CN205697888U - The cardiac ventricular septal defect closer of developed degradable - Google Patents
The cardiac ventricular septal defect closer of developed degradable Download PDFInfo
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- CN205697888U CN205697888U CN201521139044.9U CN201521139044U CN205697888U CN 205697888 U CN205697888 U CN 205697888U CN 201521139044 U CN201521139044 U CN 201521139044U CN 205697888 U CN205697888 U CN 205697888U
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Abstract
The utility model discloses the cardiac ventricular septal defect closer of a kind of developed degradable, including the first plate-like net being sequentially connected with, tubular reticulum and the second plate-like net, first plate-like net is additionally provided with closing in line, closing in line is arranged in all of ring-type netting twine, and after closing in line closes up, the outer wire side of the first plate-like net forms netted of continuous print；Second plate-like net is provided with the connector for being closed up by wire side, and connector is shaped by the dictyosome hot melt of the interior wire side center of the second plate-like net and forms, and the material of the first plate-like net, tubular reticulum, the second plate-like net and connector is the degradation material that can develop.The structure that this utility model stopper closing in line closes up adds support force and the recovery of stopper, and reduces manufacture difficulty, decreases manufacturing cost.This utility model not only makes the degradable silk developed of composition plate-like net to be securely attached together, and makes connector can be securely attached together with the degradable silk developed of composition plate-like net, it is not easy to come off.
Description
Technical field
This utility model relates to the cardiac ventricular septal defect closer of a kind of developed degradable.
Background technology
Ventricular septal defect is the one in common congenital heart disease.Human heart is made up of (left four chambers
Atrium, left ventricle, right atrium and right ventricle), should there is a complete interventricular septum between left ventricle and right ventricle, if
Cardiac septum has opening the most referred to as ventricular septal defect.Ventricular septal defect is mainly formed in the growth and development process of fetus
In, grown owing to be have impact on heart by certain factor, thus defined ventricular septal defect.Patient for ventricular septal defect comes
Saying, blood would generally be flow to right ventricle by left ventricle through ventricular septal defect, makes the blood volume of right ventricle increase.Ventricular septal defect
Long-term existence pulmonary artery pressure can be caused to increase, congestive heart failure, cardiopalmus, asthma, the disease such as weak, recurrent pulmonary infection
Disease.The thickness of the apex in cardiac septum face from top to bottom is by thin thickening, between the relatively thin part of cardiac septum is heart chamber
Diaphragm portion, the thicker part of cardiac septum is cardiac septum pars muscularis.
Ventricular septal heart defect is common congenital heart disease, and traditional therapeutic modality is surgical operation.Surgical operation
Therapeutic Method, patient need to surgically open breast, and the shortcoming of its maximum is: needs extracorporeal circulation in (1) art, and operation may
Complication is caused to cause death；(2) surgery operating wound is big, postoperative leaves cicatrix；(3) surgery cost is expensive.
From the eighties in 20th century along with intubation intervention diagnosis and the development for the treatment of technology and raising, China is gradually introducing Wicresoft
Interventional technique treatment congenital heart disease, is developed rapidly by the method for Minimally Interventional Therapy ventricular septal defect, becomes the most very much
Ripe.Comparing traditional surgery, Minimally Interventional Therapy is the treatment of a kind of modern high technology invasive, by femoral venous puncture,
Use guide wire to set up arteriovenous track under the guiding of medical imaging device, subsequently delivery conduit is placed in room along guide wire
Septal defect position, finally pushes to ventricular septal defect implement closure at ventricular septal defect in delivery conduit and controls
Treat.Such Minimally Interventional Therapy have do not operate on, wound is little, few intercurrent disease, recovery are fast, effective, indication scope is wide and
The advantages such as surgery cost is relatively low.
Though the Therapeutic Method being got involved operation implantation ventricular septal defect by Wicresoft has many of the above relative to tradition
Operating advantage.But, the material master used by the main body rack of the ventricular septal defect of present Clinical practice
Nitinol alloy wire to be, owing to this metalloid material can not be degraded, be chronically implanted can and tissue be inflamed, blood coagulation etc. is anti-
Should, the most a certain degree of damage, therefore there is certain defect, it is possible to there is risk used below in it: (1) NiTi
Alloy is nondegradable metal alloy compositions, although its biocompatibility is proved, but the long term of long-term Permanent implantation
Risk still cannot be perfectly controlled；(2) due to Nitinol Permanent implantation and non-degradable, heart is forever retained to human body
Safety, the impact of heart of fixed-size heart occluder growth promoter continuous on child still lack long-term follows up a case by regular visits to money
Material, it may affect the growing of patient's heart of undeveloped mature；(3) complication such as nickel precipitation, nickel allergy have not yet
Clear and definite scientific appraisal.
On heart occluder surface by complete endothelialization, after heart defect is repaired by body autologous tissue, heart blocks
Device is entirely without the necessity retained in vivo.Therefore, preferable heart occluder should be to repair for heart self to provide one
Temporary bridge, is degraded by body after completing historic mission, makes defect be repaired by autologous tissue completely, thus avoids metal to retain body
The long term complication inside brought and potential safety hazard.
The supporting construction of the degradable stopper introduced in United States Patent (USP) US08480709B2 is formed by pipe cutting, closure
The junction point of two cards of device is similar with dual welding spots, makes two card centers protruding, can increase stopper surface local thrombus
The risk formed, is unfavorable for the endothelialization process on stopper surface, meanwhile, makes the release of stopper during implant surgery
Length is longer, easy impair cardiac tissue, and the stopper compliance and the recovery that are fabricated to by this method are poor, needs
Locking device to be passed through assists it to reply original shape.
Utility model content
The technical problems to be solved in the utility model is to deposit to solve the ventricular septal defect of existing Clinical practice
In the problem of long term risk, and prior art is overcome to there is the compliance of degradable stopper and the defect that recovery is poor,
The cardiac ventricular septal defect closer of a kind of developed degradable is provided.
This utility model is to solve above-mentioned technical problem by following technical proposals:
The cardiac ventricular septal defect closer of a kind of developed degradable, its feature is, it includes be sequentially connected with
First plate-like net, a tubular reticulum and one second plate-like net, described first plate-like net and described second plate-like net are double-deck guard,
The two ends of described tubular reticulum are connected to interior wire side and the outer wire side of described second plate-like net of described first plate-like net, described
First plate-like net, described tubular reticulum and described second plate-like net are formed in one；The interior wire side center of described second plate-like net
Being provided with the connector for being closed up by wire side, described connector is by the dictyosome hot melt of the interior wire side center of described second plate-like net
Shaping forms, and the material of described first plate-like net, tubular reticulum, the second plate-like net and connector is the degradable material that can develop
Material, the height of described tubular reticulum is 3.5-9.5mm.
It is preferred that described first plate-like net includes that a closing in end, described closing in end are multiple ring-type netting twines adjacent successively,
Described first plate-like net is additionally provided with a closing in line, and described closing in line is arranged in all of described ring-type netting twine, through described closing in line
After closing in, the outer wire side of described first plate-like net forms netted of continuous formation.So so that outer wire side is more smooth, Ke Yizeng
Add support force and the recovery of stopper, it is possible to reduce the risk that stopper surface local thrombus is formed, be conducive to accelerating closure
The endothelialization process on device surface, makes at ventricular septal heart defect being repaired by autologous tissue earlier.Meanwhile, operation process is decreased
The release length of middle stopper, can be greatly reduced the damage to heart, makes operation more effective, safer.
It is preferred that described connector is tubulose, the height of described connector is 1.5-2.0mm.So make the second plate-like
Enough intensity is had at the interior wire side closing in of net.If the height of connector is too small, the thread turns within connector is very few, meeting
Cause and be connected insecure with induction system and there is the risk that stopper comes off.Whereas if the height of connector is excessive, can increase
Add the risk that stopper surface local thrombus is formed, the side stopper superficial cell climbing with connector can be caused relatively slow,
Extend the endothelialization process on stopper surface.Meanwhile, the release length making stopper during implant surgery is longer, easily
Impair cardiac tissue.
It is preferred that the external diameter of described connector is 2.5-3.2mm.So make to have at the interior wire side closing in of the second plate-like net
Enough intensity.If additionally, connector outside dimension is too small, being easily caused and be connected with connector during connecting member forming
Degraded silk occur fracture or bonding strength decline.Whereas if connector outside dimension is excessive, stopper can be reduced and be suitable for
The size range of delivery sheath, and it is unfavorable for stopper propelling movement in delivery sheath.
Cave at described connector it is preferred that the Intranet of described second plate-like net faces.The wire side of depression is so that seal
Stifled device can stably and firmly be plugged at ventricular septal heart defect when using.
It is preferred that the external diameter of described first plate-like net is bigger or isometrical than the external diameter of described second plate-like net.First plate-like net
Being positioned at left ventricle, the second plate-like net is positioned at right ventricle, and for the patient of ventricular septal defect, blood would generally be by left ventricle warp
Ventricular septal defect flows to right ventricle, and this structure makes the first plate-like net being positioned at left ventricle have bigger support force, it is possible to support
The impact of anti-blood flow, beneficially stopper are firmly clamped at ventricular septal defect, so can be effectively by cardiac septum
Block at defect.Meanwhile, can avoid surrounding tissue is impeded, reduce the infringement to surrounding tissue.
It is preferred that a length of 3.5-5.5mm of described tubular reticulum.This length and the thickness of membranous part of interventricular septum defective tissue
Corresponding, in order to make stopper preferably be fixed at defect not damaging tissue, and realize effectively closure.
It is preferred that a length of 6.0-9.5mm of described tubular reticulum.This length and the thickness of muscular part of interventricular septum defective tissue
Corresponding, in order to make stopper preferably be fixed at defect not damaging tissue, and realize effectively closure.
It is preferred that the material of one first described plate-like net, a tubular reticulum, one second plate-like net and described connector is
The high molecular degradable silk that can develop.The described high molecular degradable silk developed is high by developing material and biodegradable
Molecular material forms by spinning after blended method mix homogeneously again, Biodegradable polymer material and the ratio of developing material
Example scope is 70-98wt%:30-2wt%, and Biodegradable polymer material is polylactic acid, polyglycolic acid, polycaprolactone, gathers
A kind of or at least two in Lanthanum Isopropoxide, poly butyric ester, condensing model, poly phosphate, polyurethane, Merlon
Copolymer, developing material is iohexol, iotalamic acid, amidotrizoic acid, sodium iodide, ioversol, cardiografin, Iopromide, iodine gram
Husky alcohol, barium sulfate, bismuth subcarbonate, iron powder or hydroxyapatite.These materials have good biocompatibility, in human body
Can fully absorb, it is to avoid implant the foreign body long-term impact on human body.This stopper simply provides one for cardiac repair
Temporary bridge, is degraded by body after completing historic mission, makes defect be repaired by autologous tissue completely, thus avoids metal to retain body
The long term complication inside brought and potential safety hazard.
It is preferred that described connector is tubulose, described connector is provided with female thread in the end relative with described dictyosome.Logical
Crossing the connector of this helicitic texture, the connection with induction system is more firm, easily stopper can be passed through induction system
It is transported at ventricular septal heart defect.
A kind of webmaster weaving method, including in the pinhole that pin inserts mould rod, penetrates the degradable silk that can develop
Sewing needle pin hole, knotting compact siro spinning technology.The starting point degradable silk that can develop closely is tied a knot, and during braiding, uplink is with descending
The intersection point of line aligns with centre mark point, with the trend of specification silk.Woven webmaster carries out thermal finalization together with mould rod.Fixed
After type is good, pull out pin, take off webmaster.This weaving method makes the grid of webmaster more uniform, it is easy to operation, decreases making
Cost.
A kind of manufacture method of connector, making step includes:
Step 1, webmaster is closed up；
Step 2, webmaster is put into mould；
Step 3, finishing dictyosome；
The degradable silk that step 4, heating can be developed；
Step 5, molding connector profile and internal whorl；
Step 6, removal dictyosome；
It is preferred that in step 1, first regulate the closing in end margin length of webmaster, make justified margin, with the degradable that can develop
Silk closes up.
It is preferred that in step 2, the webmaster that will have closed up, through the sleeve pipe in mould.
It is preferred that in step 3, original assembling length is stayed a part for making connector, removes the unnecessary of webmaster
Length.
It is preferred that in step 4, open attemperating unit, adjust temperature, facing to developing at connector above mould
Degradable silk continuous heating, wherein, adjusting temperature is on high molecular polymer fusing point 30 DEG C-90 DEG C, continuous heating time 5-
15 seconds, in heating process, over-heating can cause other parts hot melt together of dictyosome, thus causes dictyosome destructurized,
And greatly reduce the material molecule amount of connector part, material premature breakdown can be caused.Otherwise, heat insufficient, can cause
Degradable silk at connector can not be integrated by fully hot melt, it is impossible to forms complete connector female thread structure, the company of causing
Fitting is inadequate with the bonding strength of induction system.Accordingly, it would be desirable to suitably acid extraction just can complete hot melt.
It is preferred that in step 5, after continuous heating, the degradable silk developed of connector part is fused together, move
Open attemperating unit, the slide block being then shut off in mould, and the thread head of mould is inserted in the slot above mould, keep one section
Time.
It is preferred that in step 6, after cooling, the thread head of mould is rotated removal mould, and slide block is slowly removed,
Dictyosome is removed mould.
The manufacture method of this connector is easily operated, can obtain the connector of dimensionally stable, and decrease stopper
The kind of upper use material, makes the degradable silk of composition plate-like net to be securely attached to together, and makes connector and composition
The degradable silk of plate-like net can be securely attached to together, it is not easy to comes off.
A kind of dictyosome method for shaping, is packed into dictyosome shaper including the dictyosome with connector, and solid with fixture
Fixed, it is carried out together thermal finalization, stereotyped after, dictyosome is removed from the molds.With suture, degradable membrane is packed into dictyosome,
And to carry out closing at closing in end be a smooth card.This dictyosome method for shaping is easily operated, and the occluder size of making is stable,
The stopper made by this kind of method has bigger support force and preferable recovery of shape, meets the requirement of operation technique,
Make operation more effective, safer.
Positive progressive effect of the present utility model is:
This utility model stopper is knitted to form by the high molecular degradable silk that can develop, and its biodegradation period is 6
Month to 2 years, can fully absorb in human body, it is to avoid implant the foreign body long-term impact on human body.This high score developed
Sub-degradable silk be by developing material and Biodegradable polymer material by after the method mix homogeneously that is blended again spinning and
Become, make stopper in interventional procedure under x-ray equipment radiography, image definition, it is simple to Wicresoft get involved operation operation, carry
The accuracy of high operation and success rate.This utility model used can developing material be also degradable or human body absorbable
Material, harmless to human non-toxic, there is good biocompatibility.The choked flow film of stopper is biological degradable membrane, and it is biological
Degradation cycle be 6 months to 2 years, complete in human body its treatment mission after degradation in vivo disappear, noresidue foreign body.Second
The dictyosome of the interior wire side center of plate-like net is connector through high-temperature hot fusion welding, specifically, by the second plate-like net
The dictyosome at high temperature hot melt of interior wire side center, and with mould, heat-fused portion dictyosome is shaped into connector, so makes group
The degradable silk developed of discoid net is not easy to scatter, and can be securely attached together；Simultaneously so that connector and composition
The degradable silk developed of plate-like net can be securely attached together, it is not easy to comes off.The wire side being not installed with connector is adopted
The structure closed up with closing in line so that outer wire side is more smooth, can increase support force and the recovery of stopper, it is possible to reduce envelope
The risk that stifled device surface local thrombus is formed, is conducive to accelerating the endothelialization process on stopper surface, makes ventricular septal heart defect
Place's being repaired by autologous tissue earlier.Meanwhile, decrease the release length of stopper in operation process, can be greatly reduced heart
Damage, make operation more effective, safer；Additionally, the advantage that this stopper also has low cost of manufacture.
Accompanying drawing explanation
Fig. 1 is the stopper perspective view of this utility model preferred embodiment.
Fig. 2 is the stopper connector schematic diagram of this utility model preferred embodiment.
Fig. 3 is the A direction view in Fig. 1.
Fig. 4 is partial enlargement signal at the closing in end of the outer wire side of the first plate-like net of this utility model preferred embodiment
Figure.
Fig. 5 is the mould bar structure schematic diagram of this utility model preferred embodiment.
Fig. 6 is the braiding threading schematic diagram of the webmaster of this utility model preferred embodiment.
Fig. 7 is that the closing in end of the webmaster of this utility model preferred embodiment launches schematic diagram.
Detailed description of the invention
Name preferred embodiment, and combine accompanying drawing and become apparent from intactly illustrating this utility model.
As shown in Figure 1, Figure 2, Figure 3, Figure 4, the cardiac ventricular septal defect closer of a kind of developed degradable, it includes depending on
First plate-like net 10 of secondary connection, tubular reticulum 30 and the second plate-like net 20, the first plate-like net 10 and the second plate-like net 20 are double
Layer guard, the two ends of tubular reticulum 30 are connected to interior wire side 11 and the outer wire side of the second plate-like net 20 of the first plate-like net 10
22, the first plate-like net 10, tubular reticulum 30 and the second plate-like net 20 are formed in one；Interior wire side 21 center of the second plate-like net 20
Being provided with the connector 40 closed up by wire side, the interior wire side 21 of the second plate-like net 20 is connected for sweat soldering between connector 40；
The outer wire side 12 of the first plate-like net 10 includes that closing in end 13, closing in end 13 are multiple ring-type netting twines 14 adjacent successively, the first dish
Shape net 10 is additionally provided with closing in line 15, and closing in line 15 is arranged in all of ring-type netting twine 14, the first plate-like after closing in line 15 closes up
The outer wire side 12 of net 10 forms netted of continuous print.First plate-like net 10, tubular reticulum the 30, second plate-like net 20 and connector 40
Material is the degradation material that can develop.
The stopper of the present utility model dictyosome in the interior wire side center of the second plate-like net 20 is through high-temperature hot fusion welding
For connector, specifically, by the dictyosome at high temperature hot melt of the interior wire side center to the second plate-like net 20, and use mould
Heat-fused portion dictyosome is shaped into connector 40, so makes the degradable silk developed of composition plate-like net be not easy to scatter, energy
It is securely attached together；Simultaneously so that connector 40 can be firmly attached with the degradable silk developed of composition plate-like net
Together, it is not easy to come off.
Connector 40 is tubulose, and height is 1.5-2.0mm, and external diameter is 2.5-3.2mm.The interior wire side 21 of the second plate-like net 20
Cave at connector 40.The external diameter of the first plate-like net 10 is bigger or isometrical than the external diameter of the second plate-like net 20；The length of tubular reticulum 30
Degree is 3.5-9.5mm.During a length of 3.5-5.5mm, corresponding with the thickness of membranous part of interventricular septum defective tissue；A length of 6.0-
9.5mm time, corresponding with the thickness of muscular part of interventricular septum defective tissue.Connector 40 is tubulose, connector 40 with the net connected
Relative end, face 21 is provided with female thread.
The material of the first plate-like net 10, tubular reticulum 30 and the second plate-like net 20 and connector 40 is the macromolecule that can develop
Degradable silk.The described high molecular degradable silk developed is to be passed through altogether by developing material and Biodegradable polymer material
After mixed method mix homogeneously, spinning forms again, and Biodegradable polymer material is 70-with the proportion of developing material
98wt%:30-2wt%, Biodegradable polymer material is polylactic acid, polyglycolic acid, polycaprolactone, gathers dioxocyclohex
The copolymer of a kind of or at least two in ketone, poly butyric ester, condensing model, poly phosphate, polyurethane, Merlon, aobvious
Shadow material is iohexol, iotalamic acid, amidotrizoic acid, sodium iodide, ioversol, cardiografin, Iopromide, iodixanol, sulphuric acid
Barium, bismuth subcarbonate, iron powder or hydroxyapatite.In stopper can filling polylactic acid film thus play stop blood flow effect.
This utility model connector is to be formed by degradable silk hot melt, and needs to meet use condition, not only structure
Excessive can not cause hindering stopper propelling movement in delivery sheath, also to avoid the connector caused not because of bonding strength
Pull.
Table 1, connector size, anti-pulling-out force and propelling movement test table in delivery sheath
| Highly mm | External diameter mm | Anti-pulling-out force N | Whether obstruction pushes | |
| 1 | 2.0 | 1.8 | 6 (weak) | Do not hinder |
| 2 | 2.0 | 2.0 | 11 (weak) | Do not hinder |
| 3 | 2.0 | 2.5 | 25 (by force) | Do not hinder |
| 4 | 1.5 | 2.5 | 20 (by force) | Do not hinder |
| 5 | 1.8 | 2.8 | 31 (by force) | Do not hinder |
| 6 | 1.5 | 3.0 | 34 (by force) | Do not hinder |
| 7 | 2.0 | 3.2 | 41 (by force) | Do not hinder |
| 8 | 2.0 | 3.5 | 52 (by force) | Hinder |
Test finds, ensures that in use, connector will not be pulled when anti-pulling-out force reaches 15N.By upper table
It can be seen that the size of connector directly influences whether stopper can normally apply among operation in 1.Connector
Inappropriate size design connector can be caused to be pulled, or cannot be introduced into delivery sheath pushes, these all can
Product is caused to use.
This stopper the first mesh-covered tray is netted of continuous print, uses closing in line to close up so that outside first between its netting twine
Dropbox is the wire side of flat smooth, and without protruding, this structure is conducive to the reply of stopper shapes and support force to improve, and is more conducive to add
The endothelialization process on speed stopper surface, makes heart defect earlier be repaired by autologous tissue.Stopper of the present utility model exists
The dictyosome of the interior wire side center of the second plate-like net is connector through high-temperature hot fusion welding, specifically, by the second dish
The dictyosome at high temperature hot melt of the interior wire side center of shape net, and with mould, heat-fused portion dictyosome is shaped into connector, so
The degradable silk developed making composition plate-like net is not easy to scatter, and can be securely attached together；Simultaneously so that connector with
The degradable silk developed of composition plate-like net can be securely attached together, it is not easy to comes off.
The making of this utility model stopper is mainly through webmaster molding, connector making, dictyosome sizing and polylactic acid membrane
Sew several step.
During webmaster braiding, pin is inserted as, in the pinhole 51 of the mould rod 5 of Fig. 5, penetrated by the degradable silk that can develop
Sewing needle pin hole, knotting compact siro spinning technology.Braiding threading rule as shown in Figure 6, including connector manufacturing terminal D, closing in end B
(after molding, becoming closing in end 13) and starting point C.Closely tie a knot with the degradable silk that can develop at starting point C, during braiding uplink with
The intersection point of downlink aligns with centre mark point, with the trend of specification silk.It is fixed that woven webmaster carries out heat together with mould rod
Type.After stereotyped, pull out pin, take off webmaster.
Connector making step includes:
1, webmaster is closed up；
2, webmaster is put into mould；
3, finishing dictyosome；
4, the degradable silk that can develop is heated；
5, molding connector profile and internal whorl；
6, removal dictyosome；
Wherein, in step 1, first regulate the closing in end margin length of webmaster, make justified margin, with the degradable silk that can develop
Closing up, concrete closing in mode is as it is shown in fig. 7, including going out pin mark 61 and entry point 62, the order of threading is according in Fig. 7
Go out pin mark 61 and entry point 62 closes up.In step 2, the webmaster that will have closed up, through the sleeve pipe in mould.Step 3
In, original assembling length is stayed a part for making connector, remove the additional length of webmaster.In step 4, open temperature control
Device, adjusts temperature, facing to the degradable silk continuous heating developed at connector above mould.In step 5, continuing
After heating, the degradable silk developed of connector part is fused together, and removes attemperating unit, the cunning being then shut off in mould
Block, and the thread head of mould is inserted in the slot above mould, keep a period of time.In step 6, after cooling, by mould
Thread head rotate removal mould, and slide block is slowly removed, dictyosome is removed mould.
Additionally, in step 4, adjusting temperature is on high molecular polymer fusing point 30 DEG C-90 DEG C, continuous heating time 5-15
Second.Shown in table 2-table 4 specific as follows, in heating process, over-heating can cause other parts hot melt together of dictyosome, thus leads
Cause dictyosome is destructurized, and greatly reduces the material molecule amount of connector part, thus can cause material premature breakdown.Instead
It, heat insufficient, the degradable silk at connector can be caused to be integrated by fully hot melt, it is impossible to form complete company
Fitting female thread structure, causes connector inadequate with the bonding strength of induction system.Accordingly, it would be desirable to suitably heating-up temperature and time
Between just can complete hot melt.
The developed degradable material that table 2,70wt%L-lactide/glycolides (82/18) and 30wt% iodixanol are made
Material hot melt test table
| Heat time heating time s | Heating-up temperature DEG C | Connector hot melt situation | Other part holt melt situations | |
| 1 | 2 | 230 | Inabundant hot melt | Non-hot melt |
| 2 | 15 | 160 | Inabundant hot melt | Non-hot melt |
| 3 | 5 | 230 | Fully hot melt | Non-hot melt |
| 4 | 5 | 170 | Fully hot melt | Non-hot melt |
| 5 | 15 | 230 | Fully hot melt | Non-hot melt |
| 6 | 15 | 170 | Fully hot melt | Non-hot melt |
| 7 | 5 | 240 | Fully hot melt | Part holt melt |
| 8 | 20 | 170 | Fully hot melt | Part holt melt |
The developed degradable material hot melt test that table 3,85wt% PPDO and 15wt% iohexol are made
Table
| Heat time heating time s | Heating-up temperature DEG C | Connector hot melt situation | Other part holt melt situations | |
| 1 | 2 | 190 | Inabundant hot melt | Non-hot melt |
| 2 | 15 | 120 | Inabundant hot melt | Non-hot melt |
| 3 | 5 | 190 | Fully hot melt | Non-hot melt |
| 4 | 5 | 130 | Fully hot melt | Non-hot melt |
| 5 | 15 | 190 | Fully hot melt | Non-hot melt |
| 6 | 15 | 130 | Fully hot melt | Non-hot melt |
| 7 | 5 | 200 | Fully hot melt | Part holt melt |
| 8 | 20 | 130 | Fully hot melt | Part holt melt |
The developed degradable material heat that table 4,98wt%L-lactide/caprolactone (70/30) and 2wt% barium sulfate are made
Molten test table
| Heat time heating time s | Heating-up temperature DEG C | Connector hot melt situation | Other part holt melt situations | |
| 1 | 2 | 200 | Inabundant hot melt | Non-hot melt |
| 2 | 15 | 130 | Inabundant hot melt | Non-hot melt |
| 3 | 5 | 200 | Fully hot melt | Non-hot melt |
| 4 | 5 | 140 | Fully hot melt | Non-hot melt |
| 5 | 15 | 200 | Fully hot melt | Non-hot melt |
| 6 | 15 | 140 | Fully hot melt | Non-hot melt |
| 7 | 5 | 210 | Fully hot melt | Part holt melt |
| 8 | 20 | 140 | Fully hot melt | Part holt melt |
Dictyosome sizing includes dictyosome upper mold and dictyosome heat treatment shaping.During dictyosome upper mold, the aforementioned net with connector
Body is packed into dictyosome shaper, and fixes with fixture, it is carried out together thermal finalization, stereotyped after, by dictyosome from mould
Take out.With suture, polylactic acid membrane is packed into dictyosome, and to carry out closing at closing in end be a smooth card.
In description of the present utility model, it is to be understood that term " on ", D score, "front", "rear", "left", "right",
The orientation of the instruction such as " vertically ", " level ", " top ", " end ", " interior ", " outward " or position relationship be based on orientation shown in the drawings or
Position relationship, is for only for ease of and describes this utility model and simplify description rather than instruction or the device of hint indication or unit
Part must have specific orientation, with specific azimuth configuration and operation, therefore it is not intended that to restriction of the present utility model.
Although the foregoing describing detailed description of the invention of the present utility model, it will be appreciated by those of skill in the art that
This is merely illustrative of, and protection domain of the present utility model is defined by the appended claims.Those skilled in the art
On the premise of without departing substantially from principle of the present utility model and essence, these embodiments can be made various changes or modifications,
But these changes and amendment each fall within protection domain of the present utility model.
Claims (10)
1. the cardiac ventricular septal defect closer of a developed degradable, it is characterised in that it includes one be sequentially connected with
One plate-like net, a tubular reticulum and one second plate-like net, described first plate-like net and described second plate-like net are double-deck guard, institute
The two ends stating tubular reticulum are connected to interior wire side and the outer wire side of described second plate-like net of described first plate-like net, and described
One plate-like net, described tubular reticulum and described second plate-like net are formed in one；The interior wire side center of described second plate-like net sets
Having the connector for being closed up by wire side, described connector is become by the dictyosome hot melt of the interior wire side center of described second plate-like net
Shape forms, and the material of described first plate-like net, tubular reticulum, the second plate-like net and connector is the degradation material that can develop,
The height of described tubular reticulum is 3.5-9.5mm.
2. the cardiac ventricular septal defect closer of developed degradable as claimed in claim 1, it is characterised in that described first
Plate-like net includes that a closing in end, described closing in end are multiple ring-type netting twines adjacent successively, and described first plate-like net is additionally provided with one
Closing in line, described closing in line is arranged in all of described ring-type netting twine, described first plate-like net after described closing in line closes up
Outer wire side forms netted of continuous formation.
3. the cardiac ventricular septal defect closer of developed degradable as claimed in claim 1, it is characterised in that described connection
Part is tubulose, and the height of described connector is 1.5-2.0mm.
4. the cardiac ventricular septal defect closer of developed degradable as claimed in claim 3, it is characterised in that described connection
The external diameter of part is 2.5-3.2mm.
5. the cardiac ventricular septal defect closer of developed degradable as claimed in claim 1, it is characterised in that described second
The Intranet of plate-like net faces and caves at described connector.
6. the cardiac ventricular septal defect closer of developed degradable as claimed in claim 1, it is characterised in that described first
The external diameter of plate-like net is bigger or isometrical than the external diameter of described second plate-like net.
7. the cardiac ventricular septal defect closer of developed degradable as claimed in claim 1, it is characterised in that described tubulose
The a length of 3.5-5.5mm of net.
8. the cardiac ventricular septal defect closer of developed degradable as claimed in claim 1, it is characterised in that described tubulose
The a length of 6.0-9.5mm of net.
9. the cardiac ventricular septal defect closer of developed degradable as claimed in claim 1, it is characterised in that described first
The material of plate-like net, described tubular reticulum, described second plate-like net and described connector is the high molecular degradable silk that can develop.
10. the cardiac ventricular septal defect closer of developed degradable as claimed in claim 1, it is characterised in that described company
Fitting is tubulose, and described connector is provided with female thread in the end relative with the wire side connected.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201521139044.9U CN205697888U (en) | 2015-12-31 | 2015-12-31 | The cardiac ventricular septal defect closer of developed degradable |
| PCT/CN2016/078758 WO2017113532A1 (en) | 2015-12-31 | 2016-04-08 | Imageable and degradable occluder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201521139044.9U CN205697888U (en) | 2015-12-31 | 2015-12-31 | The cardiac ventricular septal defect closer of developed degradable |
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| Publication Number | Publication Date |
|---|---|
| CN205697888U true CN205697888U (en) | 2016-11-23 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201521139044.9U Active CN205697888U (en) | 2015-12-31 | 2015-12-31 | The cardiac ventricular septal defect closer of developed degradable |
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| CN (1) | CN205697888U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113017718A (en) * | 2019-12-25 | 2021-06-25 | 先健科技(深圳)有限公司 | Occlusion device |
| WO2024119405A1 (en) * | 2022-12-07 | 2024-06-13 | 心弦跳动生物医疗科技(青岛)有限公司 | Integrated degradable heart ventricular septal defect occluder and preparation method therefor |
-
2015
- 2015-12-31 CN CN201521139044.9U patent/CN205697888U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113017718A (en) * | 2019-12-25 | 2021-06-25 | 先健科技(深圳)有限公司 | Occlusion device |
| WO2024119405A1 (en) * | 2022-12-07 | 2024-06-13 | 心弦跳动生物医疗科技(青岛)有限公司 | Integrated degradable heart ventricular septal defect occluder and preparation method therefor |
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Address after: 15th Building, 388 Yindu Road, Xuhui District, Shanghai, 200231 Patentee after: Shanghai Jinkui Medical Devices Co., Ltd. Address before: Room 102, D Workshop, 1618 Yishan Road, Minhang District, Shanghai, 201103 Patentee before: Shanghai Jinkui Medical Implements Co., Ltd. |
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