CN208104384U - A kind of bioreactor of the collet with degassing function - Google Patents
A kind of bioreactor of the collet with degassing function Download PDFInfo
- Publication number
- CN208104384U CN208104384U CN201820256295.2U CN201820256295U CN208104384U CN 208104384 U CN208104384 U CN 208104384U CN 201820256295 U CN201820256295 U CN 201820256295U CN 208104384 U CN208104384 U CN 208104384U
- Authority
- CN
- China
- Prior art keywords
- valve
- bioreactor
- collet
- tank body
- water inlet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Abstract
The utility model provides a kind of bioreactor of the collet with degassing function, including：Tank body and the chuck layer outside tank body, form closed cavity between the inner wall of chuck layer and the outer wall of tank body；One medium circulation pipeline, both ends pass through the top of water inlet pipe connection cavity on one respectively, and the lower part of cavity is connected to by water inlet pipe once, and the medium circulation pipe road is provided with a circulating pump and a heat exchanger；One drainpipe, is connected to the lower part of cavity, and drainpipe is equipped with shut-off valve and/or drain valve；Wherein, an exhaust valve is provided on the upper water inlet pipe.Compared with the jacketed pipeline of existing bioreactor, the embodiment of the utility model can make collet water inlet more thorough, guarantee that the circulatory mediator of bioreactor is single, improve the heating efficiency of bioreactor tank body, guarantee the stability of biological pot temperature.
Description
Technical field
The utility model relates to animal cell culture technology fields, and in particular to a kind of biology of the collet with degassing function is anti-
Answer device.
Background technique
Bioreactor is carried out in vitro biochemical anti-using biological function possessed by enzyme or organism (such as microorganism)
The device answered, it is a kind of biological function analog machine, such as fermentor, immobilised enzymes or immobilized cell reactor.It is biological anti-
Device is answered to can be used for the animal cell culture of pharmaceuticals industry.
By now on the market for certain bioreactor comprising the chuck layer outside tank body and tank body, the collet
Closed cavity is formed between layer and the outer wall of tank body, respectively has an inlet pipeline, upper water inlet pipe in the upper and lower part of chuck layer
Routing metal hose is directly connected with chuck layer, lower inlet valve is equipped on lower inlet pipeline, a drainpipe is arranged at chuck layer lower part
In the connecting tube of road, circulating pump and heat exchanger being set between upper and lower two inlet pipelines, pass through power supply power supply.
The water in cavity is set to recycle to get up sterilize to the product in tank, protect by circulating pump in process of production
Temperature.The supplement of jacket water (J.W.) should follow the principle of bottom in and top out, can guarantee that cavity is filled with water in this way.It sterilizing, keeping the temperature
Cheng Zhong, all water circulations just can guarantee that the heating of tank body is stablized in cavity, heat preservation homeostasis.
However, the supplement of recirculated water does not follow the rule unidirectionally passed in and out in the collet design of existing bioreactor,
When opening lower inlet valve progress moisturizing, recirculated water can intake in cavity simultaneously through two pipelines, cause residual in cavity
Stay gas that cannot be discharged, thus when the water in cavity is shown by the liquidometer set up and filled, actually it is likely to water and sky
Gas mixing is full of collet, and two kinds of different circulatory mediator heat absorptions and capacity of heat transmission are inconsistent, and then cause circulating water temperature unstable
It is fixed, therefore will lead to during sterilizing, heat preservation, the unstable situation of pot temperature influences sterilizing or heat insulation effect.
Utility model content
The purpose of the utility model is to overcome the deficiencies in the prior art, and it is anti-to provide a kind of biology of the collet with degassing function
Device is answered, compared with the jacketed pipeline of existing bioreactor, the embodiment of the utility model can make collet water inlet more thorough, protect
The circulatory mediator for demonstrate,proving bioreactor is single, improves the heating efficiency of bioreactor tank body, guarantees the steady of biological pot temperature
It is qualitative.
The utility model solves its technical problem and adopts the following technical solutions to achieve：
A kind of bioreactor of the collet with degassing function, including：
Tank body and the chuck layer outside tank body, form closed sky between the inner wall of chuck layer and the outer wall of tank body
Chamber；
One medium circulation pipeline, both ends pass through the top of water inlet pipe connection cavity on one respectively, are connected by water inlet pipe once
The lower part of logical cavity, the medium circulation pipe road are provided with a circulating pump and a heat exchanger；
One drainpipe, is connected to the lower part of cavity, and drainpipe is equipped with shut-off valve and/or drain valve；
Wherein, an exhaust valve is provided on the upper water inlet pipe.
Further, the exhaust valve is three-way valve or automatic exhaust steam valve.
Further, shut-off valve and/or regulating valve are equipped on the drainpipe, upper water inlet pipe and lower water inlet pipe.
Further, the shut-off valve and regulating valve are ball valve.
It further, further include the water pipe being connected to medium circulation pipeline.
Further, water pipe is equipped with filter device.
The utility model has the beneficial effects that：By taking above-mentioned technical proposal, the bioreactor of the utility model can
The residual gas in reactor jacket is effectively discharged, makes recirculated water well into collet, guaranteeing that circulating water temperature is stablized, improve
The heating efficiency of bioreactor tank body makes during sterilizing, heat preservation, and pot temperature is stablized, and guarantees sterilizing or heat preservation effect
Fruit.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of bioreactor of the collet with degassing function in an embodiment of the present invention.
In figure：1, tank body, 2, chuck layer, 3, lower inlet valve, 4, outlet valve, 5, heat exchanger, 6, circulating pump, 7, exhaust
Valve, 8, upper inlet valve.
Specific embodiment
The utility model is further described below in conjunction with attached drawing：
As shown in Figure 1, a kind of bioreactor of the collet with degassing function, including tank body 1 are provided in one embodiment, with
And the chuck layer 2 outside tank body, closed cavity is formed between the chuck layer 2 and the outer wall of tank body 1, in the upper of chuck layer 2
One inlet pipeline is respectively arranged at portion and lower part, and inlet valve 8 and exhaust valve 7 are equipped on upper inlet pipeline, is installed on lower inlet pipeline
There is lower inlet valve 3, a drainpipe is arranged at collet lower part, and containing outlet valve 4, the position of circulating pump 6 and heat exchanger 5 is located at upper and lower two
Between a inlet valve, is energized and driven by power supply.Wherein, exhaust valve is selected from three-way valve or automatic exhaust steam valve.Upper inlet valve, under into
Water valve and outlet valve are selected from shut-off valve or regulating valve, and concrete type is, for example, ball valve.Upward water inlet pipe and lower water inlet pipe are mended
The water pipe of water is equipped with filter device, to prevent impurity from entering to damage circulating pump in pipe-line system, also influences heating
Effect.
Increase a three-way connection by the upper inlet pipeline of the chuck layer 2 in bioreactor tank body 1, in three-way connection
One end install exhaust valve 7, when being heated or being cooled down to bioreactor, recirculated water by heat exchanger 5 keep stablize
Temperature after opening exhaust valve 7 and closing upper inlet valve 8, opens lower inlet valve 3, can recirculated water from upper inlet pipeline simultaneously
While in into collet, the residual gas in collet is discharged by exhaust valve 7.Then inlet valve 8 is opened again, and water is allowed to fill
Point enter in bioreactor collet, exhaust valve 7 is closed when heat preservation, can effectively accelerate the fluctuation of equilibrium temperature, to maintain biology
The temperature of reacting tank body.
In addition, in a preferred embodiment, it is also contemplated that flow-guiding structure is arranged on the outer wall of tank body in the cavities.It leads
Flow structure can be spiral plate continuously or discontinuously.Spiral board width is equal to or less than chuck layer at a distance from tank wall.Spiral
Board width is not less than 70% of chuck layer at a distance from tank wall.The spiral number of plies of spiral plate is not less than three layers.Spiral plate
Helix angle is 5 to 40 °." dead angle " that medium circulation in cavity can be reduced by water conservancy diversion may make heating more abundant.
The utility model is described in detail in above embodiments, but the content is only the preferable reality of the utility model
Example is applied, should not be considered as limiting the scope of the present invention.Equalization made according to the scope of application of this utility model
Variation and improvement etc., should still belong within the patent covering scope of the utility model.
Claims (6)
1. a kind of bioreactor of collet with degassing function, which is characterized in that including：
Tank body and the chuck layer outside tank body, form closed cavity between the inner wall of chuck layer and the outer wall of tank body；
One medium circulation pipeline, both ends pass through the top of water inlet pipe connection cavity on one respectively, are connected to by water inlet pipe once empty
The lower part of chamber, the medium circulation pipe road are provided with a circulating pump and a heat exchanger；
One drainpipe, is connected to the lower part of cavity, and drainpipe is equipped with shut-off valve and/or drain valve；
Wherein, an exhaust valve is provided on the upper water inlet pipe.
2. bioreactor of the collet as described in claim 1 with degassing function, which is characterized in that the exhaust valve is three-dimensional
Valve or automatic exhaust steam valve.
3. bioreactor of the collet as claimed in claim 2 with degassing function, which is characterized in that the drainpipe, enterprising
Shut-off valve and/or regulating valve are equipped on water pipe and lower water inlet pipe.
4. bioreactor of the collet as claimed in claim 3 with degassing function, which is characterized in that the shut-off valve and adjusting
Valve is ball valve.
5. bioreactor of the collet as described in claim 1 with degassing function, which is characterized in that further include and medium circulation
One water pipe of pipeline connection.
6. bioreactor of the collet as claimed in claim 5 with degassing function, which is characterized in that water pipe was equipped with
Filter device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820256295.2U CN208104384U (en) | 2018-02-13 | 2018-02-13 | A kind of bioreactor of the collet with degassing function |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820256295.2U CN208104384U (en) | 2018-02-13 | 2018-02-13 | A kind of bioreactor of the collet with degassing function |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN208104384U true CN208104384U (en) | 2018-11-16 |
Family
ID=64125284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201820256295.2U Active CN208104384U (en) | 2018-02-13 | 2018-02-13 | A kind of bioreactor of the collet with degassing function |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN208104384U (en) |
-
2018
- 2018-02-13 CN CN201820256295.2U patent/CN208104384U/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN201778022U (en) | Oil-rich microalgae culture device | |
| CN107384755A (en) | A kind of three-level anaerobic fermentation system | |
| CN108795706A (en) | A kind of light sensation thermal-insulating type fermentation stirring system | |
| CN110656043A (en) | Microbial fermentation tank for producing liquid feed additive | |
| CN208104384U (en) | A kind of bioreactor of the collet with degassing function | |
| CN107828649B (en) | Large-scale full-mixing type anaerobic biogas fermentation tank thermal compensation system and process method thereof | |
| CN101818114A (en) | Annually constant and stable methane production system by solar heating | |
| CN201284344Y (en) | Constant temperature anaerobic reactor | |
| CN204174211U (en) | A kind of high-temperature anaerobic fermentation device | |
| CN207483762U (en) | Large-scale full-mixing type anaerobic marsh-gas fermentation tank thermal compensation system | |
| US20100105131A1 (en) | Circulatory packed bed reactor | |
| CN207468623U (en) | A kind of alcohol fuel fermentation tank | |
| CN110042046A (en) | The built-in stirring mocromembrane of continuous immobilization is aerated internal circulation gas-lift type bioreactor | |
| CN105316230A (en) | Two-way temperature control device of minitype fermentation tank | |
| CN205590707U (en) | Fermentation cylinder cooling back installation | |
| CN204509322U (en) | A kind of anaerobic reaction experimental installation of temperature-controllable | |
| CN208829655U (en) | A kind of light sensation thermal-insulating type fermentation stirring system | |
| CN209352882U (en) | A kind of low energy consumption constant temperature pickle fermentation system | |
| CN208098082U (en) | A kind of waterproofing agent production reaction kettle with temperature control system | |
| CN202350388U (en) | Composite low-grade heat source heat pump heating system used in two-stage anaerobic fermentation process | |
| CN214991623U (en) | Automatic temperature control system of microbial fermentation tank | |
| CN207775209U (en) | A kind of automatic culture apparatus of wastewater treatment microbial | |
| CN218710506U (en) | Temperature control device for bacillus coagulans fermentation tank | |
| CN117348421B (en) | Self-adaptive automatic control system and method for oil product preparation | |
| CN219824172U (en) | Methane reaction device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address |
Address after: No. 1 and No. 2 Juli Road 280, China (Shanghai) Free Trade Pilot Area, Pudong New Area, Shanghai, 2003 Patentee after: Tian Shi Li biological medicine Limited by Share Ltd Address before: 201203 No. 280 Curie Road, Zhangjiang High-tech Park, Pudong New Area, Shanghai Patentee before: Shanghai Tasly Pharmaceutical Co., Ltd. |
|
| CP03 | Change of name, title or address |