CN206995284U - Degradable foramen ovale of heart arteriosus occluder - Google Patents
Degradable foramen ovale of heart arteriosus occluder Download PDFInfo
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- CN206995284U CN206995284U CN201521138998.8U CN201521138998U CN206995284U CN 206995284 U CN206995284 U CN 206995284U CN 201521138998 U CN201521138998 U CN 201521138998U CN 206995284 U CN206995284 U CN 206995284U
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Abstract
The utility model discloses a kind of degradable foramen ovale of heart arteriosus occluder, including the first plate-like net, tubular reticulum and the second plate-like net being sequentially connected, first plate-like net is additionally provided with closing in line, closing in line is arranged in all ring-type netting twines, and the outer wire side of the first plate-like net forms continuous netted face after the closing in of closing in line；Second plate-like net is provided with the connector for being used for that wire side to close up, and connector is formed by the dictyosome hot melt shaping at the outer wire side center of the second plate-like net, and the first plate-like net, tubular reticulum, the material of the second plate-like net and connector are degradation material.The structure that the utility model plugging device closing in line closes up adds the support force and recovery of plugging device, and reduces manufacture difficulty, reduces manufacturing cost.The utility model not only enables the degradable silk of composition plate-like net be securely attached together, and connector is securely attached together with forming the degradable silk of plate-like net, it is not easy to comes off.
Description
Technical field
It the utility model is related to a kind of degradable foramen ovale of heart arteriosus occluder.
Background technology
Acleistocardia is one kind in common congenital heart disease.Acleistocardia is mainly formed in the growth of fetus
In growth course, in embryonic development, first every right side grow again a falciform every, claim second every or secondary septum, this is every also
Grown to endocardial cushion direction, cover foramen secundum, but do not merged with endocardial cushion, and form an ovate hole, claim ovum
Circular hole.After fetal birth, oval foramen closes in typically after birth the 1st year, if child's oval foramen more than three years old does not close still,
Referred to as acleistocardia.There is 20%~25% adult's oval foramen not completely closed, the crack or probe for leaving very little can lead to
The aperture crossed.If oval foramen fails normally closed after birth, merged because septum primum fails nature adhesion with secondary septum, two
Remaining crack sample abnormal passage between person, a similar feature valve, when right atrial pressure is higher than left atrial pressure, left side weakness
Septum primum is open, that is, right-left shunt occurs.The long-term existence of acleistocardia can cause antimigraine, cerebral ischemia, cerebral apoplexy,
Decompression sickness, clinostatism breathe the illnesss such as upright hypoxemia syndrome and altitude sickness.
Foramen ovale of heart patent is common congenital heart disease, and traditional therapeutic modality is surgical operation.Surgical operation
Treatment method, the shortcomings that patient need to surgically open chest, and its is maximum is：(1) extracorporal circulatory system is needed in art, operation may
Cause complication and cause death；(2) surgery operating wound is big, postoperative to leave scar；(3) surgery cost is expensive.
From the 1980s with intubation intervention diagnosis and the development and raising for the treatment of technology, China is gradually introducing minimally invasive
Interventional technique treat congenital heart disease, developed rapidly by the method for Minimally Interventional Therapy acleistocardia, very into
It is ripe.Compared to traditional surgery, Minimally Interventional Therapy is a kind of modern high technology minimal invasive treatment, is confirmed through atrium dextrum radiography right
To after left shunt, end-hole catheter is placed in atrium sinistrum or left superior pulmonary vein through oval foramen, through end-hole catheter be sent into exchange guidewire in
Atrium sinistrum or left superior pulmonary vein, correspondingly sized conveying sheath is sent to enter atrium sinistrum；Plugging device is loaded, plugging device is sent into the left heart through sheath
Room, after the atrium sinistrum disk of plugging device opens completely and eel-like figure portion goes out sheath, conveying lever and long sheath are withdrawn together, make atrium sinistrum disk
Closely it is affixed with left atrial wall, eel-like figure portion is stuck at oval foramen completely, and then withdrawing sheath opens atrium dextrum disk.Through perspective and
When Echocardiography plugging device position and form meet to require, row atrium dextrum radiography is without right-left shunt, release envelope again
Stifled device, withdraw from conveying device and complete operation.Such Minimally Interventional Therapy have do not operate on, wound is small, few intercurrent disease, recovery
It hurry up, effect is good, indication scope is wide and the relatively low advantage of surgery cost.
Though have by the treatment method of minimally invasive intervention operation implantation oval hole plugging device many of the above relative to tradition
The advantage of surgical operation.But due to the material master used in the main body rack of the oval hole plugging device of present Clinical practice
To be nitinol alloy wire, because this metalloid material can not degrade, be chronically implanted can and tissue be inflamed, blood coagulation etc. it is anti-
Should, even a certain degree of damage, therefore the defects of certain be present, it is possible to risk used below be present in it：(1) NiTi
Alloy is nondegradable metal alloy compositions, although its biocompatibility is proved, the long term of long-term Permanent implantation
Risk can not be still perfectly controlled；(2) due to Nitinol Permanent implantation and non-degradable, heart is forever retained to human body
The influence for the heart that security, fixed-size heart occluder are constantly grown to children still lacks long-term follow-up money
Material, it may influence the growing of the patient's heart of undeveloped mature；(3) complication such as nickel precipitation, nickel allergy does not have yet
Clear and definite scientific appraisal.
On heart occluder surface by complete endothelialization, after heart defect is repaired by body autologous tissue, heart closure
Necessity that device is not retained in vivo completely.Therefore, preferable heart occluder should repair to provide one for heart itself
Temporary bridge, degraded after completing historic mission by body, defect is repaired completely by autologous tissue, so as to avoid metal from retaining body
The long term complication and potential safety hazard inside brought.
The supporting construction for the degradable plugging device introduced in United States Patent (USP) US08480709B2 is formed by pipe cutting, is blocked
The tie point of two cards of device is similar with dual welding spots, makes projection at two card centers, can increase plugging device surface local thrombus
The risk of formation, it is unfavorable for the endothelialization process on plugging device surface, meanwhile, the release of plugging device is made during implant surgery
Length is longer, easy impair cardiac tissue, and the plugging device compliance and recovery that are fabricated to by this method are poor, needs
It is assisted to reply original shape by locking device.
Utility model content
The technical problems to be solved in the utility model is deposited to solve the oval hole plugging device of existing Clinical practice
The long term risk the problem of, and prior art is overcome the defects of compliance and poor recovery of degradable plugging device to be present,
A kind of degradable foramen ovale of heart arteriosus occluder is provided.
The utility model is that solve above-mentioned technical problem by following technical proposals：
A kind of degradable foramen ovale of heart arteriosus occluder, its feature are that it includes one first disk being sequentially connected
Shape net, a tubular reticulum and one second plate-like net, the first plate-like net and the second plate-like net are double-deck guard, the pipe
The both ends of shape net are connected to the interior wire side of the first plate-like net and the interior wire side of the second plate-like net, first disk
Shape net, the tubular reticulum and the second plate-like net are formed in one；It is provided with and uses at the outer wire side center of the second plate-like net
In the connector that wire side closes up, the connector by the second plate-like net outer wire side center the shaping of dictyosome hot melt and
Material into, the first plate-like net, tubular reticulum, the second plate-like net and connector is degradation material, second plate-like
The outer net of net faces raised at the connector.
It is preferred that the first plate-like net includes a closing in end, the closing in end is multiple ring-type netting twines abutted successively,
The first plate-like net is additionally provided with a closing in line, and the closing in line is arranged in all ring-type netting twines, through the closing in line
The outer wire side of the first plate-like net forms the netted face of continuous formation after closing in.So so that outer wire side is more smooth, Ke Yizeng
Add the support force and recovery of plugging device, it is possible to reduce the risk that plugging device surface local thrombus is formed, be advantageous to accelerate closure
The endothelialization process on device surface, make at foramen ovale of heart patent being repaired by autologous tissue earlier.Meanwhile reduce surgical procedure
The release length of middle plugging device, can be greatly reduced the damage to heart, make operation more effective, safer.
It is preferred that the connector is tubulose, the height of the connector is 1.5-2.0mm.So cause the second plate-like
There is enough intensity at the outer wire side closing in of net.If the height of connector is too small, the thread turns inside connector is very few, meeting
Cause and be connected with induction system insecure and the risk that plugging device comes off be present., whereas if the height of connector is excessive, can increase
The risk for adding plugging device surface local thrombus to be formed, the side plugging device superficial cell climbing with connector can be caused slower,
Extend the endothelialization process on plugging device surface.Meanwhile make the release length of plugging device longer during implant surgery, easily
Impair cardiac tissue.
It is preferred that the external diameter of the connector is 2.5-3.2mm.So cause have at the outer wire side closing in of the second plate-like net
Enough intensity.In addition, if connector outside dimension is too small, easily cause to be connected with connector during connecting member forming
Degraded silk occur fracture or bonding strength decline., whereas if connector outside dimension is excessive, plugging device can be reduced and be applicable
The size range of delivery sheath, and it is unfavorable for push of the plugging device in delivery sheath.
It is preferred that the external diameter of the second plate-like net is bigger or isometrical than the external diameter of the first plate-like net.First plate-like net
Positioned at atrium sinistrum, the second plate-like net is located at atrium dextrum, for the patient of acleistocardia, when right atrial pressure is higher than atrium sinistrum
During pressure, the weak septum primum in left side is open, that is, right-left shunt occurs, and this structure makes the second plate-like net positioned at atrium dextrum
With larger support force, the impact of blood flow can be resisted, is advantageous to plugging device and is firmly clamped at acleistocardia, so
It will effectively can be blocked at foramen ovale of heart patent.
It is preferred that one first described plate-like net, a tubular reticulum, the material of one second plate-like net and the connector are
High molecular degradable silk.Biodegradable polymer material be PLA, polyglycolic acid, polycaprolactone, PPDO,
One kind or at least two copolymer in poly butyric ester, condensing model, polyphosphate, polyurethane, makrolon.These materials
Material has good biocompatibility, can be fully absorbed in human body, avoids long-term influence of the implantation foreign matter on human body.This
Kind of plugging device simply provides a temporary bridge for cardiac repair, is degraded after completion historic mission by body, make defect completely by
Autologous tissue repairs, so as to avoid metal from retaining the long term complication brought in vivo and potential safety hazard.
It is preferred that the connector is tubulose, the connector is provided with internal thread in the end relative with the dictyosome.It is logical
The connector of this helicitic texture is crossed, it is more firm with the connection of induction system, plugging device easily can be passed through into induction system
It is transported at foramen ovale of heart patent.
A kind of webmaster weaving method, including pin is inserted in the pinhole of mould rod, degradable silk is penetrated into sewing needle pin
Hole, knot and closely connect.Starting point is closely knotted with degradable silk, and the intersection point of uplink and downlink is marked with center during braiding
Note point alignment, with the trend of specification silk.Woven webmaster carries out thermal finalization together with mould rod.After stereotyped, pin is pulled out,
Remove webmaster.This weaving method makes the grid of webmaster more uniform, easily operated, reduces cost of manufacture.
A kind of preparation method of connector, making step include：
Step 1, webmaster is closed up；
Step 2, webmaster is put into mould；
Step 3, finishing dictyosome；
Step 4, the degradable silk of heating；
Step 5, shaping connector profile and internal whorl；
Step 6, remove dictyosome；
It is preferred that in step 1, the closing in end margin length of webmaster is first adjusted, edge is alignd, closed up with degradable silk.
It is preferred that in step 2, the webmaster that will close up, through the sleeve pipe in mould.
It is preferred that in step 3, stay a part to be used for making connector in original assembling length, remove the unnecessary of webmaster
Length.
It is preferred that in step 4, temperature control device is opened, adjusts temperature, against the degradable silk at connector above mould
Continuous heating, wherein, adjustment temperature is 40 DEG C -100 DEG C on high molecular polymer fusing point, 5-15 seconds continuous heating time, is added
In thermal process, over-heating can cause the other parts of dictyosome to heat together, so as to cause dictyosome destructurized, and greatly
The material molecule amount of connector part is reduced, material premature breakdown can be caused.Conversely, heating is insufficient, can cause at connector
Degradable silk can not fully heat and be integrated, complete connector female thread structure can not be formed, cause connector with it is defeated
Send the bonding strength of system inadequate.Therefore, it is necessary to which suitable acid extraction could be completed to heat.
It is preferred that in step 5, after continuous heating, the degradable silk of connector part is fused together, and removes temperature control dress
Put, the sliding block being then shut off in mould, and by the slot above the thread head insertion mould of mould, kept for a period of time.
It is preferred that in step 6, after cooling, the thread head rotation of mould is removed into mould, and sliding block is slowly removed,
Dictyosome is removed into mould.
The preparation method of this connector is easily operated, can obtain the connector of dimensionally stable, and reduces plugging device
On using material species, the degradable silk of composition plate-like net is securely attached to together, and make connector and composition
The degradable silk of plate-like net can be securely attached to together, it is not easy to be come off.
A kind of dictyosome method for shaping, including the dictyosome with connector is packed into dictyosome shaper, and consolidated with fixture
It is fixed, it is carried out thermal finalization together, after stereotyped, dictyosome be removed from the molds.Degradable membrane is packed into dictyosome with suture,
And it is a smooth card to carry out closing up at closing in end.This dictyosome method for shaping is easily operated, and the occluder size of making is stable,
The plugging device made by this kind of method has larger support force and preferable recovery of shape, meets the requirement of operation technique,
Make operation more effective, safer.
Positive effect of the present utility model is：
The utility model plugging device is knitted to form by high molecular degradable silk, and its biodegradation period is 6 months to 2 years,
It can be fully absorbed in human body, avoid long-term influence of the implantation foreign matter on human body.It is degradable used in the utility model
Or the absorbable material of human body, it is nontoxic to human body, there is good biocompatibility.The choked flow film of plugging device is biology
Degradable membrane, its biodegradation period are 6 months to 2 years, and degradation in vivo after it treats mission is completed in human body and is disappeared, nothing
Retained foreign body.Dictyosome at the outer wire side center of the second plate-like net is connector by high temperature sweat soldering, specifically, is led to
The dictyosome crossed at the outer wire side center to the second plate-like net is heated at high temperature, and heat-fused portion dictyosome is shaped into company with mould
Fitting, so make the degradable silk of composition plate-like net be not easy to scatter, can be securely attached together；Simultaneously so that connector
Degradable silk with forming plate-like net can be securely attached together, it is not easy to be come off.The wire side for being not installed with connector uses
The structure that closing in line closes up so that outer wire side is more smooth, can increase the support force and recovery of plugging device, it is possible to reduce closure
The risk that device surface local thrombus is formed, be advantageous to accelerate the endothelialization process on plugging device surface, make at foramen ovale of heart patent
Being repaired by autologous tissue earlier.Meanwhile reduce the release length of plugging device in surgical procedure, it can be greatly reduced to heart
Damage, makes operation more effective, safer；In addition, this plugging device also has the advantages of manufacturing cost is low.
Brief description of the drawings
Fig. 1 is the plugging device dimensional structure diagram of the utility model preferred embodiment.
Fig. 2 is the plugging device side portion structure schematic diagram of the utility model preferred embodiment.
Fig. 3 is the plugging device connector schematic diagram of the utility model preferred embodiment.
Fig. 4 is the A direction views in Fig. 1.
Fig. 5 is partial enlargement signal at the closing in end of the outer wire side of the first plate-like net of the utility model preferred embodiment
Figure.
Fig. 6 is the mould rod structural representation of the utility model preferred embodiment.
Fig. 7 is that the braiding of the webmaster of the utility model preferred embodiment threads schematic diagram.
Fig. 8 is the closing in end expanded schematic diagram of the webmaster of the utility model preferred embodiment.
Embodiment
Name preferred embodiment, and become apparent from intactly illustrating the utility model with reference to accompanying drawing.
As shown in Figure 1, Figure 2, shown in Fig. 3, Fig. 4, Fig. 5, a kind of degradable foramen ovale of heart arteriosus occluder, it is included successively
The first plate-like net 10, the plate-like net 20 of tubular reticulum 30 and second of connection, the first plate-like net 10 and the second plate-like net 20 are bilayer
Guard, the both ends of tubular reticulum 30 are connected to the interior wire side 22 of the plate-like net 20 of interior wire side 11 and second of the first plate-like net 10,
First plate-like net 10, the plate-like net 20 of tubular reticulum 30 and second are formed in one；Set at the center of outer wire side 21 of second plate-like net 20
There is the connector 40 that wire side closes up, connected between the outer wire side 21 and connector 40 of the second plate-like net 20 for sweat soldering；The
The outer wire side 12 of one plate-like net 10 includes closing in end 13, and closing in end 13 is multiple adjacent ring-type netting twines 14 successively, the first plate-like
Net 10 is additionally provided with closing in line 15, and closing in line 15 is arranged in all ring-type netting twines 14, the first plate-like net after the closing in of closing in line 15
10 outer wire side 12 forms continuous netted face.First plate-like net 10, tubular reticulum 30, the material of the second plate-like net 20 and connector 40
Material is degradation material.
Dictyosome of the plugging device of the present utility model at the outer wire side center of the second plate-like net 20 passes through high temperature sweat soldering
For connector, specifically, heated at high temperature by the dictyosome at the outer wire side center to the second plate-like net 20, and use mould
Heat-fused portion dictyosome is shaped into connector 40, so makes the degradable silk of composition plate-like net be not easy to scatter, can connect securely
It is connected together；Simultaneously so that connector 40 can be securely attached together with forming the degradable silk of plate-like net, it is not easy to de-
Fall.
Connector 40 is tubulose, is highly 1.5-2.0mm, external diameter 2.5-3.2mm.The outer wire side 21 of second plate-like net 20
It is raised at towards connector 40.The external diameter of second plate-like net is bigger or isometrical than the external diameter of the first plate-like net；Connector 40 is with connecting
The relative end of wire side 21 be provided with internal thread.
The material of first plate-like net 10, the plate-like net 20 of tubular reticulum 30 and second and connector 40 is high molecular degradable
Silk.Biodegradable polymer material is PLA, polyglycolic acid, polycaprolactone, PPDO, poly butyric
One kind or at least two copolymer in ester, condensing model, polyphosphate, polyurethane, makrolon.It can be filled in plugging device poly-
Lactic acid film so as to play a part of stop blood flow.
The utility model connector is formed by degradable silk hot melt, and needs to meet use condition, not only structure
It excessive can not cause to hinder push of the plugging device in delivery sheath, also to avoid because not caused enough the connector of bonding strength
Pull.
Table 1, connector size, anti-pulling-out force and the push test table in delivery sheath
| Height mm | External diameter mm | Anti- pulling-out force N | Whether obstruction pushes | |
| 1 | 2.0 | 1.8 | 6 (weak) | Do not hinder |
| 2 | 2.0 | 2.0 | 11 (weak) | Do not hinder |
| 3 | 2.0 | 2.5 | 25 (strong) | Do not hinder |
| 4 | 1.5 | 2.5 | 20 (strong) | Do not hinder |
| 5 | 1.8 | 2.8 | 31 (strong) | Do not hinder |
| 6 | 1.5 | 3.0 | 34 (strong) | Do not hinder |
| 7 | 2.0 | 3.2 | 41 (strong) | Do not hinder |
| 8 | 2.0 | 3.5 | 52 (strong) | Hinder |
Found in test, ensure that connector will not be pulled in use when anti-pulling-out force reaches 15N.Pass through upper table
It can be seen that the size of connector directly influences whether plugging device normally can be applied among operation in 1.Connector
Inappropriate size design connector can be caused to be pulled, or cannot be introduced into delivery sheath and pushed, these all can
Product is caused not use.
The mesh-covered tray of this plugging device first is continuous netted face, is closed up between its netting twine using closing in line so that outside first
Dropbox is the wire side of flat smooth, and no projection, the structure is advantageous to the reply of stopper shapes and support force improves, and more conducively adds
The endothelialization process on fast plugging device surface, makes heart defect be repaired earlier by autologous tissue.Plugging device of the present utility model exists
Dictyosome at the outer wire side center of second plate-like net is connector by high temperature sweat soldering, specifically, by the second disk
Dictyosome at the outer wire side center of shape net is heated at high temperature, and heat-fused portion dictyosome is shaped into connector with mould, so
Make the degradable silk of composition plate-like net be not easy to scatter, can be securely attached together；Simultaneously so that connector and composition plate-like
The degradable silk of net can be securely attached together, it is not easy to be come off.
The making of the utility model plugging device is mainly by webmaster shaping, connector making, dictyosome sizing and polylactic acid membrane
Sew several steps.
When webmaster weaves, by the pinhole 51 of pin insertion such as Fig. 6 mould rod 5, degradable silk is penetrated into sewing needle pin
Hole, knot and closely connect.The threading rule of braiding as shown in fig. 7, comprises connector manufacturing terminal D, closing in end B (after shaping into
For closing in end 13) and starting point C.Closely knotted with degradable silk at starting point C, intersection point and the center of uplink and downlink during braiding
Mark point is alignd, with the trend of specification silk.Woven webmaster carries out thermal finalization together with mould rod.After stereotyped, pin is pulled out
Son, remove webmaster.
Connector making step includes：
1st, webmaster is closed up；
2nd, webmaster is put into mould；
3rd, dictyosome is repaired；
4th, degradable silk is heated；
5th, connector profile and internal whorl are molded；
6th, dictyosome is removed；
Wherein, in step 1, the closing in end margin length of webmaster is first adjusted, edge is alignd, closed up with degradable silk, tool
For the closing in mode of body as shown in figure 8, including pin mark 61 and entry point 62 is gone out, the order of threading goes out pin mark according in Fig. 7
61 and entry point 62 closed up.In step 2, the webmaster that will have been closed up, through the sleeve pipe in mould.In step 3, in original
Have stays a part to be used for making connector in assembling length, removes the additional length of webmaster.In step 4, temperature control device is opened, is adjusted
Whole temperature, against the degradable silk continuous heating at connector above mould.In step 5, after continuous heating, connector portion
The degradable silk divided is fused together, and removes temperature control device, the sliding block being then shut off in mould, and the thread head of mould is inserted
In slot above mould, kept for a period of time.In step 6, after cooling, the thread head rotation of mould is removed into mould, and
Sliding block is slowly removed, dictyosome is removed into mould.
In addition, in step 4, adjustment temperature is continuous heating time 5- 40 DEG C -100 DEG C on high molecular polymer fusing point
15 seconds.Shown in table 2- tables 4 specific as follows, in heating process, over-heating can cause the other parts of dictyosome to heat together, so as to
Cause dictyosome destructurized, and greatly reduce the material molecule amount of connector part, so as to which material premature breakdown can be caused.
Conversely, heating is insufficient, the degradable silk at connector can be caused fully to heat and be integrated, can not formed complete
Connector female thread structure, cause the bonding strength of connector and induction system inadequate.Therefore, it is necessary to suitable heating-up temperature and
Time could complete to heat.
Table 2, L- lactide/glycolides (82/18) degradation material hot melt test table
| Heat time s | Heating-up temperature DEG C | Connector heats situation | Other parts heat situation | |
| 1 | 2 | 240 | Do not heat fully | Do not heat |
| 2 | 15 | 170 | Do not heat fully | Do not heat |
| 3 | 5 | 240 | Fully hot melt | Do not heat |
| 4 | 5 | 180 | Fully hot melt | Do not heat |
| 5 | 15 | 240 | Fully hot melt | Do not heat |
| 6 | 15 | 180 | Fully hot melt | Do not heat |
| 7 | 5 | 250 | Fully hot melt | Part holt melt |
| 8 | 20 | 180 | Fully hot melt | Part holt melt |
Table 3, PPDO degradation material hot melt test table
Table 4, L- lactides/caprolactone (70/30) degradation material hot melt test table
| Heat time s | Heating-up temperature DEG C | Connector heats situation | Other parts heat situation | |
| 1 | 2 | 210 | Do not heat fully | Do not heat |
| 2 | 15 | 140 | Do not heat fully | Do not heat |
| 3 | 5 | 210 | Fully hot melt | Do not heat |
| 4 | 5 | 150 | Fully hot melt | Do not heat |
| 5 | 15 | 210 | Fully hot melt | Do not heat |
| 6 | 15 | 150 | Fully hot melt | Do not heat |
| 7 | 5 | 220 | Fully hot melt | Part holt melt |
| 8 | 20 | 150 | Fully hot melt | Part holt melt |
Dictyosome sizing includes mould and dictyosome heat treatment shaping on dictyosome.On dictyosome during mould, the foregoing net with connector
Body is packed into dictyosome shaper, and is fixed with fixture, it is carried out thermal finalization together, after stereotyped, by dictyosome from mould
Take out.Polylactic acid membrane is packed into dictyosome with suture, and it is a smooth card at closing in end close up.
In description of the present utility model, it is to be understood that term " on ", " under ", "front", "rear", "left", "right",
The orientation or position relationship of the instruction such as " vertical ", " level ", " top ", " bottom ", " interior ", " outer " be based on orientation shown in the drawings or
Position relationship, it is for only for ease of description the utility model and simplifies description, rather than indicates or imply signified device or member
Part must have specific orientation, with specific azimuth configuration and operation, therefore it is not intended that to limitation of the present utility model.
Although the foregoing describing specific embodiment of the present utility model, it will be appreciated by those of skill in the art that
This is merely illustrative of, and the scope of protection of the utility model is defined by the appended claims.Those skilled in the art
On the premise of without departing substantially from principle of the present utility model and essence, various changes or modifications can be made to these embodiments,
But these changes and modification each fall within the scope of protection of the utility model.
Claims (5)
1. a kind of degradable foramen ovale of heart arteriosus occluder, it is characterised in that it includes one first plate-like being sequentially connected
Net, a tubular reticulum and one second plate-like net, the first plate-like net and the second plate-like net are double-deck guard, the tubulose
The both ends of net are connected to the interior wire side of the first plate-like net and the interior wire side of the second plate-like net, first plate-like
Net, the tubular reticulum and the second plate-like net are formed in one；It is provided with and is used at the outer wire side center of the second plate-like net
By wire side close up connector, the connector by the second plate-like net outer wire side center dictyosome hot melt shaping and
Material into, the first plate-like net, tubular reticulum, the second plate-like net and connector is degradation material, second plate-like
The outer net of net faces at the connector raised, and the connector is tubulose, and the height of the connector is 1.5-2.0mm, institute
The external diameter for stating the second plate-like net is bigger or isometrical than the external diameter of the first plate-like net.
2. degradable foramen ovale of heart arteriosus occluder as claimed in claim 1, it is characterised in that the first plate-like net
Including a closing in end, the closing in end is multiple ring-type netting twines abutted successively, and the first plate-like net is additionally provided with a closing in line,
The closing in line is arranged in all ring-type netting twines, the outer wire side shape of the first plate-like net after closing in line closing in
Into the netted face of continuous formation.
3. degradable foramen ovale of heart arteriosus occluder as claimed in claim 1, it is characterised in that outside the connector
Footpath is 2.5-3.2mm.
4. degradable foramen ovale of heart arteriosus occluder as claimed in claim 1, it is characterised in that first plate-like
Net, the tubular reticulum, the material of the second plate-like net and the connector are high molecular degradable silk.
5. degradable foramen ovale of heart arteriosus occluder as claimed in claim 1, it is characterised in that the connector is pipe
Shape, the connector are provided with internal thread in the relative end of the wire side with connecting.
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201521138998.8U CN206995284U (en) | 2015-12-31 | 2015-12-31 | Degradable foramen ovale of heart arteriosus occluder |
| EP16880339.3A EP3398533A4 (en) | 2015-12-31 | 2016-04-08 | Degradable occluder |
| SG11201805561SA SG11201805561SA (en) | 2015-12-31 | 2016-04-08 | Degradable occluder |
| US16/066,399 US11337683B2 (en) | 2015-12-31 | 2016-04-08 | Degradable occluder |
| PCT/CN2016/078756 WO2017113531A1 (en) | 2015-12-31 | 2016-04-08 | Degradable occluder |
| JP2018553276A JP6752289B2 (en) | 2015-12-31 | 2016-04-08 | Disassembleable occluder |
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| CN201521138998.8U CN206995284U (en) | 2015-12-31 | 2015-12-31 | Degradable foramen ovale of heart arteriosus occluder |
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| CN206995284U true CN206995284U (en) | 2018-02-13 |
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| CN111248953A (en) * | 2018-11-30 | 2020-06-09 | 广州启骏生物科技有限公司 | Patent foramen ovale plugging device, patent foramen ovale plugging system and method thereof |
| CN112773418A (en) * | 2020-12-31 | 2021-05-11 | 上海锦葵医疗器械股份有限公司 | Degradable heart foramen ovale closure device and manufacturing method thereof |
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| CN114340516A (en) * | 2019-08-30 | 2022-04-12 | 波士顿科学医学有限公司 | Left atrial appendage implant with sealing disk |
| US11337683B2 (en) | 2015-12-31 | 2022-05-24 | Mallow Medical (Shanghai) Co., Ltd. | Degradable occluder |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US11337683B2 (en) | 2015-12-31 | 2022-05-24 | Mallow Medical (Shanghai) Co., Ltd. | Degradable occluder |
| CN111248953A (en) * | 2018-11-30 | 2020-06-09 | 广州启骏生物科技有限公司 | Patent foramen ovale plugging device, patent foramen ovale plugging system and method thereof |
| CN114340516A (en) * | 2019-08-30 | 2022-04-12 | 波士顿科学医学有限公司 | Left atrial appendage implant with sealing disk |
| CN112773418A (en) * | 2020-12-31 | 2021-05-11 | 上海锦葵医疗器械股份有限公司 | Degradable heart foramen ovale closure device and manufacturing method thereof |
| CN112773419A (en) * | 2020-12-31 | 2021-05-11 | 上海锦葵医疗器械股份有限公司 | Heart patent foramen ovale plugging device with flat two end surfaces and manufacturing method thereof |
| CN112773418B (en) * | 2020-12-31 | 2021-10-01 | 上海锦葵医疗器械股份有限公司 | Degradable heart foramen ovale closure device and manufacturing method thereof |
| CN112773419B (en) * | 2020-12-31 | 2022-01-07 | 上海锦葵医疗器械股份有限公司 | Heart patent foramen ovale plugging device with flat two end surfaces and manufacturing method thereof |
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Address after: 15th Building, 388 Yindu Road, Xuhui District, Shanghai, 200231 Patentee after: Shanghai Jinkui Medical Devices Co., Ltd. Address before: Room 102, D Workshop, 1618 Yishan Road, Minhang District, Shanghai, 201103 Patentee before: Shanghai Jinkui Medical Implements Co., Ltd. |