CN112630355A

CN112630355A - Enrichment column of liquid chromatograph

Info

Publication number: CN112630355A
Application number: CN202011316577.5A
Authority: CN
Inventors: 章志尧
Original assignee: Jiangsu Tongji Analytical Instrument Co ltd
Current assignee: Jiangsu Tongji Analytical Instrument Co ltd
Priority date: 2020-11-23
Filing date: 2020-11-23
Publication date: 2021-04-09

Abstract

The invention discloses a liquid chromatograph enriching column, belonging to the technical field of chromatographs, comprising a column body, a tube body and a connecting cover, wherein fixing mechanisms are respectively arranged above the left side and the right side in the column body, the left side and the right side of the bottom of the connecting cover are respectively connected with a first buckle, the first buckle is inserted in the fixing mechanisms, the connecting cover is fixed at the top of the column body through the first buckle, the top of the tube body is connected with the bottom of the connecting cover, a liquid inlet pipe is arranged in the middle of the top of the connecting cover, the liquid inlet pipe is communicated with the tube body, a slot is transversely arranged above the tube body, a filter plate is inserted in the slot, the right side of the filter plate is connected with a fixed block, clamping slots are transversely arranged above and below the right side of the slot, the connecting cover can be more quickly and more conveniently detached from the column body through the fixing mechanisms, thereby replacing parts on the tube body, the filter effect is better, and the pollution of strong retention substances to the chromatographic column is avoided.

Description

Enrichment column of liquid chromatograph

Technical Field

The invention relates to the technical field of chromatographs, in particular to an enrichment column of a liquid chromatograph.

Background

The liquid chromatograph is an instrument which utilizes the difference of the distribution ratio of a mixed solution between two liquids which are liquid-solid or immiscible to separate and identify the mixture, the sample is required to be prepared into a solution and is not limited by the volatility of the sample, the selectable range of a mobile phase is wider, and the variety of stationary phases is various, so that substances which are unstable in heat, non-volatile, dissociative and non-dissociative and have various molecular weight ranges can be separated, the enrichment column is an indispensable part in the liquid chromatograph and can filter impurities in the sample, thereby protecting the chromatographic column.

Disclosure of Invention

The invention aims to provide an enrichment column of a liquid chromatograph, which aims to solve the problems that the filtering effect provided by the background technology is not ideal enough, and the existing enrichment column is inconvenient to disassemble an internal filtering pipe and wastes time when in use.

In order to achieve the purpose, the invention provides the following technical scheme: a liquid chromatograph enrichment column comprises a column body, a tube body and a connecting cover, wherein fixing mechanisms are arranged above the left side and the right side in the column body, the left side and the right side of the bottom of the connecting cover are connected with a first buckle, the first buckle is inserted in the fixing mechanisms, the connecting cover is fixed at the top of the column body through the first buckle, the top of the tube body is connected with the bottom of the connecting cover, a liquid inlet pipe is arranged in the middle of the top of the connecting cover, the liquid inlet pipe is communicated with the tube body, an inserting groove is transversely formed above the tube body, a filter plate is inserted in the inserting groove, a fixed block is connected to the right side of the filter plate, clamping grooves are transversely formed above and below the right side of the inserting groove, a second buckle matched with the clamping grooves is arranged above and below the left side of the fixed block, the left side wall of the fixed block is attached to the upper side wall of the right side, the filter ring is installed to the body bottom, the body bottom is equipped with the sealing washer with the filter ring junction, filter ring bottom intermediate junction has spacing post one, be equipped with the spacing ring in the middle of the bottom in the cylinder, peg graft in the spacing ring in spacing post one bottom, the liquid outlet tank has all vertically been seted up to the cylinder bottom left and right sides.

Preferably, the fixing mechanism comprises a second limiting column, a guide column, a third buckle and a spring, a movable groove is transversely formed in the second limiting column, the guide column is inserted into the movable groove, and the third bottom of the buckle is connected with the top of the guide column.

Preferably, the spring is sleeved on the outer wall of the guide post, one outward side end of the spring is connected with the second limiting post, and one inward side end of the spring is connected with the inner wall of the post body.

Preferably, the bottom of the pipe body is connected with a stud, a thread groove matched with the stud is longitudinally formed in the middle of the inside of the filter ring, the outer wall of the stud is in threaded connection with the thread groove, the seal ring is located at the top of the filter ring, and a filter layer is arranged in the filter ring.

Preferably, the filtering layer consists of a plurality of filtering particles, and the size of the filtering particles is 1cm-2 cm.

Preferably, the filter layer is one or more of a Hypersil filter layer, a BETASIL filter layer, a Spherisorb filter layer, and a LiChrosorb filter layer.

Preferably, a waterproof layer II is arranged at the joint of the bottom of the connecting cover and the top of the column body.

Compared with the prior art, the invention has the beneficial effects that:

1) according to the invention, the connecting cover can be detached from the column body more quickly and conveniently through the fixing mechanism, so that parts on the tube body are replaced, the time is saved, and the maintenance and replacement efficiency is improved.

2) According to the invention, the filter plate is arranged above the tube body in an inserting manner and is fixed through the second buckle, so that the filter plate can be replaced more quickly, meanwhile, the filter layer arranged in the filter ring can retain the strong retention substances in the mixed liquid in the filter layer, the filter effect is better, and the strong retention substances are prevented from polluting the chromatographic column. .

Drawings

FIG. 1 is a schematic structural view of the present invention;

FIG. 2 is an enlarged view of the invention at A;

FIG. 3 is a schematic view of a stud construction of the present invention;

FIG. 4 is a diagram illustrating a socket structure according to the present invention.

In the figure: the filter comprises a cylinder 1, a connecting cover 2, a pipe body 3, a liquid inlet pipe 4, a fixing block 5, a sealing ring 6, a filter ring 7, a first limiting column 8, a limiting ring 9, a liquid outlet groove 10, a first buckle 11, a third buckle 12, a second limiting column 13, a guide column 14, a stud 15, a spiral groove 16, a filter layer 17, a slot 18 and a filter plate 19.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In the description of the present invention, it is to be understood that the terms "upper", "lower", "front", "rear", "left", "right", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, are merely for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention.

Example (b):

referring to fig. 1-4, the present invention provides a technical solution: an enrichment column of a liquid chromatograph comprises a column body 1, a tube body 3 and a connecting cover 2, wherein fixing mechanisms are arranged above the left side and the right side in the column body 1, the left side and the right side of the bottom of the connecting cover 2 are connected with a first buckle 11, the first buckle 11 is inserted into the fixing mechanisms, the connecting cover 2 is fixed at the top of the column body 1 through the first buckle 11, the top of the tube body 3 is connected with the bottom of the connecting cover 2, the connecting cover 2 can be detached from the column body 1 more quickly and more conveniently through the fixing mechanisms, so that parts on the tube body 3 can be replaced, the time is saved, the maintenance and replacement efficiency is improved, a liquid inlet pipe 4 is arranged in the middle of the top of the connecting cover 2, the liquid inlet pipe 4 enters a mixed liquid 3 through the liquid inlet pipe 4, the liquid inlet pipe 4 is communicated with the tube body 3, a slot 18 is transversely formed above the tube body 3, filtering the particles in the mixed liquid, preventing the particles from flowing into the chromatographic column to cause blockage, generating unnecessary troubles, wherein the right side of the filter plate 19 is connected with a fixed block 5, the upper part and the lower part of the right side of the slot are transversely provided with a clamping groove, the upper part and the lower part of the left side of the fixed block 5 are respectively provided with a buckle II matched with the clamping groove, the buckle II is clamped in the clamping groove, the left side wall of the fixed block 5 is attached to the upper part of the right side wall of the tube body 3, a waterproof layer I is arranged at the joint part of the left side wall of the fixed block 5 and the upper part of the right side wall of the tube body 3, the fixed block 5 is pulled, so that the filter plate 19 is taken out from the slot 18, the filter plate 19 can be replaced, the bottom of the tube body 3 is provided with a filter ring 7, secondary filtering is carried out on the mixed liquid, the, the utility model discloses a filter cylinder, including body 3, filter ring 7, spacing post 8, limiting ring 9, the guide effect plays when installing body 3, easy to assemble, liquid groove 10 has all vertically been seted up to the both sides about 1 bottom of cylinder, and the mixed liquid after the filtration gets into next process through liquid groove 10 discharge cylinder 1.

The fixing mechanism comprises a second limiting column 13, a guide column 14, a third buckle 12 and a spring, a movable groove is transversely formed in the second limiting column 13, the guide column 14 is inserted into the movable groove, the bottom of the third buckle 12 is connected with the top of the guide column 14, the third buckle 12 is driven to move by pressing the second limiting column 13, the third buckle 12 is separated from the first buckle 11, and the connecting cover 2 can be taken out of the column body 1.

The spring is sleeved on the outer wall of the guide post 14, one outward side end of the spring is connected with the second limiting post 13, one inward side end of the spring is connected with the inner wall of the post body 1, and the spring can drive the third buckle 12 to reset when working.

The bottom of the pipe body 3 is connected with a stud 15, a thread groove 16 matched with the stud 15 is longitudinally formed in the middle of the inner portion of the filter ring 7, the outer wall of the stud 15 is in threaded connection with the thread groove 16, when the filtering life of the filtering layer 17 is prolonged, the filter ring 7 is screwed, the thread groove 16 is separated from the stud 15, the filter ring 7 can be replaced, the sealing ring 6 is located at the top of the filter ring 7, and the filtering layer 17 is arranged in the filter ring 7.

The filter layer 17 is composed of a plurality of filter particles, and the specification of the filter particles is 1cm-2 cm.

The filter layer 17 is one or more of a Hypersil filter layer, a BETASIL filter layer, a Spherisorb filter layer, and a LiChrosorb filter layer.

And a waterproof layer II is arranged at the joint of the bottom of the connecting cover 2 and the top of the column body 1.

The working principle is as follows: the mixed liquid enters the pipe body 3 through the liquid inlet pipe 4 and is filtered for the first time through the filter plate 19, particles in the mixed liquid are filtered, the particles are prevented from flowing into the chromatographic column to cause blockage and cause unnecessary troubles, the mixed liquid after the first filtering enters the filtering ring 7 after being discharged from the stud 15, the filtering layer 17 carries out secondary filtering on the mixed liquid, strong retention substances in the mixed liquid can be retained in the filtering layer 17, the filtering effect is better, the strong retention substances are prevented from polluting the chromatographic column, the filtered mixed liquid is discharged out of the cylinder 1 through the liquid outlet groove 10 to enter the next process, the limiting column 13 is pressed to drive the buckle III 12 to move, the buckle III 12 is separated from the buckle I11, the connecting cover 2 can be taken out of the cylinder 1, the fixing block 5 is pumped, the filter plate 19 is taken out of the slot 18, the filter plate 19 can be replaced, when the filtering life of the filtering layer 17 is reached, the filter ring 7 is screwed, and the screw groove 16 is separated from the stud 15, so that the filter ring 7 can be replaced, and the filter ring is simple to operate and convenient to replace.

While there have been shown and described the fundamental principles and essential features of the invention and advantages thereof, it will be apparent to those skilled in the art that the invention is not limited to the details of the foregoing exemplary embodiments, but is capable of other specific forms without departing from the spirit or essential characteristics thereof; the present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein, and any reference signs in the claims are not intended to be construed as limiting the claim concerned.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. The utility model provides a liquid chromatograph enrichment column, includes cylinder (1), body (3) and connecting cover (2), its characterized in that: the device is characterized in that fixing mechanisms are arranged above the left side and the right side in the cylinder body (1), a first buckle (11) is connected to the left side and the right side of the bottom of the connecting cover (2), the first buckle (11) is inserted into the fixing mechanisms, the connecting cover (2) is fixed to the top of the cylinder body (1) through the first buckle (11), the top of the pipe body (3) is connected with the bottom of the connecting cover (2), a liquid inlet pipe (4) is arranged in the middle of the top of the connecting cover (2), the liquid inlet pipe (4) is communicated with the pipe body (3), a slot (18) is transversely arranged above the pipe body (3), a filter plate (19) is inserted into the slot, a fixed block (5) is connected to the right side of the filter plate (19), clamping grooves are transversely arranged above and below the right side of the slot, clamping grooves matched with a second buckle are arranged above and below the left side of the fixed block, the utility model discloses a spacing post is including body (1), fixed block (5) left side wall and body (3) right side wall top laminating, just fixed block (5) left side wall and body (3) right side wall top laminating department are equipped with waterproof layer one, body (3) bottom is installed and is filtered ring (7), body (3) bottom is equipped with sealing washer (6) with filtering ring (7) junction, filter ring (7) bottom intermediate junction has spacing post one (8), be equipped with spacing ring (9) in the middle of the bottom in cylinder (1), peg graft in spacing post one (8) bottom in spacing ring (9), liquid groove (10) have all vertically been seted up in both sides about cylinder (1) bottom.

2. The enrichment column of a liquid chromatograph of claim 1, wherein: the fixing mechanism comprises a second limiting column (13), a guide column (14), a third buckle (12) and a spring, a movable groove is transversely formed in the second limiting column (13), the guide column (14) is inserted into the movable groove, and the bottom of the third buckle (12) is connected with the top of the guide column (14).

3. The enrichment column of a liquid chromatograph of claim 2, wherein: the spring is sleeved on the outer wall of the guide post (14), one outward side end of the spring is connected with the second limiting post (13), and one inward side end of the spring is connected with the inner wall of the post body (1).

4. The enrichment column of a liquid chromatograph of claim 1, wherein: the pipe body (3) bottom is connected with double-screw bolt (15), filter ring (7) interior middle part vertically seted up with double-screw bolt (15) assorted thread groove (16), double-screw bolt (15) outer wall spiro union is in thread connection in thread groove (16), sealing washer (6) are located filter ring (7) top, be equipped with filter layer (17) in filtering ring (7).

5. The enrichment column of a liquid chromatograph of claim 4, wherein: the filter layer (17) is composed of a plurality of filter particles, and the specification of the filter particles is 1cm-2 cm.

6. The enrichment column of a liquid chromatograph of claim 4, wherein: the filter layer (17) is one or more of a Hypersil filter layer, a BETASIL filter layer, a Spherisorb filter layer and a LiChrosorb filter layer.

7. The enrichment column of a liquid chromatograph of claim 1, wherein: and a waterproof layer II is arranged at the joint of the bottom of the connecting cover (2) and the top of the column body (1).