CN207649986U - A kind of Full-automatic slice-dyeing machine - Google Patents
A kind of Full-automatic slice-dyeing machine Download PDFInfo
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- CN207649986U CN207649986U CN201820016189.7U CN201820016189U CN207649986U CN 207649986 U CN207649986 U CN 207649986U CN 201820016189 U CN201820016189 U CN 201820016189U CN 207649986 U CN207649986 U CN 207649986U
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- liquid zone
- glass frame
- dyeing
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- pancreatin
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Abstract
The utility model discloses a kind of Full-automatic slice-dyeing machines, including organism, operating mechanism and electric-control system, it is provided with glass frame rest area in body, rinses liquid zone, dyeing liquid zone, pancreatin liquid zone and slide air drying area, it is placed with glass frame in glass frame rest area, in glass frame there are several slides to place position；It is equipped with the machinery folder for the crawl glass frame that can move up and down in the top of slide rest area.The utility model can at most put down 300 sample slides, have the advantages that high throughput；Optimize stirring means, is not necessarily to agitating device, is moved up and down and be stirred using mechanical arm, it is highly uniform；Preheating step is set, ensures that temperature is at 37 degree when slide carries out pancreatin resolution；Using dyeing or pancreatin digestion time compensation technique, change with stin of thickness and increase dyeing or pancreatin digestion time, ensure that Coplin or resolution effect reach consistency.
Description
Technical field
The utility model is related to technical field of medical auxiliary equipment, and in particular to it is a kind of for the sample on glass slide into
The machinery of row dyeing.
Background technology
In medical test and scientific research, it is often necessary to carry the preparation such as sample such as living tissue, cell, chromosome
The surface of slide obtains diagnostic result to carry out observation analysis to features such as its form, color, constructions with microscope.And
During prepared by slide specimen, need by a critical step：The sample on glass slide is dyed.It carries
The dyeing course generally use manual operations of slide specimen or mechanical arm and intelligent program cooperation are automatically brought into operation, that is, will
Multi-disc glass slide is placed in a glass frame, and glass frame is sent to one or more color ponds by mechanical gripper and the control of XY axis
In dyed.
However, there are following problems for current automatic slide stainer：First, slide specimen is to be immersed in dyeing examination
It is dyed in agent pond, every time after dyeing, the liquid measure and concentration of staining reagent all can be reduced and be reduced in pond, make front and back dyeing
Sample cannot be carried out under same stain concentration, cannot get consistent coloring, influence diagnostic analysis.Second, dyeing
Crossing range request color pond keeps temperature constant, such as 37 degree ± 1 degree.But carry glass when that will be opened equipped with 10-30 under room temperature state
When the glass frame of piece is put into color pond, the temperature of staining reagent is lower the several years immediately in pond, and to wait for a period of time could be permanent
Fixed, dyeing temperature is difficult control, seriously affects coloring.Third is often stirred in color pond using bar magnet in dyeing course
Staining reagent is mixed to reach uniform reagent concentration, but agitating device will increase the volume of reagent, increases amount of reagent.The
Four, the flux of automatic slide stainer is too small at present, cannot be satisfied the requirement in high-throughput laboratory.
Utility model content
The utility model is directed to disadvantage of the existing technology, provides a kind of simple in structure, easy to use, high-throughput, nothing
Need the better Full-automatic slice-dyeing machine of agitating device, coloring.
In order to solve the above technical problems, the utility model adopts the following technical solution：A kind of Full-automatic slice-dyeing machine, feature
It is：Including organism, operating mechanism and electric-control system, dying operation area is provided in body, dying operation is equipped in area
Liquid zone, dyeing liquid zone, pancreatin liquid zone and slide air drying area are rinsed in glass frame rest area, and being placed in glass frame rest area can
With the glass frame removed, in glass frame there are several slides to place position；It is equipped in the top of slide rest area for capturing glass
The machinery folder of horse, machinery folder are mounted on a Z-axis mechanism moving up and down, and Z-axis mechanism is mounted on an X that can be moved left and right
Machinery folder is formed on axis mechanism can carry out glass frame in mobile structure, machinery folder, Z-axis mechanism and X-axis mechanism attended operation machine
Structure and electric-control system；It rinses liquid zone and holds flushing liquor, dyeing liquid zone holds dyeing liquor, and pancreatin liquid zone holds trypsin solution.
Further, the glass frame rest area, rinse liquid zone, dyeing liquid zone, pancreatin liquid zone and slide air drying area from a left side
It is arranged in a linear successively to the right side and is set to the lower section of X-axis mechanism, and installed respectively rinsing liquid zone, dyeing liquid zone and trypsin solution area
There is liquid level sensor；The flushing liquid zone includes that the first flushing liquid zone, the second flushing liquid zone and third rinse liquid zone.
Further, the glass frame rest area is provided with the glass frame placement position of 10 word orders, each glass frame
It places position and places a glass frame.
Preferably, each glass frame is provided with 30 slides and places position.
Further, it is provided with water gauge between slide air drying area and pancreatin liquid zone.
Further, it is provided with detector on the subsequent body in pancreatin liquid zone；It is additionally provided on body for prompting work
Make the alarm of state.
Further, it can be placed multiple equipped with the reagent bottle bracket that can place several reagent bottles in the side of body
Reagent bottle, to facilitate addition test solution.
Further, a glass protecting cover that can be opened and closed is equipped on body, in glass protecting the cover after by the dye
Color operating space is covered in inside；Cooling fan is equipped on body, dying operation area is in communication with the outside by cooling fan.
Further, a gathering hole is equipped on glass protecting cover, gathering hole covers rear alignment function mechanism, the operation
Mechanism is contact action mechanism, can be operated to contact action mechanism after covering glass protecting cover by gathering hole.
Workflow：
1, the sample slide prepared is first put into glass frame, each glass frame can place 1-30 piece slides；
2,10 glass frames are placed in the slide rack position of equipment；
3, various reagents have been configured, including coloring agent, trypsin solution, flushing liquor A (can be water or physiological saline or alcohol
Deng), flushing liquor B (can be water or physiological saline or alcohol etc.), flushing liquor C (water) etc. be placed in corresponding reagent bottle；
4, setting computer intelligent control program, including：The immersion of each reagent and washing time, glass frame preheating are done
The dry time, concentration, which reduces, impregnates compensation time, the functions such as fluid injection, drain, cleaning；
5, it brings into operation：By program setting, dyeing, the drying process of most 300 piece sample slides will be completed incessantly,
Reach best effects.Carrying out practically process：1) mechanical gripper takes a glass frame, arrive first air-dry be preheated to 37 degree；2) it is moved to
Pancreatin digester；3) flushing liquor A is arrived；4) flushing liquor B is arrived；5) color pond is arrived；6) it arrives water to rinse, i.e. flushing liquor C；7) it air-dries dry；
8) it is put back into original position.Second glass frame is taken again, is repeated.All liq has liquid level sensing device, if liquid level reduces, can start certainly
Dynamic liquid feeding, maintains like liquid reagent amount.
The slide that the utility model can place 10 glass frames by setting is placed, and each can at most place 30,
300 sample slides can be at most put down altogether, have the advantages that high throughput；Optimize stirring means, be not necessarily to agitating device, uses
Mechanical arm, which moves up and down, to be stirred, highly uniform；Preheating step is set, and when ensureing that slide carries out pancreatin resolution, temperature is 37
± 1 degree of degree；Using dyeing or pancreatin digestion time compensation technique, when changing increase dyeing or pancreatin resolution with stin of thickness
Between, it ensure that Coplin or resolution effect reach consistency.
Description of the drawings
Fig. 1 is the utility model structure chart；
Fig. 2 is the partial enlarged view of Fig. 1.
In figure, 1 is body, and 2 be operating mechanism, and 3 be glass frame rest area, and 4 be glass frame, and 5 be machinery folder, and 6 be X-axis machine
Structure, 7 be Z-axis mechanism, and 8 rinse liquid zone for first, and 9 rinse liquid zone for second, and 10 rinse liquid zone for third, and 11 be dyeing liquid zone,
12 be pancreatin liquid zone, and 13 be slide air drying area, and 14 be liquid level sensor, and 15 be detector, and 16 be water gauge, and 17 be reagent bottle holder
Frame, 18 be reagent bottle, and 19 be cooling fan, and 20 be glass protecting cover, and 21 be gathering hole.
Specific implementation mode
In the present embodiment, referring to Figures 1 and 2, the Full-automatic slice-dyeing machine, including organism 1, operating mechanism 2 and automatically controlled
System is provided with dying operation area in body 1, and glass frame rest area 3 is equipped in dying operation area, rinses liquid zone, dyeing liquor
Area 11, pancreatin liquid zone 12 and slide air drying area 13 are placed with the glass frame 4 that can be removed, glass frame in glass frame rest area 3
In 4 there are several slides to place position；It is equipped with the machinery folder 5 for capturing glass frame 4, machinery in the top of slide rest area 3
Folder 5 is mounted on a Z-axis mechanism 7 moving up and down, and Z-axis mechanism 7 is mounted in an X-axis mechanism 6 that can be moved left and right and is formed
Glass frame 4 can be carried out mobile structure, machinery folder 5, Z-axis mechanism 7 and 6 attended operation mechanism 2 of X-axis mechanism and electricity by machinery folder 5
Control system；It rinses liquid zone and holds flushing liquor, dyeing liquid zone 11 holds dyeing liquor, and pancreatin liquid zone 12 holds trypsin solution.
The glass frame rest area 3, rinse liquid zone, dyeing liquid zone 11, pancreatin liquid zone 12 and slide air drying area 13 from a left side to
The right side is arranged in a linear successively is set to the lower section of X-axis mechanism 6, and distinguishes rinsing liquid zone, dyeing liquid zone 11 and pancreatin liquid zone 12
Liquid level sensor 14 is installed；The flushing liquid zone includes that the first flushing liquid zone 8, second rinses liquid zone 8 and third flushing liquor
Area 9.
The glass frame that the glass frame rest area 3 is provided with 10 word orders places position, and each glass frame placement position is put
Set a glass frame 4.
Each glass frame 4 is provided with 30 slides and places position.
Water gauge 16 is provided between slide air drying area 13 and pancreatin liquid zone 12.
It is provided with detector 15 on 12 subsequent body of pancreatin liquid zone；It is additionally provided on body 1 for prompting work shape
The alarm of state.
The reagent bottle bracket 17 of several reagent bottles 18 can be placed by being equipped in the side of body 1, can place multiple reagents
Bottle 18, to facilitate addition test solution.
A glass protecting cover 20 that can be opened and closed is equipped on body 1, glass protecting cover 20 grasps the dyeing after covering
It is covered in inside as area；Cooling fan 19 is equipped on body 1, dying operation area is in communication with the outside by cooling fan 19.
A gathering hole 21 is equipped on glass protecting cover 20, gathering hole 21 covers rear alignment function mechanism, the operation machine
Structure is contact action mechanism, can be operated to contact action mechanism after covering glass protecting cover 20 by gathering hole 21.
Workflow：
1, the sample slide prepared is first put into glass frame 4, each glass frame 4 can place 1-30 piece slides；
2,10 glass frames 4 are placed in the slide rack position of equipment；
3, various reagents have been configured, including (physiological saline can also be alcohol or water by coloring agent, trypsin solution, flushing liquor A
Deng), flushing liquor B (alcohol can also be physiological saline or water etc.), flushing liquor C (water can also be physiological saline or alcohol etc.)
Etc. being placed in corresponding reagent bottle；
4, setting computer intelligent control program, including：The immersion of each reagent and washing time, glass frame preheating are done
The dry time, concentration, which reduces, impregnates compensation time, the functions such as fluid injection, drain, cleaning；
5, it brings into operation：By program setting, dyeing, the drying process of most 300 piece sample slides will be completed incessantly,
Reach best effects.Carrying out practically process：1) machinery folder 5 crawl one glass frame 4, arrive first air-dry be preheated to 37 degree；2) mobile
To pancreatin digester；3) flushing liquor A is arrived；4) flushing liquor B is arrived；5) color pond is arrived；6) it arrives water to rinse, i.e. flushing liquor C；7) it air-dries
It is dry；8) it is put back into original position.Second glass frame is taken again, is repeated.All liq has liquid level sensing device, if liquid level reduces, can open
Dynamic automatic liquid-feeding, maintains like liquid reagent amount.
The utility model is described in detail above, it is described above, only the preferred embodiment of the utility model and
, when the utility model practical range cannot be limited, i.e., all according to the made equivalent changes and modifications of the application range, it all should still belong to this
In utility model covering scope.
Claims (9)
1. a kind of Full-automatic slice-dyeing machine, it is characterised in that：Including organism, operating mechanism and electric-control system, it is arranged in body
There is dyeing operating space, glass frame rest area is equipped in dying operation area, rinses liquid zone, dyeing liquid zone, pancreatin liquid zone and slide wind
Dry area is placed with the glass frame that can be removed in glass frame rest area, in glass frame there are several slides to place position；In glass
The top of piece rest area is equipped with the machinery folder for capturing glass frame, and machinery folder is mounted on a Z-axis mechanism moving up and down,
Z-axis mechanism, which is mounted on formation machinery folder in an X-axis mechanism that can be moved left and right, can carry out glass frame mobile structure, machinery
Folder, Z-axis mechanism and attended operation mechanism of X-axis mechanism and electric-control system；It rinses liquid zone and holds flushing liquor, dyeing liquid zone holds dyeing
Liquid, pancreatin liquid zone hold trypsin solution.
2. Full-automatic slice-dyeing machine according to claim 1, it is characterised in that：Liquid zone, dye are rinsed in the glass frame rest area
Color liquid zone, pancreatin liquid zone and slide air drying area are from left to right arranged in a linear successively is set to the lower section of X-axis mechanism, and is rinsing
Liquid zone, dyeing liquid zone and trypsin solution area are separately installed with liquid level sensor；The flushing liquid zone includes the first flushing liquid zone,
Two rinse liquid zone and third flushing liquid zone.
3. Full-automatic slice-dyeing machine according to claim 1, it is characterised in that：The glass frame rest area is provided with 10 one
The glass frame of word arrangement places position, and each glass frame places position and places a glass frame.
4. Full-automatic slice-dyeing machine according to claim 1, it is characterised in that：Each glass frame is provided with 30 slides and places
Position.
5. Full-automatic slice-dyeing machine according to claim 2, it is characterised in that：It is set between slide air drying area and pancreatin liquid zone
It is equipped with water gauge.
6. Full-automatic slice-dyeing machine according to claim 1, it is characterised in that：It is provided on the subsequent body in pancreatin liquid zone
Detector；The alarm for prompting working condition is additionally provided on body.
7. Full-automatic slice-dyeing machine according to claim 1, it is characterised in that：Several can be placed by being equipped in the side of body
The reagent bottle bracket of reagent bottle.
8. Full-automatic slice-dyeing machine according to claim 1, it is characterised in that：The glass that can be opened and closed is equipped on body
Protective cover, in glass protecting the cover after the dying operation area is covered in inside；Cooling fan, cooling fan are equipped on body
Dying operation area is in communication with the outside.
9. Full-automatic slice-dyeing machine according to claim 8, it is characterised in that：A gathering hole is equipped on glass protecting cover,
Gathering hole covers rear alignment function mechanism, and the operating mechanism is contact action mechanism.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820016189.7U CN207649986U (en) | 2018-01-02 | 2018-01-02 | A kind of Full-automatic slice-dyeing machine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820016189.7U CN207649986U (en) | 2018-01-02 | 2018-01-02 | A kind of Full-automatic slice-dyeing machine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207649986U true CN207649986U (en) | 2018-07-24 |
Family
ID=62876094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201820016189.7U Active CN207649986U (en) | 2018-01-02 | 2018-01-02 | A kind of Full-automatic slice-dyeing machine |
Country Status (1)
| Country | Link |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109297794A (en) * | 2018-10-18 | 2019-02-01 | 广州安必平医药科技股份有限公司 | All-in-one machine is dyed in dyed plate and film-making |
| CN109855941A (en) * | 2019-03-12 | 2019-06-07 | 上海皓信生物科技有限公司 | Dip dyeing formula dyeing instrument |
| CN111610079A (en) * | 2020-05-22 | 2020-09-01 | 佛山科学技术学院 | Multifunctional glass slide device |
| CN112611620A (en) * | 2020-12-15 | 2021-04-06 | 成都朴华科技有限公司 | Automatic change sperm staining equipment |
| CN113759136A (en) * | 2021-09-09 | 2021-12-07 | 珠海圣美生物诊断技术有限公司 | Full-automatic sample slide treatment instrument and sample slide treatment method |
| CN114323882A (en) * | 2021-12-31 | 2022-04-12 | 迈克医疗电子有限公司 | Slide glass making devices |
| CN114323883A (en) * | 2021-12-31 | 2022-04-12 | 迈克医疗电子有限公司 | Slide glass processing device |
-
2018
- 2018-01-02 CN CN201820016189.7U patent/CN207649986U/en active Active
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109297794A (en) * | 2018-10-18 | 2019-02-01 | 广州安必平医药科技股份有限公司 | All-in-one machine is dyed in dyed plate and film-making |
| CN109297794B (en) * | 2018-10-18 | 2023-12-26 | 广州安必平医药科技股份有限公司 | Dyeing plate and slice-making dyeing integrated machine |
| CN109855941A (en) * | 2019-03-12 | 2019-06-07 | 上海皓信生物科技有限公司 | Dip dyeing formula dyeing instrument |
| CN111610079A (en) * | 2020-05-22 | 2020-09-01 | 佛山科学技术学院 | Multifunctional glass slide device |
| CN112611620A (en) * | 2020-12-15 | 2021-04-06 | 成都朴华科技有限公司 | Automatic change sperm staining equipment |
| CN113759136A (en) * | 2021-09-09 | 2021-12-07 | 珠海圣美生物诊断技术有限公司 | Full-automatic sample slide treatment instrument and sample slide treatment method |
| CN114323882A (en) * | 2021-12-31 | 2022-04-12 | 迈克医疗电子有限公司 | Slide glass making devices |
| CN114323883A (en) * | 2021-12-31 | 2022-04-12 | 迈克医疗电子有限公司 | Slide glass processing device |
| CN114323883B (en) * | 2021-12-31 | 2023-11-14 | 迈克医疗电子有限公司 | Slide processing apparatus |
| CN114323882B (en) * | 2021-12-31 | 2024-03-29 | 迈克医疗电子有限公司 | Slide glass making device |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP02 | Change in the address of a patent holder |
Address after: Room 901, 902, 903, 904 and 907, 9th floor, F Block, Foshan Hi-tech Industrial Park, 70 Guxin Road, Chancheng District, Foshan City, Guangdong Province (Residence Declaration) Patentee after: Foshan Ai Dasi Precision Instrument Co., Ltd. Address before: 528200 No. 301, 3rd floor, Block C, No. 1, middle section of Luocun Floro Road, Shishan Town, Nanhai District, Foshan City, Guangdong Province Patentee before: Foshan Ai Dasi Precision Instrument Co., Ltd. |
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| CP02 | Change in the address of a patent holder |