CN208542657U - A kind of performance liquid chromatographic column cleaning device - Google Patents
A kind of performance liquid chromatographic column cleaning device Download PDFInfo
- Publication number
- CN208542657U CN208542657U CN201820729151.4U CN201820729151U CN208542657U CN 208542657 U CN208542657 U CN 208542657U CN 201820729151 U CN201820729151 U CN 201820729151U CN 208542657 U CN208542657 U CN 208542657U
- Authority
- CN
- China
- Prior art keywords
- chromatographic column
- shell
- bath box
- exhausted bath
- jointing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The utility model relates to a kind of performance liquid chromatographic column cleaning devices, belong to testing instruments technical field, it is simple to provide a kind of structure, it is easy to use, it being capable of automatic identification, automatic cleaning, the high performance liquid chromatographic column cleaning device of cleaning efficiency, used technical solution is to be provided with jointing on shell and exhausted bath box, chromatographic column is installed on each chromatographic column support base, the both ends of chromatographic column are connected with jointing respectively, case top is equipped with multiple mobile phase storage bottles, multiple liquid pumps are provided in shell, controller is additionally provided in shell, drain pipe and collecting tank are provided in exhausted bath box, drain pipe is connected with jointing, collecting tank sliding is inserted into exhausted bath box, RFID electronic label is additionally provided in chromatographic column, RFID identification device is provided on exhausted bath box, it is also installed on shell There are work light, selection indicator light and control switch；The utility model is widely used in the cleaning of chromatographic column.
Description
Technical field
The utility model relates to a kind of performance liquid chromatographic column cleaning devices, belong to testing instruments technical field.
Background technique
Liquid chromatography technology is that one kind efficiently separates purification technique, is widely applied in many fields, such as: chemical industry,
Biology, food, medicine etc..Wherein, chromatographic column is the core of liquid chromatogram, is the main place for realizing substance separation, energy
The performance isolated and purified is directly affected, is all core and the forward position of liquid chromatography technology research field all the time.
Liquid-phase chromatographic column is the core component in liquid chromatograph.In use, salt, esters, fatty compound have
Machine acid, hydrophobin and other biological component are the substances that a part may interact with chromatographic column.With target analysis
Object is compared, possible stronger, the weaker compound of reserve capability of the reserve capability of these substances, such as salt, the quilt usually in dead volume
Chromatographic column is gone out, these interference beyond expection can be detected by the detector, and show as chromatographic peak bifurcated, baseline fluctuation is even
Negative peak.If the reserve capability of sample substrate ingredient on a column is very strong, and the eluting power of mobile phase is always all without strong
To being enough to rush out these compounds, then these matrix components of absorption on a column are just assembled after multiple sample introduction
Collection, when enough, they will show property, the phase interaction of analyte and these pollutants as new stationary phase
With will affect separation mechanism, retention time fluctuation and peak hangover may cause.If pollutant is more, column pressure may be risen to very
High level, even more than column press the upper limit, it is also possible to cause chromatographic column to collapse and form dead volume, this depends on what blocking was formed
Position.
But current existing chromatographic column cleaning method is mainly utilized on performance liquid chromatographic column instrument and is cleaned,
When being detected in batches, cleaning efficiency is low, and the time is long；Simultaneously in batch detection, since different types of chromatographic column needs
It is cleaned using different mobile phases, as polarity chromatographic column can be cleaned with methylene chloride；Building conjunction phase chromatographic column can be clear with methanol
It washes；Anion-exchange column can use the buffer solution for cleaning etc. of chlorohexidene to need manually to remove selective flow in this way in cleaning
Phase, then setting time and flow velocity are cleaned, troublesome in poeration, once selecting wrong mobile phase, chromatographic column are be easy to cause to scrap.
Utility model content
To solve technical problem of the existing technology, it is simple that the utility model provides a kind of structure, easy to use, energy
Enough automatic identifications, automatic to clean, the high performance liquid chromatographic column cleaning device of cleaning efficiency.
To achieve the above object, technical solution used by the utility model is a kind of performance liquid chromatographic column cleaning dress
It sets, including bottom plate, the surrounding of the bottom plate is provided with non-slip mat, and one end of the bottom plate is equipped with shell, the other end of bottom plate
Exhausted bath box is installed, multiple chromatographic column support bases are installed in the middle part of bottom plate, are provided with connection on the shell and exhausted bath box
Connector is installed with chromatographic column on each chromatographic column support base, and the both ends of the chromatographic column are connected with jointing respectively
It connects, the case top is equipped with multiple fixing seats, and mobile phase storage bottle, setting in the shell are equipped in the fixing seat
There are multiple liquid pumps, the liquid feeding end of each liquid pump is connected with mobile phase storage bottle, and outlet end is connected with jointing, and
It is provided with flow control valve between outlet end and jointing, controller is additionally provided in the shell, is set in the exhausted bath box
It is equipped with drain pipe and collecting tank, the drain pipe is connected with jointing, and is located at the top of collecting tank, and the collecting tank is sliding
It is dynamic to be inserted into exhausted bath box, it is additionally provided with RFID electronic label in the chromatographic column, is provided with RFID identification on the exhausted bath box
Device is also equipped with work light, selection indicator light and control switch on the shell.
Preferably, multiple guide rails are provided on the bottom plate, the end of the guide rail is equipped with block, the chromatographic column branch
Support seat and exhausted bath box are slidably fitted on guide rail.
Preferably, non-slip mat is installed in the card slot of the chromatographic column support base.
Compared with prior art, the utility model has following technical effect that the utility model structure is simple, user
Just, it does not need to be cleaned on chromatograph, and uses RFID identification technology, chromatographic column is identified automatically, is then led to
It crosses which kind of mobile phase selection indicator light prompt staff selects, after then connecting chromatographic column, starts control switch, work refers to
Show that lamp is lighted, chromatographic column is cleaned automatically, easy to clean, work light lights extinguishing after the completion of cleaning, without artificial
Management, cleaning efficiency significantly improve.The distance between shell and exhausted bath box can also be adjusted simultaneously, to meet different length chromatography
The cleaning of column.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the utility model.
Fig. 2 is the top view of Fig. 1.
Specific embodiment
In order to which technical problem to be solved in the utility model, technical solution and beneficial effect is more clearly understood, with
Lower combination accompanying drawings and embodiments, the present invention will be further described in detail.It should be appreciated that specific reality described herein
It applies example to be only used to explain the utility model, is not used to limit the utility model.
As shown in Figure 1 and Figure 2, a kind of performance liquid chromatographic column cleaning device, including bottom plate 1, the surrounding of bottom plate 1 are provided with
Non-slip mat 2, one end of bottom plate 1 are equipped with shell 3, and the other end of bottom plate 1 is equipped with exhausted bath box 4, and the middle part of bottom plate 1 is equipped with more
It is provided with jointing 6 on a chromatographic column support base 5, shell 3 and exhausted bath box 4, is installed on each chromatographic column support base 5
Chromatographic column 7, the both ends of chromatographic column 7 are connected with jointing 6 respectively, and multiple fixing seats 8, fixing seat 8 are equipped at the top of shell 3
Mobile phase storage bottle 9 is inside installed, multiple liquid pumps 10, the liquid feeding end and mobile phase of each liquid pump 10 are provided in shell 3
Storage bottle 9 is connected, and outlet end is connected with jointing 6, and is provided with flow control valve between outlet end and jointing 6
11, controller 12 is additionally provided in shell 3, drain pipe 13 and collecting tank 14 is provided in exhausted bath box 4, drain pipe 13 connects with connection
First 6 are connected, and are located at the top of collecting tank 14, and collecting tank sliding is inserted into exhausted bath box 4, are additionally provided in chromatographic column 7
RFID electronic label 15 is provided with RFID identification device 16 on exhausted bath box 4, and work light 17, selection are also equipped on shell 3
Indicator light 18 and control switch 19.
For storing different mobile phases in mobile phase storage bottle in the utility model.RFID electronic label is for recording color
Compose the relevant information of column.When needing to clean chromatographic column, the RFID electronic label in chromatographic column is connect with RFID identification device
Touching, then controller reads the information in RFID electronic label automatically, and lights the selection indicator light of corresponding mobile phase storage bottle,
Prompt staff is cleaned using this mobile phase, and then chromatographic column is stuck on chromatographic column support base, is then pressed pair
The control switch answered, work light are lighted, and are cleaned automatically, and the work light after the completion of cleaning lights extinguishing.Cleaning
The waste liquid generated in the process enters in collecting tank, focuses on to waste liquid.
Wherein, multiple guide rails 20 are provided on bottom plate 1, the end of guide rail 20 is equipped with block 21,5 He of chromatographic column support base
Exhausted bath box 4 is slidably fitted on guide rail 20.Column support base 5 and exhausted bath box 4 can move on guide rail, can satisfy so not
With the use of length chromatographic column.
In addition, being equipped with non-slip mat in the card slot of chromatographic column support base 5, guarantee that chromatographic column is fixed reliable.
The above is only the preferred embodiment of the utility model only, is not intended to limit the utility model, all at this
Made any modifications, equivalent replacements, and improvements etc., should all wrap in the utility model model within the spirit and principle of utility model
In enclosing.
Claims (3)
1. a kind of performance liquid chromatographic column cleaning device, it is characterised in that: including bottom plate, the surrounding of the bottom plate is provided with anti-skidding
Pad, one end of the bottom plate are equipped with shell, and the other end of bottom plate is equipped with exhausted bath box, multiple chromatographies are equipped in the middle part of bottom plate
Column support base is provided with jointing on the shell and exhausted bath box, clamps on each chromatographic column support base coloured
Column is composed, the both ends of the chromatographic column are connected with jointing respectively, and the case top is equipped with multiple fixing seats, described solid
Mobile phase storage bottle is installed in reservation, multiple liquid pumps, the liquid feeding end of each liquid pump and flowing are provided in the shell
Phase storage bottle is connected, and outlet end is connected with jointing, and flow control valve is provided between outlet end and jointing,
It is additionally provided with controller in the shell, drain pipe and collecting tank are provided in the exhausted bath box, the drain pipe connects with connection
Head is connected, and is located at the top of collecting tank, and the collecting tank sliding is inserted into exhausted bath box, is additionally provided in the chromatographic column
RFID electronic label is provided with RFID identification device on the exhausted bath box, and work light, selection are also equipped on the shell
Indicator light and control switch.
2. a kind of performance liquid chromatographic column cleaning device according to claim 1, it is characterised in that: be arranged on the bottom plate
There are multiple guide rails, the end of the guide rail is equipped with block, and the chromatographic column support base and exhausted bath box are slidably fitted with guide rail
On.
3. a kind of performance liquid chromatographic column cleaning device according to claim 1, it is characterised in that: the chromatographic column support
Non-slip mat is installed in the card slot of seat.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820729151.4U CN208542657U (en) | 2018-05-16 | 2018-05-16 | A kind of performance liquid chromatographic column cleaning device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820729151.4U CN208542657U (en) | 2018-05-16 | 2018-05-16 | A kind of performance liquid chromatographic column cleaning device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN208542657U true CN208542657U (en) | 2019-02-26 |
Family
ID=65421514
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201820729151.4U Active CN208542657U (en) | 2018-05-16 | 2018-05-16 | A kind of performance liquid chromatographic column cleaning device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN208542657U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113533541A (en) * | 2020-04-15 | 2021-10-22 | 中国科学院上海药物研究所 | Nano-liter liquid phase system with automatic cleaning function and control method |
-
2018
- 2018-05-16 CN CN201820729151.4U patent/CN208542657U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113533541A (en) * | 2020-04-15 | 2021-10-22 | 中国科学院上海药物研究所 | Nano-liter liquid phase system with automatic cleaning function and control method |
| CN113533541B (en) * | 2020-04-15 | 2022-07-08 | 中国科学院上海药物研究所 | Nano-liter liquid phase system with automatic cleaning function and control method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN201518030U (en) | Full automatic multi-channel multi-parameter simultaneous measuring flow injection analyzer | |
| CN104870993A (en) | Sample injector | |
| CN208542657U (en) | A kind of performance liquid chromatographic column cleaning device | |
| CN201368879Y (en) | Biological test sensor | |
| CN101349647B (en) | Novel capillary electrophoresis electrochemical luminescence testing device and use method thereof | |
| CN108845056A (en) | A kind of on-line automatic pretreating device of aflatoxin based on flow path switching | |
| TW201331359A (en) | Nucleic acid extraction method | |
| WO2021249347A1 (en) | Static sample injection and fraction collection apparatus for use with liquid chromatograph | |
| CN104155462B (en) | A kind of micro-fluidic immune detection analysis chip and analytical instrument thereof | |
| CN202822863U (en) | Embedded type solid phase extraction device | |
| CN202649010U (en) | Settling type automatic smear-making and dyeing machine for liquid-based cell | |
| CN205484222U (en) | Liquid chromatograph improves device | |
| CN206362811U (en) | A kind of automatic sampler for quantitative capillary tube electrophoresis apparatus | |
| CN2811989Y (en) | Fluorescent detection pool for micro-liquid phase flow analysis system | |
| CN111141714A (en) | Integrated multifunctional rapid detection equipment | |
| JP2000500858A (en) | Method and apparatus for analyzing volatile substances in gas | |
| CN210021750U (en) | Rapid sample batch membrane-passing device for chromatographic analysis and detection | |
| CN102688749A (en) | Extraction material and preparation method thereof, and device and extraction method used for solid-phase micro-extraction | |
| CN208206865U (en) | A kind of interchangeable capillary electrophoresis | |
| CN202548092U (en) | Capillary electrophoresis detection system for relative content of glycosylated hemoglobin HbA1c | |
| CN220940801U (en) | Liquid phase solvent bottle | |
| CN216771504U (en) | Liquid sample injector combined with infrared spectrometer and infrared spectrum analysis system | |
| CN2650127Y (en) | Integrated micropump type capillary electrophoresis chip capable of rapid feeding and changing samples | |
| CN102539512B (en) | Multichannel capillary electrophoresis method for detecting glycosylated hemoglobin HbA1c in multiple samples simultaneously | |
| CN205263041U (en) | Opposition high performance liquid chromatography post washs and regenerating unit |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant |