CN205322404U - Degradable heart acleistocardia of can developing plugging device - Google Patents
Degradable heart acleistocardia of can developing plugging device Download PDFInfo
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- CN205322404U CN205322404U CN201521137275.6U CN201521137275U CN205322404U CN 205322404 U CN205322404 U CN 205322404U CN 201521137275 U CN201521137275 U CN 201521137275U CN 205322404 U CN205322404 U CN 205322404U
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Abstract
The utility model discloses a degradable heart acleistocardia of can developing plugging device, including the first disc net, tubulose net and the second disc net that connect gradually, first disc net still is equipped with the binding off line, and all cyclic annular net twines are worn to locate by the binding off line, and the outer net shape of face of first disc net becomes continuous mesh faces after the binding off line closes up, second disc net is equipped with and is used for the connecting piece that closes up the wire side, and the connecting piece is taken shape by the dictyosome hot melt of the outer wire side center department of second disc net and forms, the degradation material of material for developing of first disc net, tubulose net, second disc net and connecting piece. The utility model discloses the structure that plugging device binding off line closed up has increased the holding power and the resilience of plugging device to reduce the manufacturing degree of difficulty, reduced manufacturing cost. The utility model discloses not only make the degradable silk that develops of constituteing the disc net firmly to link together, make the connecting piece and the degradable silk that develops of constitution disc net firmly link together moreover, be difficult to drop.
Description
Technical field
This utility model relates to the foramen ovale of heart arteriosus occluder of a kind of developed degradable。
Background technology
Patent foramen ovale is the one in common congenital heart disease。Patent foramen ovale is mainly formed in the growth and development process of fetus, when fetal development, first every right side grow again a falciform every, claim second every or secondary septum, this is every also growing to endocardial cushion direction, covers foramen secundum, but does not merge with endocardial cushion, and form an ovate hole, claim oval foramen。After fetal birth, oval foramen generally closes in the 1st year after birth, if the child's oval foramen more than three years old does not still close, is called patent foramen ovale。Have 20%～25% adult's oval foramen not completely closed, leave the aperture that only small crack or probe can pass through。If oval foramen fails normally closed after birth, merge owing to septum primum and secondary septum fail nature adhesion, at the crack sample abnormal passage of remaining between the two, a similar functional valve, when right atrial pressure is higher than left atrial pressure, the septum primum of left side weakness is open, and right-left shunt namely occurs。The long-term existence of patent foramen ovale can cause migraine, cerebral ischemia, apoplexy, decompression sickness, clinostatism to breathe the disease such as upright hypoxia syndrome and altitude sickness。
Foramen ovale of heart patent is common congenital heart disease, and traditional therapeutic modality is surgical operation。Operating Therapeutic Method, patient need to surgically open breast, and what it was maximum has drawbacks in that in (1) art needs extracorporeal circulation, and operation is likely to result in complication and causes death；(2) surgery operating wound is big, postoperative leaves cicatrix；(3) surgery cost is expensive。
From the eighties in 20th century along with intubation intervention diagnosis and the development for the treatment of technology and raising, China is gradually introducing Wicresoft's interventional technique treatment congenital heart disease, is developed rapidly by the method for Minimally Interventional Therapy patent foramen ovale, now highly developed。Compare traditional surgery, Minimally Interventional Therapy is a kind of modern high technology invasive treatment, confirm after right-left shunt through right atrium radiography, end-hole catheter is placed in through oval foramen left atrium or left superior pulmonary vein, send into exchange guidewire in left atrium or left superior pulmonary vein through end-hole catheter, send correspondingly sized conveying sheath to enter left atrium；Loading stopper, stopper sends into left atrium through sheath pipe, after the left atrium dish of stopper opens completely and eel-like figure portion goes out sheath, conveying lever is withdrawn together with long sheath, making left atrium dish and left atrial wall closely be affixed, eel-like figure portion is stuck in oval foramen place completely, then withdraws sheath pipe and makes right atrium dish open。Through perspective and Echocardiography stopper position and form meet require time, row right atrium radiography is without right-left shunt again, discharges stopper, withdraws from conveyer device and completes operation。Such Minimally Interventional Therapy have do not operate on, the advantage such as wound is little, few intercurrent disease, recovery is fast, effective, indication scope is wide and surgery cost is relatively low。
Though the Therapeutic Method being got involved operation implantation oval hole plugging device by Wicresoft has the many of the above advantage relative to traditional surgery。But, material used by the main body rack of the oval hole plugging device of present Clinical practice is mainly nitinol alloy wire, owing to this metalloid material can not be degraded, it is chronically implanted the reaction such as meeting and tissue be inflamed, blood coagulation, or even a degree of damage, therefore there is certain defect, it is possible to there is risk used below in it: (1) Nitinol is nondegradable metal alloy compositions, although its biocompatibility obtains demonstration, but the long term risk of long-term Permanent implantation still cannot be perfectly controlled；(2) due to Nitinol Permanent implantation and non-degradable, forever retaining heart and on the impact of the heart of child's continuous growth promoter, the safety of human body, fixed-size heart occluder are still lacked long-term Follow-up Data, it may affect the growing of patient's heart of undeveloped mature；(3) complication such as nickel precipitation, nickel allergy do not have clear and definite scientific appraisal yet。
On heart occluder surface by complete endothelialization, after heart defect is repaired by body autologous tissue, heart occluder is entirely without the necessity retained in vivo。Therefore, desirable heart occluder should be repair for heart self to provide a temporary bridge, is degraded by body, make defect be repaired by autologous tissue completely after completing historic mission, thus avoiding metal to retain the internal long term complication brought and potential safety hazard。
The supporting construction of the degradable stopper introduced in US Patent No. 08480709B2 is formed by pipe cutting, the junction point of two cards of stopper is similar with dual welding spots, make two card centers protruding, the risk that stopper surface local thrombus is formed can be increased, it is unfavorable for the endothelialization process on stopper surface, simultaneously, the release length making stopper in the process of implant surgery is longer, easy impair cardiac tissue, and the stopper compliance being fabricated to by this method and recovery are poor, it is necessary to assist it to reply original shape by locking device。
Utility model content
The technical problems to be solved in the utility model is to solve the problem that the oval hole plugging device of existing Clinical practice exists long term risk, and overcome prior art to there is the compliance of degradable stopper and the defect that recovery is poor, it is provided that the foramen ovale of heart arteriosus occluder of a kind of developed degradable。
This utility model is to solve above-mentioned technical problem by following technical proposals:
A kind of foramen ovale of heart arteriosus occluder of developed degradable, it is characterized in that, it includes the one first plate-like net, a tubular reticulum and the one second plate-like net that are sequentially connected with, described first plate-like net and described second plate-like net are double-deck guard, the two ends of described tubular reticulum are connected to the interior wire side of described first plate-like net and the interior wire side of described second plate-like net, and described first plate-like net, described tubular reticulum and described second plate-like net are formed in one；The outer wire side center of described second plate-like net is provided with the connector for being closed up by wire side, described connector is shaped by the dictyosome hot melt of the outer wire side center of described second plate-like net and forms, the material of described first plate-like net, tubular reticulum, the second plate-like net and connector is the degradation material that can develop, and it is protruding that the outer net of described second plate-like net faces described connector place。
Preferably, described first plate-like net includes a closing in end, described closing in end is multiple ring-type netting twines adjacent successively, described first plate-like net is additionally provided with a closing in line, described closing in line is arranged in all of described ring-type netting twine, and after described closing in line closes up, the outer wire side of described first plate-like net forms netted of continuous formation。So, make outer wire side more smooth, it is possible to increase support force and the recovery of stopper, it is possible to reduce the risk that stopper surface local thrombus is formed, be conducive to accelerating the endothelialization process on stopper surface, make foramen ovale of heart patent place being repaired by autologous tissue earlier。Meanwhile, decrease the release length of stopper in operation process, damage to heart can be greatly reduced, make operation more effective, safer。
It is preferred that described connector is tubulose, the height of described connector is 1.5-2.0mm。Outer wire side closing in place so making the second plate-like net has enough intensity。If the height of connector is too small, the thread turns within connector is very few, can cause and be connected insecure with induction system and there is the risk that stopper comes off。Whereas if the height of connector is excessive, the risk that stopper surface local thrombus is formed can be increased, the side stopper superficial cell climbing with connector can be caused relatively slow, extend the endothelialization process on stopper surface。Meanwhile, the release length making stopper in the process of implant surgery is longer, it is easy to impair cardiac tissue。
It is preferred that the external diameter of described connector is 2.5-3.2mm。Outer wire side closing in place so making the second plate-like net has enough intensity。If additionally, connector outside dimension is too small, it is easy to cause that the degraded silk being connected with connector in connecting member forming process occurs fracture or bonding strength to decline。Whereas if connector outside dimension is excessive, the size range of the delivery sheath that stopper is suitable for can be reduced, and be unfavorable for stopper propelling movement in delivery sheath。
It is preferred that the external diameter of described second plate-like net is bigger or isometrical than the external diameter of described first plate-like net。First plate-like net is positioned at left atrium, second plate-like net is positioned at right atrium, patient for patent foramen ovale, when right atrial pressure is higher than left atrial pressure, the septum primum of left side weakness is open, and right-left shunt namely occurs, this structure makes the second plate-like net being positioned at right atrium have bigger support force, the impact of blood flow can be resisted, be conducive to stopper to be firmly clamped in patent foramen ovale place, so can effectively foramen ovale of heart patent place be blocked。
It is preferred that the material of one first described plate-like net, a tubular reticulum, one second plate-like net and described connector is the high molecular degradable silk that can develop。The described high molecular degradable silk developed is to be formed by spinning after blended method mix homogeneously by developing material and Biodegradable polymer material again, the proportion of Biodegradable polymer material and developing material is 70-98wt%:30-2wt%, Biodegradable polymer material is polylactic acid, polyglycolic acid, polycaprolactone, PPDO, poly butyric ester, condensing model, poly phosphate, polyurethane, the copolymer of a kind of or at least two in Merlon, developing material is iohexol, iotalamic acid, amidotrizoic acid, sodium iodide, ioversol, cardiografin, Iopromide, iodixanol, barium sulfate, bismuth subcarbonate, iron powder or hydroxyapatite。These materials have good biocompatibility, can fully absorb in human body, it is to avoid implant the foreign body long-term impact on human body。This stopper simply provides a temporary bridge for cardiac repair, is degraded by body, make defect be repaired by autologous tissue completely after completing historic mission, thus avoiding metal to retain the internal long term complication brought and potential safety hazard。
It is preferred that described connector is tubulose, described connector is provided with female thread in the end relative with described dictyosome。By the connector of this helicitic texture, the connection with induction system is more firm, it is possible to easily by induction system, stopper is transported to foramen ovale of heart patent place。
A kind of webmaster weaving method, including, in the pinhole that pin inserts mould rod, the degradable silk that can develop penetrating sewing needle pin hole, knotting compact siro spinning technology。The starting point degradable silk that can develop closely is tied a knot, and during braiding, uplink aligns with centre mark point with the intersection point of downlink, with the trend of specification silk。Woven webmaster carries out thermal finalization together with mould rod。After stereotyped, pull out pin, take off webmaster。This weaving method makes the grid of webmaster more uniform, it is easy to operation, decreases cost of manufacture。
A kind of manufacture method of connector, making step includes:
Step 1, webmaster is closed up；
Step 2, webmaster is put into mould；
Step 3, finishing dictyosome；
The degradable silk that step 4, heating can be developed；
Step 5, molding connector profile and internal whorl；
Step 6, removal dictyosome；
It is preferred that in step 1, first regulate the closing in end margin length of webmaster, make justified margin, close up with the degradable silk that can develop。
It is preferred that in step 2, the webmaster that will have closed up, through the sleeve pipe in mould。
It is preferred that in step 3, original assembling length is stayed a part for making connector, removes the additional length of webmaster。
It is preferred that in step 4, open attemperating unit, adjust temperature, facing to the degradable silk continuous heating developed at connector place above mould, wherein, adjusting temperature is on high molecular polymer fusing point 30 DEG C-90 DEG C, 5-15 second continuous heating time, in heating process, over-heating can cause other parts hot melt together of dictyosome, thus causing that dictyosome is destructurized, and greatly reduce the material molecule amount of connector part, material premature breakdown can be caused。Otherwise, heat insufficient, can cause that the degradable silk at connector place can not fully be integrated by hot melt, it is impossible to form complete connector female thread structure, cause connector inadequate with the bonding strength of induction system。Accordingly, it would be desirable to suitable acid extraction just can complete hot melt。
It is preferred that in step 5, after continuous heating, the degradable silk developed of connector part is fused together, and removes attemperating unit, it is then shut off the slide block in mould, and the thread head of mould is inserted in the slot above mould, keep a period of time。
It is preferred that in step 6, after cooling, the thread head of mould is rotated removal mould, and slide block is slowly removed, dictyosome is removed mould。
The manufacture method of this connector is easily operated, the connector of dimensionally stable can be obtained, and decrease the kind using material on stopper, the degradable silk making composition plate-like net can be securely attached to together, and make connector together with the degradable silk forming plate-like net can be securely attached to, it is not easy to come off。
A kind of dictyosome method for shaping, is packed into dictyosome shaper including the dictyosome with connector, and fixes with fixture, it is carried out together thermal finalization, after stereotyped, be removed from the molds by dictyosome。With suture, degradable membrane is packed into dictyosome, and to carry out closing at closing in end be a smooth card。This dictyosome method for shaping is easily operated, and the occluder size of making is stable, this kind of method the stopper made has bigger support force and good recovery of shape, meets the requirement of operation technique, makes operation more effective, safer。
Positive progressive effect of the present utility model is in that:
This utility model stopper is knitted to form by the high molecular degradable silk that can develop, its biodegradation period be 6 months to 2 years, can fully absorb in human body, it is to avoid implant the foreign body long-term impact on human body。This high molecular degradable silk developed is to be formed by spinning after blended method mix homogeneously by developing material and Biodegradable polymer material again, make stopper in interventional procedure under x-ray equipment radiography, image definition, it is easy to Wicresoft and gets involved the operation of operation, improve accuracy and the success rate of operation。What this utility model used can developing material also be degradable or the absorbable material of human body, and human non-toxic is harmless, has good biocompatibility。The choked flow film of stopper is biological degradable membrane, its biodegradation period be 6 months to 2 years, complete in human body its treatment mission after degradation in vivo disappear, noresidue foreign body。Dictyosome in the outer wire side center of the second plate-like net is connector through high-temperature hot fusion welding, specifically, dictyosome at high temperature hot melt by the outer wire side center to the second plate-like net, and with mould, heat-fused portion dictyosome is shaped into connector, the degradable silk developed so making composition plate-like net is not easy to scatter, and can be securely attached together；Simultaneously so that connector and the degradable silk developed forming plate-like net can be securely attached together, it is not easy to come off。It is not installed with the structure that the wire side of connector adopts closing in line to close up, make outer wire side more smooth, support force and the recovery of stopper can be increased, the risk that stopper surface local thrombus is formed can be reduced, be conducive to accelerating the endothelialization process on stopper surface, make foramen ovale of heart patent place being repaired by autologous tissue earlier。Meanwhile, decrease the release length of stopper in operation process, damage to heart can be greatly reduced, make operation more effective, safer；Additionally, the advantage that this stopper also has low cost of manufacture。
Accompanying drawing explanation
Fig. 1 is the stopper perspective view of this utility model preferred embodiment。
Fig. 2 is the stopper side portion structure schematic diagram of this utility model preferred embodiment。
Fig. 3 is the stopper connector schematic diagram of this utility model preferred embodiment。
Fig. 4 is the A direction view in Fig. 1。
Fig. 5 is the closing in end place close-up schematic view of the outer wire side of the first plate-like net of this utility model preferred embodiment。
Fig. 6 is the mould bar structure schematic diagram of this utility model preferred embodiment。
Fig. 7 is the braiding threading schematic diagram of the webmaster of this utility model preferred embodiment。
The closing in end that Fig. 8 is the webmaster of this utility model preferred embodiment launches schematic diagram。
Detailed description of the invention
Name a preferred embodiment, and become apparent from intactly illustrating this utility model in conjunction with accompanying drawing。
As shown in Figure 1, Figure 2, shown in Fig. 3, Fig. 4, Fig. 5, a kind of foramen ovale of heart arteriosus occluder of developed degradable, it includes the first plate-like net 10, tubular reticulum 30 and the second plate-like net 20 that are sequentially connected with, first plate-like net 10 and the second plate-like net 20 are double-deck guard, the two ends of tubular reticulum 30 are connected to the interior wire side 11 of the first plate-like net 10 and the interior wire side 22 of the second plate-like net 20, and the first plate-like net 10, tubular reticulum 30 and the second plate-like net 20 are formed in one；Outer wire side 21 center of the second plate-like net 20 is provided with the connector 40 closed up by wire side, is connected for sweat soldering between the outer wire side 21 of the second plate-like net 20 and connector 40；The outer wire side 12 of the first plate-like net 10 includes closing in end 13, closing in end 13 is multiple ring-type netting twines 14 adjacent successively, first plate-like net 10 is additionally provided with closing in line 15, closing in line 15 is arranged in all of ring-type netting twine 14, and after closing in line 15 closes up, the outer wire side 12 of the first plate-like net 10 forms netted of continuous print。The material of the first plate-like net 10, tubular reticulum the 30, second plate-like net 20 and connector 40 is the degradation material that can develop。
The stopper of the present utility model dictyosome in the outer wire side center of the second plate-like net 20 is connector through high-temperature hot fusion welding, specifically, dictyosome at high temperature hot melt by the outer wire side center to the second plate-like net 20, and with mould, heat-fused portion dictyosome is shaped into connector 40, the degradable silk developed so making composition plate-like net is not easy to scatter, and can be securely attached together；Simultaneously so that connector 40 and the degradable silk developed forming plate-like net can be securely attached together, it is not easy to come off。
Connector 40 is tubulose, is highly 1.5-2.0mm, and external diameter is 2.5-3.2mm。The outer wire side 21 of the second plate-like net 20 is protruding towards connector 40 place。The external diameter of the second plate-like net is bigger or isometrical than the external diameter of the first plate-like net；Connector 40 is provided with female thread in the end relative with the wire side 21 connected。
The material of the first plate-like net 10, tubular reticulum 30 and the second plate-like net 20 and connector 40 is the high molecular degradable silk that can develop。The described high molecular degradable silk developed is to be formed by spinning after blended method mix homogeneously by developing material and Biodegradable polymer material again, the proportion of Biodegradable polymer material and developing material is 70-98wt%:30-2wt%, Biodegradable polymer material is polylactic acid, polyglycolic acid, polycaprolactone, PPDO, poly butyric ester, condensing model, poly phosphate, polyurethane, the copolymer of a kind of or at least two in Merlon, developing material is iohexol, iotalamic acid, amidotrizoic acid, sodium iodide, ioversol, cardiografin, Iopromide, iodixanol, barium sulfate, bismuth subcarbonate, iron powder or hydroxyapatite。In stopper can filling polylactic acid film thus play stop blood flow effect。
This utility model connector is to be formed by degradable silk hot melt, and needs to meet use condition, and not only structure can not excessive cause hindering stopper propelling movement in delivery sheath, also to avoid because the connector that bonding strength causes not pulls。
Table 1, connector size, anti-pulling-out force and propelling movement test chart in delivery sheath
| Height mm | External diameter mm | Anti-pulling-out force N | Whether obstruction pushes | |
| 1 | 2.0 | 1.8 | 6 (weak) | Do not hinder |
| 2 | 2.0 | 2.0 | 11 (weak) | Do not hinder |
| 3 | 2.0 | 2.5 | 25 (by force) | Do not hinder |
| 4 | 1.5 | 2.5 | 20 (by force) | Do not hinder |
| 5 | 1.8 | 2.8 | 31 (by force) | Do not hinder |
| 6 | 1.5 | 3.0 | 34 (by force) | Do not hinder |
| 7 | 2.0 | 3.2 | 41 (by force) | Do not hinder |
| 8 | 2.0 | 3.5 | 52 (by force) | Hinder |
Test finds, ensures that in use, connector will not be pulled when anti-pulling-out force reaches 15N。By in upper table 1 it can be seen that the size of connector directly influences whether stopper can normally apply among operation。Inappropriate size design of connector can cause that connector is pulled, or cannot be introduced into pushing in delivery sheath, and these all can cause that product cannot use。
This stopper the first mesh-covered tray is netted of continuous print, closing in line is adopted to close up between its netting twine, making the first outer Dropbox is the wire side of flat smooth, without protruding, this structure is conducive to the reply of stopper shapes and support force to improve, it is more conducive to accelerate the endothelialization process on stopper surface, makes heart defect earlier be repaired by autologous tissue。The stopper of the present utility model dictyosome in the outer wire side center of the second plate-like net is connector through high-temperature hot fusion welding, specifically, dictyosome at high temperature hot melt by the outer wire side center to the second plate-like net, and with mould, heat-fused portion dictyosome is shaped into connector, the degradable silk developed so making composition plate-like net is not easy to scatter, and can be securely attached together；Simultaneously so that connector and the degradable silk developed forming plate-like net can be securely attached together, it is not easy to come off。
The making of this utility model stopper mainly sews several steps through webmaster molding, connector making, dictyosome sizing and polylactic acid membrane。
During webmaster braiding, pin is inserted in the pinhole 51 of the mould rod 5 of Fig. 6, the degradable silk that can develop is penetrated sewing needle pin hole, knotting compact siro spinning technology。The threading rule of braiding is as it is shown in fig. 7, comprises connector manufacturing terminal D, closing in end B (becoming closing in end 13 after molding) and starting point C。The starting point C place degradable silk that can develop closely is tied a knot, and during braiding, uplink aligns with centre mark point with the intersection point of downlink, with the trend of specification silk。Woven webmaster carries out thermal finalization together with mould rod。After stereotyped, pull out pin, take off webmaster。
Connector making step includes:
1, webmaster is closed up；
2, webmaster is put into mould；
3, finishing dictyosome；
4, the degradable silk that can develop is heated；
5, molding connector profile and internal whorl；
6, removal dictyosome；
Wherein, in step 1, first regulate the closing in end margin length of webmaster, making justified margin, close up with the degradable silk that can develop, concrete closing in mode is as shown in Figure 8, including going out pin mark 61 and entry point 62, the order of threading according in Fig. 7 go out pin mark 61 and entry point 62 closes up。In step 2, the webmaster that will have closed up, through the sleeve pipe in mould。In step 3, original assembling length is stayed a part for making connector, remove the additional length of webmaster。In step 4, open attemperating unit, adjust temperature, facing to the degradable silk continuous heating developed at connector place above mould。In step 5, after continuous heating, the degradable silk developed of connector part is fused together, and removes attemperating unit, is then shut off the slide block in mould, and is inserted by the thread head of mould in the slot above mould, keeps a period of time。In step 6, after cooling, the thread head of mould is rotated removal mould, and slide block is slowly removed, dictyosome is removed mould。
Additionally, in step 4, adjusting temperature is on high molecular polymer fusing point 30 DEG C-90 DEG C, 5-15 second continuous heating time。Shown in table 2-table 4 specific as follows, in heating process, over-heating can cause other parts hot melt together of dictyosome, thus causing that dictyosome is destructurized, and greatly reduce connector part material molecule amount, thus material premature breakdown can be caused。Otherwise, heat insufficient, can cause that the degradable silk at connector place can not fully be integrated by hot melt, it is impossible to form complete connector female thread structure, cause connector inadequate with the bonding strength of induction system。Accordingly, it would be desirable to suitable acid extraction just can complete hot melt。
The developed degradable material hot melt test chart that table 2,70wt%L-lactide/glycolides (82/18) and 30wt% iodixanol are made
| Heat time heating time s | Heating-up temperature DEG C | Connector hot melt situation | Other part holt melt situations | |
| 1 | 2 | 230 | Inabundant hot melt | Non-hot melt |
| 2 | 15 | 160 | Inabundant hot melt | Non-hot melt |
| 3 | 5 | 230 | Abundant hot melt | Non-hot melt |
| 4 | 5 | 170 | Abundant hot melt | Non-hot melt |
| 5 | 15 | 230 | Abundant hot melt | Non-hot melt |
| 6 | 15 | 170 | Abundant hot melt | Non-hot melt |
| 7 | 5 | 240 | Abundant hot melt | Part holt melt |
| 8 | 20 | 170 | Abundant hot melt | Part holt melt |
The developed degradable material hot melt test chart that table 3,85wt% PPDO and 15wt% iohexol are made
| Heat time heating time s | Heating-up temperature DEG C | Connector hot melt situation | Other part holt melt situations | |
| 1 | 2 | 190 | Inabundant hot melt | Non-hot melt |
| 2 | 15 | 120 | Inabundant hot melt | Non-hot melt |
| 3 | 5 | 190 | Abundant hot melt | Non-hot melt |
| 4 | 5 | 130 | Abundant hot melt | Non-hot melt |
| 5 | 15 | 190 | Abundant hot melt | Non-hot melt |
| 6 | 15 | 130 | Abundant hot melt | Non-hot melt |
| 7 | 5 | 200 | Abundant hot melt | Part holt melt |
| 8 | 20 | 130 | Abundant hot melt | Part holt melt |
The developed degradable material hot melt test chart that table 4,98wt%L-lactide/caprolactone (70/30) and 2wt% barium sulfate are made
Dictyosome sizing includes mould and dictyosome heat treatment shaping on dictyosome。On dictyosome during mould, the aforementioned dictyosome with connector is packed into dictyosome shaper, and fixes with fixture, it is carried out together thermal finalization, after stereotyped, dictyosome is removed from the molds。With suture, polylactic acid membrane is packed into dictyosome, and to carry out closing at closing in end be a smooth card。
In description of the present utility model, it will be appreciated that, term " on ", D score, "front", "rear", "left", "right", " vertically ", " level ", " top ", " end ", " interior ", the orientation of the instruction such as " outward " or position relationship be based on orientation shown in the drawings or position relationship, it is for only for ease of description this utility model and simplifies description, rather than the device of instruction or hint indication or element must have specific orientation, with specific azimuth configuration and operation, therefore it is not intended that to restriction of the present utility model。
Although the foregoing describing detailed description of the invention of the present utility model, it will be appreciated by those of skill in the art that this is merely illustrative of, protection domain of the present utility model is defined by the appended claims。Those skilled in the art is under the premise without departing substantially from principle of the present utility model and essence, it is possible to these embodiments are made various changes or modifications, but these change and amendment each falls within protection domain of the present utility model。
Claims (7)
1. the foramen ovale of heart arteriosus occluder of a developed degradable, it is characterized in that, it includes the one first plate-like net, a tubular reticulum and the one second plate-like net that are sequentially connected with, described first plate-like net and described second plate-like net are double-deck guard, the two ends of described tubular reticulum are connected to the interior wire side of described first plate-like net and the interior wire side of described second plate-like net, and described first plate-like net, described tubular reticulum and described second plate-like net are formed in one；The outer wire side center of described second plate-like net is provided with the connector for being closed up by wire side, described connector is shaped by the dictyosome hot melt of the outer wire side center of described second plate-like net and forms, the material of described first plate-like net, tubular reticulum, the second plate-like net and connector is the degradation material that can develop, and it is protruding that the outer net of described second plate-like net faces described connector place。
2. the foramen ovale of heart arteriosus occluder of developed degradable as claimed in claim 1, it is characterized in that, described first plate-like net includes a closing in end, described closing in end is multiple ring-type netting twines adjacent successively, described first plate-like net is additionally provided with a closing in line, described closing in line is arranged in all of described ring-type netting twine, and after described closing in line closes up, the outer wire side of described first plate-like net forms netted of continuous formation。
3. the foramen ovale of heart arteriosus occluder of developed degradable as claimed in claim 1, it is characterised in that described connector is tubulose, and the height of described connector is 1.5-2.0mm。
4. the foramen ovale of heart arteriosus occluder of developed degradable as claimed in claim 3, it is characterised in that the external diameter of described connector is 2.5-3.2mm。
5. the foramen ovale of heart arteriosus occluder of developed degradable as claimed in claim 1, it is characterised in that the external diameter of described second plate-like net is bigger or isometrical than the external diameter of described first plate-like net。
6. the foramen ovale of heart arteriosus occluder of developed degradable as claimed in claim 1, it is characterised in that the material of described first plate-like net, described tubular reticulum, described second plate-like net and described connector is the high molecular degradable silk that can develop。
7. the foramen ovale of heart arteriosus occluder of developed degradable as claimed in claim 1, it is characterised in that described connector is tubulose, and described connector is provided with female thread in the end relative with the wire side connected。
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201521137275.6U CN205322404U (en) | 2015-12-31 | 2015-12-31 | Degradable heart acleistocardia of can developing plugging device |
| PCT/CN2016/078758 WO2017113532A1 (en) | 2015-12-31 | 2016-04-08 | Imageable and degradable occluder |
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| CN201521137275.6U CN205322404U (en) | 2015-12-31 | 2015-12-31 | Degradable heart acleistocardia of can developing plugging device |
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| CN205322404U true CN205322404U (en) | 2016-06-22 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017113531A1 (en) * | 2015-12-31 | 2017-07-06 | 常州锦葵医疗器械有限公司 | Degradable occluder |
| CN107397561A (en) * | 2017-07-20 | 2017-11-28 | 上海心玮医疗科技有限公司 | A kind of oval hole plugging device |
| CN109077756A (en) * | 2018-09-07 | 2018-12-25 | 赵天力 | Heart atrial septal defect plugging device |
| CN109820548A (en) * | 2018-12-21 | 2019-05-31 | 先健科技(深圳)有限公司 | Plugging device, preparation method and plugging system |
-
2015
- 2015-12-31 CN CN201521137275.6U patent/CN205322404U/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017113531A1 (en) * | 2015-12-31 | 2017-07-06 | 常州锦葵医疗器械有限公司 | Degradable occluder |
| US11337683B2 (en) | 2015-12-31 | 2022-05-24 | Mallow Medical (Shanghai) Co., Ltd. | Degradable occluder |
| CN107397561A (en) * | 2017-07-20 | 2017-11-28 | 上海心玮医疗科技有限公司 | A kind of oval hole plugging device |
| CN109077756A (en) * | 2018-09-07 | 2018-12-25 | 赵天力 | Heart atrial septal defect plugging device |
| CN109820548A (en) * | 2018-12-21 | 2019-05-31 | 先健科技(深圳)有限公司 | Plugging device, preparation method and plugging system |
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Address after: 15th Building, 388 Yindu Road, Xuhui District, Shanghai, 200231 Patentee after: Shanghai Jinkui Medical Devices Co., Ltd. Address before: Room 102, D Workshop, 1618 Yishan Road, Minhang District, Shanghai, 201103 Patentee before: Shanghai Jinkui Medical Implements Co., Ltd. |