CN208721676U - The detection device of analyte in a kind of detection fluid sample - Google Patents

Abstract

The utility model provides a kind of detection device for detecting analyte in fluid sample, the device includes base, there is the slot for accommodating testing element in base, further include the sample cavity for collecting fluid sample in base, further include fluid passage on the sample cavity.By the detection device can in fluid sample analyte carry out quickly, detection efficiently and accurately, and can allow operator it is more convenient, freely using the detection device without will cause incorrect testing result.

Description

The detection device of analyte in a kind of detection fluid sample

Technical field

The utility model relates to a kind of device and method for detecting the analyte in fluid sample.

Background technique

Following background technique is used to help reader and understands the utility model, and is not construed as the prior art.

In our society, illicit drug use has become the social concern generally acknowledged and deteriorated increasingly. 2003 Year, U.S. Department of Health and Human Service investigation discovery there are about 19,500,000 Americans or 8.2% age 12 years old or more crowd just Sucking illicit drugs." using illicit drugs recently ", which refers to, investigate in the previous moon in U.S. Department of Health and Human Service Used a kind of illicit drugs.Hemp is found to be most common illicit drugs, accounts for 6.2% (14,600,000).Estimate 2,300,000 people (1.0%) cocaine is used now, 604,000 people have used crack, and there are 1,000,000 people using psychedelic, and estimate 119, Heroin is used in 000 people.

In order to hit drug abuse and monitor this social concern, drug test for example employs in every profession and trade, educates, body It educates, enforce the law etc. and having become standard test procedure.In order to push this effort, drug test industry has been formed.This production Industry provides various drug test product.It can be the test product of a classics to the A urine sample collection device cup that sample is analyzed. These devices may be complicated, difficult or dirty for user, or to conceal the case where using illicit drugs recently, can The adulterated problem of sample can be will cause.In addition, urine sample can not be collected in certain occasions, for example in roadside or public arena.

Many other sample collections and test device is inefficiency in terms of extracting sample from collection device, always There are many problems, such as sample leakage pollution environment, and the sample size either collected is very little or too many and influences testing result, Or there are multiple operating procedures, and detection is allowed to become complicated.Many such devices design and manufacture aspect also very at it It is complicated and need using fairly expensive material.Therefore better method and device is needed to be collected and detect sample.

Utility model content

In order to solve the problems in the existing technology, the utility model provides a kind of detection device for detecting fluid-like Analyte and the method for carrying out the analyte in detection fluid sample using the detection device in product, using in this way Device and detection method can provide the more superior operating method of performance and more reliable detection knot to avoid many problems Fruit.

The one aspect of the utility model, the utility model provide a kind of detection device, which includes being used to support survey The base for trying element, has the slot for accommodating testing element in base, further includes the sample for collecting fluid sample in base Product chamber.

In some preferred modes, testing element is provided in the slot, the partially liq sample of testing element is applied Region is added to be located in sample cavity.

In some preferred modes, the device further includes coating, and coating covering is located at the slot in base, To form the channel of part sealing, which can be used to accommodate testing element.Optionally, the coating cover slot from And seal groove.It optionally, include testing element in the channel.

In some preferred modes, the passage portion of the sealing forms the sample cavity to collect fluid sample. In some preferred modes, the sample cavity has an opening, which is located on slot；Optionally, partial groove is not close Envelope, to form the opening, which forms the opening of sample cavity.

In some preferred modes, the base is a slab construction, and multiple receivings are provided in slab construction and are surveyed Try the slot of element.

In some preferred modes, base is the base of rigidity, and coating is coating flexible.Optionally, base With certain thickness base, and the thickness of coating is less than the thickness of base.

In some preferred modes, base be it is transparent, coating be it is opaque, the described opening is located at transparent base On layer；Optionally, base be it is opaque, and coating be it is transparent, the opening is positioned on layer；Alternatively, upper It states in two modes, corresponding opening is provided in base and coating all as the opening of sample cavity.

In some preferred modes, the testing element includes test zone and sample applying zone, wherein test Region is in the downstream of sample applying zone.

In some preferred modes, one layer of coating flexible is covered in the base, the coating allows card Slot forms the channel of part sealing.In some preferred modes, opening is located in base, and the opening is for allowing fluid sample stream Enter into sample cavity.In some preferred modes, opening is positioned on layer.The opening is for allowing fluid sample to be flowed into sample In product chamber, contacted into the fluid sample in sample cavity with the sample segment applying zone on testing element, thus, allow fluid-like Product flow to test zone from sample applying zone, to complete the detection of analyte in sample matter.In some preferred modes In, the partial region of the sample applying zone of testing element is located in sample cavity.In some preferred modes, the sealing For liquid sealing or hermetic seal.

In some preferred modes, in the card slot for accommodating testing element, in addition to for allowing fluid sample to be flowed into sample Remaining card slot part outside opening in product chamber is coated cap rock covering sealing and forms channel.

In some preferred modes, base's rigid structure is disposal molding, in particular, for disposable injection molding Molding.The coating is flexible or rigid, can be covered in base and seal the card slot, to be formed Open at one end, the channel of one end sealing, the partial test item is located in the channel, it is preferred that the marked region of test-strips It is located in the channel of the sealing with detection zone.Wherein, the opening is located in the base of rigidity.Some preferred In mode, opening is located in the base for forming card slot and corresponding with sample segment applying zone.

It include reduction, limitation or the structure for eliminating capillary flow, the structure bit on card slot in some preferred modes In on card slot, particularly, on the face for forming card slot bottom or on the side wall of card slot, so that liquid be allowed to exist to greatest extent It is flowed on testing element without being flowed along the gap formed between test-strips and card slot.So-called gap is capillary gap.Institute The reduction of meaning is to allow partially liq not pass through capillary gap to flow, and so-called limitation is exactly that liquid is allowed not pass through capillary maximumlly Gap flowing, so-called elimination is exactly to allow all liquid not pass through capillary gap to flow, such as 100% prevention, 95% It prevents, 90% prevention, 89% prevention.

In some preferred modes, including the blocked shoot structure of protrusion on the side wall of card slot, which can be with blocking portion Liquid separation body is flowed along the capillary gap formed before test-strips and side wall.For example, being located at the use on card slot bottom or side wall In reduction, limitation or the structure for eliminating capillary flow, on the one hand such as these tenons are for blocking capillary flow.Meanwhile The gap of test-strips and card slot side wall is allowed to be greater than the size that can form capillary flow for these structures so that eliminating liquid passes through survey Strip and the capillary flow of card slot side wall enter sealing card slot channel, generate so-called " mighty torrent " (flooding) phenomenon.

In some preferred modes, the structured channel for reducing capillary flow is located at the upstream of testing element marked region, Perhaps positioned at the downstream of test zone or positioned at the upstream of sample cavity；Preferably, the structured channel for reducing capillary flow is located at The upstream of testing element marked region, alternatively, the structure for reducing capillary flow corresponds to the marked region of testing element and is arranged. In some preferred modes, the capillary gap that so-called capillary flow is formed between test-strips and card slot also or refers to Test-strips and card slot bottom section are formed by capillary gap.

Certainly, the structure of these such as tenons also plays the effect of fixed test-strips simultaneously.

It include the structure released stress or exhaust structure on card slot, when liquid passes through survey in some preferred modes When strip capillary flow enters sealing card slot channel, sealing card slot channel pressure increases.If this pressure is not in channel Structure discharge release, then capillary flow can not continue, test-strips cisco unity malfunction, and it is existing to form so-called " not running plate " As.It is described to release stress or exhaust structure is groove structure in some preferred modes.In a preferred mode In, the groove forms the shape of " a " son or arrow.Preferably, wherein the direction and sample at the top of the arrow Flow direction on testing element is consistent.In some preferred modes, the exhaust or the groove knot released stress Structure is located at the upstream of testing element marked region, perhaps positioned at the downstream of test zone or positioned at the upstream of sample cavity；It is preferred that , the exhaust or the groove structure released stress are located at the upstream of testing element marked region, alternatively, the exhaust Or the groove structure released stress corresponds to the marked region of testing element and is arranged.It is described in some preferred modes Release stress or exhaust structure is located at the bottom of card slot, wherein the structure one end is communicated with the inside of card slot, another part It communicates with the outside world, to be conducive to the exclusion of gas.In some modes, the inside phase of described groove structure one end and card slot Logical, another part communicates with the outside world (such as passing through opening), to be conducive to the exclusion of gas.In some preferred modes, release It bleeds off pressure power or exhaust structure is located at the bottom of card slot, wherein the structure one end is communicated with the inside of card slot, another part and institute The opening stated communicates, to be conducive to the exclusion of gas.

It include the support knot for supporting the sample applying zone of testing element in sample cavity in some preferred modes Structure, so that each region of test-strips be allowed to be in a plane.In some preferred modes, described is used to support sample The support construction of applied area is located in sample cavity.In some preferred modes, sample cavity is by or including bottom, part of covering layer With part base and formed, optionally, sample cavity is by bottom, opening, part of covering layer, and the slot of part is constituted.Some preferred Mode in, in sample cavity include recess side wall.

It include one or more fluid passage on sample cavity in some preferred modes.

Preferably, testing element is provided in the slot, the partially liq sample applying zone of testing element is located at sample In product chamber.

Preferably, detection device further includes coating, and coating covering is located at the slot in base, to form part the The channel of one sealing and the second sealed passage, the first and second sealed passage accommodating portion testing elements, second sealing Channel forms the sample cavity.

Preferably, wherein the base includes the back side and front, the slot position in the back side or front of base, The cladding element is covered on the front or the back side of base.

Preferably, the detection device further includes an opening, and the opening and sample cavity are in fluid communication, to allow liquid It is entered in sample cavity from the opening.

Preferably, the fluid passage is one or more, and the sample of the fluid passage and test-strips applies Regional fluid connection.

Preferably, the upstream of opening is arranged in the fluid passage.Preferably, fluid passage setting is being collected On chamber.

Preferably, the bottom of collecting chamber is arranged in the fluid passage.Preferably, the fluid passage expose portion Test-strips.

Preferably, the fluid passage exposes the end of test-strips.

Preferably, the size of the fluid passage allow the liquid sample being stored in sample cavity because surface tension without It can be by outside fluid passage efferent tract sample cavity.

The utility model provides a kind of method for detecting analyte in fluid sample, this method comprises: providing as before The device in any embodiment is stated, one end with sample cavity is allowed to be immersed in fluid sample, allows it to be kept for a period of time, so After take out, the testing result on read test element.

Alternatively, the utility model provides a kind of method for detecting analyte in fluid sample, this method comprises: providing Such as the device in aforementioned any embodiment, entire detection device is allowed to be immersed in fluid sample, allows it to be kept for a period of time, so After take out, the testing result on read test element.

In some preferred modes, the time for allowing it to keep is -1 hour 1 second.Preferably, allow its keep 1 second, 3 seconds, 5 seconds, 20 seconds, 30 seconds, 40 seconds, 50 seconds, 1 minute, 2 minutes, 3 minutes, 5 minutes, 10 minutes, 20 minutes, 30 minutes, 45 minutes, 1 hour.

In some preferred modes, the mode of immersion is part, is all impregnated.In some modes, including arbitrarily or The free mode of person is thrown into detection device, is inserted into, being dipped into any time in liquid sample.Here any time be 1 second- 1 hour.It can be holding 1 second, 3 seconds, 5 seconds, 20 seconds, 30 seconds, 40 seconds, 50 seconds, 1 minute, 2 minutes, 3 minutes, 5 minutes, 10 points Clock, 20 minutes, 30 minutes, 45 minutes, 1 hour.

Detailed description of the invention

Fig. 1 is the theory structure schematic diagram of the detection device of the utility model, and wherein Figure 1A is the structure of card slot in base Schematic diagram, wherein the left side is the structural schematic diagram of the detection device combined, and centre is the base layer structure signal for including card slot Figure, the right are the structural schematic diagram of coating；Figure 1B is the structural schematic diagram of the testing element in a specific embodiment；Figure 1C is the overlooking structure diagram that testing element is placed in card slot.

Fig. 2 is the schematic perspective view of the testing element of one specific embodiment of the utility model.

Fig. 3 is the structural schematic diagram (back side) of the base in one specific embodiment of the utility model.

Fig. 4 is the part-structure amplification schematic perspective view of the base in Fig. 3.

Fig. 5 is the partial structurtes enlarged diagram of the card slot of the base layer structure in a specific embodiment.

Fig. 6 is the partial structurtes enlarged diagram of the card slot of (products in kind) base layer structure in a specific embodiment (sample cavity position).

Fig. 7 is that the stereochemical structure behind the covering base covering base back side in one specific embodiment of the utility model is shown It is intended to (coating is the back side).

Fig. 8 is the cross-section structure behind the coating covering base back side of the utility model one by one in specific embodiment Schematic diagram (sample cavity).

Fig. 9 is the Facad structure pictorial diagram of base.

Figure 10 is the schematic perspective view that testing element is placed in base.

Figure 11 is the in vitro structural schematic diagram of the lid in one specific embodiment of the utility model, and Figure 11 A is lid Shape solid connects structural schematic diagram；Figure 11 B is schematic diagram of internal structure.The schematic diagram of the section structure of Figure 11 C lid.

Figure 12 be the matrix in the utility model in a specific embodiment schematic perspective view (there is card slot, There is no test-strips).

Figure 13 is the front elevation view of base shown in Figure 12.

Figure 14 is to be provided with test-strips in base shown in Figure 12 in card slot, covers the vertical of one layer of coating on the test strip Body structural schematic diagram.

Figure 15 is the front schematic view (having test in card slot) of the base of detection device shown in Figure 14.

Figure 16 is the use state diagram of detection device shown in figure 15.

Specific embodiment

Below to the utility model relates to structure or technical term used in these be described further.These are said Bright is only how to realize in such a way that example way is illustrated the utility model, can not be to the utility model Constitute any limitation.

Detection

Detection indicates chemical examination or tests a kind of substance or material to whether there is, for example, but it is not limited to this, chemical substance, Organic compound, inorganic compound, metabolism product, drug or drug metabolite, organic organization or organic organization generation Thank object, nucleic acid, protein or polymer.In addition, detection indicates the quantity of test substances or material.Furtherly, table is gone back in chemical examination Show immune detection, chemical detection, enzyme detection etc..

Downstream and upstream

Downstream or upstream are that liquid flow direction is divided, and general liquid flows from upstream to downstream area.Position Receive the liquid from upstream region in downstream area, liquid can also flow to downstream area along upstream region.Here general It is also to be divided according to the direction of liquid flowing, for example, liquid can be on some materials for promoting liquid to flow using capillary force Gravity and flowed to the opposite direction of gravity, divide upstream and downstream also according to the flow direction of liquid this when.

Gas circulation or liquid communication

Gas circulation or liquid communication refer to that liquid or gas can flow to another place from a place, flow In dynamic process guiding function may be played by the structure of some physics.The so-called structure by physics generally refers to liquid warp Cross the space on the surface of the structure of these physics or the inside of these structures and passive or with actively flowing to another Side, passive is usually the flowing received under flowing caused by external force, such as capillarity.Here flowing is also possible to liquid Either gas is also possible to passively flow because of self-acting (gravity or pressure).

Testing element

A variety of testing elements can be with combined application into the utility model.Testing element includes test-strips, analytical test strip It can be there are many form, for example, by using immune or test chemical form, for the analyte in test sample, such as drugs Or the correlative metabolites of instruction physical condition.In some forms, test-strips are (to apply) sample application zone, reagent area with fluid sample With the water-absorbing material of test results zone.Sample is added to sample application zone, flows into reagent area using capillarity.In reagent area, Sample solubilising reagent simultaneously mixed can be used for detecting analyte (if there are analytes in sample), certainly, reagent area It may be the same region with sample applied area, the reagent of some treatment liquid samples is by advanced processing in sample applied area Domain.The sample with reagent continues to flow to test results zone at this time.Other reagent is fixed on test results zone.These quilts The reagent for being fixed on detection zone is reacted and is combined with analyte (if present) or with the first reagent of reagent area. In noncompetitive test format, if there are analytes will generate signal in sample, if analyte is not present, Do not generate signal.In competition test format, signal is generated if analyte is not present in sample, if there is analyzed Object does not generate signal then.The utility model is suitable for the testing element of various analytical forms.

Such as shown in Fig. 1 C and Fig. 2, when testing element is test-strips 20, it can use water suction or unwetted property material Material is made, and multiple material can be used in a test-strips, the transmitting for liquid.A kind of material of test-strips can be superimposed upon separately On a kind of test strip material, for example, filter paper overlaid is on nitrocellulose.Alternatively, at least containing the one of a kind of material in test-strips A region is located at after a kind of another at least region containing different materials.In this case, liquid is between each region Circulation, it can be overlapped mutually or not be superimposed between them.Material in test-strips can be fixed on such as plastics liner It, can holding force to reinforce test-strips on support 27 or hard surface.The test-strips being made of water-absorbent material, liquid is because of capillary Effect, can be flowed on the test strip, the material in each different region can first is that the same, be also possible to it is different, Liquid flowing is kept between the region of these identical materials or unused material composition, in this way, for example sample solution can To be flowed along test-strips.

It (such as at least one enzyme and is detected in the embodiment that some detected materials are detected by signal generation system Specific reaction occurs for object), at least one substance for generating signal can be attracted to the analyte detection zone of test-strips, just It is specifically adsorbed on the material of test-strips as described above the same.Additionally, there are in the sample application zone, reagent area, quilt of test-strips Analyte detection zone, or the generation signal throughout entire test-strips substance can pre-process in advance at one of test-strips or On multiple materials.It can be by the way that the substance solution for generating signal to be added to the surface of application area or by one or more of test-strips Material is immersed in signal solutions and realizes.After test-strips joined signal solutions or impregnate in the solution, test-strips are dried It is dry.In addition, above method is present in the sample application zone, reagent area, analyte detection zone of test-strips, or throughout entire test The substance of the generation signal of item can be pre-processed in advance on one or more materials of test-strips.Additionally, there are add in test-strips The semiochemicals of sample area, reagent area or detection zone can be added to one or more tables of test strip material as labelled reagent Face.

Each region of test-strips 20 can be arranged as follows: a complete necessary test-strips may include that sample applies Region 23, test zone 22.In general, liquid first contacts sample applying zone, it is then based on capillarity and is flowed to test zone 22 Dynamic, certainly, test-strips can also include the following region, sample pipetting volume area or sample applying zone 23 as needed, or Person can include a test results zone 24 on test zone, or also at least one reagent area, at least test zone 22 It including at least one control zone 25, or may include at least one detection of adulterations area and liquid absorption area 21.If detection zone Including a control zone, preferably control zone is located at after the analyte detection zone of test results zone.All these areas or its group Closing can be in the single test strips containing a kind of material.In addition, these areas are made from a variety of materials, and by liquid transmitting Direction links together.For example, different zones can directly or indirectly carry out liquid transmitting.In the present example, different area It can be connected along the direction end that liquid transmits with end, or be overlapped mutually along liquid direction of transfer, or pass through other materials It is connected, such as connection dielectric material (preferably water-absorbing material such as filter paper, glass fibre or nitrocellulose).With connection When material, connecting material can make end and material, the end comprising each region and the end phase of joining distal ends comprising each region It connects but material that liquid does not circulate or comprising each region overlapped (being such as, but not limited to overlapped from the beginning to the end) but liquid does not flow Logical material forms liquid communication.

If test-strips contain detection of adulterations control zone, which can be placed on before or after result detection zone.Work as knot Fruit determines that control zone is contained in area, and adulterated control zone is preferably positioned at before control zone, may not be such situation.This is practical Novel one embodiment, test-strips are the control test-strips for judging and/or controlling for adulteration analyte, and adulterated control zone can be with Before or after control zone, it is preferably placed at before control zone.

In specific embodiment of the present utility model, the testing element or test-strips of any mode can be located at base 104,30 card slot is perhaps in slot 100 or channel that the card slot that is positioned in element covering base is formed.It is formed in this way Channel wish that it is provided solely for accommodating test-strips place, and be not intended to the transmission for carrying out or participating in fluid sample, It is flowed on the test strip in this way, only hoping tested fluid sample by the capillarity of test-strips itself.But often Often consider cost and be desired with the test of a variety of different analytes, often places and test in each of multiple card slots Item, such as 10 test-strips can test 10 different analytes.The card slot formed in this way just influences whether to survey test Testing result on item, this may be that card slot and test have the reason of physical contact, and this physical contact just will affect test The elaboration performance of liquid on item, and then influence the accuracy and validity of test.How test-strips are arranged in the utility model Detection device in can elaborate explanation below, and how effectively to be avoided above-mentioned technical problem, also can be Followed by detailed description.

Sample

It include biofluid (such as casing fluids or clinic with the sample that the detection device of the utility model can detecte Sample).Fluid sample or fluid sample can be from the sample of solid-state or semisolid, including excreta, biological tissues And food samples.The sample of solid-state or semisolid can be converted to fluid sample using any method appropriate, such as mix, It smashs to pieces, macerate, being incubated for, dissolving or (such as water, phosphate solution or other buffer solutions) utilize enzymatic hydrolysis in a suitable solution Act on digestion of solid sample." biological sample " includes deriving from animal, plant and food samples, for example including from people or dynamic The urine of object, saliva, blood and its ingredient, spinal fluid, vaginal fluid, sperm, excrement, sweat, secretion, tissue, organ, Tumor, the culture of tissue and organ, cell culture and medium.It is preferred that biological sample is urine.Food samples include food processing Substance, final products, meat, cheese, wine, milk and reference water.Plant sample includes being derived from any plant, and plant tissue is planted Object cell culture and medium." environmental sample " from environment (for example, from lake or the fluid sample of other water bodys, Sewage sample, soil property sample, underground water, seawater and waste liquid sample).Environmental sample may also include sewage or other waste water.

Using the utility model and suitable detecting element, any analyte can detecte.It is practical new preferably by this Drugs small molecule in type detection saliva, urine.

Analyte

It can include some haptens substances, these haptens packets with the example of the analyte involved in the utility model Include drugs (such as drug abuse)." drug abuse " (DOA) refers to that the work of paralysis nerve (is usually played using drug in non-medical destination With).It abuses these drugs and will lead to body & mind and be damaged, generate dependence, addicted and/or dead.Drug is indiscriminate Example includes cocaine；Amphetamine AMP is (for example, black beauty, white amphetamine tablet, dextroamphetamine, dextrorotation Amphetamine tablet, Beans)；Crystal methamphetamine MET (crank, meth, crystal, speed)；Barbiturate BAR (such as Valium, Roche Pharmaceuticals, Nutley, New Jersey)；Sedative (i.e. sleep adjuvant Product)；Lysergic acid diethylamide (LSD)；Inhibitor (downers, goofballs, barbs, blue devils, yellow Jackets, methaqualone)；The anti-antidepressant of tricyclic antidepressants (TCA, i.e. imipramine, amitriptyline and doxepin)；Two methylenedioxy groups Methylaniline MDMA；Phencyclidine (PCP)；Tetrahydrocannabinol (THC, pot, dope, hash, weed, etc..)；Opiate (i.e. morphine MOP or opium, cocaine COC, heroin, hydroxyl dihydrocodeinone)；Anxiolytic and hypnotic sedative agent resist Anxiety medicine is that one kind is mainly used for anxiety reduction, anxiety, fear, sets the mind at rest, has the drug of hypnosis sedation, including benzene concurrently Diazepine BZO (benzodiazepines), atypia BZ class, fusion phenodiazine NB23C class, benzene nitrogen Zhuo class, BZ receptor are matched Body class, open loop BZ class, diphenylmethane derivatives, piperazine carboxylic acid salt, piperidine carboxylic acid salt, Kui oxazoline ketone, thiazine and thiazole Derivative, other heterocyclics, imidazole type calmness/anodyne (such as hydroxyl dihydrocodeinone OXY, methadone MTD), propylene glycol are derivative Object-carbamates, aliphatic compound, anthracene derivative etc..It can be used for examining using the detection device of the utility model The detection for belonging to medical usage but being easy overdose is surveyed, such as tricyclic antidepressant (imipramine or the like) and acetyl ammonia Base phenol etc..These drugs can resolve into different small-molecule substances after being absorbed by the body, these small-molecule substances be present in blood, In the body fluid such as urine, saliva, sweat or part body fluid there are above-mentioned small-molecule substances.

For example, with the utility model detect analyte include but is not limited to, creatinine, bilirubin, nitrite, Albumen (non-specificity), hormone (for example, human chorionic promotes sex hormone, luteinizing hormone, follicular stimulating hormone etc.), blood, white blood Ball, sugar, heavy metal or toxin, bacterial components (albumen or glucide as being directed to specific bacterial, such as such as Escherichia coli 0157:H7, staphylococcus, salmonella, fusobacterium, Campylobacter, L.monocytogenes, vibrio or cactus bar Bacterium) and urine sample in substance relevant to physiological characteristic, such as pH and specific gravity.Other any Clinical Urinary chemical analyses are all using lateral Flow test format cooperation utility model device is detected.

Detection device

The so-called detection device of the utility model, which is available with any technical principle, can detecte sample (such as fluid-like This) in analyte presence whether perhaps existing quantity, that is, qualitative or quantitative detection.Detection device includes detection sample Middle analyte exists in product or the testing element of quantity can also include accommodating testing element other than testing element Device.

The detection device of the utility model includes base, includes the slot for accommodating testing element in base, and cover Lid seals the cladding element of the slot.In this way, cladding element can cover testing element or be sealed in slot, so as to Carry out the test of sample.Preferably, detection device further includes sample cavity, wherein the sample applying zone position of partial test element In sample cavity.Preferably, sample cavity is by partial groove, coating composition.In some preferred modes, has in base and open Mouthful, the opening is for allowing liquid sample to enter in sample cavity.In some preferred modes, there is opening, this is opened on coating Mouth is for allowing liquid sample to enter in sample cavity.

The detection device of the utility model can also be combined with other equipment, to complete analyte in sample The detection of matter, such equipment can be testing result and reads equipment, and scanning device etc. reads testing result, storage result number According to or carry out data transmission etc..Certainly, the detection device of the utility model can also be arranged in some containers, such as In cup body, cup body includes some cavitys for collecting fluid sample, and the detection device of the utility model is arranged on the cavity of cup body In, after cup body collection has fluid sample, test-strips contact of the fluid sample just and in detection device, to complete detectionization It tests.

Base, cladding element, testing element

The detection device of the utility model includes base, includes one or more card slot in base.Example is as shown in figure 1 Figure 1A among schematic diagram indicate one include card slot detection device.It include a card slot 100, base 104 in base 104 With certain thickness, the slot (and being properly termed as card slot, the channel of opening) of certain depth, the card slot can be opened in base 100 width with the width of testing element is suitable for accommodating, the width of test-strips, such as test-strips 20, card can also be greater than Groove depth is suitable with the thickness of test-strips, can also be greater than the thickness of test-strips.Generally, for save the cost and detection device Miniaturization, the width of card slot less times greater than test-strips width, the depth of card slot less times greater than test-strips thickness, sometimes, Allow the width of card slot be equal to perhaps the width card slot of slightly less than test-strips depth be slightly less than or equal to test-strips thickness Degree.Since card slot is located in base (the intermediate schematic diagram of Figure 1A), it is only necessary to cover one layer of coating 101 in base, so that it may To seal entire card slot, card slot is allowed to form the channel of sealing, the channel formed in this way can accommodate testing element (the right of Figure 1A Schematic diagram)；Such as the channel of sealing accommodates the detection zone and marked region of testing element.Certainly, optionally, sealing is logical Road accommodates the suction zone of testing element, marked region and testing result region and testing result control area (Fig. 1 C).

Generally, first provide include card slot base, in the one side of base be provided with the comparable card slot of test-strips length, Then the card slot is placed on test-strips 20 in card slot outside being completely exposed to, allow the back side of test-strips downward (with support construction 27 One side), allow face-up (one side that can see that detection zone or filter paper).One cladding element 101, covering member are provided Part includes the opening 103 between the first overlay area 810 and the second overlay area 102 and the firstth area and second area.Most Afterwards, cladding element is covered in base, thus, it allows the test zone of 810 coverage test element of the first overlay area, allows second Overlay area 102 covers sample segment applying zone, allow opening 103 expose portion sample applying zones, in this way, such as Figure 1A In 102 positions, this 102 actually belongs to a part of cladding element 101, and covers the part cladding element 810 of card slot Also card slot is covered, so that the channel for forming one end sealing is used to accommodating portion test strip element.It is provided on cladding element 101 Opening 103 is for exposing the sample segment absorption region 23 of testing element.In this way, one end of card slot is by the part card slot in base Sample cavity is formd with the second overlay area 102 of cladding element.For collecting sample, the height of the sample cavity takes the sample cavity Absolutely in the length of part cladding element 102, volume depends on the depth of card slot and the height of cladding element 102, so sample Volume can be changed by the depth of card slot and the height of cladding element 102 come any adjusting, typically upon the ruler of test-strips After very little and card slot size determines, the volume of sample cavity is also determined that, to play the role of fixed sample volume.In addition, covering First overlay area 810 of cap member forms the channel of sealing with part card slot, allow testing element testing result region and mark Note region is located in the channel of the sealing.It can say in this way, due to cladding element opening 103, thus the card slot entirely sealed It is divided into the channel of two sealings, is partially covered sealed passage (one end sealing, the other end that the card slot of the covering of element 810 is formed Non-tight, the first sealed passage) it is used to accommodating portion test strip element, such as accommodate testing result region and the mark of testing element Remember region, which is known as the first sealed passage；And the channel of another section of sealing (is partially covered the covering of element 102 The sealed passage that card slot is formed) sample cavity is then formed, the channel of two sealings is communicated with the outside world by common opening 103, And opening 103 is used to that fluid sample is allowed to enter in sample cavity.In this way, facilitating collection fluid sample, fast and easy detection is also square Just more flexible arbitrarily to be detected, it can be completed without too many professional knowledge and technical ability, to increase detection Easiness and use friendly letter.

It is a concrete form of testing element, test-strips 20 as shown in Figure 1B comprising sample applying zone 23 and survey Region 22 is tried, if it is possible, test-strips can also include marked region 26 and sample absorption region 21, such as test zone 22 For nitrocellulose filter, sample applying zone can be glass fibre.It may include test result region 24 on test zone With test result control area 25.The downstream of sample applying zone 23 is marked region 26, and the downstream of marked region is detection zone Domain 22 includes test result region 24 and test result control area in detection zone, and the downstream of test result control area is Sample absorption region.

When assembling the detection device of the utility model, card slot 100, this formation are formed first in base 104 The mode of card slot can be that injection molding is disposable to be formed, and then test-strips 20 are placed in card slot 100, allow the liquid absorptions of test-strips The one end in region 21 is located at the top of card slot, and allows the region 23 for applying sample to be positioned near element opening, and corresponding The position of opening 103.Finally, covering one layer of cladding element 101 in base, opening 103 is provided on cladding element, to allow survey The sample segment applying zone 23 of examination element is exposed to outside by opening 103, in addition, applying on testing element in sample Add the end in region 23 be located in sample cavity (left side of Figure 1A is the test device 10 completelying form, centre be include card slot Base, the right are cladding element).Form top view such as Fig. 1 C of complete test device, the only sample on partial test element Outside product applying zone is exposed to, and in the sample cavity of another part sample applying zone position.Here, base can be it is transparent or It is nontransparent, and coating can be partially transparent, for example, corresponding to testing result region and/or the testing result of testing element Control area be it is transparent, thus aspect read detection zone as a result, and other parts can be nontransparent.

When needing to detect, test device (is shown shown in the schematic diagram or Fig. 1 C on the left side as shown in Figure 1A It is intended to) it is inserted into fluid sample, such as in urine, fluid sample is entered in the sample cavity in card slot by opening 103, is inserted into The depth of liquid, which can be, just floods the entire cladding element 102 for constituting sample cavity or liquid level higher than part cladding element 102 any height, or even entire test device is submerged in fluid sample.Allow in this way liquid be easy by opening 103 into Enter into sample cavity.It in insertion fluid sample, can take out at once, or slightly equal a period of time further takes out, then level It places, test device can also be stayed in fluid sample will always, in this way as fluid sample enters sample cavity, liquid contacts sample Product applying zone, liquid flow to marked region 26 from sample applying zone 23 along test-strips, then flow to the test in downstream Region is finally absorbed region 21 and absorbs and (flow in the direction of such as arrow of Fig. 1 C).Due to also collecting or protecting in sample cavity There are samples, for the absorption of test-strips and can complete to test enough, overcome the insufficient defect of amount of liquid on traditional technology, Because sample deficiency can cause the possibility that cannot complete test, this is because fluid low, cannot complete in testing element On completion flowing, such as only flow to the upstream in testing result region 24 and just do not flow, or flow to test results zone When domain 24, liquid is seldom, cannot moisten the region.

The device of the utility model provides more free operation comfort and randomness for tester or operator. For example, it is also possible to entire test device is submerged in fluid sample, it is this flood during, liquid can't enter packet Include in the channel of the sealing of marked region and detection zone that (referred to as the first sealed passage here, one end sealed, and the other end is logical Cross the opening 103 on such as cladding element and non-tight), this is because this section of one end of the channel is sealing, the other end is by opening Mouth 103 can enter hydraulic seals of the liquid to be entered, so, there is one section of gas to be sealed in the channel, in this way, liquid Almost downstream can only be flowed from upstream to along test-strips based on the capillarity in test-strips, without having additional liquid It enters in channel, avoids excessive detection liquid and enter in the first sealed passage, to cause so-called " mighty torrent " existing As and to test result causes the influence of inaccuracy.This provides greatly operation for detection and freely facilitates, and allows operation in this way Person (such as doctor or laboratory testing personnel) can directly throw away detection device into liquid sample, wait reactions complete or After person has testing result, the reading that detection device carries out testing result is just taken out.

In addition, traditional similar detection device needs to be inserted into time enough in fluid sample, it is desirable to obtain enough Sample, and sample cavity is arranged close to one end of test-strips sample absorption region in one end of card slot in the utility model, it can be quick Insertion liquid in, quickly take out because having there is enough samples to enter in sample cavity, to improve the effect of detection Rate, especially when detecting multiple samples in the limited time, the advantage of the present apparatus is more prominent.This is because this reality With novel detection device tool there are two the channel sealed, the channel of two sealings is opened on extraneous phase by being located in the middle Together, long sealed passage accommodates the marked region of test-strips, test zone and test result control area, it might even be possible to wrap Include sample absorption region, and shorter sealed passage accommodating portion sample applying zone, and a part of sample of exposure that is open applies Region, in this way when such detection device, one end with sample applying zone is immersed in liquid sample, such as urine In, it is thus only necessary to it is sufficient within several seconds, because sample just passes through opening, and to have entered shorter second close during immersing It is inner into storage that (sample cavity is formd) in envelope channel, to continue to provide fluid-like after taking out in fluid sample to be subsequent This, because liquid sample is open by the capillary flow of test-strips on the test strip from upstream in the moment for immersing liquid sample It to downstream flow, takes out quickly, the liquid being stored in sample cavity can continue to provide the flowing of liquid, to complete to detect. So the efficiency of operator can be with the improve of highly significant.And the detection device of the similar the utility model card form of tradition, do not have There is included sample cavity, thus need more times that the sample applying zone of test-strips is allowed to be immersed in fluid sample, thus Detection effect is not high.

In other modes, since part cladding element 810 covers the card slot of part, when testing element is located at card slot In, due to the state of part card slot (parts of 810 covering card slots) in one end sealing；When detection device is inserted into liquid-like When in product, sample will not be entered in the channel formed by the card slot that part cladding element 810 covers, due to the channel one End for sealing, one section of gas of hydraulic seal of entrance in the channel of the card slot, thus, no matter detection device is inserted into liquid-like Time in product have how long, being inserted into liquid has mostly deep, and liquid will not all flood test zone and marked region, to guarantee The accuracy of detection.More preferably in mode, marked region and test zone on testing element are partially covered element 810 cover sealing.More preferably, be open 103 position is located under marked region and retains sample segment applying zone 23.More preferably, sample segment applying zone is located in sample cavity (Fig. 1 C).The detection device formed in this way, in operation When, operator does not need that the detection for observing such card form always is needed to fill as the detection device of traditional card form It sets and whether is correctly inserted into all certain liquid level, worry whether have sufficient time to contact liq sample, also do not need one It is straight to pay attention to whether keeping vertically in a liquid.And the detection device of the card form for the utility model, it can also arbitrarily put very much Enter into fluid sample, even if the entire detection device of the utility model is submerged in liquid sample completely, will not influence to survey Test result has in the reagent areas for playing detection function because liquid cannot enter, and only in sample applying zone Position provides more sufficient liquid sample, ensure that the amount of liquid required for detecting.Below can in conjunction with specific embodiment into The elaboration of one step.

It is described above only single test-strips be example come illustrate the utility model device this how to realize, certainly, base It may include multiple similar card slots on layer, cladding element can equally seal the multiple notchs of covering, to be formed multiple Opening, each corresponding sample cavity that is open, and each sample cavity is relatively independent existing, in this way, can be for A same fluid sample detects a variety of unused analytes.

The base of the utility model can be rigid base, such as plastics, aluminium alloy etc., coating can be flexible or The coating of person's rigidity.Optionally, base and coating are all rigid, and base and coating are bonded；Or base is Flexible layer, coating are rigid.In some preferred modes, base generally has certain thickness, in the slot of upper formation With suitable depth and width, covering is covered on slot at an only film layer and seal groove.In some preferred modes In, base has certain thickness, and coating also has certain thickness, card slot slot is provided in base, on the cover layer It is provided with card slot, when base and cover layer face opposite bonding, respective slot is corresponding, so as to form channel, in the channel Testing element is placed, no matter is provided with an opening in base or on coating, which is located at the centre of slot close to test-strips Sample applying zone attachment one end, in this way, being formed sample cavity, which can be with accommodating portion sample.For example, in base Do not include the opening 112, and opening 112 (such as Fig. 1 C) is set on the covering element, the opening and sample cavity fluid connect Logical or base is provided with opening 112, and is not open 112 (Fig. 8) in cladding element；Again alternatively, in base and cladding element On all identical position setting opening 112, two opening with sample cavity be in fluid communication.

In some preferred modes, base is rigid, and in the multiple card slots of base's upper opening, person's coating is transparent With it is flexible or partially transparent, particularly, the place corresponding to test zone is transparent.It is preferred in other In mode, base is not transparent, and coating is transparent；Alternatively, base is transparent, and coating is not transparent. When the front of testing element faces base, base can be fully transparent perhaps partially transparent or base and correspond to Test zone and/or marked region on testing element are transparent (Fig. 3).Optionally, when the front of testing element is in face of covering When cap rock, coating can be fully transparent perhaps partially transparent or coating corresponding to the test on testing element Region and/or marked region are transparent (Fig. 1 C), and base can be it is transparent or opaque.

The method that card slot is formed in base can be through injection model and disposably complete, can also by laser erosion come Form notch.The material that the base of rigidity can be such as " thermoplasticity " is constituted, and " thermoplasticity " is referred to herein as hot melt Plastic polymer, becomes fluid when being heated, and cold enough is that can be frozen into vitreous substance.This heat Plasticity can be the polymer of high molecular weight material, connect between its chain and chain by weak Van der Waals force, stronger dipole- The accumulation of dipolar interaction and Hydrogenbond or aromatic ring.Thermoplastic material may include other component substances, such as swash Light sensitive species.Some examples of thermoplastic material can be the polymerization of acronitrile-butadiene-styrene polymerization (ABS) acrylic acid (PMMA), celluloid, cellulose acetate or cellulose ethanoate, the dilute copolymer of ring (COC), ethylene-vinyl acetate (EVA), ethylene-vinyl alcohol (EVOH), fluoroplastics (PTFE, have FEP, PFA, CTFE, ECTFE, ETFE), ionomer or from Sub- cross-linked polymer, acrylic acid/PVC, alloy, liquid crystal polymer (LCP), polyethylene (POM or acetal), polyethylene (propylene Acid), polyacrylonitrile (PAN or acrylonitrile), polyamide (PA), polyamide-imides (PAI), poly(aryl ether ketone) (PAEK or ketone), Polybutadiene (PBD), polyethylene (PB), polyethylene terephthalate (PBT), polycaprolactone (PCL), polytrifluorochloroethylene (PCTFE), polyethylene terephthalate (PET), ethylene terephthalate (PCT), polycarbonate (PC), poly- hydroxy aliphatic Sour (PHAs), polyketone (PK), polyester, polyethylene (PE), polyether-ether-ketone (PEEK), polyether ketone ketone (PEKK), polyetherimide (PEI), polyether sulfone (PES), polyethylene chlorine (PEC), polyimides (PI), polylactic acid (PLA), polymethylpentene (PMP), oxygen Change polyphenyl (PPO), vulcanizes polyphenyl (PPS), polyphthalamide (PPA), polypropylene (PP), polystyrene (PS), polysulfones (PSU), polypropylene terephthalate (PTT), polyurethane (PU), polyvinyl acetate (PVA), polyvinyl chloride (PVC), Polyvinylidene chloride (PVDC) and polystyrene-acrylonitrile (SAN).

Cladding element can be polymer formation, such as plastic film, and the flexibility that the materials such as double-sided adhesive, polymer are formed is covered Cap member, the element can be covered in rigid base, so that sealing is located at the card slot in the base of rigidity, be also possible to The thin layer material for stating base material formation is formed, or the thin layer flexible material formed.Here so-called " rigidity " and " flexibility " It is opposite concept, and nisi concept.

In other some specific embodiments, as shown in figure 3, the detection device of the utility model includes base 30, The material for forming the base can be plastics, and by being molded disposable formation, one or more is arranged in the base 30 Card slot 100, card slot have certain depth and width, and the width of testing element of width and receiving of card slot is suitable, can wait Wide or slightly wider than test-strips width, the length of card slot and the length of test-strips are suitable, can also be slightly longer than test-strips The length back view of base (Fig. 3 be).As preferred mode, one end of card slot, setting is solid on one end of base 130 Determine structure, such as the blocked shoot structure 108,1081 of a pair of of protrusion is separately positioned on 1002 on the opposite side wall for constituting card slot, 1003 (Fig. 4), the protrusion keep testing element to be in relatively fixed position in card slot.

There is opening 112 in one end close to base 132, there is opening 112 on each card slot, but the opening is simultaneously Do not reach the bottom end 132 of card slot, but reserve certain position 902 (Fig. 7), the reserved part 902 in front with it is subsequent The cladding element being covered on card slot is formed together sample cavity (Fig. 8), in this way, when multiple card slots are formed in base, Sample cavity just is formed in one end of each card slot 132, to just have test-strips or each sample in each sample cavity All the sample applying zone of accommodating portion, each test-strips can be directed to the detection of different analytes in chamber.Each A relatively independent space is formed due to the side wall of card slot between sample cavity.Be between these sample cavities be individually present without It can be carried out being exchanged with each other for liquid, in this way, all with the fluid sample of same property in multiple sample cavities, but due to test member Part sets different analytes, so, it can detecte a variety of different analytes.One is both met in this way Kind fluid sample can detect a variety of different analytes simultaneously, while also avoid the test with different assay substances Interfering with each other between item, each sample cavity is relatively independent after all.In addition, test-strips (the test for the assay substance having Region, marked region) one section be sealed in channel, in generally longer vertical passage, and the card slot other end, formation compared with The sample applying zone of (sample cavity) only accommodating portion, more seals the phase between different test-strips in short sealed passage Mutually influence.

Certainly optional, in the position of opening 112, each card slot is also possible to not be individualism, and is being open Place forms a region not separated without partition 1120, in this way and feasible (partition-type structures as shown in Fig. 4).When So optional, sample cavity generally corresponds to a test-strips, and certainly, the side wall for forming the card slot of sample cavity can also remove, in this way, Multiple public big sample cavities of test-strips.

In addition, including that can play reduction, prevention or the structure for limiting capillary flow on card slot.What is designed in this way In card slot, mainly there are two positions in the place in generation capillary gap, and one is between test-strips side and the sidewall surfaces of card slot Distance there may be capillary gaps, to generate capillary flow, such capillary flow is not intended to generate, this is because Capillary flow as producing will lead to the liquid that liquid is flowed earlier than the capillarity based on test-strips itself in advance and arrive Up to downstream area, so that liquid in advance can dissolve or moisten test-strips, and cause abnormal detection, we term it not Normal liquid sample or additional liquid sample.It is only fluid sample that this, which is primarily due to improper capillary flow, Circulation, and rely on the normal liquid of test-strips capillarity itself can be with the reagent of dissolution process on the test strip, such as mark Reagent, reagent of handling liquid samples etc., to will not influence the accuracy and sensibility of detection.Generally, it reduces to greatest extent Improper liquid enters in the channel of sealing, and more normal liquid is allowed to pass through the absorptions of test-strips itself, in this way It could preferably allow result more accurate, on the contrary, will affect the hair in test-strips if not controlling the entrance of improper liquid Spy uses, to eventually lead to the testing result of inaccuracy.

As shown in figure 4, for example, card slot side wall close to opening 112 position on be also provided with a pair of of blocked shoot structure 1008, 1018, which can not only play the role of fixed test, but also have the structure for more having other functional meanings.The structure Reduction, prevention or limitation capillary flow can be played.For example, the structure can be from side wall protrusion, when testing element and card slot Width quite or it is close when, testing element is put into card slot, the tenon of the protrusion squeezes test-strips, Cong Errang Side wall of the side of test-strips apart from card slot has certain distance, which is greater than the size for forming capillary, to cannot be formed Capillary flow, in this way, tenon plays the role of reduction or limitation capillary.In addition, just at last may be in test-strips and card slot side There is capillary gap between wall, but blocked shoot structure and the close forceful contact of test-strips, in the liquid that tenon upstream is come in tenon Place is blocked, so that liquid cannot continue flow further downstream along capillary gap, so that the liquid for avoiding passing through capillary gap is early Downstream area, such as marked region or detection zone are reached in the liquid of test-strips.The position one of the card structure of this protrusion As be preferably placed at the upstream of marked region perhaps sample applying zone downstream perhaps positioned at the upstream of detection zone or It is correspondingly arranged with marked region.Preferably, it is close to be generally located on first for this structure for reducing, preventing or limit capillary flow It seals in channel.This structure for reducing, preventing or limit capillary flow, when the upstream for being arranged on marked region, in addition One advantage is exactly that in some cases, more liquid will not be allowed to enter in the first sealed passage, and make the first sealing logical The more deterministic hydraulic seal being entered in road, so that one section of closed gas is formed in the first sealed passage, to guarantee The independent detection of testing element.This is to should be, and liquid enters the first sealed passage by opening, is one from microcosmic A progressive process, it is always desirable to after liquid can be open by opening into the first sealed passage, no longer enter in channel, position Blocked shoot structure in marked region upstream, which just plays, prevents liquid from entering the barrier in channel, to more ensure the sealing of liquid Performance.In this way, can just better meet can arbitrarily immersing in liquid sample for utility model device, or even freely it is thrown into It can be entered in the first sealed passage into liquid sample without worry liquid, enter all first so as to cause improper liquid In sealed passage.

In some preferred modes, the structure of capillary flow is reduced, such as blocked shoot structure is located at testing element mark zone The upstream in domain, perhaps positioned at the downstream of test zone or positioned at the upstream of sample cavity；Preferably, the knot of capillary flow is reduced Structure groove is located at the upstream of testing element marked region, alternatively, the structure for reducing capillary flow corresponds to the label of testing element Region and be arranged.In some preferred modes, the capillary gap that so-called capillary flow is formed between test-strips and card slot, Also or refer to that test-strips and card slot bottom section are formed by capillary gap.In addition, the structure of similar tenon can also be one A little others structures, as long as one or more functionally similar structure with above-mentioned introduction, such as blocked shoot structure It is actually upward from the surface of card slot side wall, higher than the plane of side wall, so that card slot be allowed to become narrow, tenon at tenon It can be the surface for being symmetrically distributed in two side walls, it is certain also not necessarily symmetrical.In addition, reducing, preventing or limiting The quantity of the structure of capillary flow can be multiple, and any position that they are distributed in card slot is ok, and can be single card Bamboo shoot structure is also possible to the distribution straggly of multiple blocked shoot structures, and not necessarily symmetrical.Certainly, such structure can be The side wall of card slot has recess, although this recess will not enhance stationarity of the test-strips in card slot, allows test-strips The side wall of side and card slot increases distance, and this distance is greater than the distance of capillarity.The position of recess, which can be located at, to be surveyed The upstream of strip marked region, the latter are located at the downstream of opening, or the non-tight end entrance positioned at the first sealed passage Downstream.

In some preferred modes, as shown in figure 4, further including reducing, prevent or blocking capillary flow in card slot Other structure, which can reduce liquid sample along shape between test-strips and the bottom 1001 of card slot to greatest extent At capillary structure flowing (this be another there may be the positions of capillary flow), thus allow to greatest extent liquid sample only Only along being flowed in test-strips.This is because when test-strips are placed in card slot, in general situation, the front of test-strips (one side of the test zone and marked region that can visually see) is all the bottom faces 1001 of direct contact card slot, thus, Will form gap structure, such as capillary gap structure between the bottom faces 1001 and test-strips of card slot, when detection device according to The above method is inserted into (immersion) into liquid sample, and partially liq specimen port is absorbed by sample segment applying zone, is partially entered To sample cavity, may partially be flowed up by will form capillary gap between bottom faces 1001 and the test-strips front of card slot, To which liquid sample can be caused to moisten marked region or test zone in advance, and can postpone to reach mark from the liquid in test-strips Region and test zone are remembered, so as to cause the inaccuracy of test result.When serious, will cause test-strips be can not work normally.

In order to avoid such problems appearance, the utility model further includes the structure for reducing capillary flow in card slot, should Structure can reduce or avoid the liquid capillary flow outside test-strips.That is, the capillary structure can be maximum It allows liquid only to flow on testing element by the capillary force of test-strips itself, and reduces and formed between test-strips and card slot Capillary gap flowing.In some preferred modes, as shown in figure 4, reducing the structure bit of the capillary flow except test-strips In on the bottom of card slot 1001, the structure is one or more groove 1004,1005,1006, these grooves can be inhaled Receiving portions fluid sample continues to flow so as to avoid the capillary gap that liquid sample is formed along test-strips with card slot bottom. Groove structure can be multiple or one, and multiple grooves can be as shown in Figure 4, and groove forms " Y " sub- shape, also cocoa To be in the form of other are any, such as cross, letter shapes are round, rectangle, square, diamond shape, ellipse etc..Certainly, Groove is a kind of one of structure for reducing capillary flow, such as can also make hole, hole, the trace portrayed or channel etc., this Liquid sample can be generally adsorbed by huge surface area a bit or liquid sample is prevented to continue to flow, such as liquid once encounters When reducing the structure of capillary flow, liquid, which is just adsorbed, perhaps to be stopped and cannot or cannot downstream flow substantially forward It is dynamic.

These structures for reducing capillary flow can be covered in the bottom faces 1001 of entire card slot, can also be confined to Position.Preferably, these structures for reducing capillary flow are located at a certain position of card slot.In some modes, these reduce hair The dynamic structure of thread is located at the upstream of test-strips marked region 26, when meeting between the bottom faces and test-strips for having liquid to pass through card slot Capillary gap is formed when flow up, the presence of the structure due to reducing capillary flow, liquid be prevented from here or It reduces, so that liquid sample will not moisten marked region in advance.In some preferred modes, the structure bit of capillary flow is reduced In the corresponding position of marked region.

In some preferred modes, reduce capillary flow structure be located at opening 112 downstream, marked region it is upper Trip.Alternatively, the structure for reducing capillary flow is located on the bottom 1001 of the card slot near opening.

It can also include the another of fixed test-strips in the structural acessory for reducing capillary flow in some preferred modes To structure 1018,1008, to test-strips can be allowed to be fixed in card slot with the fixed structure of different location on card slot (Fig. 4).From Fig. 4 and 3 it can also be seen that card slot 100 has the side wall 1002 of bottom 1001 and two corresponding edge formation, 1003 form, and along come the depth that limits card slot, bottom 1001 limits the width of card slot.When card slot is formed in base It waits, base has certain thickness, in this way, the slot of certain depth could be formed in base easily to place with one Determine the testing element of thickness.In fact, being used to form the base of card slot has two sides, it is that (having can be with for one side for opening card slot The referred to as back side of base), it is another side (front for being properly termed as base) as card slot bottom 1001.As bottom surface 1001 The one side of the thickness of card slot, such as the thickness signified with a thickness of mark 1007 are set, and thickness can be 1 millimeter to 8 millimeters, example Such as the different thickness such as 1 millimeter, 2 millimeters, 4 millimeters, 5 millimeters or 8 millimeters, the thickness of this base can be according to different needs Arbitrarily selected.Herein, the bottom 1001 of card slot is not complete, but is the knot of hollow out with a distance Structure, i.e. hollow out formation opening 112, but the not all hollow outs in the bottom 1001 of card slot, but the position hollow out in centre, Other two part is remained, a part is exactly to reduce capillary for supporting the detection zone part for surveying test-strips or being formed The structure of flowing, and another is exactly a part of structure to form sample cavity.The opening 112 for forming hollow out can be any length Degree, any area, the opening of any shape, such as rectangle, square, circle, diamond shape are generally open for receiving liquid Sample into sample cavity, on the other hand, the opening be used for expose portion test-strips, such as expose portion sample applied area Domain.

In addition, allowing test-strips to balance placement in card slot, in pair of tenon 1008,1018 for more preferably fixed test-strips The bottom for the card slot answered has slightly convex region, such as shown in the figure, region represented by region 1130,1131 Position is slightly higher than 1132 region of region.The height in two regions can be higher by 11321 millimeters, 2 millimeters of region or its Its height.

In this way, the back side of base is as shown in figure 3, front is as shown in Figure 8.It is placed in card slot when testing element 20, allows survey One end of the suction zone 21 (Fig. 2) of element 20 is tried close to 130 ends of base, one end with sample applying zone 23 is close to base One end of layer 132, and sample applying zone is allowed facing to the front, to can see sample by opening 112 with absorbing material The absorbing material of absorption region, such as glass fibre or other fibrous materials (Fig. 1 C or Figure 10 or Fig. 2).Place test-strips Afterwards, the coating 900 (Fig. 8) of one layer of flexible material is covered at the back side of base.To seal entire card slot 100.To be located at The entire card slot at the base back side seals covering (Fig. 7), this when, in each card slot, close to base 132 in coating cap rock One end forms sample cavity (the second sealed passage), and the sample segment applying zone 23 (Figure 10) on testing element is located at sample cavity In, part of sample applying zone is exposed in opening 112, and remaining part, such as marked region, test zone and suction It receives all coating cap rock covering in region to be sealed in the card slot of the other end of base 130 (front shown in Fig. 9), so-called the One sealed passage, two channels all have an entrance, at the same two channels by opening 112 by partial partition, also all and outside Boundary communicates.When base is the plastics of transparent material, test zone and marked region can be seen through the front of base. Certainly, herein, test-strips be also possible to be with the test-strips direction in previous example it is opposite, allow the back side (bands of test-strips Have the one side of support chip 27) directly by the bottom 1001 of contact card slot, and allow sample absorption region, detection zone or absorption The one side of region or marked region is arranged in face of cladding element, in this way, cladding element 900 is covered on again the back side of base, To seal entire card slot, but cladding element is transparent, and seen in the opening 112 for passing through base is the sample of testing element The back side of supporting surface 27 where product applying zone, rather than have the front of absorbing material.When detection, transmission is transparent Cladding element can directly be seen that the testing result of the detection zone on testing element.This when, cladding element do not have Opening 112, and only there is in base opening 112.

Certainly, opening 112 can be formed simultaneously on cladding element and base, the shape and size of the opening can be phase With, be also possible to it is different, thus formed two openings communicated with sample cavity.It is analyzed when needing to detect in fluid sample When substance, the test device being made of base, test-strips and cladding element is inserted into fluid sample, is allowed with opening 112 one end is inserted into fluid sample, is then taken out, and is allowed liquid sample along reagent strip, is flowed to and mark from sample applying zone Remember region, then flow to test zone, into testing result region and testing result control area is crossed, finally reaches absorption region, Complete detection.Since sample cavity remains with enough samples, enough liquid can be provided for flowing and avoiding on the test strip The defect of the insufficient existing traditional technology of liquid sample.In addition, it is also extremely simple and low to manufacture such test device Cost, because base can disposably complete, test-strips are existing test-strips, then just whole after one layer of cladding element of covering It completes, production stage is simple, fast.Alternatively, it is also possible to as already mentioned it is possible to directly such detection device it is completely random Be dipped into liquid sample to be detected, no matter be put into using what mode of putting, the time no matter being immersed in liquid sample Length, liquid can normally be flowed on the test strip, can obtain correct result.There is no need to such as traditional classes for this As detection device, give operator and much limit.

In some preferred modes, the detection device further include exhaust, decompression or buck configuration, the structure one end with The channel phase gas circulation sealed, the other end and ambient atmosphere are in fluid communication, which is used to exclude the portion in sealed passage Point gas, when especially liquid is entered in the channel of sealing, due in channel by one section of gas of hydraulic seal, pressure Increase, so that liquid be prevented to enter.In fact, the width and thickness of card slot is all slightly big in order to which test card is small and exquisite and inexpensive In test-strips, in this way, when test-strips are located in card slot, test-strips are surrounded by card slot, in this way, test-strips are in card slot and covering Layer package channel in, when liquid enters the entrance in channel (such as sealed passage entrance and sample cavity opening It is public one), liquid is easy to the entrance of sealed passage.Designing the structure, that gas can be allowed to exclude is outer, thus allow liquid into Enter into the channel of sealing, to provide enough liquid samples.In some preferred modes, as shown in figure 4, the structure of exhaust In the bottom of card slot 1001.Groove structure can be multiple or one, and multiple grooves 1004,1005,1006 can be As shown in Figure 4, groove forms " Y " sub- shape, is also possible to other any forms, such as cross, and letter shapes are round, Rectangle, square, diamond shape, ellipse etc..Certainly, groove is one of a kind of exhaust or the structure depressurized, for example, also It can make hole, hole, the trace portrayed or channel etc..In the channel that liquid enters sealing, these groove one end and sealing Gas circulates in channel, and the other end and atmosphere circulate, so as to exclude extra gas, thus more liquid Body enters in sealed passage, once the groove structure is by hydraulic seal, then the inside of sealed passage and ambient atmosphere reach flat Weighing apparatus, liquid just do not enter back into channel.In some preferred modes, one end and opening of groove and atmosphere circulation 112 connect, and the gas in channel is excluded by opening.

The structure of these exhausts can be covered in the bottom faces 1001 of entire card slot, can also be confined to some positions.It is excellent Choosing, the structure of these exhausts is located at a certain position of card slot.In some modes, the structure of these exhausts is located at test-strips mark Remember the upstream in region 26.In some preferred modes, the structure of exhaust is located at the corresponding position of marked region.The row Depressed structure is one or more groove 1004,1005,1006, these grooves can allow in channel it is other be rejected to it is extraneous big In compression ring border.Groove structure can be multiple or one, and multiple grooves can be as shown in Figure 4, and groove forms " Y " son Shape can also can be other any forms, such as cross, and letter shapes are round, rectangle, square, diamond shape, ellipse Etc..

Here exhaust trench structure and the mentioned-above groove for reducing capillary can be a structure, the structure jointly Have the function of it is dual, first is that reduce capillarity, another effect be exactly exhaust decompression act on.Certainly, two kinds of structures can also Think different structures, the respective respective function of form.

In some preferred modes, sample cavity is located at one end of base and the sample applying zone of close test-strips is attached Closely.As shown in Figure 3, Figure 5 and Figure 6, sample cavity is that a part 902 of card slot in base and cladding element 900 surround, because of base Layer has certain thickness, and the card slot in base has depth, and depth of the card slot close to 132 one end of base is card slot bottom 107 height determines, which constitutes the bottom section of sample cavity, and cladding element and the card slot being isolated that is open Another part region 110 of bottom and two part edges 125,127 to oppose for forming card slot form the side wall of sample cavity, To form the sample cavity of the utility model.The sample applying zone of accommodating portion testing element in the sample cavity.Some In preferred mode, at the bottom position 107 close to sample cavity, there is a protrusion upwards from all regions of the bottom of card slot 802 Structure 111, the raised structures by the sample applying zone of test-strips close to cladding element 102, first is that playing fixed test-strips Effect, in addition, vacateing certain space position to accommodate more liquid samples.This is because test-strips also have certain thickness Degree, the height of raised structures 111 is slightly shorter than the depth of card slot, and low height out is suitable with the thickness of test-strips, due to The sample applying zone of test-strips is generally the materials such as glass fibre, has certain elasticity, so raised structures 111 can press Compel the support sheet at the sample applying zone back side of test-strips close to cladding element.In addition, since test-strips have certain thickness, And the depth of card slot is in a certain range less times greater than the thickness of test-strips, and it is general with 2-5 millimeters, when one end of test-strips When positioned at sample cavity, most of volume of sample cavity is occupied, in this way, it was originally full to allow sample cavity to accommodate more liquid-likes Sufficient test-strips are completely wet to have certain difficulty, so, it raised structures 111 on the one hand can be set compresses soft sample and apply Add the material in region, on the other hand, the thickness for constituting the bottom of card slot can be allowed thinning, such as with inclined-plane 115, the inclined-plane The thickness of card slot bottom is reduced, thus, increase the volume of sample cavity.In addition, if position of the test-strips in sample cavity The bottom (shape position in the slope) of too close card slot, will form capillary gap, such liquid sample is not easily accessed sample Chamber, and due to the complexity of capillary gap structure, the volume into the sample cavity in each card slot is also different, to increase The inaccuracy and uncertainty of detection are added.So in the place close to opening 112, sell the thin side wall of sample cavity (such as The bottom section 1001 of card slot), increase card slot and test-strips the distance between, facilitate liquid sample to enter sample cavity, together When, the volume of sample cavity is also increased, enough liquid-likes can be provided and completed the wet of test-strips originally.Certainly, in order to increase The volume of large sample chamber, can allow besieged city sample cavity side wall (region 110 of the thickness of base and formed two of card slot it is right Vertical side 125,127) it becomes thinner, or the hole of recess is set on these side walls, but these methods are although feasible, still Not as good as allow card slot bottom 110 region become thinner it is easy.The structure setting of the above sample cavity, allows the detection device of card form It is more small and exquisite singly to have no effect on superior function brought by the utility model, it is low in cost in this way, but performance is more superior.

In some preferred modes, a lid element can be provided, after in detection device insertion all fluid samples, is taken Detection device out allows one end of opening 112 to be inserted into 10 lumen 12 of lid element, so that the place of contact sample is protected, thus It prevents and remedies pollution.In order to limit the depth of lid, symmetrical position limiting structure 30,31 can be set in base, to limit lid The depth (Figure 11 A-B) of insertion.Lid is stable to be covered tightly in base in order to increase, and the tight of two protrusions is arranged in the inside of lid Gu item 13,14, when one end of base is inserted into lid, bracket 13,14 increases the adhesive force of lid and base, lid is allowed Body is not easy to fall off to get off, to prevent leakage liquid sample in base open at one end 112 and cause the pollution of external environment. Lid bottom further includes the part 11 of an extension, enters lid element 10 for guiding 112 one end of detection device opening, prevents from grasping Author contacts sample.There are also the cover rims that one is higher than bottom surface (higher than the plane where extended surface) at the edge of lid extension 11 15, such design can prevent from taking out liquid leakage when covering lid entrained when detection device from fluid sample And cause the pollution of external environment.In some preferred modes, position and the extension that bracket 13,14 is arranged are phase Opposition setting, in this way, allowing base to be inserted into lid is single direction position insertion.

In another preferred mode, if liquid sample is seldom, when the one end of detection device with sample cavity is inserted into Into liquid sample, liquid sample can hardly be entered in sample cavity by opening 112, then cannot moisten testing element, Detection device can only be allowed to tilt this when, this mode, which increases, allows operator's difficulty.It is such in order to preferably overcome Detection device, allows on sample cavity or attachment is arranged some fluid passages, and the sample applying zone of these liquid and test-strips is It is in fluid communication.Preferably, position of the position of these fluid passages setting lower than opening 112.Even if in this way, encountering some liquid Liquid level lower than the position of opening 112, can also allow the fluid sample to be by the sample applying zone of these fluid passages and strip It is in fluid communication.

It is for the utility model other more preferably mode, these channels 1046 are just such as shown in Figure 12-16 The bottom of collecting chamber is set, the end 1047 of the sample applying zone 23 of test-strips is allowed to be exposed from hole 1046, in this way when One end with opening 112 is inserted into liquid sample, and the end 1047 of sample applying zone is just contacted with liquid sample.? In some modes, the shape of these fluid passages 1046 is rectangle, and the size in channel and the size of test-strips are adapted, substantially The end of test-strips can be allowed more exposed, such as 1-2 millimeters exposed, 2-3 millimeters.In this way, having opening 112 and fluid passage 1046 setting, so that it may meet more situations, be just not particularly limited for the amount of liquid sample.It can not certainly It makes the end 1047 of test-strips not exposed, but is located at the inside of fluid passage.Size setting for fluid passage 1046, one As be to be adapted to the size of test-strips, for example, less times greater than the size of test-strips, the size of fluid passage and the end of test-strips Size between gap liquid sample will not be allowed to drip down naturally even if substantially there is liquid sample, this is because surface The effect of tension.If in the more situation of liquid, such as when detection device is inserted into liquid sample, liquid level In the position of A, liquid sample can be entered in sample cavity by opening 112, while liquid sample can pass through fluid passage 1046 and test-strips sample applying zone contact.Even if it means that being taken in a short period of time after insertion liquid sample The device of the utility model out ensure that liquid can come into full contact with liquid sample first, then also retain in sample cavity again Liquid sample provides sufficient liquid sample to continue the flowing of test-strips.Fluid passage is set on sample cavity, there is this The advantage of sample, the volume in general sample cavity is smaller, is in addition also inserted into test-strips in sample cavity, if only allowing liquid Sample 112 is entered in collecting chamber by opening, the wall reduced thickness of collecting chamber is allowed in addition to the utility model describes, to mention Carry out aqueous liquids sample for more spaces.But actually, the space of sample cavity is still restricted, in this way, liquid is not allowed Easy Fast Filling expires sample cavity, although the volume of sample cavity can be set, the size of test-strips is not often stringent Unanimously, the problem of bringing in this way is exactly sample cavity within the regular hour, and the liquid sample that each sample cavity is collected is not Equally.But fluid passage 1046 is set on sample cavity, once the liquid level of liquid is higher than the position of opening 112, liquid can Full sample cavity (sample cavity that the second sealed passage is formed) is filled with quick, this is because the air in sample cavity can pass through Fluid passage is excluded, to accelerate time and validity of the liquid full of sample cavity.During this time, fluid passage 1046 On the one hand the air excluded in sample cavity is played, liquid sample Fast Filling is allowed expire outside collecting chamber, another aspect can also allow liquid Body sample passes through the sample applying zone 23 of fluid passage engaged test item.The requirement that the size setting in channel meets is exactly to work as sample After filling in product chamber or storing liquid sample, after detection device leaves liquid sample, do not allow the liquid sample in sample cavity logical Crossing fluid passage outflow can.This is because liquid has surface tension, the size in channel is to need to consider that sample cavity holds Receive the maximum volume of liquid, then the size of fluid passage is set make way for the liquid of sample cavity can because of surface tension and It is unlikely to flow out from fluid passage 1046.In this way, such detection device can satisfy the test of different samples, meanwhile, more The considerations of adding a variety of different applications for improving detection device to propose condition.

If the amount of liquid sample is fewer, for instance in the position of liquid level B, although liquid sample will not be by opening Mouth 112 enters in collecting chamber, but can be contacted by fluid passage 1046 with the sample applying zone 23 of test-strips.

Mouth generally is left from liquid sample, due to the size of fluid passage, the liquid that is stored in collecting chamber Hole 1046 is easily detected by leak out, this ensure that flowing of the subsequent liquid from the lasting supply test-strips of collecting chamber, To complete entire detection.Here the shape of fluid passage can be rectangle as described in Figure 12, be also possible to circle, water chestnut Shape, square, the combination of ellipse and these shapes.

Other than the fluid passage of similar Figure 12 is set in the bottom of collecting chamber, also it can be set elsewhere more Hole, or providing holes elsewhere, a principle are exactly that some similar liquids channels are arranged in the place lower than opening 112 Structure, increase test-strips sample applying zone 23 contacted with liquid chance (in the case that liquid is fewer, the height of liquid When degree is lower than opening 112), the simplicity of operation is increased in this way, meanwhile, overcome one when liquid is fewer A little defects.What needs to be explained here is that these increased fluid passages of the utility model design it is not necessary to, but this One preferred embodiment of utility model.

The assemble method of detection device

The utility model provides a kind of method for manufacturing detection device, and this method is simple and at low cost.In some modes In, the base of one-time injection molding is provided, includes card slot as shown in Figure 3 in the base, which has certain depth Degree and width, the width of testing element of width and receiving of card slot is suitable, can wide or slightly wider than test-strips width Degree, the length of card slot and the length of test-strips are suitable, can also be slightly longer than test-strips length (Fig. 3 be base face back figure, Fig. 8 is the front view of base).As preferred mode, fixed knot is arranged on one end of base 130 in one end of card slot Structure, such as a pair of of protrusion 108,1081.There is opening 112 in one end close to base 132, there is opening on each card slot 112, but the opening does not reach the bottom end 132 of card slot, but certain position 102 (Fig. 5) is reserved, as previously described Hollow out opening 112.Testing element is provided, which includes sample applying zone, marked region, test zone and suction Water area, wherein sample applying zone is located at the upstream of marked region, and test zone is located at the downstream of marked region, in test section It include testing result region and testing result control area (such as Figure 1B and Fig. 2) on domain.Test-strips are placed in card slot, are allowed One end of sample applying zone corresponds to the opening 112 of card slot, allows one end of suction zone close to one end of base 130, meanwhile, it allows Sample segment applying zone is located in sample cavity, and relies on the raised structures 111 in sample cavity, in addition, allowing the mark of reagent strip Remember that region is located at the upstream for reducing capillary structure, while making the one side with support sheet 27 of test exposed by card slot.It mentions For flexible cover, which is covered on the back side of base, to seal entire card slot, while being also bonded test Surface with support sheet 27, meanwhile, cladding element, for example, double faced adhesive tape, adhering film etc., positive 902 part of card slot Sample cavity is formed, allows sample segment applying zone to be exposed to by opening 112 outer, marked region and test zone is allowed to be coated cap rock It is sealed in card slot.It certainly, may include multiple similar notchs in base, and the back side size of cladding element and base It being adapted, it is only necessary to a piece of cladding element can seal multiple card slots, thus, different detections are placed in each card slot to be divided The testing element for analysing substance, forms sample cavity in each card slot, can detect multiple and different quilts simultaneously for same sample Analyze substance.

Detection method

On the other hand, the utility model provides a kind of method for detecting analyte in fluid sample, and this method includes The detection device insertion in aforementioned any mode, arbitrarily impregnates, into fluid sample, then take out, through transparent base Test result on front or cladding element read test region, the mode of this reading can be naked eyes interpretation, can also be with It is to carry out quantitative reading using machine interpretable, such as using the machine of photovoltaic principals design, or tested by scanner The result is that scanning save test result.Insertion is arbitrarily impregnated, and the time into fluid sample can be 1-10 seconds, can be 1 Second, 2 seconds, 3 seconds, 4 seconds, 5 seconds, 6 seconds, 7 seconds, 8 seconds, 10 seconds, 12 seconds, 15 seconds, then take out, carry out test-strips chemical examination or Detection.

Here insertion refers to first one end elder generation contact liq sample for having sample cavity, then takes out, or first band There is one end of sample cavity first to contact sample, then proceed to be inserted into, entire detection device is allowed to be dipped into fluid sample.

Example 1

It is a detection device of the utility model in conjunction with Fig. 2-8, a plastics rigid base structure is provided, in rigid base 8 mutually isostructural card slots as shown in Figure 2 are set on layer.Each reagent strip for providing reagent strip can detecte urine respectively The analytes such as middle amphetamine, cocaine, crystal methamphetamine, opiate, THC and phencyclidine.Made using gold particle For mark substance, the detection of these analytes is carried out using competing method.The side for just facing toward opening 112 of reagent strip To being installed in card slot, the absorbing material in the sample applying zone of reagent strip, such as glass can see through opening 112 Fiber.Then in the upper transparent non-setting adhesive as base's size shape of the back side of base covering, material is thus formed detections to fill It sets.

Mixed with the mixture of drug abuse, including amphetamine, cocaine, crystal methamphetamine, crow in 50 negative samples Tablet, THC and phencyclidine, while 50 also negative samples being also provided.

When detection, it is inserted into the detection device (detection card) into these urine specimens, is soaked respectively in urine 30 seconds, 1 minute, 2 minutes, 3 minutes, 5 minutes, or allow entire detection device to be arbitrarily thrown in liquid sample and impregnate 15 points More than clock, detection device is allowed to be detected.Finally the flowing of liquid can be correctly completed, while obtain effective result.It says The bright device use is more random, friendly, while ensure that the accuracy of result.

Examples of implementation 2

Unlike examples of implementation 1, the detection device as described in Figure 12-16 is provided, in sample cavity bottom opening liquid Channel 1046.The size of test-strips is thick millimeter, and the volume (when test) of wide millimeter, sample cavity is milliliter.Liquid The length in channel, wide is millimeter respectively.

Mixed with the mixture of drug abuse, including amphetamine, cocaine, crystal methamphetamine, crow in 50 negative samples Tablet, THC and phencyclidine, while 50 also negative samples being also provided.

When detection, it is inserted into the detection device (detection card) into these urine specimens, 1 is soaked respectively in urine Second, 3 seconds, 5 seconds, 7 seconds, 1 minute 9 seconds, 2 minutes, 3 minutes, 5 minutes, or entire detection device is allowed arbitrarily to be thrown to liquid It is impregnated 15 minutes or more in sample, detection device is allowed to be detected.The flowing that finally can correctly complete liquid, obtains simultaneously Effective result.Illustrate that the device use is more random, it is friendly, while ensure that the accuracy of result.

In the case where lacking any element specifically disclosed herein, limitation, may be implemented illustrated and described herein Utility model.Used terms and expressions method is used as the term of explanation rather than limits, and is not intended in these terms Any equivalent of shown and described feature or part thereof with exclusion in the use of representation, and should be realized that various change Type is all feasible in the scope of the utility model.It is therefore to be understood that although passing through various embodiments and optional feature The utility model is specifically disclosed, but the modifications and variations of concept as described herein can be by those of ordinary skill in the art institute Using, and think that these modifications and variations are fallen within the scope of the utility model of the appended claims restriction.

It is described herein or record article, patent, patent application and every other document and can electronically obtain The content of information to a certain extent in full include herein by reference, just as each individual publication by specific and single Solely point out by reference.Applicant retains from any of any this article, patent, patent application or other documents And all material and information are incorporated into the right in the application.

Claims (18)

1. the detection device of analyte in a kind of detection fluid sample, which is characterized in that the device includes base, in base Above there is the slot for accommodating testing element, further include the sample cavity for collecting fluid sample in base, wherein described Sample cavity on further include fluid passage, the fluid passage be one or more, the fluid passage and test-strips Sample applying zone be in fluid communication.

2. detection device according to claim 1, which is characterized in that be provided with testing element, test member in the slot The partially liq sample applying zone of part is located in sample cavity.

3. detection device according to claim 1, which is characterized in that the device further includes coating, the coating Covering is located at the slot in base, to form channel and the second sealed passage of the sealing of part first, the first and second sealings are logical Road accommodating portion testing element, second sealed passage form the sample cavity.

4. detection device according to claim 3, which is characterized in that the base includes the back side and front, described In the back side of base, perhaps the front coating is covered on the front or the back side of base to slot position.

5. detection device according to claim 3, which is characterized in that the detection device further includes an opening, this is opened Mouth is in fluid communication with sample cavity, so that liquid be allowed to enter in sample cavity from the opening.

6. detection device according to claim 5, which is characterized in that base is the base of rigidity, coating be it is flexible or The coating of person's rigidity.

7. detection device according to claim 6, which is characterized in that base has certain thickness base, and coating Thickness be less than base thickness.

8. detection device according to claim 5, which is characterized in that the opening is located in base, which is used for Fluid sample is allowed to be flowed into sample cavity.

9. detection device according to claim 5, which is characterized in that the opening is positioned on layer, which uses In allowing fluid sample to be flowed into sample cavity.

10. detection device according to claim 5, which is characterized in that the sample in the opening and test-strips applies Region is corresponding, or opening exposes sample segment applying zone.

11. detection device according to claim 5, which is characterized in that the opening by slot bottom partial region Hollow out is formed.

12. detection device described in one of -11 according to claim 1, which is characterized in that the sample cavity is located at the one of base End, the upstream of the marked region in testing element.

13. detection device according to claim 1, which is characterized in that the upstream of opening is arranged in the fluid passage.

14. detection device according to claim 1, which is characterized in that the fluid passage is arranged on collecting chamber.

15. detection device according to claim 14, which is characterized in that the bottom of collecting chamber is arranged in the fluid passage Portion.

16. detection device according to claim 14, which is characterized in that the fluid passage expose portion test-strips.

17. detection device according to claim 16, which is characterized in that the fluid passage exposes the end of test-strips Portion.

18. detection device according to claim 1, which is characterized in that the fluid passage, which has to allow, to be stored in Liquid sample in sample cavity cannot pass through the size outside fluid passage efferent tract sample cavity because of surface tension.