CN208206865U - A kind of interchangeable capillary electrophoresis - Google Patents
A kind of interchangeable capillary electrophoresis Download PDFInfo
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- CN208206865U CN208206865U CN201820778331.1U CN201820778331U CN208206865U CN 208206865 U CN208206865 U CN 208206865U CN 201820778331 U CN201820778331 U CN 201820778331U CN 208206865 U CN208206865 U CN 208206865U
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Abstract
The utility model provides a kind of interchangeable capillary electrophoresis, including capillary, fixed structure and switching construction.Separating medium is perfused in capillary in advance, so that capillary is in serviceable condition, can directly carry out sample detection without reprocessing, capillary is affixed by fixed structure and switching construction；Its input end is connected on the connectivity port of switching construction, and the outlet end of capillary is in buffer solution；It include buffer solution space and test sample space in switching construction, when it is in first state, buffer solution space is connected to by connectivity port with input end, and when it is in the second state, test sample space is connected to by connectivity port with input end；Before being detected using capillary electrophoresis, switching construction is in first state.Capillary electrophoresis can directly be replaced used capillary electrophoresis with new capillary electrophoresis after completing one-time detection, without cleaning, shorten and be spaced duration between detecting twice.
Description
Technical field
The utility model relates to detection technique fields, more particularly to a kind of interchangeable capillary electrophoresis.
Background technique
Capillary Electrophoresis (capillary electrophoresis, CE) technology is using capillary as split tunnel, with height
Pressing DC electric field is the novel liquid-phase isolation technics of driving force.Capillary Electrophoresis generally uses quartz capillary column, in capillary
Under external high pressure electric field action, the separating medium of side is mobile to cathode direction due to positively charged.Simultaneously, it is situated between in separation
In matter, charged biomolecules are outside the capillary under high voltage electric field effect, with respective friction speed, to the charged biomolecules
The electrically charged opposite polarity electrode direction of institute is mobile, forms electrophoresis.
Capillary of the fixed placement for test sample in traditional analysis system of capillary electrophoresis passes through capillary electricity
The type of substance in the adjustable injection capillary of the conversion equipment for detection system itself of swimming, such as injection buffer solution, detection
Sample, cleaning solution etc..After being detected in analysis system of capillary electrophoresis to substance contained in a test sample, institute
Sample of detection etc. can pollute the detection parts such as capillary, sample slot, in order to carry out pattern detection next time, need to hair
It may thoroughly be cleaned by the polluted detection part of last detection in cons electrophoresis detection system.In cleaning process, need
Each based cleaning liquid wanted can be implanted sequentially the detection parts such as capillary with conversion equipment, after the completion of cleaning, it is also necessary to again to
Capillary carries out a series of processing and uses when in case detecting next time such as injecting separating medium.
As it can be seen that analysis system of capillary electrophoresis needs to carry out complex procedures to detection parts such as capillaries in detection twice
Cleaning, and again handle capillary to reach the requirement that can continue to test subsequent samples, so as to cause it is detected twice
Between be spaced too long, need patient to fall into a long wait, user experience is bad.
Utility model content
The utility model intends to solve the technical problem by providing a kind of interchangeable capillary electrophoresis, thus completing
After one-time detection, directly used capillary electrophoresis can be replaced with new capillary electrophoresis, be not necessarily to
Cleaning is shortened and is spaced duration between detection twice, improves user experience.
For this purpose, the technical solution that the utility model solves technical problem is:
The utility model provides a kind of interchangeable capillary electrophoresis, and described device includes: capillary, fixed knot
Structure and switching construction:
Separating medium is perfused in the capillary in advance, the capillary is tied by the fixed structure and the switching
Structure is affixed；The input end that the capillary is used to receive test sample is connected to the connectivity port of the switching construction, described
The outlet end of capillary is in buffer solution；
It include the buffer solution space and test sample space for prestoring buffer solution, the switching in the switching construction
In first state, the buffer solution space is connected to by the connectivity port with the input end structure, the switching knot
In the second state, the test sample space is connected to by the connectivity port with the input end structure；Wherein, passing through
It states before capillary electrophoresis detects test sample, the switching construction is in the first state.
Optionally, the switching construction further includes injection port, and the injection port is used to inject to the test sample space
Test sample；When the capillary electrophoresis is inserted into analysis system of capillary electrophoresis, the injection port is located at the hair
Except cons electrophoresis detection system.
Optionally, the switching construction includes control mechanism, and the switching construction is existed by triggering the control mechanism
Switch between the first state and the second state, when the capillary electrophoresis is inserted into analysis system of capillary electrophoresis,
The control mechanism is located at except the analysis system of capillary electrophoresis.
Optionally, if test sample is filled with to the test sample space by the injection port, in the capillary
When electrophoresis detection system detects test sample by the capillary electrophoresis, the switching construction is switched to institute
The second state is stated to inject the test sample into the capillary.
Optionally, after injecting the test sample to the capillary, the switching construction is switched to described first
State, to drive the test sample to move in the capillary using the buffer solution in the buffer solution space.
Optionally, described device further includes electrode, and the both ends of the capillary are arranged in the electrode, and the electrode is used for
It is connect with the power supply in the analysis system of capillary electrophoresis, pushes the test sample so that the power supply can provide voltage
It is moved in the capillary.
Optionally, described device further includes detection window, and the nearly outlet end of the capillary is arranged in the detection window
Place is detected with will pass through the detection window to the substance in the capillary in the detection window.
Optionally, the detection window is the transparent region on the poroid or described fixed structure.
Optionally, the fixed structure is card-like, and the capillary is fixed on the inside of the fixed structure.
Optionally, the shape of the capillary is U-shaped.
According to the above-mentioned technical solution, the utility model has the advantages that:
The utility model provides a kind of interchangeable capillary electrophoresis, including capillary, fixed structure and switching
Structure.It include the buffer solution space and test sample space for prestoring buffer solution in switching construction, switching construction is first
When state, buffer solution space is connected to by connectivity port with input end, and switching construction is in the second state, test sample space
It is connected to by connectivity port with input end.Due to before being detected by the device to test sample, switching construction is in the
One state, in this way, be connected by the switching construction with the input end that capillary is used to receive test sample, the outlet of the capillary
End can make the inlet end and an outlet end of capillary all in buffer solution, to realize to capillary in the buffer solution
The separating medium being perfused in advance in pipe is sealed preservation, allows capillary electrophoresis independently of capillary electrophoresis detection system
System exists, and makes capillary be in serviceable condition in addition, being perfused with separating medium in capillary in advance, no longer needs to carry out it
Pretreatment, activation etc. can directly detect sample.Due to having switching construction on the device, and the switching construction is simultaneously
With buffer solution space and test sample space, allow the device it is independent realize switching construction in first state and
It is switched between second state, in this way, carrying out sample the capillary electrophoresis to be placed in analysis system of capillary electrophoresis
It is primary when completing since separating medium, buffer solution and test sample are all present in the capillary electrophoresis when product examine is surveyed
When detection, the test sample before new test sample quilt or before used buffer solution pollution in order to prevent, it is only necessary to will
The capillary electrophoresis is entirely replaced, clear without carrying out to capillary even buffer solution space and test sample space
It washes, a new capillary electrophoresis can be placed in directly in analysis system of capillary electrophoresis can be to new test sample
Start sample detection next time.It can be seen that since the capillary electrophoresis has capillary, fixed structure and switching simultaneously
Structure so that the capillary electrophoresis when independently of analysis system of capillary electrophoresis, can be good at save capillary and
Separating medium therein, and it is able to carry out the switching of buffer solution and test sample, so that capillary electrophoresis is convenient for and hair
Cons electrophoresis system rationally cooperates, and realizes replaceability, that is to say, that after completing one-time detection, can directly use newly
Capillary electrophoresis is replaced used capillary electrophoresis, without cleaning, shortens and is spaced between detection twice
Duration improves user experience.
Detailed description of the invention
In order to illustrate the embodiment of the utility model or the technical proposal in the existing technology more clearly, below will be to embodiment
Or attached drawing needed to be used in the description of the prior art is briefly described, it should be apparent that, the accompanying drawings in the following description is only
It is some embodiments of the utility model, for those of ordinary skill in the art, in the premise not made the creative labor
Under, it is also possible to obtain other drawings based on these drawings.
Fig. 1 is a kind of structure chart of interchangeable capillary electrophoresis provided by the embodiment of the utility model；
Fig. 2 is a kind of structure chart of interchangeable capillary electrophoresis provided by the embodiment of the utility model；
Fig. 3 is a kind of structure chart of switching construction provided by the embodiment of the utility model；
Fig. 4 is a kind of structure chart of switching construction provided by the embodiment of the utility model；
Fig. 5 is a kind of structure chart of interchangeable capillary electrophoresis provided by the embodiment of the utility model；
Fig. 6 is a kind of structure chart of interchangeable capillary electrophoresis provided by the embodiment of the utility model；
Fig. 7 is a kind of structure chart of interchangeable capillary electrophoresis provided by the embodiment of the utility model.
Specific embodiment
In order to provide the implementation for the detection speed for improving Capillary Electrophoresis, the utility model embodiment provides one kind
Interchangeable capillary electrophoresis is illustrated below in conjunction with preferred embodiment of the Figure of description to the utility model.
The process of traditional analysis system of capillary electrophoresis cleaning is more complicated, and the cleaning consuming time is longer, so as to cause
It is spaced too long between detection twice, user experience is bad；In addition, carrying out cleaning used cleaning to detection parts such as capillaries
Machine price is high, cause using traditional analysis system of capillary electrophoresis to substance contained in test sample detected at
This is excessively high.
For this purpose, the utility model embodiment provides a kind of interchangeable capillary electrophoresis, by capillary, fixed knot
Capillary electrophoresis is formed together with the component combinations such as structure and switching construction, is independently gone out from analysis system of capillary electrophoresis
Come, realizes the replaceable of capillary electrophoresis.The apparatus may include capillary, fixed structure and switching constructions.Wherein, hair
Separating medium is perfused in tubule in advance, capillary is affixed by fixed structure and switching construction；Capillary is for receiving detection
The input end of sample is connected on the connectivity port of switching construction, and the outlet end of capillary is in buffer solution, so as to hair
Tubule is sealed preservation.Include the buffer solution space and test sample space for prestoring buffer solution in switching construction, cuts
Structure is changed in first state, buffer solution space is connected to by connectivity port with input end, switching construction in the second state,
Test sample space is connected to by connectivity port with input end, so that switching construction can be between the first state and a second state
It switches over, to inject corresponding solution into capillary according to the different conditions of switching construction, wherein passing through capillary
Before electrophoretic apparatus detects test sample, switching construction is in the first state.
The utility model is by targetedly improving the members in script analysis system of capillary electrophoresis and selecting
It selects out and be combined, and increased some components newly and together formed capillary electrophoresis detection provided by the embodiment of the utility model
This functional entity of device, allow capillary electrophoresis detection device it is independent be present in analysis system of capillary electrophoresis it
Outside, and it can independently save, transport, while can simply, be easily used cooperatively with analysis system of capillary electrophoresis.
Since device provided by the embodiment of the utility model is when independently of analysis system of capillary electrophoresis, can be good at
Capillary and separating medium therein are saved, and is able to carry out the switching of buffer solution and test sample；The device is inserted into
Into analysis system of capillary electrophoresis, test sample can be detected using the device.Therefore, which is applied to
When analysis system of capillary electrophoresis, which can be replaced, i.e., can be directly with new capillary after completing one-time detection
Electrophoresis tube device is replaced used capillary electrophoresis, without cleaning, thus by with capillary electrophoresis detection
Device is used cooperatively, can not only shorten electrophoresis detection system detect twice between be spaced duration, improve user experience, Er Qieke
To greatly simplify the complex degree of structure of analysis system of capillary electrophoresis, such as be used cooperatively with capillary electrophoresis detection device
Analysis system of capillary electrophoresis can be not required to setting cleaning assembly, the component handled again capillary etc., effective to drop
The low manufacturing cost of analysis system of capillary electrophoresis.
It should be noted that the separating medium being previously mentioned in the utility model embodiment can be each gellike, such as poly-
The variety classes gel such as acrylamide, agarose, glucan, is also possible to all kinds of buffer solutions.
Fig. 1 is a kind of structural schematic diagram of interchangeable capillary electrophoresis provided by the utility model, described device
It may include: capillary 100, fixed structure 200 and switching construction 300.
In the present embodiment, which can be inserted into analysis system of capillary electrophoresis,
To be detected using the interchangeable capillary electrophoresis to substance contained in test sample.
Wherein, separating medium is perfused in capillary 100 in advance, capillary 100 passes through fixed structure 200 and switching construction
300 is affixed；The input end that capillary 100 is used to receive test sample is connected to the connectivity port of switching construction 300, the hair
The outlet end of tubule 100 is in buffer solution.By taking Fig. 1 as an example, the left end of capillary 100 can be input end, capillary 100
Right end can be outlet end, outlet end, which is in, to prestore in the memory space 400 of buffer solution, so that outlet end is in
In buffer solution, separating medium in capillary is isolated with extraneous with realizing.
It may include the buffer solution space 301 and test sample space for prestoring buffer solution in switching construction 300
302.Switching construction 300 may include two states, and when switching construction 300 is in first state, buffer solution space 301 passes through
Connectivity port is connected to the input end of capillary 100, as shown in Figure 1；When switching construction 300 is in the second state, test sample
Space 302 is connected to by connectivity port with the input end of capillary 100, as shown in Figure 2.It should be noted that passing through capillary
Before electrophoresis tube device detects test sample, switching construction 300 is in first state.
Since before being detected by capillary electrophoresis to test sample, switching construction 300 is in first state,
I.e. the input end of capillary 100 is connected to by connectivity port with buffer solution space 301, at this point, input end is in buffer solution
In, and outlet end is in buffer solution, is sealed preservation to capillary 100 so as to realize, is guaranteed in capillary 100
Separating medium be not contaminated.
It should be noted that in the present embodiment, buffer solution space 301 and test sample space in switching construction 300
302 can be as shown in Figs. 1-2, and buffer solution space 301 is located at the left side in test sample space 302, certainly, buffer solution space
301 can also be located at the right in test sample space 302, and the present embodiment does not limit this.
It can also include that other are empty in switching construction 300 other than buffer solution space 301 and test sample space 302
Between, other substances that may be used when can be used for storing detection in other described spaces.
Capillary electrophoresis provided in this embodiment includes simultaneously capillary, fixed structure and switching construction, capillary
Characteristic possessed by pipe, fixed structure and switching construction so that the capillary electrophoresis be alternatively, can be independently of hair
Existing for cons electrophoresis detection system.When needing to detect detection sample using the capillary electrophoresis, can incite somebody to action
The capillary electrophoresis is inserted into analysis system of capillary electrophoresis, when the tests are completed, can be by the capillary electrophoresis
It pulls out, the capillary electrophoresis more renewed, can be detected next time from analysis system of capillary electrophoresis at once.
The utility model provides a kind of interchangeable capillary electrophoresis, including capillary, fixed structure and switching
Structure.It include the buffer solution space and test sample space for prestoring buffer solution in switching construction, switching construction is first
When state, buffer solution space is connected to by connectivity port with input end, and switching construction is in the second state, test sample space
It is connected to by connectivity port with input end.Due to before being detected by the device to test sample, switching construction is in the
One state, in this way, be connected by the switching construction with the input end that capillary is used to receive test sample, the outlet of the capillary
End can make the inlet end and an outlet end of capillary all in buffer solution, to realize to capillary in the buffer solution
The separating medium being perfused in advance in pipe is sealed preservation, allows capillary electrophoresis independently of capillary electrophoresis detection system
System exists, and is perfused with separating medium in advance in capillary and capillary is made to be in serviceable condition, no longer need to locate it in advance
Reason, activation etc..Due to having switching construction on the device, and the switching construction has buffer solution space and test sample simultaneously
Space switches over the independent realization of the device between the first state and a second state switching construction, in this way,
When the capillary electrophoresis is placed in progress sample detection in analysis system of capillary electrophoresis, due to separating medium, buffering
Solution and test sample are all present in the capillary electrophoresis, when completing one-time detection, new detection sample in order to prevent
Test sample or used buffer solution pollution before before product quilt, it is only necessary to the capillary electrophoresis is entirely replaced,
It, can be directly in capillary electrophoresis detection without being cleaned to capillary even buffer solution space and test sample space
A new capillary electrophoresis is placed in system to start sample detection next time to new test sample.Thus may be used
See, since the capillary electrophoresis has capillary, fixed structure and switching construction simultaneously, so that the capillary electrophoresis
When independently of analysis system of capillary electrophoresis, it can be good at saving capillary and separating medium therein, and be able to carry out
The switching of buffer solution and test sample, so that capillary electrophoresis is convenient for rationally cooperating with capillary electrophoresis system, and real
Existing replaceability, that is to say, that, can be directly with new capillary electrophoresis to used hair after completing one-time detection
Cons electrophoresis device is replaced, and without cleaning, is shortened and is spaced duration between detection twice, improve user experience.
It should be noted that in analysis system of capillary electrophoresis using capillary electrophoresis to including in test sample
When substance is detected, needs will test sample and be injected into test sample space, and then pass through analysis system of capillary electrophoresis
Voltage provided by power supply will test sample and be pushed in capillary.In some embodiments, switching construction 300 further include into
Sample mouth 303, as shown in Figure 3.Injection port 303 is used to inject test sample to test sample space 302, then injection port 303 should
It is directed at test sample space 302.
By the capillary electrophoresis be inserted into analysis system of capillary electrophoresis when, in order to facilitate user can by into
Sample mouth 303 injects test sample to test sample space 302, and injection port 303 can be located at except analysis system of capillary electrophoresis.
When the analysis system of capillary electrophoresis detects test sample by the capillary electrophoresis, if
Injection port 303 is passed through and has been filled with test sample into test sample space 302, has then been switched to the switching construction 300
Second state is to inject test sample into capillary 100.
After injecting test sample into capillary 100, switching construction 300 can be switched into first state, with convenience
Test sample is driven to move in capillary 100 with buffer solution.
Switching construction 300 is switched between first state and the second state in order to realize, in one implementation,
Shown in Figure 4, switching construction 300 further includes control mechanism 304, can be by switching construction 300 by triggering control mechanism 304
It is switched between first state and the second state, the capillary electrophoresis is being inserted into analysis system of capillary electrophoresis
When, control mechanism 304 can be triggered in order to facilitate user, control mechanism 304 can be located at except analysis system of capillary electrophoresis.
Wherein, the mode that user triggers control mechanism 304 can be user and press control mechanism 304, and user often presses one
Secondary, switching construction 300 is once switched between first state and the second state.
It should be noted that in the present embodiment, test sample is either injected into capillary 100, or utilize slow
Rushing solution drives test sample to move in capillary 100, may be by the power supply of analysis system of capillary electrophoresis, power supply
Voltage, which can be provided, pushes test sample to move in capillary 100, alternatively, test sample is pushed to enter in capillary 100.
The power supply of analysis system of capillary electrophoresis can be applied voltage by the cooperation with capillary electrophoresis position
The both ends of capillary 100 on capillary electrophoresis, so that voltage is provided for capillary electrophoresis, so that test sample
It is injected under the action of voltage into capillary 100, alternatively, buffer solution is made to drive test sample to exist under the action of voltage
It is moved in capillary 100.
But after this mode requires capillary electrophoresis to be inserted into analysis system of capillary electrophoresis, capillary 100
Both ends and power supply apply alive location matches, when making capillary electrophoresis, to capillary electrophoresis and capillary
Electrophoresis detection system cooperates required precision higher.
For this purpose, electrode can be arranged on capillary electrophoresis, referring to figure in an embodiment of the present embodiment
Shown in 5, electrode 500 is set at the both ends of capillary 100, electrode 500 is used for and the electricity in the analysis system of capillary electrophoresis
Source connection pushes test sample to move in capillary 100, alternatively, pushing detection sample so that the power supply can provide voltage
Product enter capillary 100.By being arranged electrode at the both ends of capillary, the power supply of analysis system of capillary electrophoresis can directly with
The electrode at both ends connects, to provide voltage for capillary electrophoresis.In this way, not having to when making capillary electrophoresis
Excessively consider that the both ends of capillary and the position of power supply cooperate on capillary electrophoresis, reduce capillary electrophoresis and hair
Cons electrophoresis detection system cooperates precision, improves applicability, thereby reduces the difficulty of production capillary electrophoresis.
It should be noted that in the present embodiment, according to the difference that power supply acts on, the voltage that power supply provides can not
Together.If desired test sample is pushed to move in capillary 100, then the voltage that power supply provides can be first kind voltage；If needing
Test sample is pushed to enter capillary 100, then the voltage that power supply provides can be the second class voltage.In some embodiments
In, first kind voltage and the second class voltage can be the different high voltage of voltage range.In some embodiments, the second class
Voltage can be higher than first kind voltage.
In some embodiments of the present embodiment, referring to Fig. 6, described device can also include detection window 600, described
Detection window 600 can be set at the nearly outlet end of capillary, will pass through detection window 600 in detection window 600
In capillary 100 in substance detected.
Since at nearly outlet end, buffer solution can drive test sample sufficiently to move in capillary, so that
Each substance for including in test sample can be sufficiently separated, in this way, carrying out in nearly outlet end setting detection window to test sample
Detection can make the accuracy of detection higher.
When due to being detected by detection window 600 to the substance in the capillary 100 in detection window 600,
Usually be irradiated capillary 100 in the side of capillary electrophoresis using detection light, wherein the detection light can
Think laser, LED, deuterium lamp etc.；It is received in the other side of capillary electrophoresis using detector.Therefore, detection window
600 should being capable of light transmission.In a kind of implementation of the present embodiment, detection window can be through hole shape or be fixed
Transparent region in structure 200.
Detection window is through poroid or be that transparent region on fixed structure 200 can be according to fixed structure 200 itself
Material determine.It is understood that if fixed structure 200 is non-transparent material, then, in order to realize in detection window
The substance in capillary 100 in 600 is detected, and one can be arranged on fixed structure 200 through fixed structure 200
Hole, using the through hole as detection window.
In some cases, it since capillary is more fragile, is easily damaged by external force, therefore, in order to avoid capillary
It is contacted by through hole with the external world, is damaged by external force, upper transparent material layer can be covered at the both ends of through hole, such as
Glass, to be protected to capillary.
It is understood that if fixed structure 200 is translucent material, such as glass, then, detection window can be will be solid
Structure 200 is determined other than closely exporting end regions, after being covered using non-transparent material, is protected in the nearly outlet end regions of capillary
The transmission region left.
In some embodiments, fixed structure 200 can be card-like, and capillary 100 can be fixed on fixed structure 200
Inside.
Card-like is set by fixed structure 200, can reduce the volume of capillary electrophoresis, it is easy to carry.By hair
Tubule 100 is fixed on the inside of fixed structure 200, can protect to capillary 100, avoid capillary 100 due to external force
Effect and damage.
In the present embodiment, capillary 100 can be fixed structure 100 with arbitrary shape and be fixed, such as linear type.?
In a kind of implementation of the present embodiment, the shape of capillary 100 can be U-shaped.By the way that capillary 100 is shaped to
U-shaped can reduce capillary occupied area on fixed structure 200, reduce the size of fixed structure 200, and then reduce
The size of capillary electrophoresis, so that capillary electrophoresis is more portable.
Certainly, the shape of capillary 100 can also be S type, M type etc., this implementation does not limit the shape of capillary 100
It is fixed.
Based on the corresponding embodiment of Fig. 1-Fig. 6, a kind of capillary electrophoresis is present embodiments provided, referring to Fig. 7, the dress
It sets including capillary 100, fixed structure 200, switching construction 300, the memory space 400 for prestoring buffer solution, 500 and of electrode
Detection window 600.Wherein, separating medium is perfused in capillary 100 in advance, capillary 100 passes through fixed structure 200 and switching
Structure 300 is affixed；The input end that capillary 100 is used to receive test sample is connected to the connectivity port of switching construction 300, institute
The outlet end for stating capillary 100 is in the buffer solution of memory space 400.Switching construction 300 includes buffer solution space
301, test sample space 302, injection port 303 and control mechanism 304, wherein the control mechanism 304 is key.Electrode 500
The both ends of capillary 100 are set.Detection window 600 is arranged in the nearly outlet end of capillary 100.
Before being detected by capillary electrophoresis to test sample, switching construction 300 is in first state.When need
When the capillary electrophoresis being used to detect detection sample, which can be inserted into capillary
The electrode 500 of capillary electrophoresis is connect by electrophoresis detection system with the power supply of analysis system of capillary electrophoresis.Then, it presses
Dynamic control mechanism 304, is switched to the second state for switching construction 300, at this point it is possible to empty to test sample by injection port 303
Between inject test sample in 302, the voltage provided using power supply will test sample and be pushed in capillary 100, wherein the electricity
Pressure can be the second class voltage.Then, control mechanism 304 is pressed, switching construction 300 is switched into first state, utilizes power supply
The voltage of offer makes buffer solution that test sample be driven to move in capillary 100, wherein the voltage can be first kind electricity
Pressure.Analysis system of capillary electrophoresis detects the test sample in capillary 100 in detection window 600, obtains detection sample
Substance included in product.When the tests are completed, which can be pulled out from analysis system of capillary electrophoresis
Out, it is inserted into new capillary electrophoresis, can be detected next time at once.
It can be seen that since the capillary electrophoresis has capillary, fixed structure and switching construction simultaneously, so that should
Capillary electrophoresis can be good at saving capillary and separation therein be situated between when independently of analysis system of capillary electrophoresis
Matter, and it is able to carry out the switching of buffer solution and test sample, so that capillary electrophoresis is convenient for and capillary electrophoresis system
Rationally cooperation, and realize replaceability；Shape can be used in addition, being perfused with separating medium in capillary in advance and being in capillary
State is no longer needed to pre-process it, be activated.That is, after completing one-time detection, it can be directly with new capillary
Electrophoretic apparatus is replaced used capillary electrophoresis, without cleaning, shortens and is spaced duration between detection twice, mention
High user experience.
The above is only the preferred embodiment of the utility model, it is noted that for the common skill of the art
For art personnel, without departing from the principle of this utility model, several improvements and modifications can also be made, these improve and
Retouching also should be regarded as the protection scope of the utility model.
Claims (10)
1. a kind of interchangeable capillary electrophoresis, which is characterized in that described device includes capillary, fixed structure and switching
Structure:
Separating medium is perfused in the capillary in advance, the capillary is solid by the fixed structure and the switching construction
It connects；The input end that the capillary is used to receive test sample is connected to the connectivity port of the switching construction, the capillary
The outlet end of pipe is in buffer solution；
It include the buffer solution space and test sample space for prestoring buffer solution, the switching construction in the switching construction
In first state, the buffer solution space is connected to by the connectivity port with the input end, and the switching construction exists
When the second state, the test sample space is connected to by the connectivity port with the input end；Wherein, passing through the hair
Before cons electrophoresis device detects test sample, the switching construction is in the first state.
2. the apparatus according to claim 1, which is characterized in that the switching construction further includes injection port, the injection port
For injecting test sample to the test sample space；The capillary electrophoresis is being inserted into capillary electrophoresis detection system
When system, the injection port is located at except the analysis system of capillary electrophoresis.
3. device according to claim 1 or 2, which is characterized in that the switching construction includes control mechanism, passes through triggering
The control mechanism switches the switching construction between the first state and the second state, fills by the Capillary Electrophoresis
When setting insertion analysis system of capillary electrophoresis, the control mechanism is located at except the analysis system of capillary electrophoresis.
4. the apparatus of claim 2, which is characterized in that if being infused by the injection port to the test sample space
Test sample is entered, test sample has been detected by the capillary electrophoresis in the analysis system of capillary electrophoresis
When, the switching construction is switched to second state to inject the test sample into the capillary.
5. device according to claim 4, which is characterized in that, will after injecting the test sample to the capillary
The switching construction switches to the first state, to drive the inspection using the buffer solution in the buffer solution space
Sample moves in the capillary.
6. the apparatus according to claim 1, which is characterized in that described device further includes electrode, and the electrode is arranged in institute
The both ends of capillary are stated, the electrode with the power supply in the analysis system of capillary electrophoresis for connecting, so as to the power supply
Voltage, which can be provided, pushes the test sample to move in the capillary.
7. the apparatus according to claim 1, which is characterized in that described device further includes detection window, the detection window
It is arranged at the nearly outlet end of the capillary, will pass through the detection window to the hair in the detection window
Substance in tubule is detected.
8. device according to claim 7, which is characterized in that the detection window is through the poroid or described fixed structure
Upper transparent region.
9. the apparatus according to claim 1, which is characterized in that the fixed structure is card-like, and the capillary is fixed
In the inside of the fixed structure.
10. the apparatus according to claim 1, which is characterized in that the shape of the capillary is U-shaped.
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| CN201820778331.1U CN208206865U (en) | 2018-05-23 | 2018-05-23 | A kind of interchangeable capillary electrophoresis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108732229A (en) * | 2018-05-23 | 2018-11-02 | 山东科立森生物股份有限公司 | A kind of interchangeable capillary electrophoresis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108732229A (en) * | 2018-05-23 | 2018-11-02 | 山东科立森生物股份有限公司 | A kind of interchangeable capillary electrophoresis |
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