CN209383791U

CN209383791U - DNA sample collector

Info

Publication number: CN209383791U
Application number: CN201821490173.6U
Authority: CN
Inventors: 陈德喜; 张志宽; 向代军
Original assignee: Beijing New Horizon Medical Technology Co Ltd
Current assignee: Beijing New Horizon Medical Technology Co Ltd
Priority date: 2018-09-12
Filing date: 2018-09-12
Publication date: 2019-09-13
Anticipated expiration: 2028-09-12

Abstract

The utility model discloses a kind of DNA sample collector, including centrifugal collecting pipe and specimen collection tube, specimen collection tube upper orifice is detachably connected with centrifugal collecting pipe upper orifice, and specimen collection tube is placed in centrifugal collecting pipe, the two coaxial arrangement；Specimen collection tube is calabash shape comprising upper tube body and lower tube body, the maximum gauge of upper tube body are greater than the maximum gauge of lower tube body；Specimen collection tube further includes the DNA preservation solution container that can be placed on upper tube body nozzle, DNA preservation solution container bottom is isolation membrane structure, bayonet fittings are equipped in upper tube body, bayonet fittings can be pierced into isolation film after DNA preservation solution container is covered on upper tube body.The utility model can ensure that sample is quickly adequately mixed with DNA preservation solution at the first time, effectively improves effective sample content, also ensures the bio-safety of detected person and operator.

Description

DNA sample collector

Technical field

The utility model relates to a kind of sample collecting device, specifically a kind of DNA sample collector.

Background technique

With the development of proteomics and genomics technologies, saliva, body fluid, drainage-fluid, human secretion or tissue Etc. the discovery of important components and the improvement of sample collection method so that above-mentioned sample become disease detection tool become can Energy.Especially saliva has many advantages, such as that sampling is convenient and safe hurtless measure, can acquire extraction repeatedly, to the early diagnosis of disease, Early treatment and Prognosis scoveillance have important practical value, and are convenient to for the generaI investigation to people at highest risk.Meanwhile it screening Nucleic acid (DNA) is widely used in the projects such as forensic identification, disease gene diagnosis and monitoring.

Currently, existing DNA storage method mainly faces three problems: first is that the disease that how may be carried in inactivated samples Pathogenic microorganism with ensure the safety of operator and detected person with it is convenient；Second is that how effectively to save in biological sample to be checked DNA is so as not to destroying；Third is that reducing use cost, there is more human-oriented and wider application range.

To solve the above-mentioned problems, those skilled in the art are it has been suggested that a kind of sample collecting device comprising collection tube sheet Body and sample collection funnel, sample collection funnel are generally taper, are placed in collection tube body upper part, and the two is spirally connected；Sample collection Funnel is equipped with DNA preservation solution container, and sample collection funnel bottom is sliced equipped with sheet, when DNA preservation solution container conduct When lid is placed on sample collection funnel, sheet, which cuts through container bottom thin film, flows out DNA preservation solution.In use, first Flow into sample in acquisition funnel, sample can flow into acquisition tube body along hopper walls, then realize by the operation of lid lid The release of DNA preservation solution, DNA preservation solution mix to flow into acquisition tube body with sample.The technical issues of this collector, is: Sample flows directly into acquisition tube body after entering funnel, since saliva equal samples have certain viscosity, is easy to wall built-up, DNA It saves liquid and often flows directly into collection tube body bottom portion, be unable to fully contact with wall built-up sample, sample cannot first time and DNA Liquid contact is saved, the pathogenic microorganism that may be carried in sample is likely to the problems such as causing subsequent operation to pollute.

How to solve the problems, such as that sample cannot be sufficiently mixed with DNA preservation solution at the first time in the prior art, still be become The hot spot of those skilled in the art's research.

Summary of the invention

DNA preservation solution can be made to contact in time with sample the technical problem to be solved by the utility model is to provide one kind to fill Divide the DNA sample collector mixed.

To achieve the goals above, the utility model adopts the following technical solutions:

A kind of DNA sample collector, including centrifugal collecting pipe and specimen collection tube, wherein on the specimen collection tube Nozzle is detachably connected with the centrifugal collecting pipe upper orifice, and the specimen collection tube is placed in the centrifugal collecting pipe, The two coaxial arrangement；

The specimen collection tube is calabash shape, including upper tube body and lower tube body, and the maximum gauge of the upper tube body is greater than institute State the maximum gauge of lower tube body；The specimen collection tube further includes that the DNA preservation solution that can be placed on the upper tube body nozzle is held Box is set, DNA preservation solution container bottom is isolation membrane structure, is equipped with bayonet fittings, the thorn-like knot in the upper tube body Structure can be pierced into the isolation film after DNA preservation solution container is covered on the upper tube body.

Wherein more preferably, the specimen collection tube upper orifice extends annular anticreep edge, and the anticreep is greater than institute along outer diameter State centrifugal collecting pipe upper orifice outer diameter.

Wherein more preferably, the centrifugal collecting pipe is additionally provided with pipe lid.

Wherein more preferably, the pipe lid is connect with affiliated centrifugal collecting pipe by connection strap.

Wherein more preferably, the bayonet fittings are set to the upper tube body and lower tube body connectivity part, and the bayonet fittings are Pinnacle cylindricality mesh screen structure.

Wherein more preferably, the lower tube body bottom is equipped with outlet tube, and the outlet tube is cylindrical tube.

Wherein more preferably, the DNA preservation solution container is connect by connection strap with the upper tube body.

In the utility model, the design of specimen collection tube can be such that sample decrease speed slows down, in upper tube body and lower tube body Inside mixed twice with DNA preservation solution, make it is more fully mixed more evenly, effectively avoid in collection process sample and save liquid mixing not Pathogenic microorganism does not inactivate, DNA saves bad situation caused by punching point is uneven.The utility model can ensure that sample rapidly with Efficiently acquiring, sample quickly can adequately be mixed in first time with DNA preservation solution, effective sample content is effectively improved, It ensure that the bio-safety of detected person and operator.The utility model can be used for saliva, blood, body fluid, drainage-fluid, secretion The acquisition of object, tissue and culture equal samples has good potential applicability in clinical practice and market prospects.

Detailed description of the invention

Fig. 1 is the structural schematic diagram of centrifugal collecting pipe in the embodiments of the present invention；

Fig. 2 is the structural schematic diagram of specimen collection tube in the embodiments of the present invention；

Fig. 3 is the overlooking structure diagram of specimen collection tube in the embodiments of the present invention；

Fig. 4 is the use state diagram one of the utility model；

Fig. 5 is the use state diagram two of the utility model；

Fig. 6 is the use state diagram three of the utility model.

Specific embodiment

As shown in Figure 1, Figure 2 and Figure 3, this DNA sample collector includes centrifugal collecting pipe 1 and specimen collection tube 2 two Part.Centrifugal collecting pipe 1 is additionally provided with pipe lid 11, and pipe lid 11 is connect by connection strap 12 with centrifugal collecting pipe 1, sample collection Mixing save liquid after can lid upper tube cap 11, centrifugal collecting pipe 1 can sample collection mix save liquid after as its transport deposit And detection uses.

In the present invention, one of the primary object for being designed as the utility model of specimen collection tube 2.Above-mentioned sample The upper orifice 21 of collection tube 2 is detachably connected with centrifugal 1 upper orifice 13 of collecting pipe, can be main using being spirally connected or inserting mode Syllabus is that specimen collection tube 2 is placed in centrifugal collecting pipe 1 in collection process, and specimen collection tube 2 is removed after acquisition only Retain centrifugal collecting pipe 1 in the present embodiment, 2 upper orifice 21 of specimen collection tube extends annular anticreep along 22, and anticreep is along 22 Outer diameter is greater than 11 outer diameter of upper orifice of centrifugal collecting pipe, and anticreep can be set up on upper orifice 13 along 22, to make sample collection Pipe 2 is placed in centrifugal collecting pipe 1 and does not fall off.The coaxial arrangement of both specimen collection tube 2 and centrifugal collecting pipe 1.

The shape of specimen collection tube 2 is calabash shape, and global shape is inverted cucurbit, including upper tube body 23 and lower tube body 24.The maximum gauge of upper tube body 23 is greater than the maximum gauge of lower tube body 24, that is to say, that upper tube body 23 is with respect to 24 volume of lower tube body It is bigger, in order to have the sufficient enough samples of space convenient for picker.Specimen collection tube 2, which further includes one, to be covered In the DNA preservation solution container 25 of upper orifice 21,25 bottom of DNA preservation solution container is isolation membrane structure, which can quilt Sharp objects or slice object puncture preservation liquid stream.DNA preservation solution container 25 can be separately provided, but in order to avoid Fall off pollution in collection process, is connect in the present embodiment by a connection strap 26 with upper tube body 23.It is equipped in upper tube body 23 Bayonet fittings 27, bayonet fittings 27 its by several thorn columns 271 constitute the sharp cylindricality mesh screen structure in top, the bayonet fittings It is covered in upper tube body 23 and 24 connectivity part of lower tube body.Bayonet fittings 27 can be covered on upper tube body 23 in DNA preservation solution container 25 It is pierced into isolation film afterwards, DNA preservation solution is drained.For the ease of wall built-up, 24 bottom of lower tube body are not set in sample downflow processes There is outlet tube 28, outlet tube 28 is cylindrical tube.

As shown in Figure 4, Figure 5 and Figure 6, by taking saliva sample as an example, when the utility model is used, first by specimen collection tube 2 It is placed in centrifugal collecting pipe 1, picker spits saliva into the upper tube body 23 of specimen collection tube 2, due to the knot of upper tube body 23 Structure designs the smaller saliva in addition of its liquid outlet area with certain viscosity, and saliva dropping velocity is relatively slow.Saliva amount reaches target The DNA preservation solution container 25 of specimen collection tube 2 is covered when amount rapidly, bayonet fittings 27 can be covered in DNA preservation solution container 25 It is pierced into isolation film after upper tube body 23, DNA preservation solution can flow into along the direction of the arrow A in Figure 5 in upper tube body 23, and saliva is mixed The direction for closing the arrow B along Fig. 5 after saving liquid is entered in lower tube body 24 by the outflow of upper tube body 23.Since lower tube body 24 is spherical knot Structure, saliva and DNA preservation solution can further mix in lower tube body 24, then be flowed out by lower tube body 24 and outlet tube 28, finally It flows into centrifugal collecting pipe 1, saliva acquisition finishes.After taking out specimen collection tube 2, centrifugal collecting pipe 1 closes the lid laggard The detection of row next step operates.The entire use process of the utility model can be described as connect-adopt-press-take-covering, and entirely make Convenient with process smoothness, saliva mixes with preservation liquid by secondary, is mixed full and uniform, the effective sample content of preservation Height also ensures the bio-safety of detected person and operator.

Claims

1. a kind of DNA sample collector, including centrifugal collecting pipe and specimen collection tube, it is characterised in that:

The specimen collection tube upper orifice is detachably connected with the centrifugal collecting pipe upper orifice, and the specimen collection tube is placed in In the centrifugal collecting pipe, the two coaxial arrangement；

The specimen collection tube is calabash shape, including upper tube body and lower tube body；The maximum gauge of the upper tube body be greater than it is described under The maximum gauge of tube body；

The specimen collection tube further includes the DNA preservation solution container that can be placed on the upper tube body nozzle, and the DNA is saved Liquid container bottom is isolation membrane structure, is equipped with bayonet fittings in the upper tube body, the bayonet fittings can hold in DNA preservation solution Box cover is set to be pierced into the isolation film after the upper tube body.

2. DNA sample collector as described in claim 1, it is characterised in that:

The specimen collection tube upper orifice extends annular anticreep edge, and the anticreep is greater than on the centrifugal collecting pipe along outer diameter Nozzle outer diameter.

3. DNA sample collector as described in claim 1, it is characterised in that:

The centrifugal collecting pipe is additionally provided with pipe lid.

4. DNA sample collector as claimed in claim 3, it is characterised in that:

The pipe lid is connect with affiliated centrifugal collecting pipe by connection strap.

5. DNA sample collector as described in claim 1, it is characterised in that:

The bayonet fittings are set to the upper tube body and lower tube body connectivity part, and the bayonet fittings are pinnacle cylindricality mesh screen knot Structure.

6. DNA sample collector as described in claim 1, it is characterised in that:

The lower tube body bottom is equipped with outlet tube, and the outlet tube is cylindrical tube.

7. DNA sample collector as described in claim 1, it is characterised in that:

The DNA preservation solution container is connect by connection strap with the upper tube body.