CN208705286U - A kind of liquid chromatograph and liquid chromatograph enriching column - Google Patents
A kind of liquid chromatograph and liquid chromatograph enriching column Download PDFInfo
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- CN208705286U CN208705286U CN201821067680.9U CN201821067680U CN208705286U CN 208705286 U CN208705286 U CN 208705286U CN 201821067680 U CN201821067680 U CN 201821067680U CN 208705286 U CN208705286 U CN 208705286U
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- column
- enriching
- inner tube
- conduit
- liquid chromatograph
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Abstract
The utility model relates to chromatographs, disclose a kind of liquid chromatograph and liquid chromatograph enriching column, liquid chromatograph includes several mobile phase liquid source, chromatographic column and detector, it further include enriching column, strainer, packing layer are provided in enriching column, several mobile phase liquid source is separately connected the entrance of enriching column by conduit, and the outlet of enriching column connects the entrance of chromatographic column by conduit, and the outlet of chromatographic column passes through conduit connecting detection device.The utility model has the characteristics that replacement strainer is simple, detection limit is low and using life of chromatographic column is long.
Description
Technical field
The utility model relates to chromatograph more particularly to a kind of liquid chromatographs.
Background technique
Liquid chromatograph is the difference using mixed liquor distribution ratio between liquid-solid or immiscible two kinds of liquid, to mixed
It closes object and is first separated the instrument then identified, it is desirable that solution can be made in sample, and not by the volatile limitation of sample, mobile phase can
Wider range of selection, stationary phase it is many kinds of, thus can separate thermally labile and it is non-volatile, dissociation and it is non-from
The substance of solution and various molecular weight ranges.
Currently, existing liquid chromatograph detection is by carrying out repeated multiple times absorption-desorption, each group in the chromatography column
Divide and generate biggish difference in movement speed, is separated into after single component is successively flowed out out of column and is detected through detector, examined
Limit is surveyed generally at ppm grades；Furthermore as adsorbent is more and more, the impurity remained in chromatographic column can be accumulated constantly, finally
Cause separative efficiency lower and lower, the service life of chromatographic column shortens.
Summary of the invention
The utility model provides a kind of inspection for the low disadvantage of limit for height, using life of chromatographic column is detected in the prior art
The liquid chromatograph that rising limit is low, using life of chromatographic column is high.
In order to solve the above-mentioned technical problem, the utility model is addressed by following technical proposals:
A kind of liquid chromatograph, including several mobile phase liquid source, chromatographic column and detector, enriching column, several flowings
Phase liquid source is separately connected the entrance of enriching column by conduit, and the outlet of enriching column connects the entrance of chromatographic column, chromatography by conduit
The outlet of column passes through conduit connecting detection device.Enriching column includes cylinder and the interior column adapter tube with axially extending bore, and cylinder is by mutually embedding
The outer tube and inner tube of set form, and bottom of inner tube is provided with sieve plate, and packing layer is filled in inner tube, and upper end of inner tube is cased with band internal screw thread
Loop, loop be connected to being threadedly coupled with externally threaded pressure cap for column adapter tube outer wall, column adapter tube respectively with it is described several
The outside of the connection of mobile phase liquid source, column adapter tube is equipped with groove, and groove is communicated with axially extending bore, the circle of groove and axially extending bore composition
Be placed with support frame in the cross section of column, support frame is equipped with strainer, the connection ring set on strainer on the bracket of support frame,
Bracket bottom end is connected with lanyard.Sieve plate is used to support the filler in inner tube, and filler is prevented to be lost, while not interfering mobile phase
Circulation；According to the type of detection substance and impurity, suitable filler is selected；Cylinder is threadedly coupled with column adapter tube, and disassembly is flexibly, square
Just the filler in inner tube is replaced, lanyard can play buffer function in instrument transportational process.
Preferably, further including sample bottle, the sample bottle is connect with the entrance that column is taken over.Holding liquid in sample bottle
Sample, fluid sample can flow into enriching column by self gravity, can also be connected by pump, fluid sample is pumped into enrichment
Column.
Preferably, further including waste liquid bottle, the outlet of the enriching column passes through conduit with detector respectively and connects waste liquid
Bottle, switch valve is provided on the conduit between the outlet and waste liquid bottle of enriching column.Mobile phase is de- to wash the waste liquid after sample, all receives
Collect waste liquid bottle, be uniformly processed, avoids pollution environment.
Preferably, chromatographic column includes several reverse chromatograms columns and several positive chromatographic columns, enriching column and chromatographic column it
Between conduit on be provided with switch valve.According to the property of detection substance, reverse chromatograms column or positive chromatographic column are selected, is conducive to mention
High separating efficiency has better separating effect.
Preferably, support frame can be extracted freely by groove and through-hole and replace strainer.Strainer can mistake in advance
The solid impurity in sample is filtered, the progress of follow-up work step is conducive to.
The utility model has the advantages that the prior art
(1) enrichment is combined with separating, the detection limit of chromatographic column, another aspect, because of enriching column on the one hand can be improved
By most of Impurity elutions, the service life of chromatographic column is increased；
(2) filter screen can be replaced in real time, can be adjusted in time on the bracket of support frame by the connection ring set on strainer
Filter diameter is saved, is suitble to the sample of different occasions, different impurities content, practicability is extremely strong；
(3) sieve plate supports adsorption stuffing, avoids filler loss；
(4) chromatographic column of opposed polarity can be selected according to detection needs.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the utility model；
Fig. 2 is the structural schematic diagram of the enriching column in the utility model；
Fig. 3 is the structural schematic diagram of the strainer in the utility model；
Fig. 4 is the structural schematic diagram of the support frame in the utility model.
The toponym that each number designation is referred in attached drawing is as follows: 1-mobile phase liquid source, 3-enriching columns, 31-columns
Body, 311-outer tubes, 312-inner tubes, 313-loops, 314-sieve plates, 32-columns adapter tube, 321-pressure caps, 322-grooves,
323-support frames, 324-strainers, 325-connection rings, 326-brackets, 327-lanyards, 5-sample bottles, 7-positive colors
Compose column, 8-detectors, 9-waste liquid bottles, 10-reverse chromatograms columns.
Specific embodiment
The utility model is described in further detail with specific embodiment with reference to the accompanying drawing.Each reality in the utility model
The technical characteristic of mode is applied under the premise of no conflict mutually, can carry out the corresponding combination.
As shown in Figure 1, a kind of liquid chromatograph, including two mobile phase liquid sources 1, chromatographic column and detector 8, enriching column 3,
Mobile phase liquid source 1 is separately connected the entrance of enriching column 3 by conduit, and the outlet of enriching column 3 connects chromatographic column by conduit
Entrance, the outlet of chromatographic column passes through conduit connecting detection device 8.
As in Figure 2-4, a kind of enriching column 3 of liquid chromatograph includes that cylinder 31 and the interior column with axially extending bore connect
Pipe 32, cylinder 31 are made of mutually nested outer tube 311 and inner tube 312, and 312 bottom of inner tube is provided with sieve plate 314, inner tube 312
Interior to be filled with packing layer, 312 upper end of inner tube is cased with tapped loop 313, loop 313 and is connected to 32 outer wall of column adapter tube
Be threadedly coupled with externally threaded pressure cap 321, column adapter tube 32 connect with the mobile phase liquid source 1 respectively, column adapter tube 32 outside
Side is equipped with groove 322, and groove 322 is communicated with axially extending bore, in the cross section of the cylinder of groove 322 and axially extending bore composition
It is placed with support frame 323, support frame 323 is equipped with strainer 324,325 sets of the connection ring branch in support frame 323 on strainer 324
On frame 326,326 bottom end of bracket is connected with lanyard 327.Sieve plate is used to support the filler in inner tube, and filler is prevented to be lost, simultaneously
The circulation of mobile phase is not interfered；According to the type of detection substance and impurity, suitable filler is selected；Cylinder and column adapter tube screw thread connect
It connects, disassembly is flexible, the filler being convenient for changing in inner tube.
It further include sample bottle 5 in one embodiment of the utility model, the sample bottle 5 enters with column adapter tube 32
Mouth connection.Fluid sample flows into or is pumped into column adapter tube 32 from sample bottle 5.
As Fig. 1 embodiment in, the utility model further includes waste liquid bottle 9, and the outlet of the enriching column 3 and detector 8 divide
Waste liquid bottle 9 is not connected by conduit, is provided with switch valve on the conduit between the outlet and waste liquid bottle 9 of enriching column 3.
As Fig. 1 embodiment in, chromatographic column includes reverse chromatograms column 10 and positive chromatographic column 7, enriching column 3 and chromatographic column
Between conduit on be provided with triple valve, required chromatographic column is selected by the opening and closing of selection triple valve.
In one embodiment of the utility model, support frame as described above 323 can be extracted freely by groove 322 and through-hole
And replace strainer 324.
The working method of the liquid chromatograph of the utility model, includes the following steps:
1) the supravasal switch valve that the outlet of enriching column 3 is connect with chromatographic column is closed, the outlet of enriching column 3 is opened and is given up
The sample of sample bottle 5 is pumped into inner tube 312 by the supravasal switch valve between liquid bottle 9, selects suitable mobile phase liquid source (1),
Mobile phase is pumped into inner tube 312, the impurity of sample take off and is washed, and the waste collection after washing will be taken off into waste liquid bottle 9, detection
Material collection is on 312 packing layer of inner tube；
2) reverse chromatograms column 10 or positive chromatographic column 7 are selected, corresponding triple valve is opened, closes enriching column 3
Supravasal switch valve between outlet and waste liquid bottle 9, selects suitable mobile phase liquid source (1), mobile phase is pumped into inner tube
312, de- wash is carried out to the detection substance being enriched on 312 packing layer of inner tube；It takes off the solution after washing and flows into selected reversed color
Spectrum column 10 is perhaps pumped into suitable mobile phase to inspection into reverse chromatograms column 10 or positive chromatographic column 7 in positive chromatographic column 7
Substance is surveyed to be separated；
3) the detection substance after separating successively flows into detector 8 with mobile phase, and 8 pairs of detection substances of detector are examined
It surveys.
Claims (6)
1. a kind of liquid chromatograph, including several mobile phase liquid source (1), chromatographic column and detector (8)；It is characterized in that, also wrapping
It includes enriching column (3), several mobile phase liquid source (1) is separately connected the entrance of enriching column (3) by conduit, enriching column (3)
Outlet connects the entrance of chromatographic column by conduit, and the outlet of chromatographic column passes through conduit connecting detection device (8)；
The enriching column (3) includes cylinder (31) and the interior column adapter tube (32) with axially extending bore, and cylinder (31) is by mutually nested
Outer tube (311) and inner tube (312) composition, inner tube (312) bottom is provided with sieve plate (314), and filler is filled in inner tube (312)
Layer, inner tube (312) upper end are cased with tapped loop (313), and loop (313) and the band for being connected to column adapter tube (32) outer wall are outer
The pressure cap (321) of screw thread is threadedly coupled, and column adapter tube (32) is connect with several mobile phase liquid source (1) respectively, column adapter tube
(32) outside is equipped with groove (322), and groove (322) is communicated with axially extending bore, the cylinder of groove (322) and axially extending bore composition
Cross section in be placed with support frame (323), support frame (323) is equipped with strainer (324), the connection ring on strainer (324)
(325) it covers on the bracket (326) of support frame (323), bracket (326) bottom end is connected with lanyard (327).
2. a kind of liquid chromatograph as described in claim 1, which is characterized in that further include sample bottle (5), the sample bottle
(5) it is connect with the entrance of column adapter tube (32).
3. a kind of liquid chromatograph as described in claim 1, which is characterized in that further include waste liquid bottle (9), the enriching column
(3) outlet is connected waste liquid bottle (9) by conduit respectively with detector (8), between the outlet and waste liquid bottle (9) of enriching column (3)
Conduit on be provided with switch valve.
4. a kind of liquid chromatograph as described in claim 1, which is characterized in that the chromatographic column includes several reverse chromatograms
Column (10) and several positive chromatographic columns (7) are provided with switch valve on the conduit between enriching column (3) and chromatographic column.
5. a kind of liquid chromatograph as described in claim 1, which is characterized in that support frame as described above (323) passes through groove (322)
It can freely be extracted with through-hole and replace strainer (324).
6. a kind of liquid chromatograph enriching column, which is characterized in that phase liquid source (1) and sample are moved in the enrichment column inlet connection flow
Bottle (5), outlet connection chromatographic column, the enriching column include cylinder (31) and the interior column adapter tube (32) with axially extending bore, cylinder
(31) it is made of mutually nested outer tube (311) and inner tube (312), inner tube (312) bottom is provided with sieve plate (314), inner tube
(312) packing layer is filled in, inner tube (312) upper end is cased with tapped loop (313), loop (313) and is connected to column
Take over (32) outer wall with externally threaded pressure cap (321) be threadedly coupled, column take over (32) respectively with several mobile phase liquid
Source (1) connection, the outside that column takes over (32) are equipped with groove (322), and groove (322) is communicated with axially extending bore, groove (322) and axis
It is placed with support frame (323) in the cross section of the cylinder formed to through-hole, support frame (323) is equipped with strainer (324), strainer
(324) connection ring (325) on covers on the bracket (326) of support frame (323), and bracket (326) bottom end is connected with lanyard
(327).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2018202513195 | 2018-02-12 | ||
| CN201820251319 | 2018-02-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN208705286U true CN208705286U (en) | 2019-04-05 |
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ID=65937484
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201821067680.9U Active CN208705286U (en) | 2018-02-12 | 2018-07-06 | A kind of liquid chromatograph and liquid chromatograph enriching column |
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| CN (1) | CN208705286U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112630355A (en) * | 2020-11-23 | 2021-04-09 | 江苏同济分析仪器有限公司 | Enrichment column of liquid chromatograph |
| CN114367788A (en) * | 2022-01-04 | 2022-04-19 | 深圳市恒谱生科学仪器有限公司 | Filtering sieve plate for fluid chromatographic analysis and processing method thereof |
-
2018
- 2018-07-06 CN CN201821067680.9U patent/CN208705286U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112630355A (en) * | 2020-11-23 | 2021-04-09 | 江苏同济分析仪器有限公司 | Enrichment column of liquid chromatograph |
| CN114367788A (en) * | 2022-01-04 | 2022-04-19 | 深圳市恒谱生科学仪器有限公司 | Filtering sieve plate for fluid chromatographic analysis and processing method thereof |
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| Date | Code | Title | Description |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20201020 Address after: 226400 chemical industry park, Rudong County, Jiangsu, Nantong Patentee after: MAX (RUDONG) CHEMICALS Co.,Ltd. Address before: 311800 Zhejiang city of Shaoxing province Zhuji City Tao Street Zhancheng Road No. 66 Zhancheng. Hu Zhuang Club Room 601 Patentee before: ZHEJIANG ZHUJI UNITED CHEMICALS Co.,Ltd. |
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| TR01 | Transfer of patent right |