It is connect with sealing element.

71. device according to claim 69, wherein the device further includes draining element, the draining element It is connect with sealing element.

72. the device according to claim 70 or 71, wherein the draining element is than sealing element far from described One lid.

73. device according to claim 68, wherein the sealing element is connect by connecting rod with the first lid.

74. device according to claim 69, wherein the sealing element is connect by connecting rod with the first lid.

75. the device according to claim 73 or 74, wherein the sealing element is removably connect with connecting rod.

76. the device according to claim 75, wherein the liquid inlet in lyophoby channel is than sealing element far from the first lid.

77. the device according to claim 76, wherein described when the sealing element is tightly connected channel Draining element or part draining element be located in the second chamber.